Research Topics
Genomes and Genes | Paul JedlickaSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Detail Information
Publications
Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusionsPaul Jedlicka
Department of Pathology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
Int J Clin Exp Pathol 3:338-47. 2010....- Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestinePaul Jedlicka
Department of Pathology, University of Colorado Denver, Anschutz Medical Center, PO Box 6511, MS 8104, Aurora CO 80045, USA
Am J Pathol 174:1280-90. 2009..Interestingly, the overall En/Erm phenotype of disturbed crypt-villus homeostasis is consistent with recently identified Ets function(s) in the restriction of intestinal epithelial tumorigenesis... - The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin micePaul Jedlicka
Department of Pathology, University of Colorado Denver, Aurora CO, USA
BMC Cancer 9:197. 2009..However, few studies have examined Ets tumorigenesis-modifying functions in vivo using model genetic systems... - The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signalingDouglas S Micalizzi
Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Clin Invest 119:2678-90. 2009..Our findings indicate that Six1, acting through TGF-beta signaling and EMT, is a powerful and global promoter of cancer metastasis... 
Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitisColm B Collins
Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
Gut 61:1154-62. 2012..Objectives To analyse the effect of inflammation on the frequency of mononuclear phagocytes (MP) and the effect of altering their frequency by administration of Flt3-L in chronic ileitis...- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaEric T Clambey
Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 109:E2784-93. 2012..These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability... - Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitisEoin N McNamee
Mucosal Inflammation Program, School of Medicine, Aurora, Colorado, USA
Gut 62:53-62. 2013..ILF/TLT are induced within effector sites by homeostatic lymphoid chemokines, but their role in the development of intestinal ILF/TLT and in the pathogenesis of Crohn's disease is poorly understood... - CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated RemodelingJoanne C Masterson
Section of Pediatric Gastroenterology, Hepatology and Nutrition Digestive Health Institute, Children s Hospital Colorado, Aurora, Colorado, USA
Am J Pathol 179:2302-14. 2011..Cellularity of local mesenteric lymph nodes, including T- and B-lymphocytes, was also significantly reduced. Thus, eosinophils participate in intestinal remodeling, supporting eosinophils as a novel therapeutic target... - SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancerChu An Wang
Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
J Clin Invest 122:1895-906. 2012.... - Retinoic acid attenuates ileitis by restoring the balance between T-helper 17 and T regulatory cellsColm B Collins
Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
Gastroenterology 141:1821-31. 2011..Retinoic acid (RA), produced by intestinal epithelial cells (IECs) and dendritic cells (DCs) promotes the induction of regulatory T cells (Tregs) and decreases the induction of T-helper (Th)17 cells... - EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistanceTyler P Robin
Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Mol Cancer Res 10:1098-108. 2012..These studies identify EYA3 as a novel mediator of chemoresistance in Ewing sarcoma and define the molecular mechanisms of both EYA3 overexpression and of EYA3-mediated chemoresistance... - Ets transcription factors in intestinal morphogenesis, homeostasis and diseasePaul Jedlicka
Department of Pathology, University of Colorado Denver, Aurora CO 80045, USA
Histol Histopathol 23:1417-24. 2008.... - Interleukin 37 expression protects mice from colitisEoin N McNamee
Department of Medicine, Section of Pediatric Gastroenterology, Digestive Health Institute, Children s Hospital Colorado, University of Colorado Denver, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 108:16711-6. 2011..Thus, IL-37 emerges as key modulator of intestinal inflammation... - Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factorsHanna B Kern
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
DNA Cell Biol 31:1403-11. 2012..Overall, our studies identify a complex relationship between oncogenic pathways and steady-state miR-21 levels in CRC, and highlight the need for greater understanding of the control of miR expression in cancer and other disease states... - The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in miceJoshua D Wermers
Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
Gastroenterology 140:1526-35.e3. 2011..We sought to determine whether interaction between the chemokine receptor 9 (CCR9) and its ligand, chemokine ligand 25 (CCL25), allows effectors or Tregs to localize to chronically inflamed small intestine... - Vascular compromise as a cause of sudden death in a pediatric patient with widely metastatic testicular germ cell tumorMindy Grunzke
Department of Pediatrics, University of Colorado Denver, CO, USA
J Pediatr Hematol Oncol 31:756-7. 2009..However, marked compression of the inferior vena cava by a large pelvicoabdominal tumor mass and findings suggestive of systemic-portal shunting were consistent with the death due to the impaired venous return via the inferior vena cava... - Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transitionErica L McCoy
Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Clin Invest 119:2663-77. 2009..Our data thus provide genetic evidence for a potent oncogenic role for Six1 in mammary epithelial neoplasia, including promotion of EMT and stem cell-like features... - Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformationRicardo D Coletta
Department of Obstretrics and Gynecology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Cancer Res 68:2204-13. 2008.... 
Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epitheliumBritta M Jacobsen
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
Cancer Res 66:8274-9. 2006..The transformed stroma-derived cells are tumorigenic with histopathologic features of malignancy, suggesting a new mechanism for tumor progression...