Research Topics
| Paul R JensenSummaryAffiliation: University of California Country: USA Publications
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Publications
Marine actinomycete diversity and natural product discoveryPaul R Jensen
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Antonie Van Leeuwenhoek 87:43-8. 2005....- Culturable marine actinomycete diversity from tropical Pacific Ocean sedimentsPaul R Jensen
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
Environ Microbiol 7:1039-48. 2005..These bacteria can be readily cultured using low nutrient media and represent an unexplored resource for pharmaceutical drug discovery... - Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropicaGreg O Buchanan
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA
Org Lett 7:2731-4. 2005..The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography... - Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomyceteIrma E Soria-Mercado
Facultad de Ciencias Marinas, , Km 103 Carretera Tijuana-Ensenada,
J Nat Prod 68:904-10. 2005.... - Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicolaPhilip G Williams
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 70:83-8. 2007..Saliniketals A and B were found to inhibit ornithine decarboxylase induction, an important target for the chemoprevention of cancer, with IC50 values of 1.95 +/- 0.37 and 7.83 +/- 1.2 microg/mL, respectively... 
An assessment of actinobacterial diversity in the marine environmentPaul R Jensen
Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA
Antonie Van Leeuwenhoek 94:51-62. 2008..Conversely, new strategies need to be developed for the cultivation of frequently observed but yet to be cultured marine actinobacteria...- Biogeography of the marine actinomycete SalinisporaPaul R Jensen
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, CA, USA
Environ Microbiol 8:1881-8. 2006.... - Species-specific secondary metabolite production in marine actinomycetes of the genus SalinisporaPaul R Jensen
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
Appl Environ Microbiol 73:1146-52. 2007.... - Linking species concepts to natural product discovery in the post-genomic eraPaul R Jensen
Scripps Institution of Oceanography, University of California San Diego, La Jolla, San Diego, CA 92093 0204, USA
J Ind Microbiol Biotechnol 37:219-24. 2010..Although much remains to be learned about the evolutionary relationships among bacteria and how fundamental units of diversity can be resolved, genus and species descriptions remain the most effective method of scientific communication... - Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus StreptomycesGlenroy D A Martin
Center for Marine Biotechnology, Scripps Insitution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 70:1406-9. 2007..For marmycin A ( 1), tumor cell cytotoxicity appeared to coincide with induction of modest apoptosis and arrest in the G1 phase of the cell cycle... - Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicolaRatnakar N Asolkar
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 72:396-402. 2009..Taken together, these data suggest that the chemoprevention and anti-inflammatory characteristics of arenamides A and B warrant further investigation... - Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-cultureDong Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 70:515-20. 2007..Emericellamides A and B show modest antibacterial activities against methicillin-resistant Staphylococcus aureus with MIC values of 3.8 and 6.0 microM, respectively... - Lodopyridone, a structurally unprecedented alkaloid from a marine actinomyceteKatherine N Maloney
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
Org Lett 11:5422-4. 2009..Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM... - Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropicaDaniel W Udwary
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
Proc Natl Acad Sci U S A 104:10376-81. 2007..This study firmly establishes the genus Salinispora as a rich source of drug-like molecules and importantly reveals the powerful interplay between genomic analysis and traditional natural product isolation studies... - Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureusNina M Haste
Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0687, USA
J Antibiot (Tokyo) 65:593-8. 2012..Nosiheptide also demonstrated in vivo activity in a murine model of MRSA infection, and therefore represents a promising antibiotic for the treatment of serious infections caused by contemporary strains of MRSA... - Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora"Hak Cheol Kwon
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA
J Am Chem Soc 128:1622-32. 2006..The discovery of these new compounds from a new, chemically rich genus further documents that marine actinomycetes are a significant resource for drug discovery... - Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus NocardiopsisSang Jip Nam
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
J Nat Prod 73:1080-6. 2010..Fijiolide B did not affect QR1 activity, indicating the importance of the nitrogen substitution pattern for biological activity. On the basis of these data, fijiolide A is viewed as a promising lead for more advanced anticancer testing... - Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces spPeng Sun
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
Bioorg Med Chem 19:6557-62. 2011..Fijimycins A-C, and etamycin A, were shown to possess significant in vitro antibacterial activity against three methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC(100) values between 4 and 16 μg mL(-1)... - Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085Ratnakar N Asolkar
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
J Nat Prod 69:1756-9. 2006..The daryamides show weak to moderate cytotoxic activity against the human colon carcinoma cell line HCT-116 and very weak antifungal activities against Candida albicans... - Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensisJi Young Cho
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 70:1321-8. 2007..Lucentamycins A (1) and B (2) showed significant in vitro cytotoxicity against HCT-116 human colon carcinoma... - Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacificaDong Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 71:570-5. 2008..This relationship was shown to be a consequence of the geometric isomerization of one double bond. The phenomenon of polyketide module skipping is proposed to explain the unusual biosynthesis of the salinipyrones and the pacificanones... - Nitropyrrolins A-E, cytotoxic farnesyl-α-nitropyrroles from a marine-derived bacterium within the actinomycete family StreptomycetaceaeHak Cheol Kwon
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
J Nat Prod 73:2047-52. 2010..Several of the nitropyrrolins, nitropyrrolin D in particular, are cytotoxic toward HCT-116 human colon carcinoma cells, but show weak to little antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)... - Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicolaPhilip G Williams
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
J Org Chem 72:5025-34. 2007..The relative and absolute stereochemistries of 1-3 were assigned by a combination of J-based configurational analyses and chemical derivatization... - Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomyceteChollaratt Boonlarppradab
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
Org Lett 10:5505-8. 2008..5 microM for marineosin A) and selective activities in diverse cancer cell types... - The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces spChambers C Hughes
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
Org Lett 10:629-31. 2008..The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus... - Piperazimycins: cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus StreptomycesEric D Miller
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
J Org Chem 72:323-30. 2007..When screened in the National Cancer Institute's 60 cancer cell line panel, piperazimycin A exhibited potent in vitro cytotoxicity toward multiple tumor cell lines with a mean GI50 of 100 nM... - Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales)Ji Young Cho
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
Org Lett 8:2471-4. 2006..The structure was rigorously determined by NMR spectroscopy and X-ray crystallography. A possible biosynthetic origin of this unusual ring system is proposed. [structure: see text].. 
Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial originAndrew W Schultz
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Am Chem Soc 130:4507-16. 2008..Assembly of this unsaturated, branched amino acid is unexpectedly related to the degradation of the environmental pollutant 3-(3-hydroxyphenyl)propionic acid...- Structures, reactivities, and antibiotic properties of the marinopyrroles A-FChambers C Hughes
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Org Chem 75:3240-50. 2010..Halogenation of this material with N-bromosuccinimide cleanly furnished the 4,4',5,5'-tetrahalogenated core that characterizes this class of marine-derived metabolites... - Phylogenetic diversity of gram-positive bacteria cultured from marine sedimentsErin A Gontang
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0204, USA
Appl Environ Microbiol 73:3272-82. 2007..2%) are likely to represent new taxa. The high degree of phylogenetic novelty observed during this study highlights the fact that a great deal remains to be learned about the diversity of gram-positive bacteria in marine sediments... - Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratumRen Xiang Tan
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
J Nat Prod 67:1374-82. 2004..Rostratins A, B, C, and D showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 8.5, 1.9, 0.76, and 16.5 microg/mL, respectively... - Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacteriumWendy K Strangman
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Med Chem 52:2317-27. 2009..This study provides the foundation for the optimization of these potent anti-inflammatory compounds for development in the treatment of asthma... - New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropicaPhilip G Williams
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA
J Org Chem 70:6196-203. 2005..New SAR data for all eight compounds, derived from extensive testing against the human colon carcinoma HCT-116 and the 60-cell-line panel at the NCI, indicate that the chloroethyl moiety plays a major role in the enhanced activity of 1... - Evolution of secondary metabolite genes in three closely related marine actinomycete speciesKelle C Freel
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
Appl Environ Microbiol 77:7261-70. 2011..The distributions and phylogenies of the biosynthetic genes examined provide insight into the complex processes driving the evolution of secondary metabolism among closely related bacterial species... - Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteriaErin A Gontang
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Appl Environ Microbiol 76:2487-99. 2010.... - Phylogenetic analyses and diterpenoid production by marine bacteria of the genus SaprospiraTracy J Mincer
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204, USA
Curr Microbiol 49:300-7. 2004..grandis Gross, and the sole member of the closely related phylotype B. The discovery of two new neoverrucosane diterpenoids produced by phylotype B has also been documented... - Culture-dependent and culture-independent diversity within the obligate marine actinomycete genus SalinisporaTracy J Mincer
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA
Appl Environ Microbiol 71:7019-28. 2005..Challenges involved with the direct sequence-based detection of spore-forming microorganisms in environmental samples are discussed... - Novel bacterial metabolite merochlorin A demonstrates in vitro activity against multi-drug resistant methicillin-resistant Staphylococcus aureusGeorge Sakoulas
Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 7:e29439. 2012.... - Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus CryptosphaeriaHyuncheol Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 73:998-1001. 2010..It also showed significant cytotoxicity against an HCT-116 human colon carcinoma cell line, indicating that the compound may be of value in exploring the Mcl-1 pathway as a target for cancer chemotherapy... - Marinisporolides, polyene-polyol macrolides from a marine actinomycete of the new genus MarinisporaHak Cheol Kwon
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
J Org Chem 74:675-84. 2009..Although polyenes, marinisporolides A (1) and B (2) showed weak to no antifungal activity against Candida albicans... - Structures and biosynthesis of the pyridinopyrones, polyenepyrones from a marine-derived Streptomyces speciesTakashi Fukuda
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 74:1773-8. 2011.... - Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira spDong Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, USA
Org Lett 9:1525-8. 2007.... - Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinosporaRobert H Feling
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
Angew Chem Int Ed Engl 42:355-7. 2003 - Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitorVenkat R Macherla
Nereus Pharmaceuticals, Inc, 10480 Wateridge Circle, San Diego, California 92121, USA
J Med Chem 48:3684-7. 2005..These findings provide insights into structure-activity relationships within this novel series... - Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competitionDong-Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA
Bioorg Med Chem 13:5267-73. 2005..The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 microM)... - Phylogenetic approaches to natural product structure predictionNadine Ziemert
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA
Methods Enzymol 517:161-82. 2012.... - Genomic islands link secondary metabolism to functional adaptation in marine ActinobacteriaKevin Penn
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA
ISME J 3:1193-203. 2009..arenicola may possess a higher level of phage immunity, whereas a highly duplicated family of polymorphic membrane proteins provides evidence for a new mechanism of marine adaptation in Gram-positive bacteria... - The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversityNadine Ziemert
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 7:e34064. 2012..The results provide a rapid method to assess secondary metabolite biosynthetic gene diversity and richness in organisms or environments and a mechanism to identify genes that may be associated with uncharacterized biochemistry... - Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'Kelle C Freel
Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, University of California San Diego, La Jolla, CA 92093, USA
Environ Microbiol 14:480-93. 2012..The inclusion of isolates from additional collection sites and other Salinispora spp. revealed a high degree of dispersal among 'S. pacifica' populations and phylogenetic support for the delineation of this lineage as a third species... - Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unitMicheal C Wilson
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, United States
J Am Chem Soc 133:1971-7. 2011.... - Widespread and persistent populations of a major new marine actinomycete taxon in ocean sedimentsTracy J Mincer
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
Appl Environ Microbiol 68:5005-11. 2002..Organic extracts from cultured members of this new group exhibit remarkable biological activity, suggesting that they represent a prolific resource for biotechnological applications... - Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virensEliane Garo
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA
J Nat Prod 66:423-6. 2003..Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC(50) of 0.32 microg/mL... - Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica"Dong-Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093, USA
Org Lett 8:1021-4. 2006..The cyanosporasides possess a new 3-keto-pyranohexose sugar as well as a cyano- and chloro-substituted cyclopenta[a]indene ring system. The cyanosporasides are proposed to be cyclization products of an enediyne precursor... - Discovery and development of the anticancer agent salinosporamide A (NPI-0052)William Fenical
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Bioorg Med Chem 17:2175-80. 2009..This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule... - Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus streptomyces (actinomycetales)Ji Young Cho
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, 92093-0204, USA
J Nat Prod 69:425-8. 2006.... - Scytalidamides A and B, new cytotoxic cyclic heptapeptides from a marine fungus of the genus ScytalidiumLik Tong Tan
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
J Org Chem 68:8767-73. 2003..Scytalidamides A (1) and B (2) showed moderate in vitro cytotoxicity toward HCT-116 human colon adenocarcinoma with IC(50) values of 2.7 and 11.0 microM, respectively... - Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicolaAnna Edlund
Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, University of California, San Diego, Mail Code 0204, La Jolla, CA 92093, USA
Appl Environ Microbiol 77:5916-25. 2011.... - An N-acyl homolog of mycothiol is produced in marine actinomycetesGerald L Newton
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
Arch Microbiol 190:547-57. 2008..The results demonstrate that major thiol/disulfide changes accompany secondary metabolite production and suggest that mycothiol-dependent detoxification is important at this developmental stage... - Developing a new resource for drug discovery: marine actinomycete bacteriaWilliam Fenical
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
Nat Chem Biol 2:666-73. 2006 - Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus AspergillusMercedes Cueto
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego La Jolla, CA 92093-0204, USA
Phytochemistry 67:1826-31. 2006..Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 microg/mL... - Halovirs A-E, new antiviral agents from a marine-derived fungus of the genus ScytalidiumDavid C Rowley
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
Bioorg Med Chem 11:4263-74. 2003..A qualitative analysis of the secondary structures of these molecules using variable temperature NMR experiments and NOE analyses is also reported... - Bohemamines from a marine-derived Streptomyces spTim S Bugni
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
J Nat Prod 69:1626-8. 2006..The structures were elucidated using NMR methods, and the relative stereochemistry was determined using double-pulsed-field-gradient spin echo (DPFGSE) NOE studies... - Comparative genomics reveals evidence of marine adaptation in Salinispora speciesKevin Penn
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
BMC Genomics 13:86. 2012..The focus was on the obligate marine actinomycete genus Salinispora and the identification of marine adaptation genes that have been acquired from other marine bacteria... - Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureusNina M Haste
Skaggs School of Pharmacy and Pharmaceutical Sciences, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0687, USA
Antimicrob Agents Chemother 55:3305-12. 2011..Marinopyrrole A has significant affinity for plastic and may therefore have potential as a potent anti-MRSA agent in cutaneous, intracatheter, or antibiotic-lock applications... - Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetesKelley A Gallagher
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Curr Opin Biotechnol 21:794-800. 2010..These strains represent a promising resource for natural product discovery and provide unique opportunities to study the evolutionary history and ecological functions of an unusual group of secondary metabolites... - Genetic complementation of the obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshockSergio A Bucarey
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA
Appl Environ Microbiol 78:4175-82. 2012..The enhanced survival of the S. tropica transformant provides experimental evidence that the loss of mscL is associated with the failure of Salinispora spp. to grow in low-osmotic-strength media... - New neoverrucosane diterpenoids produced by the marine gliding bacterium Saprospira grandisAllan Spyere
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204, USA
J Nat Prod 66:818-22. 2003..This study adds to the rare observation of terpene production by prokaryotic microorganisms and suggests that marine gliding bacteria may be a significant source for new terpenoid secondary metabolites... - Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteriaAkimasa Miyanaga
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, United States
J Am Chem Soc 133:13311-3. 2011.... - Seaweed resistance to microbial attack: a targeted chemical defense against marine fungiJulia Kubanek
Center for Marine Biotechnology and Biomedicine, The Scripps Institution of Oceanography, La Jolla, CA 92037-0204, USA
Proc Natl Acad Sci U S A 100:6916-21. 2003.... - A cyclic carbonate and related polyketides from a marine-derived fungus of the genus PhomaZimin Liu
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
Phytochemistry 64:571-4. 2003..Phomoxin contains an unusual cyclic carbonate functionality that is rare among natural products. The structures of the new metabolites were assigned by spectroscopic methods that relied heavily on 2D NMR spectroscopic analysis... - Chemical ecology of marine microbial defenseSebastian Engel
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093-0204, USA
J Chem Ecol 28:1971-85. 2002..Continued research in this field along with improved techniques will certainly provide further insight into how microbes have influenced the evolution of secondary metabolite production in marine organisms... - Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus AspergillusMercedes Cueto
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA
Org Lett 4:1583-5. 2002..The carbon skeleton of 1 represents a new addition to the architectural diversity of the sesterterpenoid (C25) class of secondary metabolites... - Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family MicromonosporaceaeLuis A Maldonado
School of Biology, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
Int J Syst Evol Microbiol 55:1759-66. 2005..nov.; the type strains of these novel species have been deposited in service culture collections as strain CNH-643(T) (=ATCC BAA-917(T)=DSM 44819(T)) and strain CNB-440(T) (=ATCC BAA-916(T)=DSM 44818(T)), respectively...
Research Grants
- A sequenced-based approach for improved small molecule discoveryPaul R Jensen; Fiscal Year: 2010..The methods developed will be made widely available to the research community and thereby have a broad impact on drug discovery and basic biomedical research. ..