Affiliation: University of Massachusetts
Campbell L, West M, Jensen A. A high content, small molecule screen identifies candidate molecular pathways that regulate rod photoreceptor outer segment renewal. Sci Rep. 2018;8:14017 pubmed publisher
..The data generated by this screen provides a foundation for further investigation of the signaling pathways that regulate photoreceptor outer segment renewal. ..
Christensen A, Jensen A. Tissue-specific requirements for specific domains in the FERM protein Moe/Epb4.1l5 during early zebrafish development. BMC Dev Biol. 2008;8:3 pubmed publisher
..1l5long, and suggest that additional C' terminal sequences are important for zebrafish retinal development. Additionally, our data provide further evidence that Moe is a negative regulator of rod outer segment size. ..
Hsu Y, Jensen A. Multiple domains in the Crumbs Homolog 2a (Crb2a) protein are required for regulating rod photoreceptor size. BMC Cell Biol. 2010;11:60 pubmed publisher
..Our results also suggest that the PDZ-binding domain in Crb2a might bring a protein(s) into the Crb complex that alters the function of the FERM-binding domain. ..
Jensen A, Westerfield M. Zebrafish mosaic eyes is a novel FERM protein required for retinal lamination and retinal pigmented epithelial tight junction formation. Curr Biol. 2004;14:711-7 pubmed
..We suggest that moe may be a necessary component of the crumbs pathway that regulates apical cell polarity and also may play a role in photoreceptor morphogenesis. ..
Jensen A. Potential roles for BMP and Pax genes in the development of iris smooth muscle. Dev Dyn. 2005;232:385-92 pubmed
..The developing iris smooth muscle coexpresses Pax6 and Pax3. I suggest that some of the eye defects caused by mutations in Pax6, BMP4, and BMP7 may be due to abnormal iris smooth muscle. ..
West M, Campbell L, Willoughby J, Jensen A. Two types of transgenic lines for doxycycline-inducible, cell-specific gene expression in zebrafish ultraviolet cone photoreceptors. Gene Expr Patterns. 2014;14:96-104 pubmed publisher
..These lines can be used in addition to the inducible, rod-specific gene expression system from the Tet-On Toolkit to elucidate the photoreceptor-specific effects of genes of interest in photoreceptor cell biology and retinal disease. ..