Research Topics
| WILLIAM JEFFERYSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Detail Information
Publications
Siphon regeneration capacity is compromised during aging in the ascidian Ciona intestinalisWilliam R Jeffery
Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA 02543, United States
Mech Ageing Dev 133:629-36. 2012..We conclude that there is a size and age threshold in Ciona after which the regenerative capacity of the OS is compromised due to effects of aging on cell proliferation...
Chordate ancestry of the neural crest: new insights from ascidiansWilliam R Jeffery
Department of Biology, University of Maryland, College Park, MD 20742, USA
Semin Cell Dev Biol 18:481-91. 2007..The primitive role of NCLC may have been in pigment cell dispersal and development. Later, additional functions may have appeared in the vertebrate lineage, resulting in the evolution of definitive NC cells...- Emerging model systems in evo-devo: cavefish and microevolution of developmentWilliam R Jeffery
Department of Biology, University of Maryland, College Park, MD 20742, USA
Evol Dev 10:265-72. 2008..Finally, we discuss several research frontiers in which Astyanax is poised to make significant contributions in the future: evolution of constructive traits, the craniofacial skeleton, the central nervous system, and behavior... - Adaptive evolution of eye degeneration in the Mexican blind cavefishW R Jeffery
Department of Biology, University of Maryland, College Park, MD 20742, USA
J Hered 96:185-96. 2005..We conclude from these studies that eye degeneration in cavefish may be caused by adaptive evolution and pleiotropy... - Migratory neural crest-like cells form body pigmentation in a urochordate embryoWilliam R Jeffery
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Nature 431:696-9. 2004..These cells may have gained additional functions or were joined by other cell types to generate the variety of derivatives typical of the vertebrate neural crest... 
Trunk lateral cells are neural crest-like cells in the ascidian Ciona intestinalis: insights into the ancestry and evolution of the neural crestWilliam R Jeffery
Department of Biology, University of Maryland, College Park, MD 20742, USA
Dev Biol 324:152-60. 2008....- Evolution and development of brain sensory organs in molgulid ascidiansWilliam R Jeffery
Department of Biology, University of Maryland, College Park, MD 20742, USA
Evol Dev 6:170-9. 2004..occulta eggs with M. oculata sperm, indicating control by a zygotic process. We conclude that PCD plays an important role in the evolution and development of brain sensory organs in molgulid ascidians... - Ascidian neural crest-like cells: phylogenetic distribution, relationship to larval complexity, and pigment cell fateWilliam R Jeffery
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
J Exp Zool B Mol Dev Evol 306:470-80. 2006..The results suggest that ascidian neural crest-like cells and vertebrate neural crest cells had a common origin during chordate evolution and that their primitive function was to generate body pigmentation... - Regressive evolution in Astyanax cavefishWilliam R Jeffery
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Annu Rev Genet 43:25-47. 2009.... - Role of PCNA and ependymal cells in ascidian neural developmentWilliam R Jeffery
Department of Biology, University of Maryland, College Park, MD 20742 4415, USA
Gene 287:97-105. 2002..The results suggest that PCNA and late dividing ependymal cells are required for normal CNS development and larval morphogenesis in ascidians... - Lens gene expression analysis reveals downregulation of the anti-apoptotic chaperone alphaA-crystallin during cavefish eye degenerationAllen G Strickler
Department of Biology, University of Maryland, College Park, MD 20742, USA
Dev Genes Evol 217:771-82. 2007..The results suggest that suppression of alphaA-crystallin antiapoptotic activity may be involved in cavefish eye degeneration... - Shadow response in the blind cavefish Astyanax reveals conservation of a functional pineal eyeMasato Yoshizawa
Department of Biology, University of Maryland, College Park, MD 20742, USA
J Exp Biol 211:292-9. 2008..We conclude that light detection by the pineal eye has been conserved in cavefish despite a million or more years of evolution in complete darkness... - The lens has a specific influence on optic nerve and tectum development in the blind cavefish AstyanaxDaphne Soares
Department of Biology, University of Maryland, College Park, MD 20742, USA
Dev Neurosci 26:308-17. 2004..The results suggest that the lens has a specific influence on optic nerve and tectum development during eye growth in Astyanax... - Evolution of a behavioral shift mediated by superficial neuromasts helps cavefish find food in darknessMasato Yoshizawa
Department of Biology, University of Maryland, College Park, 20742, USA
Curr Biol 20:1631-6. 2010..We conclude that VAB and SN enhancement coevolved to compensate for loss of vision and to help blind cavefish find food in darkness... - Programmed cell death in the ascidian embryo: modulation by FoxA5 and Manx and roles in the evolution of larval developmentWilliam R Jeffery
Department of Biology, University of Maryland, College Park, MD 20742 4415, USA
Mech Dev 118:111-24. 2002..Differences in PCD that occur between ascidian species suggest that diversity in programming apoptosis may explain differences in larval form... - Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosisThomas A Hooven
Department of Biology, University of Maryland, College Park, MD 20742, USA
Int J Dev Biol 48:731-8. 2004..We conclude that hsp90alpha plays a novel role in lens apoptosis and cavefish eye degeneration... - Hedgehog signalling controls eye degeneration in blind cavefishYoshiyuki Yamamoto
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Nature 431:844-7. 2004..These features can be mimicked in surface fish by twhh and/or shh overexpression, supporting the role of hh signalling in the evolution of cavefish eye regression... - Ascidian gene-expression profilesWilliam R Jeffery
Department of Biology, University of Maryland, College Park, MD 20742, USA
Genome Biol 3:REVIEWS1030. 2002..This approach will be particularly informative in studies of ascidians, basal chordates whose genomes and embryology are uniquely suited for mapping developmental gene networks... - Pleiotropic functions of embryonic sonic hedgehog expression link jaw and taste bud amplification with eye loss during cavefish evolutionYoshiyuki Yamamoto
Department of Biology, University of Maryland, College Park, MD 20742, USA
Dev Biol 330:200-11. 2009..Therefore, selection for constructive oral-pharyngeal traits may be responsible for eye loss during cavefish evolution via pleiotropic function of the Shh signaling pathway... - Conservation of retinal circadian rhythms during cavefish eye degenerationLuis Espinasa
Department of Biology, University of Maryland, College Park, MD 20742, USA
Evol Dev 8:16-22. 2006..The results indicate that loss of circadian retinal function does not precede and is therefore not required for eye degeneration in the blind cavefish... - Evidence for multiple genetic forms with similar eyeless phenotypes in the blind cavefish, Astyanax mexicanusThomas E Dowling
Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
Mol Biol Evol 19:446-55. 2002..The existence of multiple genetic lineages makes A. mexicanus an excellent model to study convergence and the genes and developmental pathways involved in the evolution of the eye and pigment degeneration... - Development and evolution of craniofacial patterning is mediated by eye-dependent and -independent processes in the cavefish AstyanaxYoshiyuki Yamamoto
Department of Biology, University of Maryland, College Park, MD 20742-4415, USA
Evol Dev 5:435-46. 2003..The results suggest that evolution of the cavefish craniofacial skeleton is controlled by multiple developmental events, some a direct consequence of eye degeneration and others unrelated to loss of the eye... - Retinal homeobox genes and the role of cell proliferation in cavefish eye degenerationAllen G Strickler
Department of Biology, University of Maryland, College Park 20742-4415, USA
Int J Dev Biol 46:285-94. 2002..These results were confirmed by using PCNA and BrdU markers for retinal cell division. We conclude that the CMZ is active in cell proliferation long after eye growth is diminished and is therefore not the major cause of eye degeneration... - The lens controls cell survival in the retina: Evidence from the blind cavefish AstyanaxAllen G Strickler
Department of Biology, University of Maryland, College Park, MD 20742, USA
Dev Biol 311:512-23. 2007..We conclude that the lens acts in concert with another optic component, possibly the RPE, to promote retinal cell survival. Accordingly, deficiency in both optic structures may lead to eye degeneration in cavefish... - Chapter 8. Evolution and development in the cavefish AstyanaxWilliam R Jeffery
Department of Biology, University of Maryland, College Park, MD, USA
Curr Top Dev Biol 86:191-221. 2009..We discuss how current studies of eye and pigment regression have revealed some of the mechanisms in which cavefish development has been changed during evolution... - Probing teleost eye development by lens transplantationYoshiyuki Yamamoto
Department of Biology, University of Maryland, College Park 20742, USA
Methods 28:420-6. 2002..The transplantation method will help characterize the mechanisms through which vertebrate eye development is regulated by the lens... - Expanded expression of Sonic Hedgehog in Astyanax cavefish: multiple consequences on forebrain development and evolutionArnaud Menuet
CNRS UPR2197 DEPSN, Institut Fessard, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
Development 134:845-55. 2007.... - Evolution of pigment cell regression in the cavefish Astyanax: a late step in melanogenesisDavid W McCauley
Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA
Evol Dev 6:209-18. 2004..We conclude that pigment cell regression in cavefish is mediated by an evolutionary change late in melanogenesis that may involve an impediment in the ability to convert l-tyrosine to l-dopa and melanin... - Zebrafish Hsp70 is required for embryonic lens formationTyler G Evans
Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5
Cell Stress Chaperones 10:66-78. 2005.... - Non-optical releasers for aggressive behavior in blind and blinded Astyanax (Teleostei, Characidae)Luis Espinasa
Department of Natural Sciences, Shenandoah University, Winchester, VA 22601, USA
Behav Processes 70:144-8. 2005..We conclude that reduced aggression is not the only evolutionary pathway for troglobitic Astyanax and that there is some degree of developmental plasticity in the releaser of aggression and in the selection of its triggering stimuli... - Developmental mechanisms for retinal degeneration in the blind cavefish Astyanax mexicanusAlessandro Alunni
MSNC INRA Group, Institut de Neurobiologie Alfred Fessard, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
J Comp Neurol 505:221-33. 2007.... - Genetic analysis of cavefish reveals molecular convergence in the evolution of albinismMeredith E Protas
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 38:107-11. 2006..Thus, the two cave populations evolved albinism independently, through similar mutational events...
Research Grants
- The Tunicate Ciona: A New Model for the Effects of Aging on Tissue RegenerationWilliam R Jeffery; Fiscal Year: 2010..This study will develop the tunicate Ciona intestinalis, a vertebrate relative with powerful regeneration abilities that also recede with age, as a model to study the relationship between aging and tissue regeneration. ..
- Regulation of Eye Growth and Development by the LensWilliam R Jeffery; Fiscal Year: 2010..Using the blind cavefish as a model, this study is designed to provide new information about the role of the ocular lens in coordinating eye development. The results will provide insights into abnormal eye development. ..
- Regulation of Eye Growth and Development by the LensWILLIAM JEFFERY; Fiscal Year: 2007..We expect this research to provide new insights into lens signaling processes and fill a major gap in our understanding of both normal and abnormal eye development. ..
- MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGGWILLIAM JEFFERY; Fiscal Year: 2002..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
- Regulation of Eye Growth and Development by the LensWilliam R Jeffery; Fiscal Year: 2010..Using the blind cavefish as a model, this study is designed to provide new information about the role of the ocular lens in coordinating eye development. The results will provide insights into abnormal eye development. ..