JAMES JESTER

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Wakayama Symposium: Peroxisome Proliferator-Activated Receptor-Gamma (PPARĪ³) and Meibomian Gland Dysfunction
    James V Jester
    The Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, USA Electronic address
    Ocul Surf 10:224-9. 2012
  2. ncbi Quiescent keratocytes fail to repair MMC induced DNA damage leading to the long-term inhibition of myofibroblast differentiation and wound healing
    James V Jester
    Gavin Herbert Eye Institute, University of California Irvine, CA, USA
    Mol Vis 18:1828-39. 2012
  3. ncbi Myofibroblast differentiation modulates keratocyte crystallin protein expression, concentration, and cellular light scattering
    James V Jester
    Gavin Herbert Eye Institute, University of California, Irvine, Irvine, California 92697, USA
    Invest Ophthalmol Vis Sci 53:770-8. 2012
  4. ncbi Corneal keratocytes: phenotypic and species differences in abundant protein expression and in vitro light-scattering
    James V Jester
    Department of Ophthalmology, University of California at Irvine, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 46:2369-78. 2005
  5. ncbi Extent of corneal injury as a biomarker for hazard assessment and the development of alternative models to the Draize rabbit eye test
    James V Jester
    Eye Institute, University of California at Irvine, Irvine, California 92868 4380, USA
    Cutan Ocul Toxicol 25:41-54. 2006
  6. ncbi Postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1
    James V Jester
    Department of Ophthalmology, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 48:4061-9. 2007
  7. ncbi Corneal crystallins and the development of cellular transparency
    James V Jester
    The Eye Institute, University of California Irvine, Orange, CA 92868, USA
    Semin Cell Dev Biol 19:82-93. 2008
  8. ncbi Assessing ocular irritation potential using a modified ex vivo rabbit eye test
    James V Jester
    Gavin Herbert Eye Institute and Department of Biomedical Engineering, University of California, Irvine, Orange, 92868, USA
    Cutan Ocul Toxicol 28:32-6. 2009
  9. ncbi Evaluating corneal collagen organization using high-resolution nonlinear optical macroscopy
    James V Jester
    Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine Medical Center, Orange, CA, USA
    Eye Contact Lens 36:260-4. 2010
  10. ncbi Measuring depth of injury (DOI) in an isolated rabbit eye irritation test (IRE) using biomarkers of cell death and viability
    James V Jester
    Gavin Herbert Eye Institute, University of California Irvine School of Medicine, Orange, CA, United States
    Toxicol In Vitro 24:597-604. 2010

Research Grants

  1. KERATOCYTE CRYSTALLIN PROTEINS AND CORNEAL TRANSPARENCY
    JAMES JESTER; Fiscal Year: 2003
  2. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    JAMES JESTER; Fiscal Year: 2005
  3. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    JAMES JESTER; Fiscal Year: 2006
  4. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    JAMES JESTER; Fiscal Year: 2007
  5. MYOFIBROBLASTS AND CORNEAL WOUND CONTRACTION
    JAMES JESTER; Fiscal Year: 1993
  6. MODULATION OF CORNEAL CURVATURE DURING WOUND HEALING
    JAMES JESTER; Fiscal Year: 1991
  7. REGULATION OF CORNEAL MYOFIBROBLAST TRANSFORMATION
    JAMES JESTER; Fiscal Year: 2000
  8. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010

Collaborators

Detail Information

Publications69

  1. ncbi Wakayama Symposium: Peroxisome Proliferator-Activated Receptor-Gamma (PPARĪ³) and Meibomian Gland Dysfunction
    James V Jester
    The Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, USA Electronic address
    Ocul Surf 10:224-9. 2012
    ....
  2. ncbi Quiescent keratocytes fail to repair MMC induced DNA damage leading to the long-term inhibition of myofibroblast differentiation and wound healing
    James V Jester
    Gavin Herbert Eye Institute, University of California Irvine, CA, USA
    Mol Vis 18:1828-39. 2012
    ..The purpose of this study was to determine the acute and long-term effects of mitomycin C (MMC) on quiescent rabbit corneal keratocytes regarding cell proliferation, myofibroblast differentiation and DNA repair...
  3. ncbi Myofibroblast differentiation modulates keratocyte crystallin protein expression, concentration, and cellular light scattering
    James V Jester
    Gavin Herbert Eye Institute, University of California, Irvine, Irvine, California 92697, USA
    Invest Ophthalmol Vis Sci 53:770-8. 2012
    ..The purpose of this study was to determine whether myofibroblast differentiation altered keratocyte crystallin protein concentration and increased cellular light scattering...
  4. ncbi Corneal keratocytes: phenotypic and species differences in abundant protein expression and in vitro light-scattering
    James V Jester
    Department of Ophthalmology, University of California at Irvine, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 46:2369-78. 2005
    ..The purpose of this study was to determine the protein expression pattern of keratocytes from different species and different cultured rabbit keratocyte phenotypes and to assess differences in light-scattering in vitro...
  5. ncbi Extent of corneal injury as a biomarker for hazard assessment and the development of alternative models to the Draize rabbit eye test
    James V Jester
    Eye Institute, University of California at Irvine, Irvine, California 92868 4380, USA
    Cutan Ocul Toxicol 25:41-54. 2006
    ..Overall, these findings indicate that extent of initial corneal injury can be used as a new "gold standard" for the continued refinement and ultimate replacement of the Draize rabbit eye Ocular Irritation Test...
  6. ncbi Postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1
    James V Jester
    Department of Ophthalmology, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 48:4061-9. 2007
    ..The purpose of this study was to determine the relationship between the expression of these proteins and the development of postnatal corneal transparency...
  7. ncbi Corneal crystallins and the development of cellular transparency
    James V Jester
    The Eye Institute, University of California Irvine, Orange, CA 92868, USA
    Semin Cell Dev Biol 19:82-93. 2008
    ..e. keratocytes, that support a structural role for corneal crystallins in the development of transparency similar to that of lens crystallins that would be consistent with the 'refracton' hypothesis...
  8. ncbi Assessing ocular irritation potential using a modified ex vivo rabbit eye test
    James V Jester
    Gavin Herbert Eye Institute and Department of Biomedical Engineering, University of California, Irvine, Orange, 92868, USA
    Cutan Ocul Toxicol 28:32-6. 2009
    ..We conclude that this modified ex vivo rabbit eye test using the live/dead assay may be a useful model for developing ocular irritation assays...
  9. ncbi Evaluating corneal collagen organization using high-resolution nonlinear optical macroscopy
    James V Jester
    Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine Medical Center, Orange, CA, USA
    Eye Contact Lens 36:260-4. 2010
    ..The purpose of this report is to review our efforts to greatly extend the field of view to assess the entire collagen structure using high-resolution macroscopic (HRMac) imaging...
  10. ncbi Measuring depth of injury (DOI) in an isolated rabbit eye irritation test (IRE) using biomarkers of cell death and viability
    James V Jester
    Gavin Herbert Eye Institute, University of California Irvine School of Medicine, Orange, CA, United States
    Toxicol In Vitro 24:597-604. 2010
    ..007) correlation (r=0.785). These data suggest that fluorescent staining of fixed and sectioned tissue using biomarkers can be used to objectively identify the depth of injury caused by ocular irritants...
  11. ncbi Neonatal corneal stromal development in the normal and lumican-deficient mouse
    Julia Song
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Invest Ophthalmol Vis Sci 44:548-57. 2003
    ..The purpose of this study was to characterize temporally stromal growth and transparency in lumican-deficient and normal neonatal mice...
  12. ncbi Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Invest Ophthalmol Vis Sci 46:470-8. 2005
    ..Further study of the hTCEpi cell line may be valuable in studying the molecular mechanisms regulating corneal epithelial cell differentiation and desquamation...
  13. ncbi Current concepts: contact lens related Pseudomonas keratitis
    Danielle M Robertson
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Cont Lens Anterior Eye 30:94-107. 2007
    ..Non-toxic blockade of raft formation in vitro or in vivo effectively abrogates PA internalization and may represent a unique, new strategy to prevent or ameliorate lens-related PA microbial keratitis...
  14. ncbi Corneal response to femtosecond laser photodisruption in the rabbit
    Naoyuki Morishige
    The Eye Institute, University of California at Irvine, Medical Center, Orange, CA 92868, USA
    Exp Eye Res 86:835-43. 2008
    ..However, a thicker stromal interface was seen with the higher energy suggesting greater stromal damage...
  15. ncbi PLGA micro/nanosphere synthesis by droplet microfluidic solvent evaporation and extraction approaches
    Lung Hsin Hung
    Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA 92697 3940, USA
    Lab Chip 10:1820-5. 2010
    ..With the ability to prepare high quality, monodisperse, biodegradable particles, our methods have great potential to benefit drug delivery applications...
  16. ncbi Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation
    Marjan Farid
    Gavin S Herbert Eye Institute, University of California, Irvine Medical Center, Orange, California 92868, USA
    Invest Ophthalmol Vis Sci 49:4377-83. 2008
    ..The purpose of this study was to assess whether SHG signals can detect differences in corneal fibrosis after excimer laser surface ablation (photorefractive keratectomy [PRK])...
  17. ncbi Application of second harmonic imaging microscopy to assess structural changes in optic nerve head structure ex vivo
    Donald J Brown
    University of California, Irvine, School of Medicine, The Eye Institute, Orange, California 92868, USA
    J Biomed Opt 12:024029. 2007
    ....
  18. ncbi Dynamic three-dimensional visualization of collagen matrix remodeling and cytoskeletal organization in living corneal fibroblasts
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Scanning 26:1-10. 2004
    ..Overall, the continued development and application of this new approach should provide important insights into the basic underlying biochemical and biomechanical regulatory mechanisms controlling matrix remodeling by corneal fibroblasts...
  19. ncbi Vertical movement of epithelial basal cells toward the corneal surface during use of extended-wear contact lenses
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039-9057, USA
    Invest Ophthalmol Vis Sci 44:1056-63. 2003
    ..Overall, the data suggest that EW lenses significantly inhibit the normal homeostatic turnover rate of the corneal epithelium...
  20. ncbi High resolution three-dimensional reconstruction of the collagenous matrix of the human optic nerve head
    Moritz Winkler
    The Gavin Herbert Eye Institute, University of California, Irvine, 101 The City Drive, Orange, CA 92868, USA
    Brain Res Bull 81:339-48. 2010
    ..Further application of this technique will help characterize the relationship of age, race and gender on the morphology of the LC...
  21. ncbi TGFbeta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGFbeta, PDGF and integrin signaling
    James V Jester
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Exp Eye Res 75:645-57. 2002
    ..Additionally, the similar TGFbeta1 temporal response of PDGF-stimulated compared to nai;ve keratocytes suggests that myofibroblast differentiation does not require transition through a fibroblast phenotype...
  22. ncbi Spherical indentations of human and rabbit corneal epithelium following extended contact lens wear
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Texas 75390-9057, USA
    CLAO J 28:177-80. 2002
    ..Surprisingly, stromal cells immediately beneath the holes were stimulated to proliferate, and there seemed to be an increase in localized cell density...
  23. ncbi Regulation of Pseudomonas aeruginosa internalization after contact lens wear in vivo and in serum-free culture by ocular surface cells
    Naoka Yamamoto
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Invest Ophthalmol Vis Sci 47:3430-40. 2006
    ....
  24. ncbi Can postlens tear thickness be measured using three-dimensional in vivo confocal microscopy?
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 29:S110-4; discussion S115-8, S192-4. 2003
    ..This study investigated the feasibility of using in vivo CMTF to measure postlens tear thickness (PLTT)...
  25. ncbi Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390 9057, USA
    J Cell Sci 116:1481-91. 2003
    ..Our results are consistent with the previously described 'frontal towing' model of cell motility and demonstrate for the first time that this mechanism is employed by cells interacting with a fibrillar extracellular matrix...
  26. ncbi Effects of eyelid closure and disposable and silicone hydrogel extended contact lens wear on rabbit corneal epithelial proliferation
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039-9057, USA
    Invest Ophthalmol Vis Sci 44:1843-9. 2003
    ..The effects of lens wear and eyelid suturing on the cell proliferation rate in contralateral control eyes suggests a central mechanism that regulates corneal epithelial proliferation...
  27. ncbi Noninvasive corneal stromal collagen imaging using two-photon-generated second-harmonic signals
    Naoyuki Morishige
    The Eye Institute, University of California, Irvine Medical Center, Irvine, California, USA
    J Cataract Refract Surg 32:1784-91. 2006
    ..Human corneas had a unique organizational pattern with sutural lamellae to provide important biomechanical support that was not present in mouse or rabbit corneas...
  28. ncbi Prolonged hypoxia induces lipid raft formation and increases Pseudomonas internalization in vivo after contact lens wear and lid closure
    Nobutaka Yamamoto
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, 75039-9057, USA
    Eye Contact Lens 32:114-20. 2006
    ..However, different distribution patterns of lipid raft-forming cells suggest physical effects of contact lens wear may direct localization of lipid raft-associated P. aeruginosa internalization on the corneal surface...
  29. ncbi Second-harmonic imaging microscopy of normal human and keratoconus cornea
    Naoyuki Morishige
    The Eye Institute, School of Medicine, University of California Irvine Medical Center, Orange, California
    Invest Ophthalmol Vis Sci 48:1087-94. 2007
    ..The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas...
  30. ncbi Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 32:3-7. 2006
    ....
  31. ncbi Targeted expression of a lumican transgene rescues corneal deficiencies in lumican-null mice
    Johanna T A Meij
    Department of Ophthalmology, University of Cincinnati, Cincinnati, OH, USA
    Mol Vis 13:2012-8. 2007
    ..To investigate whether targeted expression of lumican in the mouse cornea rescued the Lum(-/-) phenotype...
  32. ncbi In vivo confocal microscopy through-focusing to measure corneal flap thickness after laser in situ keratomileusis
    Fusun Gokmen
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, USA
    J Cataract Refract Surg 28:962-70. 2002
    ..The findings emphasize the importance of performing thickness measurements and the usefulness of in vivo CMTF in making these determinations to ensure the safety and effectiveness of LASIK...
  33. ncbi Effect of eyelid closure and overnight contact lens wear on viability of surface epithelial cells in rabbit cornea
    Kazuaki Yamamoto
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 75390-9057, USA
    Cornea 21:85-90. 2002
    ....
  34. ncbi Annexin V binding to rabbit corneal epithelial cells following overnight contact lens wear or eyelid closure
    Ling Li
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 75390-9057, USA
    CLAO J 28:48-54. 2002
    ..However, under very low oxygen tensions combined with lens effect, such as in low Dk/t RGP lens wear, surface cell death may be accelerated...
  35. ncbi Modulation of corneal fibroblast contractility within fibrillar collagen matrices
    Mridula Vishwanath
    Department of Ophthalmology, Southwestern Medical Center, Dallas, Texas 75390-9057, USA
    Invest Ophthalmol Vis Sci 44:4724-35. 2003
    ..Sarcomeric shortening of stress fibers in contracting corneal fibroblasts is also demonstrated for the first time...
  36. ncbi Pseudomonas aeruginosa corneal binding after 24-hour orthokeratology lens wear
    Patrick M Ladage
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390-9057, USA
    Eye Contact Lens 30:173-8. 2004
    ..Future studies are needed to determine whether these results are similar in human wear and how P. aeruginosa binding during OKL wear compares with other lens-wearing modalities, such as daily or continuous soft lens wear...
  37. ncbi A prototype two-detector confocal microscope for in vivo corneal imaging
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75390 9057, USA
    Scanning 24:163-70. 2002
    ..Thus, the instrument has the potential for improving corneal pachymetry and back-scattering measurements while still providing high-resolution corneal images...
  38. ncbi Effects of O2 transmissibility on corneal epithelium after daily and extended contact lens wear in rabbit and man
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Adv Exp Med Biol 506:885-93. 2002
  39. ncbi The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and pseudomonas binding to corneal cells: an overview
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:394-8; discussion 399-400. 2007
    ..Significantly, hyper-oxygen-transmissible lenses in any wearing mode with non-preserved care solutions appear to offer the safest potential clinical choice for contact lens wear...
  40. ncbi Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea
    Yujin Zhang
    Department of Ophthalmology, College of Medicine, University of Cincinnati, Crawley Vision Research Center, Cincinnati, OH 45267 0838, USA
    J Cell Sci 123:1285-94. 2010
    ..Taken together, these results argue that beta-catenin activation is a crucial step during OSSN pathogenesis. Thus, inhibition of beta-catenin might be beneficial for treating this disease...
  41. ncbi Effects of contact lens care solutions on surface exfoliation and bacterial binding to corneal epithelial cells
    Susanna L Li
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9057, USA
    Eye Contact Lens 29:27-30. 2003
    ....
  42. ncbi A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes
    Aziz A Chentoufi
    Laboratory of Cellular and Molecular Immunology, The Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA
    J Immunol 184:2561-71. 2010
    ..The relevance of HLA Tg rabbits for future investigation of human CD4-CD8 epitope-based therapeutic vaccines against recurrent HSV-1 is discussed...
  43. ncbi Adaptive effects of 30-night wear of hyper-O(2) transmissible contact lenses on bacterial binding and corneal epithelium: a 1-year clinical trial
    David H Ren
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA
    Ophthalmology 109:27-39; discussion 39-40. 2002
    ....
  44. ncbi Herpes simplex virus type 1 ICP0 localizes in the stromal layer of infected rabbit corneas and resides predominantly in the cytoplasm and/or perinuclear region of rabbit keratocytes
    Naoyuki Morishige
    The Eye Institute, University of California at Irvine, School of Medicine, Irvine, CA 92697, USA
    J Gen Virol 87:2817-25. 2006
    ..These findings provide new data demonstrating that anterior corneal keratocytes become infected and express ICP0 during acute HSV-1 infection...
  45. ncbi Quantitative assessment of ophthalmic viscosurgical device retention using in vivo confocal microscopy
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    J Cataract Refract Surg 31:2363-8. 2005
    ..To develop and apply a new laboratory method for in vivo quantitative assessment of the retention of ophthalmic viscosurgical devices (OVDs) following phacoemulsification...
  46. ncbi Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction
    James V Jester
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Exp Eye Res 77:581-92. 2003
    ..We further establish that changes in environmental conditions modulate the keratocyte phenotype resulting in physiologically functional differences regarding cell contractility and capacity to contract extracellular matrix...
  47. ncbi Internalization of Pseudomonas aeruginosa is mediated by lipid rafts in contact lens-wearing rabbit and cultured human corneal epithelial cells
    Naoka Yamamoto
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Invest Ophthalmol Vis Sci 46:1348-55. 2005
    ..Also, hTCEpi cells may be used as an experimental model for studying further the molecular mechanism(s) of PA infection in the corneal epithelium...
  48. ncbi Effects of age and dysfunction on human meibomian glands
    Chyong Jy Nien
    Gavin Herbert Eye Institute, Medical Center, University of California Irvine, 101 The City Drive, Orange, CA 92868, USA
    Arch Ophthalmol 129:462-9. 2011
    ..To identify age-related changes in human meibomian glands that may be associated with meibomian gland dysfunction (MGD)...
  49. ncbi Age-related changes in the meibomian gland
    Chyong Jy Nien
    The Gavin Herbert Eye Institute, University of California Irvine Medical Center, 101 The City Drive, Orange, CA 92868, USA
    Exp Eye Res 89:1021-7. 2009
    ..These results are consistent with the hypothesis that mouse meibomian glands undergo age-related changes similar to those identified in humans and may be used as a model for age-related meibomian gland dysfunction...
  50. ncbi The development of meibomian glands in mice
    Chyong Jy Nien
    Gavin Herbert Eye Institute, University of California Irvine, Orange, CA 92868, USA
    Mol Vis 16:1132-40. 2010
    ..The purpose of this study was to characterize the natural history of meibomian gland morphogenesis in the mouse...
  51. ncbi Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: an analysis of postoperative keratolysis
    Sylvia L Hargrave
    Department of Ophthalmology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    Ophthalmology 109:343-50. 2002
    ..Our study provides preliminary evidence that topical application of diclofenac sodium 0.1% may be associated with aberrant MMP expression in the cornea...
  52. ncbi Castroviejo Lecture 2009: 40 years in search of the perfect contact lens
    H Dwight Cavanagh
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Cornea 29:1075-85. 2010
    ....
  53. ncbi Effects of daily and overnight wear of a novel hyper oxygen-transmissible soft contact lens on bacterial binding and corneal epithelium: a 13-month clinical trial
    H Dwight Cavanagh
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Ophthalmology 109:1957-69. 2002
    ..To test prospectively a new biologic rationale for an advanced hyper oxygen-transmissible lens (HOTL) providing prospects for safer daily (DW) or extended (EW) contact lens wear...
  54. ncbi Successful treatment of the murine model of cystinosis using bone marrow cell transplantation
    Kimberly Syres
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA, USA
    Blood 114:2542-52. 2009
    ..This work is a proof of concept for using HSC transplantation as a therapy for cystinosis and highlights the efficiency of this strategy for a chronic, progressive degenerative disease...
  55. ncbi Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection
    Anthony B Nesburn
    Cellular and Molecular Immunology Laboratory, The Eye Institute, University of California, Irvine, CA 92697 4375, USA
    J Virol 81:7647-61. 2007
    ..It remains to be determined whether conjunctiva CD4(+) CD25(+) nT(reg) cells affect the topical/mucosal delivery of subunit vaccines that stimulate the ocular mucosal immune system...
  56. ncbi Role of oxygen in corneal epithelial homeostasis during extended contact lens wear
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9057, USA
    Eye Contact Lens 29:S2-6; discussion S26-9, S192-4. 2003
  57. ncbi Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican
    Eric C Carlson
    Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45267 0527, USA
    J Biol Chem 280:25541-7. 2005
    ..The results also suggest a critical level of small proteoglycans to be essential for collagen organization but that overabundance is not detrimental to extracellular matrix morphogenesis...
  58. ncbi Effects of daily and overnight wear of hyper-oxygen transmissible rigid and silicone hydrogel lenses on bacterial binding to the corneal epithelium: 13-month clinical trials
    H Dwight Cavanagh
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Eye Contact Lens 29:S14-6; discussion S26-9, S192-4. 2003
    ..Is this a great advance or another clinical triumph of hope over experience? What should the public know? What should patients do?..
  59. ncbi Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells
    Brant R Ward
    Department of Dermatology, University of Texas South Western Medical Center, Dallas, TX, USA
    Immunology 120:556-72. 2007
    ..Our results demonstrate rapid cytokine-mediated behavioural responses by LCs to local tissue injury, providing new insights into the biology of LCs...
  60. ncbi Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 41:1459-69. 2006
    ..g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant...
  61. ncbi Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts
    James V Jester
    Departments of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Invest Ophthalmol Vis Sci 44:1850-8. 2003
    ..The purpose of this study was to determine whether TGFbeta induces myofibroblast differentiation in cultured human keratocytes and in telomerase (hTERT)-immortalized human corneal fibroblast cell lines...
  62. ncbi In vivo fluorescent labeling of corneal wound healing fibroblasts
    Joel Gatlin
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9057, USA
    Exp Eye Res 76:361-71. 2003
    ..Our data further suggest that, in vivo, wound-healing fibroblasts have a defined life span within the wound...
  63. ncbi Extent of initial corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays
    James K Maurer
    The Procoter and Gamble Company, Cincinati, Ohio, USA
    Regul Toxicol Pharmacol 36:106-17. 2002
    ..This work also provides a well-characterized panel of materials of varying types and irritation for use in developing and validating alternative tests...
  64. ncbi Evaluation of the corneal effects of topical ophthalmic fluoroquinolones using in vivo confocal microscopy
    Timmy A Kovoor
    University of Texas Southwestern Medical School, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eye Contact Lens 30:90-4. 2004
    ..The results of this study suggest that Moxi induces less damage to the corneal epithelium than other antibiotic solutions, perhaps because it does not contain BAC...
  65. ncbi The corneas of naive mice contain both CD4+ and CD8+ T cells
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Cedars Sinai Medical Center Burns and Allen Research Institute, Los Angeles, CA 90272, USA
    Mol Vis 13:1802-12. 2007
    ..To determine if the corneas of naive mice contain resident CD4+ and CD8+ T cells...
  66. ncbi Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration
    Royce Mohan
    New England Eye Center, Tufts University School of Medicine, and the Tufts Center for Vision Research, Boston, Massachusetts 02111, USA
    J Biol Chem 277:2065-72. 2002
    ..We conclude that gelB coordinates and effects multiple events involved in the process of epithelial regeneration...
  67. ncbi Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling
    Eric Huet
    CRRET Laboratory, CNRS UMR 7149, University Paris XII, 61 av du General de Gaulle, 94010 Creteil Cedex, France
    FASEB J 22:1144-54. 2008
    ..These findings, combined with the fact that EMMPRIN and alphaSMA colocalized to the same cells in the stroma of pathological corneas, expand on the mechanism by which EMMPRIN remodels extracellular matrix during wound healing and cancer...
  68. ncbi Recovery time of corneal epithelial proliferation in the rabbit following rigid gas-permeable extended contact-lens wear
    Patrick M Ladage
    Department of Opthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039-9057, USA
    Eye Contact Lens 29:61-4. 2003
    ..Interestingly, hyperproliferation was noted within the limbal, peripheral, and mid-peripheral corneal epithelium 4 days after lens removal...

Research Grants26

  1. KERATOCYTE CRYSTALLIN PROTEINS AND CORNEAL TRANSPARENCY
    JAMES JESTER; Fiscal Year: 2003
    ....
  2. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    JAMES JESTER; Fiscal Year: 2005
    ....
  3. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    JAMES JESTER; Fiscal Year: 2006
    ....
  4. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    JAMES JESTER; Fiscal Year: 2007
    ....
  5. MYOFIBROBLASTS AND CORNEAL WOUND CONTRACTION
    JAMES JESTER; Fiscal Year: 1993
    ..These studies should provide important insights into fundamental questions concerning the mechanism of wound contraction and the role of the myofibroblast in corneal wound repair...
  6. MODULATION OF CORNEAL CURVATURE DURING WOUND HEALING
    JAMES JESTER; Fiscal Year: 1991
    ....
  7. REGULATION OF CORNEAL MYOFIBROBLAST TRANSFORMATION
    JAMES JESTER; Fiscal Year: 2000
    ....
  8. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
    ....