James David Jentsch

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Reward, interrupted: Inhibitory control and its relevance to addictions
    James David Jentsch
    Department of Psychology, University of California, Los Angeles 90095 1563, USA Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90095 1563, USA Semel Institute for Human Neuroscience and Behavior, University of California, Los Angeles 90095 1563, USA The Brain Research Institute, University of California, Los Angeles 90095 1563, USA Electronic address
    Neuropharmacology 76:479-86. 2014
  2. pmc Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the Balloon Analog Risk Task
    James David Jentsch
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 35:1797-806. 2010
  3. pmc Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice
    James David Jentsch
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 34:2601-8. 2009
  4. pmc Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys
    Emanuele Seu
    Department of Psychology, University of California Los Angeles, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 202:505-19. 2009
  5. doi request reprint Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats
    J David Jentsch
    Department of Psychology, University of California, Los Angeles, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 202:497-504. 2009
  6. ncbi request reprint Null mutation of the arginine-vasopressin gene in rats slows attentional engagement and facilitates response accuracy in a lateralized reaction time task
    J David Jentsch
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 28:1597-605. 2003
  7. ncbi request reprint Impaired visuospatial divided attention in the spontaneously hypertensive rat
    J David Jentsch
    Department of Psychology and the Brain Research Institute, University of California at Los Angeles, Los Angeles, UCLA, P O Box 951563, Los Angeles, California 90095 1563, USA
    Behav Brain Res 157:323-30. 2005
  8. ncbi request reprint Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats
    William Marrs
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 30:1500-10. 2005
  9. doi request reprint Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
    Yijun Cui
    1 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA 2 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA 3 Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA 4 David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Neurosci 17:254-61. 2014
  10. pmc Methamphetamine-induced increases in putamen gray matter associate with inhibitory control
    Stephanie M Groman
    Department of Psychology, UCLA Department of Psychology, PO Box 951563, Los Angeles, CA, 90095 1563, USA
    Psychopharmacology (Berl) 229:527-38. 2013

Research Grants

Collaborators

Detail Information

Publications35

  1. doi request reprint Reward, interrupted: Inhibitory control and its relevance to addictions
    James David Jentsch
    Department of Psychology, University of California, Los Angeles 90095 1563, USA Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90095 1563, USA Semel Institute for Human Neuroscience and Behavior, University of California, Los Angeles 90095 1563, USA The Brain Research Institute, University of California, Los Angeles 90095 1563, USA Electronic address
    Neuropharmacology 76:479-86. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  2. pmc Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the Balloon Analog Risk Task
    James David Jentsch
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 35:1797-806. 2010
    ....
  3. pmc Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice
    James David Jentsch
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 34:2601-8. 2009
    ....
  4. pmc Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys
    Emanuele Seu
    Department of Psychology, University of California Los Angeles, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 202:505-19. 2009
    ....
  5. doi request reprint Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats
    J David Jentsch
    Department of Psychology, University of California, Los Angeles, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 202:497-504. 2009
    ..Noradrenaline has been implicated in attention per se, but it is not clear whether it differentially participates in these two dimensions of attentional function...
  6. ncbi request reprint Null mutation of the arginine-vasopressin gene in rats slows attentional engagement and facilitates response accuracy in a lateralized reaction time task
    J David Jentsch
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 28:1597-605. 2003
    ..These results, taken with earlier data, indicate that vasopressin plays a critical role in regulating visual attention and cognition, either directly, or via early alterations in neurodevelopment...
  7. ncbi request reprint Impaired visuospatial divided attention in the spontaneously hypertensive rat
    J David Jentsch
    Department of Psychology and the Brain Research Institute, University of California at Los Angeles, Los Angeles, UCLA, P O Box 951563, Los Angeles, California 90095 1563, USA
    Behav Brain Res 157:323-30. 2005
    ..These data indicate that SHR exhibit performance deficits on a test of visual attention but do not resolve the predictive validity this putative model for AD/HD...
  8. ncbi request reprint Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats
    William Marrs
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 30:1500-10. 2005
    ..These data indicate that alpha-2 adrenoreceptors tonically inhibit PCP-induced deficits of spatial working memory, suggesting an important role for these receptors in cognitive deficits associated with NMDA receptor hypofunction...
  9. doi request reprint Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
    Yijun Cui
    1 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA 2 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA 3 Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA 4 David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Neurosci 17:254-61. 2014
    ....
  10. pmc Methamphetamine-induced increases in putamen gray matter associate with inhibitory control
    Stephanie M Groman
    Department of Psychology, UCLA Department of Psychology, PO Box 951563, Los Angeles, CA, 90095 1563, USA
    Psychopharmacology (Berl) 229:527-38. 2013
    ..The extent to which these structural abnormalities result from drug use or reflect neurobiological risk factors that predate drug use, however, is unknown...
  11. ncbi request reprint Haploinsufficiency of the arginine-vasopressin gene is associated with poor spatial working memory performance in rats
    Shawn M Aarde
    Department of Psychology, University of California at Los Angeles, PO Box 951563, 90095 1563, USA
    Horm Behav 49:501-8. 2006
    ....
  12. ncbi request reprint Genetic vasopressin deficiency facilitates performance of a lateralized reaction-time task: altered attention and motor processes
    J David Jentsch
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    J Neurosci 23:1066-71. 2003
    ..These results indicate that alterations of vasopressin signaling result in a clear cognitive phenotype, including faster motor initiations and superior choice accuracy in a test of visual attention...
  13. ncbi request reprint A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats
    J David Jentsch
    Department of Psychology, UCLA, PO Box 951563 Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 175:76-83. 2004
    ..The alpha(2) noradrenergic receptor agonist clonidine prevents some of the behavioral effects of NMDA antagonists, suggesting that monoaminergic systems mediate some aspects of these deficits...
  14. pmc Neural components underlying behavioral flexibility in human reversal learning
    Dara G Ghahremani
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90065, USA
    Cereb Cortex 20:1843-52. 2010
    ..These regions and lateral OFC represent distinct neural components that support behavioral flexibility important for adaptive learning...
  15. ncbi request reprint Dimensions of impulsivity are associated with poor spatial working memory performance in monkeys
    Alex S James
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 27:14358-64. 2007
    ..These data indicate that dimensions of impulsivity may impact on working memory performance in qualitatively similar ways but through different mechanisms...
  16. ncbi request reprint Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys
    Buyean Lee
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 32:2125-34. 2007
    ..These data support the hypothesis that phasic DA release, acting through D(2)-like receptors, mediates behavioral flexibility...
  17. ncbi request reprint Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat
    P Alexander Arguello
    Department of Psychology, University of California, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 177:141-50. 2004
    ..CB1 receptors (CB1Rs) mediate many of the psychoactive effects of cannabinoids, and marijuana intoxication can produce neurocognitive deficits with a similarity to those seen in schizophrenia, including impairments of attention...
  18. pmc Monoamine levels within the orbitofrontal cortex and putamen interact to predict reversal learning performance
    Stephanie M Groman
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Biol Psychiatry 73:756-62. 2013
    ....
  19. pmc Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons
    Alex S James
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
    Behav Brain Res 256:279-83. 2013
    ..Remifentanil exposure also altered the probability of glutamate release onto D1-, but not D2-MSNs. Together these results suggest a D1-pathway specific effect associated with the acquisition of opioid-seeking behaviors. ..
  20. pmc Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder
    Stephanie M Groman
    Department of Psychology, University of California at Los Angeles, CA 90095 1563, USA
    Neurosci Biobehav Rev 33:690-8. 2009
    ..New directions for research that will further explore this hypothesis and begin to reveal the underlying biological mechanisms will be proposed...
  21. pmc Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits
    Anna J Jasinska
    Center for Neurobehavioral Genetics, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:4415-27. 2009
    ....
  22. pmc Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
    Weidong Li
    Department of Neurobiology, Semel Institute, Brain Research Institute, and Department of Urology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:18280-5. 2007
    ..Our findings demonstrate that alterations in DISC1 function during brain development contribute to schizophrenia pathogenesis...
  23. pmc Neurofibromin regulates corticostriatal inhibitory networks during working memory performance
    Carrie Shilyansky
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:13141-6. 2010
    ..Collectively, these integrative mouse and human studies reveal molecular and cellular mechanisms contributing to working memory deficits in NF1...
  24. ncbi request reprint The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    Weidong Li
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Biol 15:1961-7. 2005
    ..Therefore, these results demonstrate that lovastatin may prove useful in the treatment of Neurofibromatosis Type 1...
  25. pmc A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 60:253-64. 2006
    ..Specifically, we tested whether this manipulation leads to disruptions of frontal and limbic corticostriatal circuit function, while producing schizophrenia-like, region-dependent reductions in gray matter in cortex and thalamus...
  26. ncbi request reprint Sex-related differences in spatial divided attention and motor impulsivity in rats
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Behav Neurosci 117:76-83. 2003
    ..These results demonstrate a double dissociation between components of impulse control and divided attention in male and female rats and may have implications for sex differences in disorders of attention and cognition...
  27. ncbi request reprint XXY mice exhibit gonadal and behavioral phenotypes similar to Klinefelter syndrome
    Yanhe Lue
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Box 446, 1000 West Carson Street, Torrance, California 90509, USA
    Endocrinology 146:4148-54. 2005
    ..We conclude that adult XXY mice have testicular failure and learning deficits, similar to its human counterpart, Klinefelter syndrome...
  28. ncbi request reprint Repeated nicotine exposure enhances reward-related learning in the rat
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 28:1264-71. 2003
    ..In this study, all nicotine treatment schedules increased Pavlovian discriminative approach behavior and, thus, prior repeated exposure to nicotine, repeated postsession nicotine injections, or both, facilitated reward-related learning...
  29. ncbi request reprint Repeated, intermittent delta(9)-tetrahydrocannabinol administration to rats impairs acquisition and performance of a test of visuospatial divided attention
    Christopher D Verrico
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 29:522-9. 2004
    ..Finally, amphetamine's ability to reverse the attentional impairments provides indirect evidence that monoaminergic deficits may be linked to the cognitive dysfunction...
  30. ncbi request reprint Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine
    John D Elsworth
    Neuropsychopharmacology Research Unit, Departments of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 33:491-6. 2008
    ..Thus, the present data support the hypothesis that the therapeutic effects of clozapine in this primate model and perhaps in schizophrenia may be related at least in part to the restoration of DA tone in the prefrontal cortex...
  31. ncbi request reprint DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 26:9196-204. 2006
    ....
  32. ncbi request reprint Repeated nicotine exposure enhances responding with conditioned reinforcement
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 173:98-104. 2004
    ..Clinical observations indicate that smoking depends strongly upon conditioned reinforcement (i.e., cues support smoking behavior); however, little is known about the effects of repeated nicotine exposure on these processes...
  33. ncbi request reprint Adaptation of monoaminergic responses to phencyclidine in nucleus accumbens and prefrontal cortex following repeated treatment with fluoxetine or imipramine
    Richard De La Garza
    Neuropsychopharmacology Laboratory, Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, Sterling Hall of Medicine, B 256, New Haven, CT 06510, USA
    Brain Res 958:20-7. 2002
    ..The data highlight the importance of adaptive responses to NMDA receptors resulting from chronic antidepressant treatment...
  34. ncbi request reprint Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learning
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 52:111-8. 2002
    ....
  35. ncbi request reprint Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeys
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 26:183-90. 2002
    ..These findings suggest that long-term cocaine administration may disrupt orbitofrontal efferents to the striatum, resulting in impaired inhibition of established conditioned responses...

Research Grants4

  1. Behavioral Model of Contextual Attention in the Monkey
    J Jentsch; Fiscal Year: 2003
    ..The development of such an approach to modeling contextual aspects of attention, in particular, in animals should be a major advance linking pre-clinical psychopharmacological studies and treatment-based research for schizophrenia. ..