Clark D Jeffries

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Folded RNA from an intron of one gene might inhibit expression of a counteracting gene
    Clark Jeffries
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    In Silico Biol 5:407-13. 2005
  2. ncbi request reprint Systematic discovery of the grammar of translational inhibition by RNA hairpins
    Clark Jeffries
    Renaissance Computing Institute and School of Pharmacy, Campus Box 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    J Theor Biol 241:205-15. 2006
  3. pmc A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects
    Clark D Jeffries
    Renaissance Computing Institute, CB 3127, University of North Carolina at Chapel Hill, NC
    Gene Regul Syst Bio 6:55-66. 2012
  4. pmc Nuclear and cytoplasmic localization of neural stem cell microRNAs
    Clark D Jeffries
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    RNA 17:675-86. 2011
  5. pmc Gene processing control loops suggested by sequencing, splicing, and RNA folding
    Clark D Jeffries
    Eshelman School of Pharmacy and Renaissance Computing Institute, University of North Carolina at Chapel Hill, NC, USA
    BMC Bioinformatics 11:602. 2010
  6. doi request reprint CHI conference on microRNAs: dramatic expansion of research tools and discoveries
    Clark D Jeffries
    Eshelman School of Pharmacy and Renaissance Computing Institute, University of North Carolina at Chapel Hill, NC, USA
    Expert Rev Mol Diagn 10:555-7. 2010
  7. pmc Additional layers of gene regulatory complexity from recently discovered microRNA mechanisms
    Clark D Jeffries
    Renaissance Computing Institute and Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, CB 360, Chapel Hill, NC 27599, USA
    Int J Biochem Cell Biol 42:1236-42. 2010
  8. pmc Discovering collectively informative descriptors from high-throughput experiments
    Clark D Jeffries
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA
    BMC Bioinformatics 10:431. 2009
  9. ncbi request reprint Simulating association studies: a data-based resampling method for candidate regions or whole genome scans
    Fred A Wright
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Bioinformatics 23:2581-8. 2007
  10. pmc microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007

Detail Information

Publications10

  1. ncbi request reprint Folded RNA from an intron of one gene might inhibit expression of a counteracting gene
    Clark Jeffries
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    In Silico Biol 5:407-13. 2005
    ....
  2. ncbi request reprint Systematic discovery of the grammar of translational inhibition by RNA hairpins
    Clark Jeffries
    Renaissance Computing Institute and School of Pharmacy, Campus Box 7360, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    J Theor Biol 241:205-15. 2006
    ..The result is hypothesis generation. Examples of and predictions from this approach are given in the context of apoptosis. Also discussed is application of the algorithm to rational drug design from a new development platform...
  3. pmc A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects
    Clark D Jeffries
    Renaissance Computing Institute, CB 3127, University of North Carolina at Chapel Hill, NC
    Gene Regul Syst Bio 6:55-66. 2012
    ..Together these properties validate a fundamental, first order systems view of cell dynamics. Classification Codes: 15A68...
  4. pmc Nuclear and cytoplasmic localization of neural stem cell microRNAs
    Clark D Jeffries
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    RNA 17:675-86. 2011
    ..That is, in addition to the seed sequence, 3' sequence similarity criteria identify families of mature miRNAs with consistently high nuclear or cytoplasmic expression...
  5. pmc Gene processing control loops suggested by sequencing, splicing, and RNA folding
    Clark D Jeffries
    Eshelman School of Pharmacy and Renaissance Computing Institute, University of North Carolina at Chapel Hill, NC, USA
    BMC Bioinformatics 11:602. 2010
    ..We propose that analogous hairpins from RNA molecules that function as part of the spliceosome might also be the source of small, regulatory RNAs (somewhat smaller than miRNAs)...
  6. doi request reprint CHI conference on microRNAs: dramatic expansion of research tools and discoveries
    Clark D Jeffries
    Eshelman School of Pharmacy and Renaissance Computing Institute, University of North Carolina at Chapel Hill, NC, USA
    Expert Rev Mol Diagn 10:555-7. 2010
    ..This article gives telegraphic descriptions of ten of the presentations, to illustrate the range of conference topics. At least two other mutually nonintersecting choices of ten could have been used with equal effect...
  7. pmc Additional layers of gene regulatory complexity from recently discovered microRNA mechanisms
    Clark D Jeffries
    Renaissance Computing Institute and Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, CB 360, Chapel Hill, NC 27599, USA
    Int J Biochem Cell Biol 42:1236-42. 2010
    ....
  8. pmc Discovering collectively informative descriptors from high-throughput experiments
    Clark D Jeffries
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA
    BMC Bioinformatics 10:431. 2009
    ..Combining information from these studies can increase the reliability and generalizability of results and also yield new insights that guide future research...
  9. ncbi request reprint Simulating association studies: a data-based resampling method for candidate regions or whole genome scans
    Fred A Wright
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Bioinformatics 23:2581-8. 2007
    ..Improvements in study design and analytic techniques will require the simulation of datasets with realistic patterns of linkage disequilibrium and allele frequencies for typed SNPs...
  10. pmc microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
    ..They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer...