Brian C Jensen

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure
    Brian C Jensen
    Cardiology Division, VA Medical Center, San Francisco, CA, USA
    J Mol Cell Cardiol 51:518-28. 2011
  2. pmc Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
    James W Smyth
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 120:266-79. 2010
  3. pmc BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes
    Ting Ting Hong
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Heart Rhythm 9:812-20. 2012
  4. pmc {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium
    Brian C Jensen
    Cardiology Section and Research Service, San Francisco VA Medical Center, San Francisco, Calif, USA
    Circ Heart Fail 2:654-63. 2009
  5. pmc BIN1 localizes the L-type calcium channel to cardiac T-tubules
    Ting Ting Hong
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    PLoS Biol 8:e1000312. 2010
  6. pmc Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells
    Brian C Jensen
    Cardiology Division, VA Medical Center, University of California, San Francisco, San Francisco, CA, USA
    Naunyn Schmiedebergs Arch Pharmacol 382:475-82. 2010
  7. pmc Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive
    Guan Ying Wang
    Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, 94121, USA
    Am J Physiol Heart Circ Physiol 298:H913-20. 2010
  8. ncbi request reprint Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves
    Vishal Nigam
    Department of Pediatrics Cardiology, University of California, San Francisco, USA
    J Heart Valve Dis 19:459-65. 2010
  9. pmc Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific
    Brian C Jensen
    Cardiology Section and Research Service, San Francisco VA Medical Center 111 C 8, 4150 Clement St, San Francisco, CA 94121, USA
    Naunyn Schmiedebergs Arch Pharmacol 379:409-12. 2009

Collaborators

Detail Information

Publications9

  1. pmc Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure
    Brian C Jensen
    Cardiology Division, VA Medical Center, San Francisco, CA, USA
    J Mol Cell Cardiol 51:518-28. 2011
    ..This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."..
  2. pmc Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
    James W Smyth
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 120:266-79. 2010
    ..We anticipate that protecting the microtubule-based forward delivery apparatus of connexons could improve cell-cell coupling and reduce ischemia-related cardiac arrhythmias...
  3. pmc BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes
    Ting Ting Hong
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Heart Rhythm 9:812-20. 2012
    ..2 channels at cardiac T tubules. Bridging integrator 1 (BIN1) is a membrane scaffolding protein that causes Cav1.2 to traffic to T tubules in healthy hearts. The mechanisms of Cav1.2 trafficking in heart failure are not known...
  4. pmc {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium
    Brian C Jensen
    Cardiology Section and Research Service, San Francisco VA Medical Center, San Francisco, Calif, USA
    Circ Heart Fail 2:654-63. 2009
    ..Here, we test the hypothesis that the alpha1A and alpha1B subtypes are present in human myocardium, similar to the mouse, and are not downregulated in heart failure...
  5. pmc BIN1 localizes the L-type calcium channel to cardiac T-tubules
    Ting Ting Hong
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    PLoS Biol 8:e1000312. 2010
    ..2 delivery to T-tubules. This novel Cav1.2 trafficking pathway should serve as an important regulatory aspect of EC coupling, affecting cardiac contractility in mammalian hearts...
  6. pmc Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells
    Brian C Jensen
    Cardiology Division, VA Medical Center, University of California, San Francisco, San Francisco, CA, USA
    Naunyn Schmiedebergs Arch Pharmacol 382:475-82. 2010
    ..Our findings provide another potential mechanism for adverse cardiac effects of drug antagonists that nonselectively inhibit all three α1-AR subtypes...
  7. pmc Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive
    Guan Ying Wang
    Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, 94121, USA
    Am J Physiol Heart Circ Physiol 298:H913-20. 2010
    ..Since alpha(1)-AR agonist catecholamines are elevated in heart failure, increased alpha(1)-AR inotropic responses in the RV myocardium may be adaptive in heart failure by helping the failing RV respond to increased pulmonary pressures...
  8. ncbi request reprint Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves
    Vishal Nigam
    Department of Pediatrics Cardiology, University of California, San Francisco, USA
    J Heart Valve Dis 19:459-65. 2010
    ..In-vitro experiments were also carried out to determine if these miRNAs could modulate calcification-related genes...
  9. pmc Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific
    Brian C Jensen
    Cardiology Section and Research Service, San Francisco VA Medical Center 111 C 8, 4150 Clement St, San Francisco, CA 94121, USA
    Naunyn Schmiedebergs Arch Pharmacol 379:409-12. 2009
    ..These results raise caution with prior studies using these reagents. For now, competition radioligand binding is the only reliable approach to quantify the alpha1-AR subtype proteins. Receptor protein localization remains a challenge...