M A Jensen

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Molecular population genetics and evolution of a prion-like protein in Saccharomyces cerevisiae
    M A Jensen
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 159:527-35. 2001
  2. pmc Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences
    Mark A Jensen
    Department of Microbiology, University of Washington, Seattle, Washington 98195 8070, USA
    J Virol 77:13376-88. 2003
  3. pmc Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection
    Daniel Shriner
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    Genetics 166:1155-64. 2004
  4. pmc A reliable phenotype predictor for human immunodeficiency virus type 1 subtype C based on envelope V3 sequences
    Mark A Jensen
    Department of Microbiology, University of Washington, Seattle, WA, USA
    J Virol 80:4698-704. 2006
  5. ncbi request reprint Molecular clock-like evolution of human immunodeficiency virus type 1
    Yi Liu
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, United States
    Virology 329:101-8. 2004
  6. ncbi request reprint Dual HIV-1 infection associated with rapid disease progression
    Geoffrey S Gottlieb
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
    Lancet 363:619-22. 2004
  7. ncbi request reprint Predicting HIV-1 coreceptor usage with sequence analysis
    Mark A Jensen
    Department of Microbiology, Box 358070, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    AIDS Rev 5:104-12. 2003
  8. ncbi request reprint Potential impact of recombination on sitewise approaches for detecting positive natural selection
    Daniel Shriner
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Genet Res 81:115-21. 2003
  9. pmc Evolutionary indicators of human immunodeficiency virus type 1 reservoirs and compartments
    David C Nickle
    Departmentof Microbiology, University of Washington School of Medicine, Seattle 98195, USA
    J Virol 77:5540-6. 2003
  10. ncbi request reprint HIV type 1 superinfection with a dual-tropic virus and rapid progression to AIDS: a case report
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 45:501-9. 2007

Collaborators

Detail Information

Publications22

  1. pmc Molecular population genetics and evolution of a prion-like protein in Saccharomyces cerevisiae
    M A Jensen
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 159:527-35. 2001
    ..We also conclude that the clinical strains of S. cerevisiae are not recently derived and that outcrossing between strains in S. cerevisiae may be relatively rare in nature...
  2. pmc Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences
    Mark A Jensen
    Department of Microbiology, University of Washington, Seattle, Washington 98195 8070, USA
    J Virol 77:13376-88. 2003
    ..We found that X4 viruses were lost in two ways: by the dying off of an established X4 lineage or by mutation back to low-scoring V3 loops...
  3. pmc Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection
    Daniel Shriner
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    Genetics 166:1155-64. 2004
    ..We conclude that the genetic variation in these data sets can be explained by a predominance of random genetic drift of neutral mutations with brief episodes of natural selection that were frequently masked by recombination...
  4. pmc A reliable phenotype predictor for human immunodeficiency virus type 1 subtype C based on envelope V3 sequences
    Mark A Jensen
    Department of Microbiology, University of Washington, Seattle, WA, USA
    J Virol 80:4698-704. 2006
    ..We present bioinformatic evidence that particular sites may influence coreceptor usage differently, depending on the subtype...
  5. ncbi request reprint Molecular clock-like evolution of human immunodeficiency virus type 1
    Yi Liu
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, United States
    Virology 329:101-8. 2004
    ..Natural selection alone did not appear to obscure the clock-like evolution of HIV-1...
  6. ncbi request reprint Dual HIV-1 infection associated with rapid disease progression
    Geoffrey S Gottlieb
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
    Lancet 363:619-22. 2004
    ..4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level...
  7. ncbi request reprint Predicting HIV-1 coreceptor usage with sequence analysis
    Mark A Jensen
    Department of Microbiology, Box 358070, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    AIDS Rev 5:104-12. 2003
    ..Further development of these methods, by extending analysis to regions outside the V3 loop and to clades beyond subtype B, will extend our understanding of HIV-1 pathogenesis and inform treatment strategies...
  8. ncbi request reprint Potential impact of recombination on sitewise approaches for detecting positive natural selection
    Daniel Shriner
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Genet Res 81:115-21. 2003
    ....
  9. pmc Evolutionary indicators of human immunodeficiency virus type 1 reservoirs and compartments
    David C Nickle
    Departmentof Microbiology, University of Washington School of Medicine, Seattle 98195, USA
    J Virol 77:5540-6. 2003
    ..We report that existing statistical methods work quite well at detecting viral compartments, and we learn from simulations that viral divergence from a calculated most recent common ancestor is a strong predictor of viral reservoirs...
  10. ncbi request reprint HIV type 1 superinfection with a dual-tropic virus and rapid progression to AIDS: a case report
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 45:501-9. 2007
    ..The occurrence of human immunodeficiency virus type 1 (HIV-1) superinfection has implications for vaccine development and our understanding of HIV pathogenesis and transmission...
  11. pmc Reconstruction and function of ancestral center-of-tree human immunodeficiency virus type 1 proteins
    Morgane Rolland
    Department of Microbiology SC 42, University of Washington, Seattle, WA 98195 8070, USA
    J Virol 81:8507-14. 2007
    ....
  12. ncbi request reprint Anti-S-nitrosocysteine antibodies are a predictive marker for demyelination in experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    Anne I Boullerne
    Department of Neurology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 22:123-32. 2002
    ..Anti-SNO-cysteine Abs are also elevated at times of MS attacks and in progressive disease, suggesting a possible role for these Abs, measurable in blood, as a biological marker for clinical activity...
  13. ncbi request reprint Evolutionary dynamics of HIV-1 and the control of AIDS
    J I Mullins
    Departments of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Curr Top Microbiol Immunol 299:171-92. 2006
    ..This suggests some optimism for those attempting to identify sets of antigens that can generate effective humoral and cellular immune responses against HIV...
  14. pmc HIV-specific probabilistic models of protein evolution
    David C Nickle
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS ONE 2:e503. 2007
    ..We argue that our model derivation procedure is immediately applicable to other organisms with extensive sequence data available, such as Hepatitis C and Influenza A viruses...
  15. ncbi request reprint A novel Fc gamma receptor ligand augments humoral responses by targeting antigen to Fc gamma receptors
    Mark A Jensen
    Department of Neurology, University of Chicago, Chicago, IL 60637, USA
    Eur J Immunol 37:1139-48. 2007
    ..008). Immunization with HSA1R4 yields greater T cell reactivity to HSA1 ex vivo than immunization with HSA1Fc (p<0.004). Linking antigenic peptides to linear HCH2 polymers may facilitate vaccine development...
  16. doi request reprint Immunoglobulin-like transcript 3, an inhibitor of T cell activation, is reduced on blood monocytes during multiple sclerosis relapses and is induced by interferon beta-1b
    Mark A Jensen
    Department of Neurology, The University of Chicago, Chicago, IL 60637, USA
    Mult Scler 16:30-8. 2010
    ..These findings identify a putative novel mechanism for the therapeutic benefit bestowed by Interferon beta and a new target for therapeutic intervention in relapsing-remitting multiple sclerosis...
  17. pmc Patterns of genetic variation at a chromosome 4 locus of Drosophila melanogaster and D. simulans
    Mark A Jensen
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637 1573, USA
    Genetics 160:493-507. 2002
    ..We find evidence for recombinational exchange at this locus, and both species appear to be fixed for an insertion of the transposable element HB in an intron of ankyrin...
  18. pmc Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 79:9006-18. 2005
    ..These data provide in vivo evidence that increasing HIV-1 replication efficiency may be related to a concomitant increase in HIV-1 diversity, which in turn may be a determining factor in disease progression...
  19. ncbi request reprint Consensus and ancestral state HIV vaccines
    David C Nickle
    Science 299:1515-8; author reply 1515-8. 2003
  20. pmc Genetic characterization of rebounding human immunodeficiency virus type 1 in plasma during multiple interruptions of highly active antiretroviral therapy
    Mark Dybul
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:3229-37. 2003
    ..In addition, the data suggest that there may be multiple compartments contributing to the rebound of plasma viremia and to viral diversity from cycle to cycle of intermittent therapy...
  21. ncbi request reprint Clinical and immunological impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy
    Zabrina L Brumme
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, The Faculty of Medicine, University of British Columbia, 603 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    AIDS 18:F1-9. 2004
    ..We wished to determine the impact of specific V3 genotypes associated with viral phenotype and co-receptor usage on response to initial triple antiretroviral therapy...
  22. doi request reprint Predicting disease outcomes in the clinic
    Mark A Jensen
    Nat Biotechnol 26:611-2; author reply 6112-3. 2008