M A Javors

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Sequential combination of self-report, breath carbon monoxide, and saliva cotinine to assess smoking status
    M A Javors
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Drug Alcohol Depend 113:242-4. 2011
  2. pmc Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholics
    Martin A Javors
    South Texas Addiction Research and Technology START Center, and Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:7-13. 2005
  3. ncbi request reprint Cut-off levels for breath carbon monoxide as a marker for cigarette smoking
    Martin A Javors
    Department of Psychiatry, University of Texas HSC, San Antonio, Texas 78229, USA
    Addiction 100:159-67. 2005
  4. ncbi request reprint Extraction and quantification of epibatidine in plasma
    M A Javors
    Department of Psychiatry, The University of Texas HSC, San Antonio 78229, USA
    J Chromatogr B Biomed Sci Appl 755:379-82. 2001
  5. ncbi request reprint Rat breathalyzer
    Martin A Javors
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Alcohol Clin Exp Res 29:1853-7. 2005
  6. pmc Quantification of rimonabant (SR 141716A) in monkey plasma using HPLC with UV detection
    Martin A Javors
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas, USA
    J Chromatogr Sci 48:491-5. 2010
  7. ncbi request reprint Characterization of chloride efflux from GT1-7 neurons: lack of effect of ethanol on GABAA response
    M A Javors
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284, USA
    Brain Res 780:183-9. 1998
  8. ncbi request reprint Current status of carbohydrate deficient transferrin, total serum sialic acid, sialic acid index of apolipoprotein J and serum beta-hexosaminidase as markers for alcohol consumption
    Martin A Javors
    Department of Psychiatry, The University of Texas HSC, San Antonio, Texas 78229, USA
    Addiction 98:45-50. 2003
  9. ncbi request reprint Concentration-dependent effects of muscimol to enhance pulsatile GnRH release from GT1-7 neurons in vitro
    T S King
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    Brain Res 824:56-62. 1999
  10. ncbi request reprint Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level
    S Benmansour
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Neurosci 19:10494-501. 1999

Detail Information

Publications38

  1. pmc Sequential combination of self-report, breath carbon monoxide, and saliva cotinine to assess smoking status
    M A Javors
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Drug Alcohol Depend 113:242-4. 2011
    ....
  2. pmc Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholics
    Martin A Javors
    South Texas Addiction Research and Technology START Center, and Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:7-13. 2005
    ..Our findings in currently drinking alcoholics support the hypothesis that those with the LL genotype of the 5'-HTTLPR region of the 5-HTT gene have reduced 5-HTT function...
  3. ncbi request reprint Cut-off levels for breath carbon monoxide as a marker for cigarette smoking
    Martin A Javors
    Department of Psychiatry, University of Texas HSC, San Antonio, Texas 78229, USA
    Addiction 100:159-67. 2005
    ..p.m.) or higher to identify smoking. In this study, the cut-off level of BCO as an indicator of smoking over the past 24 hours was re-examined...
  4. ncbi request reprint Extraction and quantification of epibatidine in plasma
    M A Javors
    Department of Psychiatry, The University of Texas HSC, San Antonio 78229, USA
    J Chromatogr B Biomed Sci Appl 755:379-82. 2001
    ..3 and 37.1 ng/ml in pooled male and female plasma samples from C57BL/10 J mice, respectively. This is a simple and straightforward procedure by which plasma samples may be analyzed for epibatidine...
  5. ncbi request reprint Rat breathalyzer
    Martin A Javors
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Alcohol Clin Exp Res 29:1853-7. 2005
    ....
  6. pmc Quantification of rimonabant (SR 141716A) in monkey plasma using HPLC with UV detection
    Martin A Javors
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas, USA
    J Chromatogr Sci 48:491-5. 2010
    ..Rimonabant levels ranged from 175 to 1290 ng/mL. The analytical assay described here provides a simple and accurate procedure for multiple within-subject measurements of the CB(1) antagonist rimonabant...
  7. ncbi request reprint Characterization of chloride efflux from GT1-7 neurons: lack of effect of ethanol on GABAA response
    M A Javors
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284, USA
    Brain Res 780:183-9. 1998
    ..Furthermore, the lack of an effect of ethanol observed in this study is consistent with the idea that a gamma 2L subunit may be necessary for the effects of low concentrations of ethanol at GABAA receptors...
  8. ncbi request reprint Current status of carbohydrate deficient transferrin, total serum sialic acid, sialic acid index of apolipoprotein J and serum beta-hexosaminidase as markers for alcohol consumption
    Martin A Javors
    Department of Psychiatry, The University of Texas HSC, San Antonio, Texas 78229, USA
    Addiction 98:45-50. 2003
    ....
  9. ncbi request reprint Concentration-dependent effects of muscimol to enhance pulsatile GnRH release from GT1-7 neurons in vitro
    T S King
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    Brain Res 824:56-62. 1999
    ..These results are consistent with previously published reports suggesting that activation of the GABAA receptor stimulates hypothalamic GnRH release in embryonic and neonatal animals...
  10. ncbi request reprint Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level
    S Benmansour
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Neurosci 19:10494-501. 1999
    ..Based on these results, it appears that the SERT is downregulated by chronic administration of SSRIs but not other types of antidepressants; furthermore, the downregulation is not caused by decreases in SERT gene expression...
  11. ncbi request reprint Cocaine disrupts estrous cyclicity and alters the reproductive neuroendocrine axis in the rat
    T S King
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio
    Neuroendocrinology 51:15-22. 1990
    ..Ten-minute pulses of 0.1 microM NE increased GnRH release in both saline- and cocaine-treated rats. However, the response to pulsed NE was significantly attenuated in the cocaine-treated group.(ABSTRACT TRUNCATED AT 250 WORDS)..
  12. ncbi request reprint Effect of acute administration of cocaine on pituitary gonadotrophin secretion in female rats
    T S King
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Reproduction 122:723-9. 2001
    ..Acute administration of cocaine does not appear to affect pituitary gonadotrophin secretion directly...
  13. ncbi request reprint Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepileptics
    Bankole A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Alcohol Clin Exp Res 28:295-301. 2004
    ..DiClemente; (5) Synopsis of promising medications to treat alcoholism, by Robert M. Swift; and (6) New knowledge on the development of antiepileptic medications for the treatment of alcoholism, by Robert J. Malcolm, Jr...
  14. pmc Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter
    Michael A Dawes
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Stud Alcohol Drugs 70:899-907. 2009
    ..Specifically, we wanted to examine the relationships between the following: platelet 5-HTT and 5-HTT genotype; platelet 5-HTT parameters and age at onset, as well as duration of drinking; and 5-HTT genotype and impulse control...
  15. pmc Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Aging Cell 7:641-50. 2008
    ..Further studies are warranted to find whether NDGA or aspirin, over a range of doses,might prove to postpone death and various age-related outcomes reproducibly in mice...
  16. pmc Mouse breathalyzer
    Brett C Ginsburg
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Alcohol Clin Exp Res 32:1181-5. 2008
    ..The development of a relatively simple, noninvasive method for estimating blood ethanol concentrations in mice will be useful in behavioral studies related to alcoholism. This study validated such a method...
  17. ncbi request reprint Contingencies for change in complacent smokers
    R J Lamb
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, San Antonio, TX 78229 3900, USA
    Exp Clin Psychopharmacol 15:245-55. 2007
    ....
  18. ncbi request reprint A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 59:408-14. 2006
    ..We hypothesized that venlafaxine would affect monoamine transporters dose-dependently, with low doses causing selective reduction of SERT binding sites and higher doses reducing both SERT and NET binding sites...
  19. ncbi request reprint Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Biol Psychiatry 61:210-5. 2007
    ....
  20. ncbi request reprint Oral topiramate for treatment of alcohol dependence: a randomised controlled trial
    Bankole A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Lancet 361:1677-85. 2003
    ..We aimed to see whether topiramate was more effective than placebo as a treatment for alcohol dependence...
  21. ncbi request reprint Thrombin-stimulated increases in cytosolic Ca2+ level and gonadotropin-releasing hormone release in GT1-7 neurons
    E C Chen
    Department of Obstetrics and Gynecology, The University of Texas Health Science Center, San Antonio 78284, USA
    Peptides 20:859-64. 1999
    ..2+/-67.8 pg x min x ml(-1); P = 0.001) but not the duration (22.5+/-2.4 min; P = 0.8) of GnRH release. These results suggest that thrombin increases [Ca2+]cyt and GnRH release from GT1-7 neurons via specific membrane-bound receptors...
  22. ncbi request reprint Effects of fluvoxamine on a multiple schedule of ethanol- and food-maintained behavior in two rat strains
    Brett C Ginsburg
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78228, USA
    Psychopharmacology (Berl) 180:249-57. 2005
    ..However, none of these studies matched baseline responding for reinforcers. Because behavioral effects of many drugs depend on the baseline response rate, the preferential effects of SSRIs may be due to different baseline response rates...
  23. ncbi request reprint Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine
    W Anthony Owens
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 94:1402-10. 2005
    ..These results provide exciting new evidence that actions of amphetamine on DA neurotransmission are insulin-dependent and further suggest that exposure to amphetamine may cause long-lasting changes in DAT function...
  24. ncbi request reprint Kinetic and cardiovascular comparison of immediate-release isradipine and sustained-release isradipine among non-treatment-seeking, cocaine-dependent individuals
    Bankole A Johnson
    South Texas Addiction Research and Technology Center, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:15-20. 2005
    ..The more favorable cardiovascular profile of SR isradipine would, however, make it more appropriate as an investigational medication for the treatment of stimulant dependence and related neurovascular disorders...
  25. ncbi request reprint Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial
    B A Johnson
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Dr, Mail Stop 7792, San Antonio, TX 78229 3900, USA
    JAMA 284:963-71. 2000
    ..Thus, individuals with early-onset alcoholism may be responsive to treatment with a selective serotonergic agent...
  26. ncbi request reprint In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function
    Paul D Callaghan
    Department of Physiology, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    J Neurochem 100:617-27. 2007
    ....
  27. pmc Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats
    Jun Xu Li
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, TX 78229, USA
    J Pharmacol Exp Ther 331:671-9. 2009
    ..Results in 5-HT-depleted rats further suggest that the discriminative stimulus effects of MDL100907 might involve antagonism of endogenous 5-HT and/or inverse agonism at 5-HT(2A) receptors...
  28. ncbi request reprint Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys
    Lance R McMahon
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 192:135-45. 2007
    ..Benzodiazepine treatment can result in dependence as evidenced by signs of withdrawal upon discontinuation of use...
  29. ncbi request reprint Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo
    David Weinshenker
    Howard Hughes Medical Institute, Box 357370, University of Washington, Seattle 98195, USA
    Brain Res 946:239-46. 2002
    ..There are some qualitative and quantitative differences in the down-regulation of the NET by catecholamine depletion and DMI treatment, suggesting that different mechanisms may be involved...
  30. pmc Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:209-16. 2008
    ..Thus, 5-HTT expression varies with current and lifetime drinking in L-carriers alone...
  31. ncbi request reprint An Aging Interventions Testing Program: study design and interim report
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109 2200, USA
    Aging Cell 6:565-75. 2007
    ..More data will be needed to determine if any of these compounds can extend maximal lifespan, but the current data show that NDGA reduces early life mortality risks in genetically heterogeneous mice at multiple test sites...
  32. ncbi request reprint The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice
    Todd H Ahern
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 31:730-8. 2006
    ..These results suggest that chronic antidepressant drug treatment has both proconvulsant and anticonvulsant effects, and that venlafaxine is a good candidate for the treatment of epilepsy and depression comorbidity...
  33. ncbi request reprint Use of oral topiramate to promote smoking abstinence among alcohol-dependent smokers: a randomized controlled trial
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Arch Intern Med 165:1600-5. 2005
    ..Herein, we extend that proof-of-concept study by determining whether cigarette-smoking, alcohol-dependent individuals from the earlier study also experienced improved smoking outcomes...
  34. ncbi request reprint Alcohol biomarker screening in medical and surgical settings
    Peter M Miller
    Center for Drug and Alcohol Programs, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:185-93. 2006
    ..Presentations were discussed by Raymond Anton...
  35. pmc Effects of disulfiram and dopamine beta-hydroxylase knockout on cocaine-induced seizures
    Meriem Gaval-Cruz
    Department of Human Genetics, Emory University, 301 Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 89:556-62. 2008
    ..These results suggest that disulfiram enhances CIS via two distinct mechanisms: it both increases CIS frequency by inhibiting DBH and increases CIS frequency in a DBH-independent manner...
  36. pmc Kinetic and cardiovascular effects of acute topiramate dosing among non-treatment-seeking, methamphetamine-dependent individuals
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:455-61. 2007
    ..Larger laboratory studies with chronic dosing regimens are needed to establish whether or not there is a kinetic interaction between topiramate and methamphetamine...
  37. ncbi request reprint A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Drug Alcohol Depend 84:256-63. 2006
    ..04). These results suggest the possibility of a non-linear dose-response function, with evidence supporting efficacy for the 4.0 mg group...
  38. ncbi request reprint The effects of norepinephrine transporter inactivation on locomotor activity in mice
    Heather A Mitchell
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Biol Psychiatry 60:1046-52. 2006
    ..Because norepinephrine is an important regulator of spontaneous locomotor activity, we speculated that norepinephrine transporter blockade contributes to the effects of some antidepressants on spontaneous locomotor activity...