James V Jester

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction
    James V Jester
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Exp Eye Res 77:581-92. 2003
  2. ncbi request reprint Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts
    James V Jester
    Departments of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Invest Ophthalmol Vis Sci 44:1850-8. 2003
  3. ncbi request reprint TGFbeta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGFbeta, PDGF and integrin signaling
    James V Jester
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Exp Eye Res 75:645-57. 2002
  4. ncbi request reprint Regulation of Pseudomonas aeruginosa internalization after contact lens wear in vivo and in serum-free culture by ocular surface cells
    Naoka Yamamoto
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Invest Ophthalmol Vis Sci 47:3430-40. 2006
  5. pmc Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells
    Brant R Ward
    Department of Dermatology, University of Texas South Western Medical Center, Dallas, TX, USA
    Immunology 120:556-72. 2007
  6. ncbi request reprint Current concepts: contact lens related Pseudomonas keratitis
    Danielle M Robertson
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Cont Lens Anterior Eye 30:94-107. 2007
  7. ncbi request reprint Prolonged hypoxia induces lipid raft formation and increases Pseudomonas internalization in vivo after contact lens wear and lid closure
    Nobutaka Yamamoto
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, 75039 9057, USA
    Eye Contact Lens 32:114-20. 2006
  8. ncbi request reprint Postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1
    James V Jester
    Department of Ophthalmology, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 48:4061-9. 2007
  9. ncbi request reprint Targeted expression of a lumican transgene rescues corneal deficiencies in lumican-null mice
    Johanna T A Meij
    Department of Ophthalmology, University of Cincinnati, Cincinnati, OH, USA
    Mol Vis 13:2012-8. 2007
  10. ncbi request reprint Effects of eyelid closure and disposable and silicone hydrogel extended contact lens wear on rabbit corneal epithelial proliferation
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039 9057, USA
    Invest Ophthalmol Vis Sci 44:1843-9. 2003

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction
    James V Jester
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Exp Eye Res 77:581-92. 2003
    ..We further establish that changes in environmental conditions modulate the keratocyte phenotype resulting in physiologically functional differences regarding cell contractility and capacity to contract extracellular matrix...
  2. ncbi request reprint Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts
    James V Jester
    Departments of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Invest Ophthalmol Vis Sci 44:1850-8. 2003
    ..The purpose of this study was to determine whether TGFbeta induces myofibroblast differentiation in cultured human keratocytes and in telomerase (hTERT)-immortalized human corneal fibroblast cell lines...
  3. ncbi request reprint TGFbeta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGFbeta, PDGF and integrin signaling
    James V Jester
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Exp Eye Res 75:645-57. 2002
    ..Additionally, the similar TGFbeta1 temporal response of PDGF-stimulated compared to nai;ve keratocytes suggests that myofibroblast differentiation does not require transition through a fibroblast phenotype...
  4. ncbi request reprint Regulation of Pseudomonas aeruginosa internalization after contact lens wear in vivo and in serum-free culture by ocular surface cells
    Naoka Yamamoto
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Invest Ophthalmol Vis Sci 47:3430-40. 2006
    ....
  5. pmc Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells
    Brant R Ward
    Department of Dermatology, University of Texas South Western Medical Center, Dallas, TX, USA
    Immunology 120:556-72. 2007
    ..Our results demonstrate rapid cytokine-mediated behavioural responses by LCs to local tissue injury, providing new insights into the biology of LCs...
  6. ncbi request reprint Current concepts: contact lens related Pseudomonas keratitis
    Danielle M Robertson
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Cont Lens Anterior Eye 30:94-107. 2007
    ..Non-toxic blockade of raft formation in vitro or in vivo effectively abrogates PA internalization and may represent a unique, new strategy to prevent or ameliorate lens-related PA microbial keratitis...
  7. ncbi request reprint Prolonged hypoxia induces lipid raft formation and increases Pseudomonas internalization in vivo after contact lens wear and lid closure
    Nobutaka Yamamoto
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, 75039 9057, USA
    Eye Contact Lens 32:114-20. 2006
    ..To investigate the effects of hypoxia on lipid raft formation and Pseudomonas aeruginosa internalization by the corneal epithelium with and without the physical effects of contact lens wear...
  8. ncbi request reprint Postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1
    James V Jester
    Department of Ophthalmology, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 48:4061-9. 2007
    ..The purpose of this study was to determine the relationship between the expression of these proteins and the development of postnatal corneal transparency...
  9. ncbi request reprint Targeted expression of a lumican transgene rescues corneal deficiencies in lumican-null mice
    Johanna T A Meij
    Department of Ophthalmology, University of Cincinnati, Cincinnati, OH, USA
    Mol Vis 13:2012-8. 2007
    ..To investigate whether targeted expression of lumican in the mouse cornea rescued the Lum(-/-) phenotype...
  10. ncbi request reprint Effects of eyelid closure and disposable and silicone hydrogel extended contact lens wear on rabbit corneal epithelial proliferation
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039 9057, USA
    Invest Ophthalmol Vis Sci 44:1843-9. 2003
    ..To examine the rabbit corneal epithelial cell proliferation rate after extended wear of disposable or silicone hydrogel contact lenses or prolonged eyelid closure...
  11. ncbi request reprint Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Invest Ophthalmol Vis Sci 46:470-8. 2005
    ..To develop and characterize a telomerase-immortalized human corneal epithelial cell line (hTCEpi) to serve as an in vitro model for studying the molecular mechanisms involved in regulating human corneal epithelial cell differentiation...
  12. ncbi request reprint Effects of O2 transmissibility on corneal epithelium after daily and extended contact lens wear in rabbit and man
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Adv Exp Med Biol 506:885-93. 2002
  13. ncbi request reprint Effects of daily and overnight wear of a novel hyper oxygen-transmissible soft contact lens on bacterial binding and corneal epithelium: a 13-month clinical trial
    H Dwight Cavanagh
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Ophthalmology 109:1957-69. 2002
    ..To test prospectively a new biologic rationale for an advanced hyper oxygen-transmissible lens (HOTL) providing prospects for safer daily (DW) or extended (EW) contact lens wear...
  14. ncbi request reprint Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 32:3-7. 2006
    ....
  15. ncbi request reprint Recovery time of corneal epithelial proliferation in the rabbit following rigid gas-permeable extended contact-lens wear
    Patrick M Ladage
    Department of Opthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039 9057, USA
    Eye Contact Lens 29:61-4. 2003
    ..To determine recovery time needed for the corneal epithelium to return to a normal proliferation rate following 24-hour rigid gas-permeable (RGP) lens wear...
  16. ncbi request reprint Vertical movement of epithelial basal cells toward the corneal surface during use of extended-wear contact lenses
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039 9057, USA
    Invest Ophthalmol Vis Sci 44:1056-63. 2003
    ..To study the effects of extended contact lens wear (EW) on the movement of basal epithelial cells toward the corneal surface...
  17. ncbi request reprint Annexin V binding to rabbit corneal epithelial cells following overnight contact lens wear or eyelid closure
    Ling Li
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 75390 9057, USA
    CLAO J 28:48-54. 2002
    ..To determine the effects of open or closed eye and overnight contact lens wear on rabbit corneal epithelial surface cell death, detected by annexin V binding to cell surface phosphatidylserine and propidium iodide (PI) double-labeling...
  18. ncbi request reprint The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and pseudomonas binding to corneal cells: an overview
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:394-8; discussion 399-400. 2007
    ..Significantly, hyper-oxygen-transmissible lenses in any wearing mode with non-preserved care solutions appear to offer the safest potential clinical choice for contact lens wear...
  19. pmc Corneal keratocytes: phenotypic and species differences in abundant protein expression and in vitro light-scattering
    James V Jester
    Department of Ophthalmology, University of California at Irvine, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 46:2369-78. 2005
    ..The purpose of this study was to determine the protein expression pattern of keratocytes from different species and different cultured rabbit keratocyte phenotypes and to assess differences in light-scattering in vitro...
  20. ncbi request reprint Modulation of corneal fibroblast contractility within fibrillar collagen matrices
    Mridula Vishwanath
    Department of Ophthalmology, Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 44:4724-35. 2003
    ..To investigate the migratory and contractile behavior of isolated human corneal fibroblasts in fibrillar collagen matrices...
  21. ncbi request reprint Effects of daily and overnight wear of hyper-oxygen transmissible rigid and silicone hydrogel lenses on bacterial binding to the corneal epithelium: 13-month clinical trials
    H Dwight Cavanagh
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Eye Contact Lens 29:S14-6; discussion S26-9, S192-4. 2003
    ..Is this a great advance or another clinical triumph of hope over experience? What should the public know? What should patients do?..
  22. ncbi request reprint Pseudomonas aeruginosa corneal binding after 24-hour orthokeratology lens wear
    Patrick M Ladage
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 30:173-8. 2004
    ..To examine the effect of short-term 24-hr orthokeratology lens (OKL) wear on Pseudomonas aeruginosa binding, epithelial surface cell morphology, epithelial sheet thickness, and stromal thickness in a rabbit model...
  23. ncbi request reprint Dynamic three-dimensional visualization of collagen matrix remodeling and cytoskeletal organization in living corneal fibroblasts
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Scanning 26:1-10. 2004
    ..Overall, the continued development and application of this new approach should provide important insights into the basic underlying biochemical and biomechanical regulatory mechanisms controlling matrix remodeling by corneal fibroblasts...
  24. pmc Castroviejo Lecture 2009: 40 years in search of the perfect contact lens
    H Dwight Cavanagh
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Cornea 29:1075-85. 2010
    ....
  25. ncbi request reprint Role of oxygen in corneal epithelial homeostasis during extended contact lens wear
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 29:S2-6; discussion S26-9, S192-4. 2003
  26. ncbi request reprint Spherical indentations of human and rabbit corneal epithelium following extended contact lens wear
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Texas 75390 9057, USA
    CLAO J 28:177-80. 2002
    ..The purpose of this report is to describe and quantify these spherical indentations, as examined in the human cornea by in vivo confocal microscopy and by in vitro immunocytochemistry in the rabbit cornea...
  27. ncbi request reprint Can postlens tear thickness be measured using three-dimensional in vivo confocal microscopy?
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 29:S110-4; discussion S115-8, S192-4. 2003
    ..This study investigated the feasibility of using in vivo CMTF to measure postlens tear thickness (PLTT)...
  28. ncbi request reprint Effects of contact lens care solutions on surface exfoliation and bacterial binding to corneal epithelial cells
    Susanna L Li
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9057, USA
    Eye Contact Lens 29:27-30. 2003
    ..The purpose of this study is to assess the effects of commercially available contact lens wetting solutions on bacterial binding and cell exfoliation rates in human corneal epithelium...
  29. ncbi request reprint Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390 9057, USA
    J Cell Sci 116:1481-91. 2003
    ..Our results are consistent with the previously described 'frontal towing' model of cell motility and demonstrate for the first time that this mechanism is employed by cells interacting with a fibrillar extracellular matrix...
  30. ncbi request reprint Effect of eyelid closure and overnight contact lens wear on viability of surface epithelial cells in rabbit cornea
    Kazuaki Yamamoto
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 75390 9057, USA
    Cornea 21:85-90. 2002
    ..To determine the effects of open, closed eye, and overnight contact lens wear on homeostatic epithelial surface cell death in the rabbit cornea...
  31. ncbi request reprint Evaluation of the corneal effects of topical ophthalmic fluoroquinolones using in vivo confocal microscopy
    Timmy A Kovoor
    University of Texas Southwestern Medical School, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eye Contact Lens 30:90-4. 2004
    ..To compare the effects of several fluoroquinolone antibiotics on the corneal epithelium and stroma using in vivo confocal microscopy...
  32. ncbi request reprint In vivo fluorescent labeling of corneal wound healing fibroblasts
    Joel Gatlin
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Exp Eye Res 76:361-71. 2003
    ..Our data further suggest that, in vivo, wound-healing fibroblasts have a defined life span within the wound...
  33. pmc Neonatal corneal stromal development in the normal and lumican-deficient mouse
    Julia Song
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Invest Ophthalmol Vis Sci 44:548-57. 2003
    ..The purpose of this study was to characterize temporally stromal growth and transparency in lumican-deficient and normal neonatal mice...
  34. ncbi request reprint Internalization of Pseudomonas aeruginosa is mediated by lipid rafts in contact lens-wearing rabbit and cultured human corneal epithelial cells
    Naoka Yamamoto
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Invest Ophthalmol Vis Sci 46:1348-55. 2005
    ..The purpose of this study was to investigate the role of lipid rafts in PA internalization by corneal epithelium in vivo, in vitro, and after contact lens wear...
  35. pmc Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea
    Yujin Zhang
    Department of Ophthalmology, College of Medicine, University of Cincinnati, Crawley Vision Research Center, Cincinnati, OH 45267 0838, USA
    J Cell Sci 123:1285-94. 2010
    ..Taken together, these results argue that beta-catenin activation is a crucial step during OSSN pathogenesis. Thus, inhibition of beta-catenin might be beneficial for treating this disease...
  36. ncbi request reprint In vivo confocal microscopy through-focusing to measure corneal flap thickness after laser in situ keratomileusis
    Fusun Gokmen
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, USA
    J Cataract Refract Surg 28:962-70. 2002
    ....
  37. ncbi request reprint Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli
    Akiko Nishibu
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Invest Dermatol 126:787-96. 2006
    ..These observations introduce a new concept that in situ maturation of LCs is further accompanied by coordinated reprogramming of motile activities...
  38. ncbi request reprint A prototype two-detector confocal microscope for in vivo corneal imaging
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75390 9057, USA
    Scanning 24:163-70. 2002
    ..Thus, the instrument has the potential for improving corneal pachymetry and back-scattering measurements while still providing high-resolution corneal images...
  39. pmc Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican
    Eric C Carlson
    Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45267 0527, USA
    J Biol Chem 280:25541-7. 2005
    ..The results also suggest a critical level of small proteoglycans to be essential for collagen organization but that overabundance is not detrimental to extracellular matrix morphogenesis...
  40. ncbi request reprint Quantitative assessment of ophthalmic viscosurgical device retention using in vivo confocal microscopy
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    J Cataract Refract Surg 31:2363-8. 2005
    ..To develop and apply a new laboratory method for in vivo quantitative assessment of the retention of ophthalmic viscosurgical devices (OVDs) following phacoemulsification...
  41. ncbi request reprint Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: an analysis of postoperative keratolysis
    Sylvia L Hargrave
    Department of Ophthalmology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    Ophthalmology 109:343-50. 2002
    ..To analyze tissue matrix metalloproteinase (MMP) expression in three patients who developed postoperative corneal melts after treatment with topical diclofenac sodium 0.1% (Falcon; Fort Worth, TX) ophthalmic solution...
  42. pmc Evaluating corneal collagen organization using high-resolution nonlinear optical macroscopy
    James V Jester
    Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine Medical Center, Orange, CA, USA
    Eye Contact Lens 36:260-4. 2010
    ..The purpose of this report is to review our efforts to greatly extend the field of view to assess the entire collagen structure using high-resolution macroscopic (HRMac) imaging...
  43. ncbi request reprint Hair follicles serve as local reservoirs of skin mast cell precursors
    Tadashi Kumamoto
    Department of Dermatology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Blood 102:1654-60. 2003
    ..These results, together with our findings that HFs contain c-kit+ cells and produce SCF mRNA and protein, suggest that HFs provide a unique microenvironment for local development of mast cells...
  44. ncbi request reprint Adaptive effects of 30-night wear of hyper-O(2) transmissible contact lenses on bacterial binding and corneal epithelium: a 1-year clinical trial
    David H Ren
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Ophthalmology 109:27-39; discussion 39-40. 2002
    ..To determine effects of lens type and oxygen transmissibility on human corneal epithelium during extended wear (EW)...
  45. pmc Corneal response to femtosecond laser photodisruption in the rabbit
    Naoyuki Morishige
    The Eye Institute, University of California at Irvine, Medical Center, Orange, CA 92868, USA
    Exp Eye Res 86:835-43. 2008
    ..However, a thicker stromal interface was seen with the higher energy suggesting greater stromal damage...
  46. pmc Corneal crystallins and the development of cellular transparency
    James V Jester
    The Eye Institute, University of California Irvine, Orange, CA 92868, USA
    Semin Cell Dev Biol 19:82-93. 2008
    ..e. keratocytes, that support a structural role for corneal crystallins in the development of transparency similar to that of lens crystallins that would be consistent with the 'refracton' hypothesis...
  47. doi request reprint Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation
    Marjan Farid
    Gavin S Herbert Eye Institute, University of California, Irvine Medical Center, Orange, California 92868, USA
    Invest Ophthalmol Vis Sci 49:4377-83. 2008
    ..The purpose of this study was to assess whether SHG signals can detect differences in corneal fibrosis after excimer laser surface ablation (photorefractive keratectomy [PRK])...
  48. ncbi request reprint Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration
    Royce Mohan
    New England Eye Center, Tufts University School of Medicine, and the Tufts Center for Vision Research, Boston, Massachusetts 02111, USA
    J Biol Chem 277:2065-72. 2002
    ..We conclude that gelB coordinates and effects multiple events involved in the process of epithelial regeneration...
  49. ncbi request reprint Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling
    Eric Huet
    CRRET Laboratory, CNRS UMR 7149, University Paris XII, 61 av du General de Gaulle, 94010 Creteil Cedex, France
    FASEB J 22:1144-54. 2008
    ..These findings, combined with the fact that EMMPRIN and alphaSMA colocalized to the same cells in the stroma of pathological corneas, expand on the mechanism by which EMMPRIN remodels extracellular matrix during wound healing and cancer...
  50. ncbi request reprint The corneas of naive mice contain both CD4+ and CD8+ T cells
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Cedars Sinai Medical Center Burns and Allen Research Institute, Los Angeles, CA 90272, USA
    Mol Vis 13:1802-12. 2007
    ..To determine if the corneas of naive mice contain resident CD4+ and CD8+ T cells...
  51. pmc Second-harmonic imaging microscopy of normal human and keratoconus cornea
    Naoyuki Morishige
    The Eye Institute, School of Medicine, University of California Irvine Medical Center, Orange, California
    Invest Ophthalmol Vis Sci 48:1087-94. 2007
    ..The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas...
  52. pmc Noninvasive corneal stromal collagen imaging using two-photon-generated second-harmonic signals
    Naoyuki Morishige
    The Eye Institute, University of California, Irvine Medical Center, Irvine, California, USA
    J Cataract Refract Surg 32:1784-91. 2006
    ..To investigate the feasibility of using femtosecond-pulse lasers to produce second-harmonic generated (SHG) signals to noninvasively assess corneal stromal collagen organization...
  53. ncbi request reprint Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 41:1459-69. 2006
    ..g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant...
  54. ncbi request reprint Extent of corneal injury as a biomarker for hazard assessment and the development of alternative models to the Draize rabbit eye test
    James V Jester
    Eye Institute, University of California at Irvine, Irvine, California 92868 4380, USA
    Cutan Ocul Toxicol 25:41-54. 2006
    ..Overall, these findings indicate that extent of initial corneal injury can be used as a new "gold standard" for the continued refinement and ultimate replacement of the Draize rabbit eye Ocular Irritation Test...
  55. pmc A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
    Lin Zhang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    EMBO J 22:4443-54. 2003
    ..This study also suggests that the signaling mechanisms that control eyelid closure in mammals and dorsal closure in Drosophila are evolutionarily conserved...
  56. pmc Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection
    Anthony B Nesburn
    Cellular and Molecular Immunology Laboratory, The Eye Institute, University of California, Irvine, CA 92697 4375, USA
    J Virol 81:7647-61. 2007
    ..It remains to be determined whether conjunctiva CD4(+) CD25(+) nT(reg) cells affect the topical/mucosal delivery of subunit vaccines that stimulate the ocular mucosal immune system...
  57. ncbi request reprint Herpes simplex virus type 1 ICP0 localizes in the stromal layer of infected rabbit corneas and resides predominantly in the cytoplasm and/or perinuclear region of rabbit keratocytes
    Naoyuki Morishige
    The Eye Institute, University of California at Irvine, School of Medicine, Irvine, CA 92697, USA
    J Gen Virol 87:2817-25. 2006
    ..These findings provide new data demonstrating that anterior corneal keratocytes become infected and express ICP0 during acute HSV-1 infection...
  58. ncbi request reprint Extent of initial corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays
    James K Maurer
    The Procoter and Gamble Company, Cincinati, Ohio, USA
    Regul Toxicol Pharmacol 36:106-17. 2002
    ..This work also provides a well-characterized panel of materials of varying types and irritation for use in developing and validating alternative tests...