NATHANIEL AARON JESKE
Affiliation: University of Texas Health Science Center
Jeske N. Dynamic Opioid Receptor Regulation in the Periphery. Mol Pharmacol. 2019;95:463-467 pubmed publisher
..This distinctive characteristic begs one to question whether peripheral opioid receptors maintain anatomically unique roles, and whether they may serve an analgesic advantage in providing pain relief without promoting addiction. ..
Jeske N, Por E, Belugin S, Chaudhury S, Berg K, Akopian A, et al
. A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphate. J Neurosci. 2011;31:8681-8 pubmed publisher
..These findings suggest that PIP(2) degradation increases AKAP150 association with TRPV1 in the whole-cell environment, leading to sensitization of the receptor to nociceptive stimuli. ..
Jeske N. Peripheral scaffolding and signaling pathways in inflammatory pain. Prog Mol Biol Transl Sci. 2015;131:31-52 pubmed publisher
..Together, the mediators, pathways, and scaffolding mechanisms involved in inflammatory hyperalgesia provide a unique knowledge point from which new therapeutic targets can be understood. ..
Jeske N, Diogenes A, Ruparel N, Fehrenbacher J, Henry M, Akopian A, et al
. A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1. Pain. 2008;138:604-16 pubmed publisher
..These data suggest that AKAP150 functionally regulates PKA-mediated phosphorylation/sensitization of the TRPV1 receptor. ..
Jeske N, Patwardhan A, Ruparel N, Akopian A, Shapiro M, Henry M. A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1. Pain. 2009;146:301-7 pubmed publisher
Szteyn K, Gomez R, Berg K, Jeske N. Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. ASN Neuro. 2015;7: pubmed publisher
..In contrast, Orai1 dominates as the downstream target of BK receptor activation and results in transient intracellular Ca(2+) increases and abridged nocifensive responses. ..
Brackley A, Gomez R, Akopian A, Henry M, Jeske N. GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity. Cell Rep. 2016;16:2686-2698 pubmed publisher
..Together, these results expand the known function of GRK2, identifying a non-internalizing role to maintain peripheral DOR in an analgesically incompetent state. ..
Brackley A, Sarrami S, Gomez R, Guerrero K, Jeske N. Identification of a signaling cascade that maintains constitutive ?-opioid receptor incompetence in peripheral sensory neurons. J Biol Chem. 2017;292:8762-8772 pubmed publisher
..These findings suggest that AKAP scaffolds PKA to increase plasma membrane targeting and phosphorylation of GRK2 to maintain DOR analgesic incompetence in peripheral sensory neurons. ..
Brackley A, Gomez R, Guerrero K, Akopian A, Glucksman M, Du J, et al
. A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation. Sci Rep. 2017;7:1842 pubmed publisher
..Collectively, these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity. ..