Paul Jedlicka

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions
    Paul Jedlicka
    Department of Pathology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
    Int J Clin Exp Pathol 3:338-47. 2010
  2. pmc Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine
    Paul Jedlicka
    Department of Pathology, University of Colorado Denver, Anschutz Medical Center, PO Box 6511, MS 8104, Aurora CO 80045, USA
    Am J Pathol 174:1280-90. 2009
  3. pmc The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice
    Paul Jedlicka
    Department of Pathology, University of Colorado Denver, Aurora CO, USA
    BMC Cancer 9:197. 2009
  4. pmc The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling
    Douglas S Micalizzi
    Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 119:2678-90. 2009
  5. pmc Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitis
    Colm B Collins
    Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
    Gut 61:1154-62. 2012
  6. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012
  7. pmc Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis
    Eoin N McNamee
    Mucosal Inflammation Program, School of Medicine, Aurora, Colorado, USA
    Gut 62:53-62. 2013
  8. pmc CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling
    Joanne C Masterson
    Section of Pediatric Gastroenterology, Hepatology and Nutrition Digestive Health Institute, Children s Hospital Colorado, Aurora, Colorado, USA
    Am J Pathol 179:2302-14. 2011
  9. pmc SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer
    Chu An Wang
    Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 122:1895-906. 2012
  10. doi request reprint Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
    Eric L Campbell
    Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Immunity 40:66-77. 2014

Collaborators

Detail Information

Publications23

  1. pmc Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions
    Paul Jedlicka
    Department of Pathology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
    Int J Clin Exp Pathol 3:338-47. 2010
    ....
  2. pmc Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine
    Paul Jedlicka
    Department of Pathology, University of Colorado Denver, Anschutz Medical Center, PO Box 6511, MS 8104, Aurora CO 80045, USA
    Am J Pathol 174:1280-90. 2009
    ..Interestingly, the overall En/Erm phenotype of disturbed crypt-villus homeostasis is consistent with recently identified Ets function(s) in the restriction of intestinal epithelial tumorigenesis...
  3. pmc The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice
    Paul Jedlicka
    Department of Pathology, University of Colorado Denver, Aurora CO, USA
    BMC Cancer 9:197. 2009
    ..However, few studies have examined Ets tumorigenesis-modifying functions in vivo using model genetic systems...
  4. pmc The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling
    Douglas S Micalizzi
    Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 119:2678-90. 2009
    ..Our findings indicate that Six1, acting through TGF-beta signaling and EMT, is a powerful and global promoter of cancer metastasis...
  5. pmc Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitis
    Colm B Collins
    Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
    Gut 61:1154-62. 2012
    ..Objectives To analyse the effect of inflammation on the frequency of mononuclear phagocytes (MP) and the effect of altering their frequency by administration of Flt3-L in chronic ileitis...
  6. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012
    ..These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability...
  7. pmc Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis
    Eoin N McNamee
    Mucosal Inflammation Program, School of Medicine, Aurora, Colorado, USA
    Gut 62:53-62. 2013
    ..ILF/TLT are induced within effector sites by homeostatic lymphoid chemokines, but their role in the development of intestinal ILF/TLT and in the pathogenesis of Crohn's disease is poorly understood...
  8. pmc CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling
    Joanne C Masterson
    Section of Pediatric Gastroenterology, Hepatology and Nutrition Digestive Health Institute, Children s Hospital Colorado, Aurora, Colorado, USA
    Am J Pathol 179:2302-14. 2011
    ..Cellularity of local mesenteric lymph nodes, including T- and B-lymphocytes, was also significantly reduced. Thus, eosinophils participate in intestinal remodeling, supporting eosinophils as a novel therapeutic target...
  9. pmc SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer
    Chu An Wang
    Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 122:1895-906. 2012
    ....
  10. doi request reprint Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
    Eric L Campbell
    Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Immunity 40:66-77. 2014
    ..In conclusion, transcriptional imprinting by infiltrating neutrophils modulates the host response to inflammation, via localized O2 depletion, resulting in microenvironmental hypoxia and effective inflammatory resolution. ..
  11. doi request reprint Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis
    Colm B Collins
    Mucosal Inflammation Program, Division of Gastroenterology, University of Colorado School of Medicine, Aurora, Colorado, USA
    Inflamm Bowel Dis 19:1964-73. 2013
    ....
  12. pmc Retinoic acid attenuates ileitis by restoring the balance between T-helper 17 and T regulatory cells
    Colm B Collins
    Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
    Gastroenterology 141:1821-31. 2011
    ..Retinoic acid (RA), produced by intestinal epithelial cells (IECs) and dendritic cells (DCs) promotes the induction of regulatory T cells (Tregs) and decreases the induction of T-helper (Th)17 cells...
  13. pmc EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance
    Tyler P Robin
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Mol Cancer Res 10:1098-108. 2012
    ..These studies identify EYA3 as a novel mediator of chemoresistance in Ewing sarcoma and define the molecular mechanisms of both EYA3 overexpression and of EYA3-mediated chemoresistance...
  14. pmc Interleukin 37 expression protects mice from colitis
    Eoin N McNamee
    Department of Medicine, Section of Pediatric Gastroenterology, Digestive Health Institute, Children s Hospital Colorado, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 108:16711-6. 2011
    ..Thus, IL-37 emerges as key modulator of intestinal inflammation...
  15. pmc Ets transcription factors in intestinal morphogenesis, homeostasis and disease
    Paul Jedlicka
    Department of Pathology, University of Colorado Denver, Aurora CO 80045, USA
    Histol Histopathol 23:1417-24. 2008
    ....
  16. pmc Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, Department of Anesthesiology and Perioperative Medicine, and Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    Proc Natl Acad Sci U S A 110:19820-5. 2013
    ..These findings establish a role for HIF-regulated CK in epithelial homeostasis and reveal a fundamental link between cellular bioenergetics and mucosal barrier. ..
  17. pmc Growth-promoting role of the miR-106a~363 cluster in Ewing sarcoma
    Layne Dylla
    Cancer Biology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 8:e63032. 2013
    ....
  18. pmc Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors
    Hanna B Kern
    Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    DNA Cell Biol 31:1403-11. 2012
    ..Overall, our studies identify a complex relationship between oncogenic pathways and steady-state miR-21 levels in CRC, and highlight the need for greater understanding of the control of miR expression in cancer and other disease states...
  19. pmc Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition
    Erica L McCoy
    Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 119:2663-77. 2009
    ..Our data thus provide genetic evidence for a potent oncogenic role for Six1 in mammary epithelial neoplasia, including promotion of EMT and stem cell-like features...
  20. doi request reprint Vascular compromise as a cause of sudden death in a pediatric patient with widely metastatic testicular germ cell tumor
    Mindy Grunzke
    Department of Pediatrics, University of Colorado Denver, CO, USA
    J Pediatr Hematol Oncol 31:756-7. 2009
    ..However, marked compression of the inferior vena cava by a large pelvicoabdominal tumor mass and findings suggestive of systemic-portal shunting were consistent with the death due to the impaired venous return via the inferior vena cava...
  21. pmc The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice
    Joshua D Wermers
    Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
    Gastroenterology 140:1526-35.e3. 2011
    ..We sought to determine whether interaction between the chemokine receptor 9 (CCR9) and its ligand, chemokine ligand 25 (CCL25), allows effectors or Tregs to localize to chronically inflamed small intestine...
  22. doi request reprint Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation
    Ricardo D Coletta
    Department of Obstretrics and Gynecology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Cancer Res 68:2204-13. 2008
    ....
  23. ncbi request reprint Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium
    Britta M Jacobsen
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Cancer Res 66:8274-9. 2006
    ..The transformed stroma-derived cells are tumorigenic with histopathologic features of malignancy, suggesting a new mechanism for tumor progression...