Michael Jennings

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Inactivation of Saccharomyces cerevisiae sulfate transporter Sul2p: use it and lose it
    Michael L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Biophys J 102:768-76. 2012
  2. pmc Chloride homeostasis in Saccharomyces cerevisiae: high affinity influx, V-ATPase-dependent sequestration, and identification of a candidate Cl- sensor
    Michael L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Gen Physiol 131:379-91. 2008
  3. ncbi request reprint Direct estimate of 1:1 stoichiometry of K(+)-Cl(-) cotransport in rabbit erythrocytes
    M L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Am J Physiol Cell Physiol 281:C825-32. 2001
  4. ncbi request reprint Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p
    Michael L Jennings
    Dept of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 W Markham St, Mail Slot 505, Little Rock, AR 72205, USA
    Am J Physiol Cell Physiol 293:C468-76. 2007
  5. pmc Evidence for a second binding/transport site for chloride in erythrocyte anion transporter AE1 modified at glutamate 681
    Michael L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Biophys J 88:2681-91. 2005
  6. ncbi request reprint Pre-steady state transport by erythrocyte band 3 protein: uphill countertransport induced by the impermeant inhibitor H2DIDS
    M L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Biochem Cell Biol 76:807-13. 1998
  7. pmc Volume-sensitive K(+)/Cl(-) cotransport in rabbit erythrocytes. Analysis of the rate-limiting activation and inactivation events
    M L Jennings
    Department of Physiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Gen Physiol 114:743-58. 1999
  8. ncbi request reprint Topology of the anion exchange protein AE1: the controversial sidedness of lysine 743
    Hiroyuki Kuma
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Biochemistry 41:3380-8. 2002
  9. pmc Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity
    Marina N Chernova
    Molecular and Vascular Medicine Unit, Beth Israel Deaconess Med Ctr, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Cell Physiol 295:C302-12. 2008
  10. ncbi request reprint Aquaporin-2: COOH terminus is necessary but not sufficient for routing to the apical membrane
    Peter M T Deen
    Department of Cell Physiology, University Medical Center St Radboud, Nijmegen 6500 HB, The Netherlands
    Am J Physiol Renal Physiol 282:F330-40. 2002

Research Grants

  1. MECHANISMS OF SULFATE TRANSPORT AND REGULATION
    Michael Jennings; Fiscal Year: 2007
  2. BIOCHEMICAL STUDIES OF ERYTHROCYTE ANION EXCHANGE
    Michael Jennings; Fiscal Year: 2001
  3. MECHANISMS OF SULFATE TRANSPORT AND REGULATION
    Michael Jennings; Fiscal Year: 2007

Collaborators

  • Michael Caplan
  • Donald Mock
  • Seth L Alper
  • Janos Zempleni
  • Barry Wolf
  • Marina N Chernova
  • Peter M T Deen
  • Rebecca Mardach
  • Hiroyuki Kuma
  • Andrew K Stewart
  • Parul N Barry
  • Jane Boylan
  • Theodoor R Muth
  • Todd R Howren
  • Marcel Van Raak
  • Erik Jan Kamsteeg
  • Anjali A Shinde
  • Vanathy Rajendran
  • Martin J Cannon
  • Susan Roth
  • Paul J M Savelkoul
  • Stephen Cederbaum
  • Bas W M van Balkom
  • Sally Cress

Detail Information

Publications11

  1. pmc Inactivation of Saccharomyces cerevisiae sulfate transporter Sul2p: use it and lose it
    Michael L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Biophys J 102:768-76. 2012
    ..02 mM SO(4)(=) to S-starved met3Δ cells. This transient efflux provides further protection against excessive SO(4)(=) influx and may represent an alternate transport mode of Sul2p...
  2. pmc Chloride homeostasis in Saccharomyces cerevisiae: high affinity influx, V-ATPase-dependent sequestration, and identification of a candidate Cl- sensor
    Michael L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Gen Physiol 131:379-91. 2008
    ..This is the first example of a biological system that can regulate cellular Cl- at concentrations far below 1 mM...
  3. ncbi request reprint Direct estimate of 1:1 stoichiometry of K(+)-Cl(-) cotransport in rabbit erythrocytes
    M L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Am J Physiol Cell Physiol 281:C825-32. 2001
    ..The ratio of the NEM-stimulated K(+) to Cl(-) efflux is 1.12 +/- 0.26 (SD, n = 5). We conclude that K(+)-Cl(-) cotransport in rabbit red blood cells has a stoichiometry of 1:1...
  4. ncbi request reprint Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p
    Michael L Jennings
    Dept of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 W Markham St, Mail Slot 505, Little Rock, AR 72205, USA
    Am J Physiol Cell Physiol 293:C468-76. 2007
    ..A possible role in vacuolar dynamics for Bor1p was recently reported by Decker and Wickner. Under the conditions used presently, there appears to be mildly abnormal vacuolar morphology in the deletant strain...
  5. pmc Evidence for a second binding/transport site for chloride in erythrocyte anion transporter AE1 modified at glutamate 681
    Michael L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Biophys J 88:2681-91. 2005
    ..The effects of graded modification of E681 or inhibition by H(2)DIDS are consistent with the idea that the new Cl(-) binding site is on the same E681OH-modified subunit of the AE1 dimer as the normal transport site...
  6. ncbi request reprint Pre-steady state transport by erythrocyte band 3 protein: uphill countertransport induced by the impermeant inhibitor H2DIDS
    M L Jennings
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Biochem Cell Biol 76:807-13. 1998
    ..These results are completely consistent with a ping-pong mechanism of anion exchange in which the catalytic cycle consists of one pair of exchanging anions per subunit of the band 3 dimer...
  7. pmc Volume-sensitive K(+)/Cl(-) cotransport in rabbit erythrocytes. Analysis of the rate-limiting activation and inactivation events
    M L Jennings
    Department of Physiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Gen Physiol 114:743-58. 1999
    ..The rate-limiting inactivation event may be mediated by a protein kinase that is inhibited, either directly or indirectly, by cell swelling, low Mg(2+), acid pH, and NEM...
  8. ncbi request reprint Topology of the anion exchange protein AE1: the controversial sidedness of lysine 743
    Hiroyuki Kuma
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Biochemistry 41:3380-8. 2002
    ..Therefore, the actions of trypsin on intact cells, resealed ghosts, unsealed ghosts, inside-out vesicles, and microsomes from HEK293 cells all indicate that K743 is cytoplasmic and not extracellular...
  9. pmc Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity
    Marina N Chernova
    Molecular and Vascular Medicine Unit, Beth Israel Deaconess Med Ctr, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Cell Physiol 295:C302-12. 2008
    ....
  10. ncbi request reprint Aquaporin-2: COOH terminus is necessary but not sufficient for routing to the apical membrane
    Peter M T Deen
    Department of Cell Physiology, University Medical Center St Radboud, Nijmegen 6500 HB, The Netherlands
    Am J Physiol Renal Physiol 282:F330-40. 2002
    ..The study shows that the AQP2 COOH tail is necessary but not sufficient for routing to the AM and suggests that other parts of AQP2 are needed for AQP2 accumulation in intracellular vesicles...
  11. pmc Biotin dependency due to a defect in biotin transport
    Rebecca Mardach
    Regional Metabolic Service, Kaiser Permanente, Los Angeles, California, USA
    J Clin Invest 109:1617-23. 2002
    ..These results provide evidence for a novel genetic defect in biotin transport. This child is the first known with this defect, which should now be included in the identified causes of biotin dependency...

Research Grants13

  1. MECHANISMS OF SULFATE TRANSPORT AND REGULATION
    Michael Jennings; Fiscal Year: 2007
    ..abstract_text> ..
  2. BIOCHEMICAL STUDIES OF ERYTHROCYTE ANION EXCHANGE
    Michael Jennings; Fiscal Year: 2001
    ..The mutagenesis will be performed in band 3 expressed in both Xenopus oocytes and in yeast. ..
  3. MECHANISMS OF SULFATE TRANSPORT AND REGULATION
    Michael Jennings; Fiscal Year: 2007
    ..These experiments will provide new insights into the regulation of a basic pathway (SO4 = supply to sulfotransferases) that is of importance not only in the skeletal system but in many branches of human pathophysiology. ..