WILLIAM JEFFERY

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc A potential benefit of albinism in Astyanax cavefish: downregulation of the oca2 gene increases tyrosine and catecholamine levels as an alternative to melanin synthesis
    Helena Bilandzija
    Department of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia Department of Biology, University of Maryland, Maryland, United States of America
    PLoS ONE 8:e80823. 2013
  2. pmc Evolution of space dependent growth in the teleost Astyanax mexicanus
    Natalya D Gallo
    Department of Biology, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 7:e41443. 2012
  3. pmc Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish: response to Borowsky (2013)
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, MD, 20742, USA
    BMC Biol 11:82. 2013
  4. pmc Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    BMC Biol 10:108. 2012
  5. pmc Siphon regeneration capacity is compromised during aging in the ascidian Ciona intestinalis
    William R Jeffery
    Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA 02543, United States
    Mech Ageing Dev 133:629-36. 2012
  6. ncbi request reprint Ascidian neural crest-like cells: phylogenetic distribution, relationship to larval complexity, and pigment cell fate
    William R Jeffery
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    J Exp Zool B Mol Dev Evol 306:470-80. 2006
  7. ncbi request reprint Chordate ancestry of the neural crest: new insights from ascidians
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Semin Cell Dev Biol 18:481-91. 2007
  8. pmc Emerging model systems in evo-devo: cavefish and microevolution of development
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Evol Dev 10:265-72. 2008
  9. doi request reprint Trunk lateral cells are neural crest-like cells in the ascidian Ciona intestinalis: insights into the ancestry and evolution of the neural crest
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Dev Biol 324:152-60. 2008
  10. pmc Regressive evolution in Astyanax cavefish
    William R Jeffery
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Annu Rev Genet 43:25-47. 2009

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc A potential benefit of albinism in Astyanax cavefish: downregulation of the oca2 gene increases tyrosine and catecholamine levels as an alternative to melanin synthesis
    Helena Bilandzija
    Department of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia Department of Biology, University of Maryland, Maryland, United States of America
    PLoS ONE 8:e80823. 2013
    ....
  2. pmc Evolution of space dependent growth in the teleost Astyanax mexicanus
    Natalya D Gallo
    Department of Biology, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 7:e41443. 2012
    ..We conclude that Astyanax reacts to confined spaces by exhibiting SDG, which has a genetic component and shows evolutionary regression during adaptation of cavefish to confined environments...
  3. pmc Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish: response to Borowsky (2013)
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, MD, 20742, USA
    BMC Biol 11:82. 2013
    ....
  4. pmc Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    BMC Biol 10:108. 2012
    ..Here, we introduce a new approach to this problem by investigating the phenotypic and genetic relationships between a suite of non-visual constructive traits and eye regression...
  5. pmc Siphon regeneration capacity is compromised during aging in the ascidian Ciona intestinalis
    William R Jeffery
    Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA 02543, United States
    Mech Ageing Dev 133:629-36. 2012
    ..We conclude that there is a size and age threshold in Ciona after which the regenerative capacity of the OS is compromised due to effects of aging on cell proliferation...
  6. ncbi request reprint Ascidian neural crest-like cells: phylogenetic distribution, relationship to larval complexity, and pigment cell fate
    William R Jeffery
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    J Exp Zool B Mol Dev Evol 306:470-80. 2006
    ..The results suggest that ascidian neural crest-like cells and vertebrate neural crest cells had a common origin during chordate evolution and that their primitive function was to generate body pigmentation...
  7. ncbi request reprint Chordate ancestry of the neural crest: new insights from ascidians
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Semin Cell Dev Biol 18:481-91. 2007
    ..The primitive role of NCLC may have been in pigment cell dispersal and development. Later, additional functions may have appeared in the vertebrate lineage, resulting in the evolution of definitive NC cells...
  8. pmc Emerging model systems in evo-devo: cavefish and microevolution of development
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Evol Dev 10:265-72. 2008
    ..Finally, we discuss several research frontiers in which Astyanax is poised to make significant contributions in the future: evolution of constructive traits, the craniofacial skeleton, the central nervous system, and behavior...
  9. doi request reprint Trunk lateral cells are neural crest-like cells in the ascidian Ciona intestinalis: insights into the ancestry and evolution of the neural crest
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Dev Biol 324:152-60. 2008
    ....
  10. pmc Regressive evolution in Astyanax cavefish
    William R Jeffery
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Annu Rev Genet 43:25-47. 2009
    ....
  11. ncbi request reprint Adaptive evolution of eye degeneration in the Mexican blind cavefish
    W R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    J Hered 96:185-96. 2005
    ..We conclude from these studies that eye degeneration in cavefish may be caused by adaptive evolution and pleiotropy...
  12. ncbi request reprint Migratory neural crest-like cells form body pigmentation in a urochordate embryo
    William R Jeffery
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nature 431:696-9. 2004
    ..These cells may have gained additional functions or were joined by other cell types to generate the variety of derivatives typical of the vertebrate neural crest...
  13. ncbi request reprint Evolution and development of brain sensory organs in molgulid ascidians
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Evol Dev 6:170-9. 2004
    ..occulta eggs with M. oculata sperm, indicating control by a zygotic process. We conclude that PCD plays an important role in the evolution and development of brain sensory organs in molgulid ascidians...
  14. ncbi request reprint Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis
    Thomas A Hooven
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Int J Dev Biol 48:731-8. 2004
    ..We conclude that hsp90alpha plays a novel role in lens apoptosis and cavefish eye degeneration...
  15. pmc Shadow response in the blind cavefish Astyanax reveals conservation of a functional pineal eye
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    J Exp Biol 211:292-9. 2008
    ..We conclude that light detection by the pineal eye has been conserved in cavefish despite a million or more years of evolution in complete darkness...
  16. pmc Pleiotropic functions of embryonic sonic hedgehog expression link jaw and taste bud amplification with eye loss during cavefish evolution
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Dev Biol 330:200-11. 2009
    ..Therefore, selection for constructive oral-pharyngeal traits may be responsible for eye loss during cavefish evolution via pleiotropic function of the Shh signaling pathway...
  17. pmc Evolution of a behavioral shift mediated by superficial neuromasts helps cavefish find food in darkness
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, 20742, USA
    Curr Biol 20:1631-6. 2010
    ..We conclude that VAB and SN enhancement coevolved to compensate for loss of vision and to help blind cavefish find food in darkness...
  18. pmc Ascidian gene-expression profiles
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Genome Biol 3:REVIEWS1030. 2002
    ..This approach will be particularly informative in studies of ascidians, basal chordates whose genomes and embryology are uniquely suited for mapping developmental gene networks...
  19. ncbi request reprint Programmed cell death in the ascidian embryo: modulation by FoxA5 and Manx and roles in the evolution of larval development
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742 4415, USA
    Mech Dev 118:111-24. 2002
    ..Differences in PCD that occur between ascidian species suggest that diversity in programming apoptosis may explain differences in larval form...
  20. ncbi request reprint Role of PCNA and ependymal cells in ascidian neural development
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742 4415, USA
    Gene 287:97-105. 2002
    ..The results suggest that PCNA and late dividing ependymal cells are required for normal CNS development and larval morphogenesis in ascidians...
  21. ncbi request reprint Lens gene expression analysis reveals downregulation of the anti-apoptotic chaperone alphaA-crystallin during cavefish eye degeneration
    Allen G Strickler
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Dev Genes Evol 217:771-82. 2007
    ..The results suggest that suppression of alphaA-crystallin antiapoptotic activity may be involved in cavefish eye degeneration...
  22. ncbi request reprint Hedgehog signalling controls eye degeneration in blind cavefish
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nature 431:844-7. 2004
    ..These features can be mimicked in surface fish by twhh and/or shh overexpression, supporting the role of hh signalling in the evolution of cavefish eye regression...
  23. ncbi request reprint The lens has a specific influence on optic nerve and tectum development in the blind cavefish Astyanax
    Daphne Soares
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Dev Neurosci 26:308-17. 2004
    ..The results suggest that the lens has a specific influence on optic nerve and tectum development during eye growth in Astyanax...
  24. ncbi request reprint Evidence for multiple genetic forms with similar eyeless phenotypes in the blind cavefish, Astyanax mexicanus
    Thomas E Dowling
    Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
    Mol Biol Evol 19:446-55. 2002
    ..The existence of multiple genetic lineages makes A. mexicanus an excellent model to study convergence and the genes and developmental pathways involved in the evolution of the eye and pigment degeneration...
  25. ncbi request reprint Conservation of retinal circadian rhythms during cavefish eye degeneration
    Luis Espinasa
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Evol Dev 8:16-22. 2006
    ..The results indicate that loss of circadian retinal function does not precede and is therefore not required for eye degeneration in the blind cavefish...
  26. ncbi request reprint Development and evolution of craniofacial patterning is mediated by eye-dependent and -independent processes in the cavefish Astyanax
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park, MD 20742 4415, USA
    Evol Dev 5:435-46. 2003
    ..The results suggest that evolution of the cavefish craniofacial skeleton is controlled by multiple developmental events, some a direct consequence of eye degeneration and others unrelated to loss of the eye...
  27. ncbi request reprint Retinal homeobox genes and the role of cell proliferation in cavefish eye degeneration
    Allen G Strickler
    Department of Biology, University of Maryland, College Park 20742 4415, USA
    Int J Dev Biol 46:285-94. 2002
    ..These results were confirmed by using PCNA and BrdU markers for retinal cell division. We conclude that the CMZ is active in cell proliferation long after eye growth is diminished and is therefore not the major cause of eye degeneration...
  28. pmc Chapter 8. Evolution and development in the cavefish Astyanax
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD, USA
    Curr Top Dev Biol 86:191-221. 2009
    ..We discuss how current studies of eye and pigment regression have revealed some of the mechanisms in which cavefish development has been changed during evolution...
  29. pmc The lens controls cell survival in the retina: Evidence from the blind cavefish Astyanax
    Allen G Strickler
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Dev Biol 311:512-23. 2007
    ..We conclude that the lens acts in concert with another optic component, possibly the RPE, to promote retinal cell survival. Accordingly, deficiency in both optic structures may lead to eye degeneration in cavefish...
  30. ncbi request reprint Probing teleost eye development by lens transplantation
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park 20742, USA
    Methods 28:420-6. 2002
    ..The transplantation method will help characterize the mechanisms through which vertebrate eye development is regulated by the lens...
  31. ncbi request reprint Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism
    Meredith E Protas
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:107-11. 2006
    ..Thus, the two cave populations evolved albinism independently, through similar mutational events...
  32. ncbi request reprint Non-optical releasers for aggressive behavior in blind and blinded Astyanax (Teleostei, Characidae)
    Luis Espinasa
    Department of Natural Sciences, Shenandoah University, Winchester, VA 22601, USA
    Behav Processes 70:144-8. 2005
    ..We conclude that reduced aggression is not the only evolutionary pathway for troglobitic Astyanax and that there is some degree of developmental plasticity in the releaser of aggression and in the selection of its triggering stimuli...
  33. ncbi request reprint Expanded expression of Sonic Hedgehog in Astyanax cavefish: multiple consequences on forebrain development and evolution
    Arnaud Menuet
    CNRS UPR2197 DEPSN, Institut Fessard, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Development 134:845-55. 2007
    ....
  34. pmc Zebrafish Hsp70 is required for embryonic lens formation
    Tyler G Evans
    Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5
    Cell Stress Chaperones 10:66-78. 2005
    ....
  35. ncbi request reprint Evolution of pigment cell regression in the cavefish Astyanax: a late step in melanogenesis
    David W McCauley
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Evol Dev 6:209-18. 2004
    ..We conclude that pigment cell regression in cavefish is mediated by an evolutionary change late in melanogenesis that may involve an impediment in the ability to convert l-tyrosine to l-dopa and melanin...
  36. ncbi request reprint Developmental mechanisms for retinal degeneration in the blind cavefish Astyanax mexicanus
    Alessandro Alunni
    MSNC INRA Group, Institut de Neurobiologie Alfred Fessard, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    J Comp Neurol 505:221-33. 2007
    ....

Research Grants14

  1. MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGG
    WILLIAM JEFFERY; Fiscal Year: 1999
    ..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
  2. The Tunicate Ciona: A New Model for the Effects of Aging on Tissue Regeneration
    William R Jeffery; Fiscal Year: 2010
    ..This study will develop the tunicate Ciona intestinalis, a vertebrate relative with powerful regeneration abilities that also recede with age, as a model to study the relationship between aging and tissue regeneration. ..
  3. Regulation of Eye Growth and Development by the Lens
    William R Jeffery; Fiscal Year: 2010
    ..Using the blind cavefish as a model, this study is designed to provide new information about the role of the ocular lens in coordinating eye development. The results will provide insights into abnormal eye development. ..
  4. Regulation of Eye Growth and Development by the Lens
    WILLIAM JEFFERY; Fiscal Year: 2009
    ..Using the blind cavefish as a model, this study is designed to provide new information about the role of the ocular lens in coordinating eye development. The results will provide insights into abnormal eye development. ..
  5. Regulation of Eye Growth and Development by the Lens
    WILLIAM JEFFERY; Fiscal Year: 2007
    ..We expect this research to provide new insights into lens signaling processes and fill a major gap in our understanding of both normal and abnormal eye development. ..
  6. Regulation of Eye Growth and Development by the Lens
    WILLIAM JEFFERY; Fiscal Year: 2006
    ..We expect this research to provide new insights into lens signaling processes and fill a major gap in our understanding of both normal and abnormal eye development. ..
  7. Regulation of Eye Growth and Development by the Lens
    WILLIAM JEFFERY; Fiscal Year: 2004
    ..We expect this research to provide new insights into lens signaling processes and fill a major gap in our understanding of both normal and abnormal eye development. ..
  8. MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGG
    WILLIAM JEFFERY; Fiscal Year: 2002
    ..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
  9. MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGG
    WILLIAM JEFFERY; Fiscal Year: 2001
    ..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
  10. MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGG
    WILLIAM JEFFERY; Fiscal Year: 2000
    ..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
  11. Regulation of Eye Growth and Development by the Lens
    William R Jeffery; Fiscal Year: 2010
    ..Using the blind cavefish as a model, this study is designed to provide new information about the role of the ocular lens in coordinating eye development. The results will provide insights into abnormal eye development. ..
  12. Regulation of Eye Growth and Development by the Lens
    WILLIAM JEFFERY; Fiscal Year: 2005
    ..We expect this research to provide new insights into lens signaling processes and fill a major gap in our understanding of both normal and abnormal eye development. ..
  13. Regulation of Eye Growth and Development by the Lens
    WILLIAM JEFFERY; Fiscal Year: 2003
    ..We expect this research to provide new insights into lens signaling processes and fill a major gap in our understanding of both normal and abnormal eye development. ..