L E Jensen

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein
    L E Jensen
    Department of Pharmacology, Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 164:5277-86. 2000
  2. ncbi Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 279:20221-33. 2004
  3. ncbi The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J
    Bysani Chandrasekar
    Department of Medicine, Medicine Cardiology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:26263-77. 2005
  4. ncbi The 3' untranslated region of the membrane-bound IL-1R accessory protein mRNA confers tissue-specific destabilization
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 156 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Immunol 173:6248-58. 2004
  5. ncbi Ubiquitin activated tumor necrosis factor receptor associated factor-6 (TRAF6) is recycled via deubiquitination
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    FEBS Lett 553:190-4. 2003
  6. ncbi Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein
    Liselotte E Jensen
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 171:1500-6. 2003
  7. ncbi Pellino2 activates the mitogen activated protein kinase pathway
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    FEBS Lett 545:199-202. 2003
  8. ncbi Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania, 156 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Cell Signal 15:793-802. 2003
  9. ncbi IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability
    L E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:29037-44. 2001
  10. ncbi In vitro evaluation of an enhanced human serum amyloid A (SAA2) promoter-regulated soluble TNF receptor fusion protein for anti-inflammatory gene therapy
    M Rygg
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Scand J Immunol 53:588-95. 2001

Research Grants

  1. Soluble IL-1RAcP proteins as inhibitors of inflammation
    LISELOTTE JENSEN; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. ncbi IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein
    L E Jensen
    Department of Pharmacology, Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 164:5277-86. 2000
    ..This suggests that sIL-1RAcP may act as an inhibitor of IL-1 by directly interacting with IL-1RI to abolish its capacity to transduce signal...
  2. ncbi Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 279:20221-33. 2004
    ..Taken together, our results indicate that IL-18 activates both intrinsic and extrinsic proapoptotic signaling pathways, induces endothelial cell death, and thereby may play a role in myocardial inflammation and injury...
  3. ncbi The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J
    Bysani Chandrasekar
    Department of Medicine, Medicine Cardiology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:26263-77. 2005
    ..These data provide for the first time a mechanism of IL-18-mediated CXCL16 gene transcription and CXCL16-dependent ASMC proliferation and suggest a role for IL-18-CXCL16 cross-talk in atherogenesis and restenosis following angioplasty...
  4. ncbi The 3' untranslated region of the membrane-bound IL-1R accessory protein mRNA confers tissue-specific destabilization
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 156 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    J Immunol 173:6248-58. 2004
    ..These data demonstrate that the cellular capacity to respond to IL-1 is tightly regulated in a tissue-specific manner...
  5. ncbi Ubiquitin activated tumor necrosis factor receptor associated factor-6 (TRAF6) is recycled via deubiquitination
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    FEBS Lett 553:190-4. 2003
    ..This indicates a unique mechanism of regulation of TRAF6 activity...
  6. ncbi Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein
    Liselotte E Jensen
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 171:1500-6. 2003
    ..In reporter assays Pellino3 leads to activation of c-Jun and Elk-1, but not NF-kappaB. Pellino3 also leads to activation of c-Jun N-terminal kinase. These data suggest that Pellino3 plays an important role in the innate immune response...
  7. ncbi Pellino2 activates the mitogen activated protein kinase pathway
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    FEBS Lett 545:199-202. 2003
    ..These observations suggest a role for the Pellino proteins in the IL1/Toll signaling cascades as scaffold proteins that may regulate signaling branch-points...
  8. ncbi Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania, 156 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Cell Signal 15:793-802. 2003
    ..The dramatic changes in levels of IL-1RAcP mRNAs suggest important functions in regulating sensitivity to IL-1 during stress and may play a role in oncogenic processes that are engaged during chronic inflammation...
  9. ncbi IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability
    L E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:29037-44. 2001
    ..The presence of an alternative splice variant of IRAK1, which is functionally active and highly stable following IL-1 stimulation, adds further complexity to the control mechanisms that govern IL-1 signaling...
  10. ncbi In vitro evaluation of an enhanced human serum amyloid A (SAA2) promoter-regulated soluble TNF receptor fusion protein for anti-inflammatory gene therapy
    M Rygg
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Scand J Immunol 53:588-95. 2001
    ..It may consequently be of particular use in the future treatment of diseases such as rheumatoid arthritis...
  11. ncbi Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1
    Chun Chi Lin
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Structure 16:1806-16. 2008
    ..Delineating how this E3 ligase associates with substrates, and how these interactions are regulated by phosphorylation, is crucial for a complete understanding of Toll/IL-1 receptor signaling...
  12. ncbi ELAM-1/E-selectin promoter contains an inducible AP-1/CREB site and is not NF-kappa B-specific
    Liselotte E Jensen
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Biotechniques 35:54-6, 58. 2003
  13. ncbi Interleukin-1 regulates keratinocyte expression of T cell targeting chemokines through interleukin-1 receptor associated kinase-1 (IRAK1) dependent and independent pathways
    Julio C Sanmiguel
    Department of Pharmacology, University of Pennsylvania School of Medicine, 89 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Cell Signal 21:685-94. 2009
    ..In conclusion IL-1 regulates T cell targeting chemokine production in keratinocytes through IRAK1 dependent and independent pathways. These pathways may contribute to acute and chronic skin inflammation...
  14. ncbi Staphylococcus aureus stimulates neutrophil targeting chemokine expression in keratinocytes through an autocrine IL-1alpha signaling loop
    Florina Olaru
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 130:1866-76. 2010
    ..This may represent a fail-safe system that protects the host against genetic variation and immune evasion mechanisms developed by pathogens...
  15. ncbi The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway
    Zhi Yong Lu
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Atherosclerosis 205:48-54. 2009
    ..We investigated the mechanisms underlying the modulation of MCP-1 expression by long-term "folate stress"...

Research Grants1

  1. Soluble IL-1RAcP proteins as inhibitors of inflammation
    LISELOTTE JENSEN; Fiscal Year: 2007
    ..of this work would greatly benefit arthritic and musculoskeletal therapeutic areas. ..