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Genomes and Genes | Brian C JensenSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failureBrian C Jensen
Cardiology Division, VA Medical Center, San Francisco, CA, USA
J Mol Cell Cardiol 51:518-28. 2011..This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."..- Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardiumJames W Smyth
Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
J Clin Invest 120:266-79. 2010..We anticipate that protecting the microtubule-based forward delivery apparatus of connexons could improve cell-cell coupling and reduce ischemia-related cardiac arrhythmias... - BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytesTing Ting Hong
Cardiovascular Research Institute, University of California, San Francisco, CA, USA
Heart Rhythm 9:812-20. 2012..2 channels at cardiac T tubules. Bridging integrator 1 (BIN1) is a membrane scaffolding protein that causes Cav1.2 to traffic to T tubules in healthy hearts. The mechanisms of Cav1.2 trafficking in heart failure are not known... - {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardiumBrian C Jensen
Cardiology Section and Research Service, San Francisco VA Medical Center, San Francisco, Calif, USA
Circ Heart Fail 2:654-63. 2009..Here, we test the hypothesis that the alpha1A and alpha1B subtypes are present in human myocardium, similar to the mouse, and are not downregulated in heart failure... - BIN1 localizes the L-type calcium channel to cardiac T-tubulesTing Ting Hong
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
PLoS Biol 8:e1000312. 2010..2 delivery to T-tubules. This novel Cav1.2 trafficking pathway should serve as an important regulatory aspect of EC coupling, affecting cardiac contractility in mammalian hearts... - Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cellsBrian C Jensen
Cardiology Division, VA Medical Center, University of California, San Francisco, San Francisco, CA, USA
Naunyn Schmiedebergs Arch Pharmacol 382:475-82. 2010..Our findings provide another potential mechanism for adverse cardiac effects of drug antagonists that nonselectively inhibit all three α1-AR subtypes... - Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positiveGuan Ying Wang
Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, 94121, USA
Am J Physiol Heart Circ Physiol 298:H913-20. 2010..Since alpha(1)-AR agonist catecholamines are elevated in heart failure, increased alpha(1)-AR inotropic responses in the RV myocardium may be adaptive in heart failure by helping the failing RV respond to increased pulmonary pressures... 
Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valvesVishal Nigam
Department of Pediatrics Cardiology, University of California, San Francisco, USA
J Heart Valve Dis 19:459-65. 2010..In-vitro experiments were also carried out to determine if these miRNAs could modulate calcification-related genes...- Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecificBrian C Jensen
Cardiology Section and Research Service, San Francisco VA Medical Center 111 C 8, 4150 Clement St, San Francisco, CA 94121, USA
Naunyn Schmiedebergs Arch Pharmacol 379:409-12. 2009..These results raise caution with prior studies using these reagents. For now, competition radioligand binding is the only reliable approach to quantify the alpha1-AR subtype proteins. Receptor protein localization remains a challenge...