C J Jeffery

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Recombinant expression screening of P. aeruginosa bacterial inner membrane proteins
    Vidya Madhavan
    Department of Biological Sciences, University of Illinois at Chicago, 60607, USA
    BMC Biotechnol 10:83. 2010
  2. ncbi request reprint Crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonate identifies the role of Glu357 in catalysis
    C J Jeffery
    Laboratory for Molecular Biology, MC567, Department of Biology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Biochemistry 40:1560-6. 2001
  3. doi request reprint Moonlighting proteins--an update
    Constance J Jeffery
    Laboratory for Molecular Biology, Department of Biological Sciences, MC567, University of Illinois, 900 S Ashland Ave, Chicago, IL 60607, USA
    Mol Biosyst 5:345-50. 2009
  4. ncbi request reprint Mass spectrometry and the search for moonlighting proteins
    Constance J Jeffery
    Laboratory for Molecular Biology, Department of Biological Sciences, MC567, University of Illinois, 900 S Ashland Ave, Chicago, Illinois 60607, USA
    Mass Spectrom Rev 24:772-82. 2005
  5. doi request reprint Proteins with neomorphic moonlighting functions in disease
    Constance J Jeffery
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    IUBMB Life 63:489-94. 2011
  6. ncbi request reprint Multifunctional proteins: examples of gene sharing
    Constance J Jeffery
    Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois, Chicago, Illinois 60607, USA
    Ann Med 35:28-35. 2003
  7. ncbi request reprint Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate
    J H Lee
    Laboratory for Molecular Biology, MC567, Department of Biology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Biochemistry 40:7799-805. 2001
  8. ncbi request reprint Moonlighting proteins: old proteins learning new tricks
    Constance J Jeffery
    Laboratory for Molecular Biology, MC567, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Trends Genet 19:415-7. 2003
  9. ncbi request reprint Molecular mechanisms for multitasking: recent crystal structures of moonlighting proteins
    Constance J Jeffery
    Laboratory for Molecular Biology, Department of Biological Sciences, MC567, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, Illinois 60607, USA
    Curr Opin Struct Biol 14:663-8. 2004
  10. ncbi request reprint Conformational changes in phosphoglucose isomerase induced by ligand binding
    Diana Arsenieva
    Laboratory for Molecular Biology, MC567, Department of Biological Sciences, University of Illinois, Chicago, IL 60607, USA
    J Mol Biol 323:77-84. 2002

Collaborators

  • Diana Arsenieva
  • Vidya Madhavan
  • Ji Hyun Lee
  • J H Lee
  • Forum Bhatt
  • Gloria H Mazock
  • Brian L Appavu
  • Renaud Hardre
  • Laurent Salmon
  • K Z Chang
  • V Patel

Detail Information

Publications13

  1. pmc Recombinant expression screening of P. aeruginosa bacterial inner membrane proteins
    Vidya Madhavan
    Department of Biological Sciences, University of Illinois at Chicago, 60607, USA
    BMC Biotechnol 10:83. 2010
    ..This project addressed the need for improved methods for obtaining sufficient amounts of TM proteins for determining their structures and molecular mechanisms...
  2. ncbi request reprint Crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonate identifies the role of Glu357 in catalysis
    C J Jeffery
    Laboratory for Molecular Biology, MC567, Department of Biology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Biochemistry 40:1560-6. 2001
    ..Amino acid residues Arg272 and Lys210 are predicted to be involved in stabilizing the negative charge of the intermediate...
  3. doi request reprint Moonlighting proteins--an update
    Constance J Jeffery
    Laboratory for Molecular Biology, Department of Biological Sciences, MC567, University of Illinois, 900 S Ashland Ave, Chicago, IL 60607, USA
    Mol Biosyst 5:345-50. 2009
    ..In addition, the possibility that many proteins with intrinsically unstructured regions might also moonlight is discussed...
  4. ncbi request reprint Mass spectrometry and the search for moonlighting proteins
    Constance J Jeffery
    Laboratory for Molecular Biology, Department of Biological Sciences, MC567, University of Illinois, 900 S Ashland Ave, Chicago, Illinois 60607, USA
    Mass Spectrom Rev 24:772-82. 2005
    ....
  5. doi request reprint Proteins with neomorphic moonlighting functions in disease
    Constance J Jeffery
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    IUBMB Life 63:489-94. 2011
    ..In the cases described herein, the new functions cause cancers or severe neurological impairment, although in most cases the mechanism by which the new function leads to disease is unknown...
  6. ncbi request reprint Multifunctional proteins: examples of gene sharing
    Constance J Jeffery
    Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois, Chicago, Illinois 60607, USA
    Ann Med 35:28-35. 2003
    ..However, moonlighting proteins can potentially make more difficult the determination of the molecular mechanisms of disease and the process of rational drug design...
  7. ncbi request reprint Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate
    J H Lee
    Laboratory for Molecular Biology, MC567, Department of Biology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Biochemistry 40:7799-805. 2001
    ....
  8. ncbi request reprint Moonlighting proteins: old proteins learning new tricks
    Constance J Jeffery
    Laboratory for Molecular Biology, MC567, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Trends Genet 19:415-7. 2003
    ..As well as adding to the number and types of proteins that are known to moonlight, these new examples add to our understanding of the potential importance of moonlighting proteins...
  9. ncbi request reprint Molecular mechanisms for multitasking: recent crystal structures of moonlighting proteins
    Constance J Jeffery
    Laboratory for Molecular Biology, Department of Biological Sciences, MC567, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, Illinois 60607, USA
    Curr Opin Struct Biol 14:663-8. 2004
    ....
  10. ncbi request reprint Conformational changes in phosphoglucose isomerase induced by ligand binding
    Diana Arsenieva
    Laboratory for Molecular Biology, MC567, Department of Biological Sciences, University of Illinois, Chicago, IL 60607, USA
    J Mol Biol 323:77-84. 2002
    ..Differences between the liganded and unliganded structures are limited to the region within and close to the active-site pocket...
  11. doi request reprint Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 A resolution
    Diana Arsenieva
    Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois, Chicago, Illinois 60607, USA
    Proteins 74:72-80. 2009
    ..The availability of recombinant tPGI and its first high-resolution crystal structures are initial steps in considering this enzyme as a potential drug target...
  12. pmc The crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonohydroxamic acid
    Diana Arsenieva
    Laboratory for Molecular Biology, MC567, Department of Biological Sciences, University of Illinois, Chicago, IL 60607, USA
    Proc Natl Acad Sci U S A 99:5872-7. 2002
    ..It also suggests a mechanism for proton transfer between O1 and O2...
  13. pmc The crystal structure of rabbit phosphoglucose isomerase complexed with D-sorbitol-6-phosphate, an analog of the open chain form of D-glucose-6-phosphate
    Ji Hyun Lee
    Laboratory for Molecular Biology, Department of Biological Sciences, MC567, 900 Ashland Ave, University of Illinois at Chicago, Chicago, IL 60607, USA
    Protein Sci 14:727-34. 2005
    ..The PGI/S6P structure represents the conformation of the enzyme and substrate between the ring opening (or ring closing) step and the isomerization step and helps to complete the model for PGI's catalytic mechanism...