J David Jentsch

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Genetic vasopressin deficiency facilitates performance of a lateralized reaction-time task: altered attention and motor processes
    J David Jentsch
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    J Neurosci 23:1066-71. 2003
  2. ncbi request reprint A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats
    J David Jentsch
    Department of Psychology, UCLA, PO Box 951563 Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 175:76-83. 2004
  3. pmc Dysregulation of D₂-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure
    Stephanie M Groman
    Department of Psychology, Psychiatry and Biobehavioral Sciences, and Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 32:5843-52. 2012
  4. pmc A non-human primate system for large-scale genetic studies of complex traits
    Anna J Jasinska
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 21:3307-16. 2012
  5. pmc Effect of acute and repeated treatment with desipramine or methylphenidate on serial reversal learning in rats
    Emanuele Seu
    Department of Psychology, University of California Los Angeles, PO Box 951563, Los Angeles, CA 90095 1563, USA
    Neuropharmacology 57:665-72. 2009
  6. pmc Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys
    Emanuele Seu
    Department of Psychology, University of California Los Angeles, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 202:505-19. 2009
  7. ncbi request reprint Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats
    William Marrs
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 30:1500-10. 2005
  8. pmc Neurofibromin regulates corticostriatal inhibitory networks during working memory performance
    Carrie Shilyansky
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:13141-6. 2010
  9. ncbi request reprint Haploinsufficiency of the arginine-vasopressin gene is associated with poor spatial working memory performance in rats
    Shawn M Aarde
    Department of Psychology, University of California at Los Angeles, PO Box 951563, 90095 1563, USA
    Horm Behav 49:501-8. 2006
  10. ncbi request reprint Null mutation of the arginine-vasopressin gene in rats slows attentional engagement and facilitates response accuracy in a lateralized reaction time task
    J David Jentsch
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 28:1597-605. 2003

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Genetic vasopressin deficiency facilitates performance of a lateralized reaction-time task: altered attention and motor processes
    J David Jentsch
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    J Neurosci 23:1066-71. 2003
    ..These results indicate that alterations of vasopressin signaling result in a clear cognitive phenotype, including faster motor initiations and superior choice accuracy in a test of visual attention...
  2. ncbi request reprint A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats
    J David Jentsch
    Department of Psychology, UCLA, PO Box 951563 Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 175:76-83. 2004
    ..The alpha(2) noradrenergic receptor agonist clonidine prevents some of the behavioral effects of NMDA antagonists, suggesting that monoaminergic systems mediate some aspects of these deficits...
  3. pmc Dysregulation of D₂-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure
    Stephanie M Groman
    Department of Psychology, Psychiatry and Biobehavioral Sciences, and Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 32:5843-52. 2012
    ..Identification of these factors ultimately may assist in the development of individualized treatments for substance dependence...
  4. pmc A non-human primate system for large-scale genetic studies of complex traits
    Anna J Jasinska
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 21:3307-16. 2012
    ..The imminent whole genome sequencing of many of these vervet samples will enhance the power of such investigations by providing a comprehensive catalog of genetic variation...
  5. pmc Effect of acute and repeated treatment with desipramine or methylphenidate on serial reversal learning in rats
    Emanuele Seu
    Department of Psychology, University of California Los Angeles, PO Box 951563, Los Angeles, CA 90095 1563, USA
    Neuropharmacology 57:665-72. 2009
    ..The differential outcome produced by stimulant and non-stimulant medications in this study may be explained in light of their distinct actions on brain catecholaminergic systems...
  6. pmc Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys
    Emanuele Seu
    Department of Psychology, University of California Los Angeles, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 202:505-19. 2009
    ....
  7. ncbi request reprint Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats
    William Marrs
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 30:1500-10. 2005
    ..These data indicate that alpha-2 adrenoreceptors tonically inhibit PCP-induced deficits of spatial working memory, suggesting an important role for these receptors in cognitive deficits associated with NMDA receptor hypofunction...
  8. pmc Neurofibromin regulates corticostriatal inhibitory networks during working memory performance
    Carrie Shilyansky
    Department of Neurobiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:13141-6. 2010
    ..Collectively, these integrative mouse and human studies reveal molecular and cellular mechanisms contributing to working memory deficits in NF1...
  9. ncbi request reprint Haploinsufficiency of the arginine-vasopressin gene is associated with poor spatial working memory performance in rats
    Shawn M Aarde
    Department of Psychology, University of California at Los Angeles, PO Box 951563, 90095 1563, USA
    Horm Behav 49:501-8. 2006
    ....
  10. ncbi request reprint Null mutation of the arginine-vasopressin gene in rats slows attentional engagement and facilitates response accuracy in a lateralized reaction time task
    J David Jentsch
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 28:1597-605. 2003
    ..These results, taken with earlier data, indicate that vasopressin plays a critical role in regulating visual attention and cognition, either directly, or via early alterations in neurodevelopment...
  11. doi request reprint Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats
    J David Jentsch
    Department of Psychology, University of California, Los Angeles, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 202:497-504. 2009
    ..Noradrenaline has been implicated in attention per se, but it is not clear whether it differentially participates in these two dimensions of attentional function...
  12. pmc Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder
    Stephanie M Groman
    Department of Psychology, University of California at Los Angeles, CA 90095 1563, USA
    Neurosci Biobehav Rev 33:690-8. 2009
    ..New directions for research that will further explore this hypothesis and begin to reveal the underlying biological mechanisms will be proposed...
  13. ncbi request reprint Dimensions of impulsivity are associated with poor spatial working memory performance in monkeys
    Alex S James
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 27:14358-64. 2007
    ..These data indicate that dimensions of impulsivity may impact on working memory performance in qualitatively similar ways but through different mechanisms...
  14. ncbi request reprint Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat
    P Alexander Arguello
    Department of Psychology, University of California, P O Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 177:141-50. 2004
    ..CB1 receptors (CB1Rs) mediate many of the psychoactive effects of cannabinoids, and marijuana intoxication can produce neurocognitive deficits with a similarity to those seen in schizophrenia, including impairments of attention...
  15. doi request reprint Responding in a test of decision-making under risk is under moderate genetic control in the rat
    James R Ashenhurst
    Interdepartmental Neuroscience Program, University of California, Los Angeles, CA 90095 1563, USA
    Alcohol Clin Exp Res 36:941-9. 2012
    ....
  16. pmc Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning
    Stephanie M Groman
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 31:7291-9. 2011
    ....
  17. doi request reprint Structural and functional neuroimaging phenotypes in dysbindin mutant mice
    Evan Lutkenhoff
    Interdisciplinary Neuroscience Program, University of California, Los Angeles, CA 90095, USA
    Neuroimage 62:120-9. 2012
    ..It revealed both hypothesized and novel structural and functional neural alterations related to dysbindin-1...
  18. pmc The relationship between measures of impulsivity and alcohol misuse: an integrative structural equation modeling approach
    Kelly E Courtney
    From the Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Alcohol Clin Exp Res 36:923-31. 2012
    ..This study simultaneously tested the following dimensions of impulsivity as determinants of alcohol use and alcohol problems: risky decision making, self-reported risk-attitudes, response inhibition, and impulsive decision making...
  19. pmc Reversal learning as a measure of impulsive and compulsive behavior in addictions
    Alicia Izquierdo
    Department of Psychology, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA
    Psychopharmacology (Berl) 219:607-20. 2012
    ..Consequently, reversal learning could index vulnerability for disorders characterized by impulsivity such as proclivity for initial substance abuse as well as the compulsive aspects of dependence...
  20. pmc Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
    Weidong Li
    Department of Neurobiology, Semel Institute, Brain Research Institute, and Department of Urology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:18280-5. 2007
    ..Our findings demonstrate that alterations in DISC1 function during brain development contribute to schizophrenia pathogenesis...
  21. pmc Neural components underlying behavioral flexibility in human reversal learning
    Dara G Ghahremani
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90065, USA
    Cereb Cortex 20:1843-52. 2010
    ..These regions and lateral OFC represent distinct neural components that support behavioral flexibility important for adaptive learning...
  22. ncbi request reprint Impaired visuospatial divided attention in the spontaneously hypertensive rat
    J David Jentsch
    Department of Psychology and the Brain Research Institute, University of California at Los Angeles, Los Angeles, UCLA, P O Box 951563, Los Angeles, California 90095 1563, USA
    Behav Brain Res 157:323-30. 2005
    ..These data indicate that SHR exhibit performance deficits on a test of visual attention but do not resolve the predictive validity this putative model for AD/HD...
  23. doi request reprint Cognitive control and the dopamine D₂-like receptor: a dimensional understanding of addiction
    Stephanie M Groman
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Depress Anxiety 29:295-306. 2012
    ..Consequently, we argue that measures of cognitive control and D(2) DA receptor function may be particularly informative markers of individual function and treatment response in addictions...
  24. doi request reprint Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance
    Katherine H Karlsgodt
    Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 69:28-34. 2011
    ..At a cellular level, dysbindin is thought to mediate presynaptic glutamatergic transmission...
  25. pmc Cocaine self-administration behavior in inbred mouse lines segregating different capacities for inhibitory control
    M Catalina Cervantes
    Department of Psychology, University of California, P O Box 951563, Los Angeles, CA, 90095 1563, USA
    Psychopharmacology (Berl) 229:515-25. 2013
    ....
  26. pmc Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates
    Stephanie M Groman
    Department of Psychology, University of California, Los Angeles, United States
    Curr Opin Neurobiol 23:625-31. 2013
    ..This approach aids in the development of novel targets that can be used in the treatment of addiction. ..
  27. pmc Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits
    Anna J Jasinska
    Center for Neurobehavioral Genetics, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:4415-27. 2009
    ....
  28. ncbi request reprint The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    Weidong Li
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Biol 15:1961-7. 2005
    ..Therefore, these results demonstrate that lovastatin may prove useful in the treatment of Neurofibromatosis Type 1...
  29. pmc Genetic dissection of behavioral flexibility: reversal learning in mice
    Rick E Laughlin
    Department of Psychology, University of California at Los Angeles, 90095 1563, USA
    Biol Psychiatry 69:1109-16. 2011
    ..Here, we investigate the genetic basis of individual differences in flexibility, measured using an operant reversal learning task...
  30. pmc A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 60:253-64. 2006
    ..Specifically, we tested whether this manipulation leads to disruptions of frontal and limbic corticostriatal circuit function, while producing schizophrenia-like, region-dependent reductions in gray matter in cortex and thalamus...
  31. ncbi request reprint XXY mice exhibit gonadal and behavioral phenotypes similar to Klinefelter syndrome
    Yanhe Lue
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Box 446, 1000 West Carson Street, Torrance, California 90509, USA
    Endocrinology 146:4148-54. 2005
    ..We conclude that adult XXY mice have testicular failure and learning deficits, similar to its human counterpart, Klinefelter syndrome...
  32. ncbi request reprint Repeated, intermittent delta(9)-tetrahydrocannabinol administration to rats impairs acquisition and performance of a test of visuospatial divided attention
    Christopher D Verrico
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 29:522-9. 2004
    ..Finally, amphetamine's ability to reverse the attentional impairments provides indirect evidence that monoaminergic deficits may be linked to the cognitive dysfunction...
  33. ncbi request reprint Repeated nicotine exposure enhances reward-related learning in the rat
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 28:1264-71. 2003
    ..In this study, all nicotine treatment schedules increased Pavlovian discriminative approach behavior and, thus, prior repeated exposure to nicotine, repeated postsession nicotine injections, or both, facilitated reward-related learning...
  34. ncbi request reprint Sex-related differences in spatial divided attention and motor impulsivity in rats
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Behav Neurosci 117:76-83. 2003
    ..These results demonstrate a double dissociation between components of impulse control and divided attention in male and female rats and may have implications for sex differences in disorders of attention and cognition...
  35. ncbi request reprint Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learning
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 52:111-8. 2002
    ....
  36. ncbi request reprint Adaptation of monoaminergic responses to phencyclidine in nucleus accumbens and prefrontal cortex following repeated treatment with fluoxetine or imipramine
    Richard De La Garza
    Neuropsychopharmacology Laboratory, Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, Sterling Hall of Medicine, B 256, New Haven, CT 06510, USA
    Brain Res 958:20-7. 2002
    ..The data highlight the importance of adaptive responses to NMDA receptors resulting from chronic antidepressant treatment...
  37. ncbi request reprint Repeated nicotine exposure enhances responding with conditioned reinforcement
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 173:98-104. 2004
    ..Clinical observations indicate that smoking depends strongly upon conditioned reinforcement (i.e., cues support smoking behavior); however, little is known about the effects of repeated nicotine exposure on these processes...
  38. ncbi request reprint DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 26:9196-204. 2006
    ....
  39. ncbi request reprint Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine
    John D Elsworth
    Neuropsychopharmacology Research Unit, Departments of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 33:491-6. 2008
    ..Thus, the present data support the hypothesis that the therapeutic effects of clozapine in this primate model and perhaps in schizophrenia may be related at least in part to the restoration of DA tone in the prefrontal cortex...
  40. ncbi request reprint Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeys
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 26:183-90. 2002
    ..These findings suggest that long-term cocaine administration may disrupt orbitofrontal efferents to the striatum, resulting in impaired inhibition of established conditioned responses...