Research Topics
| D M JensenSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Endoscopic diagnosis and treatment of watermelon stomachD M Jensen
UCLA/CURE, Veterans' Administration Medical Center, 11301 Wilshire Boulevard, Building 115, Room 318, Los Angeles, CA 90073, USA
Endoscopy 36:640-7. 2004- Randomized double-blind studies of polysaccharide gel compared with glue and other agents for hemostasis of large veins and bleeding canine esophageal or gastric varicesDennis M Jensen
University of California, Los Angeles School of Medicine, CURE Digestive Disease Research Center, and the VA Greater Los Angeles Healthcare System, 90073 1003, USA
J Trauma 57:S33-7. 2004..The safety and efficacy of poly-N-acetyl glucosamine (p-GlcNAc) gels were compared with standard agents in three different dog studies to assess abdominal venous collaterals, bleeding esophageal varices, and bleeding gastric varices... - Clots and spots on ulcers: why and how to treatD M Jensen
UCLA CURE Digestive Disease Research Center, Bldg 115, Room 318, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073 1003, USA
Langenbecks Arch Surg 386:82-7. 2001..Clinical presentation and comorbidity and the endoscopic appearance of the ulcer (i.e., stigmata of hemorrhage) of patients with UGI bleeding are used to determine the subsequent level of care (e.g., discharge or ward or intensive care)... - Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clotsDennis M Jensen
CURE Digestive Disease Research Center, UCLA School of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Gastroenterology 123:407-13. 2002..Our purpose was to test the hypothesis that patients treated with combination endoscopic therapy would have significantly lower rebleeding rates than those treated with medical therapy... - Endoscopic screening for varices in cirrhosis: findings, implications, and outcomesDennis M Jensen
CURE Digestive Diseases Research Center, University of California Los Angeles School of Medicine, Los Angeles, CA, USA
Gastroenterology 122:1620-30. 2002..For low or very low risk cirrhotic patients-those found to have no varices or small varices without stigmata-repeat endoscopy is recommended because screening for progression may be warranted in 2 or more years... - The economic impact of esophageal variceal hemorrhage: cost-effectiveness implications of endoscopic therapyI M Gralnek
University of California, Los Angeles UCLA School of Medicine, Center for the Health Sciences, Department of Medicine, Division of Digestive Diseases, Los Angeles, CA 90095 1684, USA
Hepatology 29:44-50. 1999..Further studies comparing costs and resource utilization in this patient population are needed... - A randomized prospective study of endoscopic bipolar electrocoagulation and heater probe treatment of chronic rectal bleeding from radiation telangiectasiaD M Jensen
CURE Digestive Disease Research Center, UCLA Center for the Health Sciences 90095 1684, USA
Gastrointest Endosc 45:20-5. 1997.... - Endoscopic treatment outcomes in watermelon stomach patients with and without portal hypertensionG S Dulai
Center for Ulcer Research and Education, Digestive Disease Research Center, Center for the Study of Digestive Healthcare Quality and Outcomes, University of California at Los Angeles School of Medicine, Los Angeles, California, USA
Endoscopy 36:68-72. 2004..The aims of this study were to describe the endoscopic appearance and treatment outcomes in watermelon stomach patients with and without portal hypertension... - Randomized controlled study of 3 different types of hemoclips for hemostasis of bleeding canine acute gastric ulcersDennis M Jensen
CURE Hemostasis Research Group, CURE Digestive Diseases Research Center, Bldg 115, Rm 318, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA 90073-1003, USA
Gastrointest Endosc 64:768-73. 2006..2) Short-term retention rates of TC were significantly less than QC or RC. (3) Long-term clip retention was significantly higher with RC. (4) All 3 hemoclips were safe, and none interfered with ulcer healing... - Urgent colonoscopy for the diagnosis and treatment of severe diverticular hemorrhageD M Jensen
Digestive Disease Research Center, University of California at Los Angeles Center for the Health Sciences, and the Veterans Affairs Greater Los Angeles Healthcare System, 90073 1003, USA
N Engl J Med 342:78-82. 2000..Although endoscopy is often used to diagnose and treat acute upper gastrointestinal bleeding, its role in the management of diverticulosis and lower gastrointestinal bleeding is uncertain... - Therapeutic endoscopy for nonvariceal gastrointestinal bleedingT J Savides
Department of Clinical Medicine, University of California, San Diego, USA
Gastroenterol Clin North Am 29:465-87, vii. 2000..Recommendations for endoscopic techniques are based on the results of UCLA-CURE hemostasis studies... - Randomized study comparing banding and propranolol to prevent initial variceal hemorrhage in cirrhotics with high-risk esophageal varicesRome Jutabha
Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Gastroenterology 128:870-81. 2005..Direct costs of medical care were not significantly different... - Endoscopic treatment of ulcer bleedingThomas O G Kovacs
Thomas O G Kovacs, MD CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 115, Room 212, Los Angeles, CA 90073 1003, USA
Curr Treat Options Gastroenterol 10:143-8. 2007..Effective endoscopic hemostasis of ulcer bleeding can significantly improve outcomes by reducing rebleeding, transfusion requirement, and need for surgery, as well as reduce cost of medical care... - Severe gastrointestinal bleeding of obscure originGareth S Dulai
Division of Gastroenterology, CURE Digestive Diseases Research Center, Center for the Study of Digestive Healthcare Quality and Outcomes, Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, CA 90073, USA
Gastrointest Endosc Clin N Am 14:101-13. 2004 - The short-term medical management of non-variceal upper gastrointestinal bleedingThomas O G Kovacs
CURE Digestive Disease Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073 1003, USA
Drugs 68:2105-11. 2008..Medical management with proton pump inhibitors is not a substitute for appropriate endoscopic therapy for patients with UGI bleeding and high-risk ulcer stigmata... - Recent advances in the endoscopic diagnosis and therapy of upper gastrointestinal, small intestinal, and colonic bleedingThomas O G Kovacs
Division of Digestive Diseases, Department of Medicine, University of California at Los Angeles, School of Medicine, CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Med Clin North Am 86:1319-56. 2002.... - Spots and clots - leave them or treat them? Why and how to treatD M Jensen
UCLA School of Medicine, Los Angeles, California 90024 1684, USA
Can J Gastroenterol 13:413-5. 1999..The clinical condition and the endoscopic appearance of the ulcer (ie, stigmata of hemorrhage) of the patient with upper gastrointestinal bleeding are used to determine the subsequent level of care (discharge, ward or intensive care)... 
Hemoclipping of chronic canine ulcers: a randomized, prospective study of initial deployment success, clip retention rates, and ulcer healingDennis M Jensen
Center for Ulcer Research and Education, Hemostasis Research Group, CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, and David Geffen School of Medicine at UCLA, Los Angeles, California CA 90073 1003, USA
Gastrointest Endosc 70:969-75. 2009..No previous reports have compared success rates of clip deployment onto bases of chronic gastric ulcers (GUs), clip retention rates, or their influence on ulcer healing...- Continuous infusion of pantoprazole versus ranitidine for prevention of ulcer rebleeding: a U.S. multicenter randomized, double-blind studyDennis M Jensen
David Geffen School of Medicine at UCLA and CURE Digestive Diseases Research Center, Los Angeles, California 90073, USA
Am J Gastroenterol 101:1991-9; quiz 2170. 2006..1%]vs 7 [9.7%], p= 0.16). CONCLUSIONS: Because of the small sample size of this study, there was an arithmetic but not significant difference in ulcer rebleeding rates... - Push enteroscopy for recurrent gastrointestinal hemorrhage due to jejunal anastomotic varices: a case report and review of the literatureS J Tang
Division of Digestive Diseases, Center for Health Sciences, UCLA School of Medicine, Los Angeles, California
Endoscopy 34:735-7. 2002..Although the treatment of segmental varices has been surgical resection, for patients with overt systemic portal hypertension, a transjugular intrahepatic portal-systemic shunt or a decompressive shunting procedure are recommended... - Current diagnosis and treatment of severe obscure GI hemorrhageDennis M Jensen
UCLA School of Medicine, Los Angeles, California, USA
Gastrointest Endosc 58:256-66. 2003 - Definitive therapy for internal hemorrhoids--new opportunities and optionsGordon V Ohning
David Geffen School of Medicine at UCLA, Greater Los Angeles VA Healthcare Center, Center for Ulcer Research and Education CURE Digestive Diseases Research Center, Los Angeles, California, USA
Rev Gastroenterol Disord 9:16-26. 2009.... - Gastric acid inhibition in the treatment of peptic ulcer hemorrhageKevin A Ghassemi
Center for Ulcer Research and Education, Digestive Diseases Research Center, VA Greater Los Angeles, Healthcare System, Building 115, Room 318, Los Angeles, CA 90073 1003, USA
Curr Gastroenterol Rep 11:462-9. 2009..High-dose oral PPIs may be as effective as intravenous infusion in achieving positive clinical outcomes, but this has not been documented by randomized studies and its cost-effectiveness is unclear... - The significance of gastric and duodenal histological ischemia reported on endoscopic biopsyJ Herman
Center of Ulcer Research and Education, Digestive Diseases Research Center, Los Angeles, California, USA
Endoscopy 43:365-8. 2011..Computed tomography scanning was frequently used (12 cases, 86 %), but led to an underlying diagnosis in only three cases. In our series, patients with underlying vascular pathology have substantial 6-month mortality (29 %)... - The novel use of an intravenous proton pump inhibitor in a patient with short bowel syndromeShou-Jiang Tang
Division of Gastroenterology and Hepatology, VA Greater Los Angeles Healthcare System, California 90073, USA
J Clin Gastroenterol 34:62-3. 2002.... - Randomized prospective study of endoscopic rubber band ligation compared with bipolar coagulation for chronically bleeding internal hemorrhoidsRome Jutabha
David Geffen School of Medicine at UCLA, Greater Los Angeles VA Healthcare Center, Los Angeles, California 90073 1003, USA
Am J Gastroenterol 104:2057-64. 2009.... - Lower gastrointestinal events in a double-blind trial of the cyclo-oxygenase-2 selective inhibitor etoricoxib and the traditional nonsteroidal anti-inflammatory drug diclofenacLoren Laine
Division of Gastrointestinal and Liver Diseases, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
Gastroenterology 135:1517-25. 2008..Cyclo-oxygenase (COX)-2 selective inhibitors decrease upper GI events, but no prospective trial has prespecified assessment of lower GI clinical events... - Endoscopic diagnosis and treatment of severe lower gastrointestinal bleedingGustavo A Machicado
UCLA Center for the Health Sciences, Veteran's Administration Greater Los Angeles Healthcare Center, Los Angeles, CA, USA
Indian J Gastroenterol 25:S43-51. 2006..Also, urgent colonoscopy after purge has been reported to be more cost-effective than elective colonoscopy or other strategies for diagnosis of severe hematochezia... - Dysplasia and risk of further neoplastic progression in a regional Veterans Administration Barrett's cohortGareth S Dulai
Greater Los Angeles Veterans Administration Healthcare System, Department of Medicine, Division of Gastroenterology, UCLA School of Medicine, Los Angeles, CA 90073, USA
Am J Gastroenterol 100:775-83. 2005..The rate of progression to high-grade dysplasia or cancer was significantly higher in those with baseline low-grade dysplasia. These data may warrant reevaluation of current Barrett's surveillance strategies... - Major stigmata of recent hemorrhage on rectal ulcers in patients with severe hematochezia: Endoscopic diagnosis, treatment, and outcomesFasiha Kanwal
Division of Digestive Diseases and Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
Gastrointest Endosc 57:462-8. 2003..For ulcers with major stigmata, endoscopic hemostasis is feasible but rates of recurrent bleeding are high... - Treatment of patients at high risk for recurrent bleeding from a peptic ulcerDennis M Jensen
Ann Intern Med 139:294-5. 2003 - Management of patients with severe hematochezia--with all current evidence availableDennis M Jensen
Am J Gastroenterol 100:2403-6. 2005..Meanwhile, further RCTs for patients with severe hematochezia are warranted... - Where next with endoscopic ulcer hemostasis?Dennis M Jensen
Am J Gastroenterol 97:2161-5. 2002 - Randomized trial of argon plasma coagulation vs. multipolar electrocoagulation for ablation of Barrett's esophagusGareth S Dulai
Gastrointest Endosc 61:232-40. 2005.... - Portal hypertensive enteropathy in a patient with polycystic liver disease: a unique endoscopic findingShou-Jiang Tang
Division of Digestive Diseases, Center for Health Sciences, University of California at Los Angeles (UCLA, USA
Gastrointest Endosc 56:924-6. 2002 - Endoscopic therapy versus medical therapy for bleeding peptic ulcer with adherent clot: a meta-analysisCharles J Kahi
Indiana University Medical Center, and Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
Gastroenterology 129:855-62. 2005..The optimal management of bleeding peptic ulcer with adherent clot is controversial and may include endoscopic therapy or medical therapy...
Research Grants
- GASTROENTEROLOGYDennis Jensen; Fiscal Year: 2007..Continued support is needed to maintain the quality and productivity of this program which is training future academicians in digestive diseases. ..
- UGI Hemorrhage and Barrett's EpitheliumDennis Jensen; Fiscal Year: 2007..This award will continue to enhance the applicant's research productivity and provide skilled mentoring for young investigators, so they can become independent patient-oriented investigators in digestive diseases. ..