Paul R Jensen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Marine actinomycete diversity and natural product discovery
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Antonie Van Leeuwenhoek 87:43-8. 2005
  2. ncbi request reprint Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica
    Greg O Buchanan
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    Org Lett 7:2731-4. 2005
  3. ncbi request reprint Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete
    Irma E Soria-Mercado
    Facultad de Ciencias Marinas, Universidad Autonoma de Baja California, Km 103 Carretera Tijuana Ensenada, BC Mexico
    J Nat Prod 68:904-10. 2005
  4. ncbi request reprint Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola
    Philip G Williams
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:83-8. 2007
  5. pmc Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola
    Philip G Williams
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 72:5025-34. 2007
  6. pmc Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria
    Kevin Penn
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA
    ISME J 3:1193-203. 2009
  7. pmc The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity
    Nadine Ziemert
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e34064. 2012
  8. pmc Challenges and triumphs to genomics-based natural product discovery
    Paul R Jensen
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093, USA
    J Ind Microbiol Biotechnol 41:203-9. 2014
  9. ncbi request reprint Biogeography of the marine actinomycete Salinispora
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, CA, USA
    Environ Microbiol 8:1881-8. 2006
  10. pmc Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora
    Paul R Jensen
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    Appl Environ Microbiol 73:1146-52. 2007

Research Grants

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Marine actinomycete diversity and natural product discovery
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Antonie Van Leeuwenhoek 87:43-8. 2005
    ....
  2. ncbi request reprint Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica
    Greg O Buchanan
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    Org Lett 7:2731-4. 2005
    ..The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography...
  3. ncbi request reprint Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete
    Irma E Soria-Mercado
    Facultad de Ciencias Marinas, Universidad Autonoma de Baja California, Km 103 Carretera Tijuana Ensenada, BC Mexico
    J Nat Prod 68:904-10. 2005
    ....
  4. ncbi request reprint Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola
    Philip G Williams
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:83-8. 2007
    ..Saliniketals A and B were found to inhibit ornithine decarboxylase induction, an important target for the chemoprevention of cancer, with IC50 values of 1.95 +/- 0.37 and 7.83 +/- 1.2 microg/mL, respectively...
  5. pmc Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola
    Philip G Williams
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 72:5025-34. 2007
    ..The relative and absolute stereochemistries of 1-3 were assigned by a combination of J-based configurational analyses and chemical derivatization...
  6. pmc Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria
    Kevin Penn
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA
    ISME J 3:1193-203. 2009
    ..arenicola may possess a higher level of phage immunity, whereas a highly duplicated family of polymorphic membrane proteins provides evidence for a new mechanism of marine adaptation in Gram-positive bacteria...
  7. pmc The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity
    Nadine Ziemert
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e34064. 2012
    ..The results provide a rapid method to assess secondary metabolite biosynthetic gene diversity and richness in organisms or environments and a mechanism to identify genes that may be associated with uncharacterized biochemistry...
  8. pmc Challenges and triumphs to genomics-based natural product discovery
    Paul R Jensen
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093, USA
    J Ind Microbiol Biotechnol 41:203-9. 2014
    ....
  9. ncbi request reprint Biogeography of the marine actinomycete Salinispora
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, CA, USA
    Environ Microbiol 8:1881-8. 2006
    ....
  10. pmc Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora
    Paul R Jensen
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    Appl Environ Microbiol 73:1146-52. 2007
    ....
  11. pmc An assessment of actinobacterial diversity in the marine environment
    Paul R Jensen
    Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA
    Antonie Van Leeuwenhoek 94:51-62. 2008
    ..Conversely, new strategies need to be developed for the cultivation of frequently observed but yet to be cultured marine actinobacteria...
  12. pmc Linking species concepts to natural product discovery in the post-genomic era
    Paul R Jensen
    Scripps Institution of Oceanography, University of California San Diego, La Jolla, San Diego, CA 92093 0204, USA
    J Ind Microbiol Biotechnol 37:219-24. 2010
    ..Although much remains to be learned about the evolutionary relationships among bacteria and how fundamental units of diversity can be resolved, genus and species descriptions remain the most effective method of scientific communication...
  13. ncbi request reprint Culturable marine actinomycete diversity from tropical Pacific Ocean sediments
    Paul R Jensen
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Environ Microbiol 7:1039-48. 2005
    ..These bacteria can be readily cultured using low nutrient media and represent an unexplored resource for pharmaceutical drug discovery...
  14. pmc Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
    Daniel W Udwary
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    Proc Natl Acad Sci U S A 104:10376-81. 2007
    ..This study firmly establishes the genus Salinispora as a rich source of drug-like molecules and importantly reveals the powerful interplay between genomic analysis and traditional natural product isolation studies...
  15. ncbi request reprint Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces
    Glenroy D A Martin
    Center for Marine Biotechnology, Scripps Insitution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:1406-9. 2007
    ..For marmycin A ( 1), tumor cell cytotoxicity appeared to coincide with induction of modest apoptosis and arrest in the G1 phase of the cell cycle...
  16. pmc Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola
    Ratnakar N Asolkar
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 72:396-402. 2009
    ..Taken together, these data suggest that the chemoprevention and anti-inflammatory characteristics of arenamides A and B warrant further investigation...
  17. ncbi request reprint Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:515-20. 2007
    ..Emericellamides A and B show modest antibacterial activities against methicillin-resistant Staphylococcus aureus with MIC values of 3.8 and 6.0 microM, respectively...
  18. pmc Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete
    Katherine N Maloney
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    Org Lett 11:5422-4. 2009
    ..Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM...
  19. pmc Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus
    Nina M Haste
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0687, USA
    J Antibiot (Tokyo) 65:593-8. 2012
    ..Nosiheptide also demonstrated in vivo activity in a murine model of MRSA infection, and therefore represents a promising antibiotic for the treatment of serious infections caused by contemporary strains of MRSA...
  20. ncbi request reprint Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora"
    Hak Cheol Kwon
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    J Am Chem Soc 128:1622-32. 2006
    ..The discovery of these new compounds from a new, chemically rich genus further documents that marine actinomycetes are a significant resource for drug discovery...
  21. pmc Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis
    Sang Jip Nam
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    J Nat Prod 73:1080-6. 2010
    ..Fijiolide B did not affect QR1 activity, indicating the importance of the nitrogen substitution pattern for biological activity. On the basis of these data, fijiolide A is viewed as a promising lead for more advanced anticancer testing...
  22. pmc Actinoranone, a cytotoxic meroterpenoid of unprecedented structure from a marine adapted Streptomyces sp
    Sang Jip Nam
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, United States
    Org Lett 15:5400-3. 2013
    ..The stereochemistry of 1 was defined by application of the advanced Mosher's method and by interpretation of spectroscopic data. Actinoranone (1) is significantly cytotoxic to HCT-116 human colon cancer cells with an LD50 = 2.0 μg/mL. ..
  23. pmc Phylogenetic diversity of gram-positive bacteria cultured from marine sediments
    Erin A Gontang
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0204, USA
    Appl Environ Microbiol 73:3272-82. 2007
    ..2%) are likely to represent new taxa. The high degree of phylogenetic novelty observed during this study highlights the fact that a great deal remains to be learned about the diversity of gram-positive bacteria in marine sediments...
  24. pmc Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes
    Amy L Lane
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    J Am Chem Soc 135:4171-4. 2013
    ..This study provides new opportunities for bioengineering of enediyne derivatives and expands the structural diversity afforded by enediyne gene clusters...
  25. pmc Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp
    Peng Sun
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    Bioorg Med Chem 19:6557-62. 2011
    ..Fijimycins A-C, and etamycin A, were shown to possess significant in vitro antibacterial activity against three methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC(100) values between 4 and 16 μg mL(-1)...
  26. ncbi request reprint Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis
    Ji Young Cho
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 70:1321-8. 2007
    ..Lucentamycins A (1) and B (2) showed significant in vitro cytotoxicity against HCT-116 human colon carcinoma...
  27. ncbi request reprint Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085
    Ratnakar N Asolkar
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    J Nat Prod 69:1756-9. 2006
    ..The daryamides show weak to moderate cytotoxic activity against the human colon carcinoma cell line HCT-116 and very weak antifungal activities against Candida albicans...
  28. pmc Nitropyrrolins A-E, cytotoxic farnesyl-α-nitropyrroles from a marine-derived bacterium within the actinomycete family Streptomycetaceae
    Hak Cheol Kwon
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    J Nat Prod 73:2047-52. 2010
    ..Several of the nitropyrrolins, nitropyrrolin D in particular, are cytotoxic toward HCT-116 human colon carcinoma cells, but show weak to little antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)...
  29. pmc Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis
    Lauge Farnaes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, United States
    J Nat Prod 77:15-21. 2014
    ....
  30. pmc Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 71:570-5. 2008
    ..This relationship was shown to be a consequence of the geometric isomerization of one double bond. The phenomenon of polyketide module skipping is proposed to explain the unusual biosynthesis of the salinipyrones and the pacificanones...
  31. pmc Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium
    Wendy K Strangman
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Med Chem 52:2317-27. 2009
    ..This study provides the foundation for the optimization of these potent anti-inflammatory compounds for development in the treatment of asthma...
  32. ncbi request reprint Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum
    Ren Xiang Tan
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 67:1374-82. 2004
    ..Rostratins A, B, C, and D showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 8.5, 1.9, 0.76, and 16.5 microg/mL, respectively...
  33. pmc Structures, reactivities, and antibiotic properties of the marinopyrroles A-F
    Chambers C Hughes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 75:3240-50. 2010
    ..Halogenation of this material with N-bromosuccinimide cleanly furnished the 4,4',5,5'-tetrahalogenated core that characterizes this class of marine-derived metabolites...
  34. ncbi request reprint Piperazimycins: cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus Streptomyces
    Eric D Miller
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 72:323-30. 2007
    ..When screened in the National Cancer Institute's 60 cancer cell line panel, piperazimycin A exhibited potent in vitro cytotoxicity toward multiple tumor cell lines with a mean GI50 of 100 nM...
  35. ncbi request reprint New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica
    Philip G Williams
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 70:6196-203. 2005
    ..New SAR data for all eight compounds, derived from extensive testing against the human colon carcinoma HCT-116 and the 60-cell-line panel at the NCI, indicate that the chloroethyl moiety plays a major role in the enhanced activity of 1...
  36. pmc Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomycete
    Chollaratt Boonlarppradab
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    Org Lett 10:5505-8. 2008
    ..5 microM for marineosin A) and selective activities in diverse cancer cell types...
  37. pmc The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp
    Chambers C Hughes
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    Org Lett 10:629-31. 2008
    ..The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus...
  38. pmc Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales)
    Ji Young Cho
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Org Lett 8:2471-4. 2006
    ..The structure was rigorously determined by NMR spectroscopy and X-ray crystallography. A possible biosynthetic origin of this unusual ring system is proposed. [structure: see text]..
  39. ncbi request reprint Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor
    Venkat R Macherla
    Nereus Pharmaceuticals, Inc, 10480 Wateridge Circle, San Diego, California 92121, USA
    J Med Chem 48:3684-7. 2005
    ..These findings provide insights into structure-activity relationships within this novel series...
  40. doi request reprint Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin
    Andrew W Schultz
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Am Chem Soc 130:4507-16. 2008
    ..Assembly of this unsaturated, branched amino acid is unexpectedly related to the degradation of the environmental pollutant 3-(3-hydroxyphenyl)propionic acid...
  41. pmc Chlorizidine, a cytotoxic 5H-pyrrolo[2,1-a]isoindol-5-one-containing alkaloid from a marine Streptomyces sp
    Xavier Alvarez-Mico
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    Org Lett 15:988-91. 2013
    ..The presence of this ring system, which was demonstrated to undergo facile nucleophilic substitution reactions at the activated carbonyl group, is essential to the molecule's cytotoxicity against HCT-116 human colon cancer cells...
  42. pmc Evolution of secondary metabolite genes in three closely related marine actinomycete species
    Kelle C Freel
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
    Appl Environ Microbiol 77:7261-70. 2011
    ..The distributions and phylogenies of the biosynthetic genes examined provide insight into the complex processes driving the evolution of secondary metabolism among closely related bacterial species...
  43. pmc Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria
    Erin A Gontang
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Appl Environ Microbiol 76:2487-99. 2010
    ....
  44. pmc Culture-dependent and culture-independent diversity within the obligate marine actinomycete genus Salinispora
    Tracy J Mincer
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Appl Environ Microbiol 71:7019-28. 2005
    ..Challenges involved with the direct sequence-based detection of spore-forming microorganisms in environmental samples are discussed...
  45. ncbi request reprint Phylogenetic analyses and diterpenoid production by marine bacteria of the genus Saprospira
    Tracy J Mincer
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    Curr Microbiol 49:300-7. 2004
    ..grandis Gross, and the sole member of the closely related phylotype B. The discovery of two new neoverrucosane diterpenoids produced by phylotype B has also been documented...
  46. ncbi request reprint Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus streptomyces (actinomycetales)
    Ji Young Cho
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, 92093 0204, USA
    J Nat Prod 69:425-8. 2006
    ....
  47. pmc Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit
    Micheal C Wilson
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, United States
    J Am Chem Soc 133:1971-7. 2011
    ....
  48. doi request reprint Phylogenetic approaches to natural product structure prediction
    Nadine Ziemert
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA
    Methods Enzymol 517:161-82. 2012
    ....
  49. pmc Novel bacterial metabolite merochlorin A demonstrates in vitro activity against multi-drug resistant methicillin-resistant Staphylococcus aureus
    George Sakoulas
    Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e29439. 2012
    ....
  50. pmc Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria
    Hyuncheol Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 73:998-1001. 2010
    ..It also showed significant cytotoxicity against an HCT-116 human colon carcinoma cell line, indicating that the compound may be of value in exploring the Mcl-1 pathway as a target for cancer chemotherapy...
  51. ncbi request reprint Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Bioorg Med Chem 13:5267-73. 2005
    ..The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 microM)...
  52. pmc Structures and biosynthesis of the pyridinopyrones, polyenepyrones from a marine-derived Streptomyces species
    Takashi Fukuda
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 74:1773-8. 2011
    ....
  53. pmc Marinisporolides, polyene-polyol macrolides from a marine actinomycete of the new genus Marinispora
    Hak Cheol Kwon
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    J Org Chem 74:675-84. 2009
    ..Although polyenes, marinisporolides A (1) and B (2) showed weak to no antifungal activity against Candida albicans...
  54. ncbi request reprint Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora
    Robert H Feling
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Angew Chem Int Ed Engl 42:355-7. 2003
  55. ncbi request reprint Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira sp
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, USA
    Org Lett 9:1525-8. 2007
    ....
  56. pmc Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'
    Kelle C Freel
    Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, University of California San Diego, La Jolla, CA 92093, USA
    Environ Microbiol 14:480-93. 2012
    ..The inclusion of isolates from additional collection sites and other Salinispora spp. revealed a high degree of dispersal among 'S. pacifica' populations and phylogenetic support for the delineation of this lineage as a third species...
  57. pmc Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments
    Tracy J Mincer
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    Appl Environ Microbiol 68:5005-11. 2002
    ..Organic extracts from cultured members of this new group exhibit remarkable biological activity, suggesting that they represent a prolific resource for biotechnological applications...
  58. ncbi request reprint Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica"
    Dong Chan Oh
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, USA
    Org Lett 8:1021-4. 2006
    ..The cyanosporasides possess a new 3-keto-pyranohexose sugar as well as a cyano- and chloro-substituted cyclopenta[a]indene ring system. The cyanosporasides are proposed to be cyclization products of an enediyne precursor...
  59. pmc Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
    William Fenical
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Bioorg Med Chem 17:2175-80. 2009
    ..This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule...
  60. ncbi request reprint Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens
    Eliane Garo
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 66:423-6. 2003
    ..Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC(50) of 0.32 microg/mL...
  61. pmc Comparative genomics reveals evidence of marine adaptation in Salinispora species
    Kevin Penn
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    BMC Genomics 13:86. 2012
    ..The focus was on the obligate marine actinomycete genus Salinispora and the identification of marine adaptation genes that have been acquired from other marine bacteria...
  62. pmc Farnesides A and B, sesquiterpenoid nucleoside ethers from a marine-derived Streptomyces sp., strain CNT-372 from Fiji
    Ella Zafrir Ilan
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, United States
    J Nat Prod 76:1815-8. 2013
    ..The farnesides are only the second example of this exceedingly rare class of microbial terpenoid nucleoside metabolites. Farneside A (1) was found to have modest antimalarial activity against the parasite Plasmodium falciparum. ..
  63. pmc Targeted search for actinomycetes from nearshore and deep-sea marine sediments
    Alejandra Prieto-Davo
    Scripps Institution of Oceanography, University of California San Diego, San Diego, CA, USA
    FEMS Microbiol Ecol 84:510-8. 2013
    ..from these samples have yet to be successful. This is the first report of Salinispora spp. from marine sediments > 1100 m and suggests that the distribution of this genus is broader than previously believed...
  64. pmc Mooreia alkaloidigena gen. nov., sp. nov. and Catalinimonas alkaloidigena gen. nov., sp. nov., alkaloid-producing marine bacteria in the proposed families Mooreiaceae fam. nov. and Catalimonadaceae fam. nov. in the phylum Bacteroidetes
    Eun Ju Choi
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Int J Syst Evol Microbiol 63:1219-28. 2013
    ..nov., sp. nov. (type strain CNU-914(T)  = DSM 25186(T)  = KCCM 90101(T)) within the new families Mooreiaceae fam. nov. and Catalimonadaceae fam. nov...
  65. ncbi request reprint Halovirs A-E, new antiviral agents from a marine-derived fungus of the genus Scytalidium
    David C Rowley
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Bioorg Med Chem 11:4263-74. 2003
    ..A qualitative analysis of the secondary structures of these molecules using variable temperature NMR experiments and NOE analyses is also reported...
  66. pmc An N-acyl homolog of mycothiol is produced in marine actinomycetes
    Gerald L Newton
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Arch Microbiol 190:547-57. 2008
    ..The results demonstrate that major thiol/disulfide changes accompany secondary metabolite production and suggest that mycothiol-dependent detoxification is important at this developmental stage...
  67. ncbi request reprint Bohemamines from a marine-derived Streptomyces sp
    Tim S Bugni
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
    J Nat Prod 69:1626-8. 2006
    ..The structures were elucidated using NMR methods, and the relative stereochemistry was determined using double-pulsed-field-gradient spin echo (DPFGSE) NOE studies...
  68. pmc Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola
    Anna Edlund
    Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, University of California, San Diego, Mail Code 0204, La Jolla, CA 92093, USA
    Appl Environ Microbiol 77:5916-25. 2011
    ....
  69. ncbi request reprint Scytalidamides A and B, new cytotoxic cyclic heptapeptides from a marine fungus of the genus Scytalidium
    Lik Tong Tan
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    J Org Chem 68:8767-73. 2003
    ..Scytalidamides A (1) and B (2) showed moderate in vitro cytotoxicity toward HCT-116 human colon adenocarcinoma with IC(50) values of 2.7 and 11.0 microM, respectively...
  70. ncbi request reprint Developing a new resource for drug discovery: marine actinomycete bacteria
    William Fenical
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Nat Chem Biol 2:666-73. 2006
  71. ncbi request reprint Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus
    Mercedes Cueto
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego La Jolla, CA 92093 0204, USA
    Phytochemistry 67:1826-31. 2006
    ..Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 microg/mL...
  72. ncbi request reprint Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetes
    Kelley A Gallagher
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
    Curr Opin Biotechnol 21:794-800. 2010
    ..These strains represent a promising resource for natural product discovery and provide unique opportunities to study the evolutionary history and ecological functions of an unusual group of secondary metabolites...
  73. pmc Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus
    Nina M Haste
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0687, USA
    Antimicrob Agents Chemother 55:3305-12. 2011
    ..Marinopyrrole A has significant affinity for plastic and may therefore have potential as a potent anti-MRSA agent in cutaneous, intracatheter, or antibiotic-lock applications...
  74. pmc Genetic complementation of the obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshock
    Sergio A Bucarey
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA
    Appl Environ Microbiol 78:4175-82. 2012
    ..The enhanced survival of the S. tropica transformant provides experimental evidence that the loss of mscL is associated with the failure of Salinispora spp. to grow in low-osmotic-strength media...
  75. ncbi request reprint New neoverrucosane diterpenoids produced by the marine gliding bacterium Saprospira grandis
    Allan Spyere
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    J Nat Prod 66:818-22. 2003
    ..This study adds to the rare observation of terpene production by prokaryotic microorganisms and suggests that marine gliding bacteria may be a significant source for new terpenoid secondary metabolites...
  76. ncbi request reprint A cyclic carbonate and related polyketides from a marine-derived fungus of the genus Phoma
    Zimin Liu
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    Phytochemistry 64:571-4. 2003
    ..Phomoxin contains an unusual cyclic carbonate functionality that is rare among natural products. The structures of the new metabolites were assigned by spectroscopic methods that relied heavily on 2D NMR spectroscopic analysis...
  77. pmc Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria
    Akimasa Miyanaga
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, United States
    J Am Chem Soc 133:13311-3. 2011
    ....
  78. pmc Seaweed resistance to microbial attack: a targeted chemical defense against marine fungi
    Julia Kubanek
    Center for Marine Biotechnology and Biomedicine, The Scripps Institution of Oceanography, La Jolla, CA 92037 0204, USA
    Proc Natl Acad Sci U S A 100:6916-21. 2003
    ....
  79. ncbi request reprint Chemical ecology of marine microbial defense
    Sebastian Engel
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093 0204, USA
    J Chem Ecol 28:1971-85. 2002
    ..Continued research in this field along with improved techniques will certainly provide further insight into how microbes have influenced the evolution of secondary metabolite production in marine organisms...
  80. ncbi request reprint Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus Aspergillus
    Mercedes Cueto
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    Org Lett 4:1583-5. 2002
    ..The carbon skeleton of 1 represents a new addition to the architectural diversity of the sesterterpenoid (C25) class of secondary metabolites...
  81. ncbi request reprint Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae
    Luis A Maldonado
    School of Biology, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Int J Syst Evol Microbiol 55:1759-66. 2005
    ..nov.; the type strains of these novel species have been deposited in service culture collections as strain CNH-643(T) (=ATCC BAA-917(T)=DSM 44819(T)) and strain CNB-440(T) (=ATCC BAA-916(T)=DSM 44818(T)), respectively...

Research Grants1

  1. A sequenced-based approach for improved small molecule discovery
    Paul R Jensen; Fiscal Year: 2010
    ..The methods developed will be made widely available to the research community and thereby have a broad impact on drug discovery and basic biomedical research. ..