Robyn Javier

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Physiology and pharmacology of striatal neurons
    Anatol C Kreitzer
    Gladstone Institute of Neurological Disease and Departments of Physiology and Neurology, University of California, San Francisco, California 94158, USA
    Annu Rev Neurosci 32:127-47. 2009
  2. pmc Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
    Alexxai V Kravitz
    Gladstone Institute of Neurological Disease, 1650 Owens St, San Francisco, California 94158, USA
    Nature 466:622-6. 2010
  3. ncbi request reprint Reassessing models of Basal Ganglia function and dysfunction
    Alexandra B Nelson
    The Gladstone Institutes, San Francisco, California 94158 email
    Annu Rev Neurosci 37:117-35. 2014
  4. pmc Distinct roles for direct and indirect pathway striatal neurons in reinforcement
    Alexxai V Kravitz
    Gladstone Institute of Neurological Disease, University of California San Francisco, San Francisco, CA, USA
    Nat Neurosci 15:816-8. 2012
  5. pmc Investigating striatal function through cell-type-specific manipulations
    A C Kreitzer
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuroscience 198:19-26. 2011
  6. pmc ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons
    Jin A Lee
    Department of Biotechnology, College of Life Science and Nanotechnology, Hannam University, Dajeon 305 811, Korea
    Mol Brain 4:37. 2011
  7. pmc Striatal plasticity and basal ganglia circuit function
    Anatol C Kreitzer
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 60:543-54. 2008
  8. pmc Distinct roles of GABAergic interneurons in the regulation of striatal output pathways
    Aryn H Gittis
    Gladstone Institute of Neurological Disease, Department of Physiology, and Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:2223-34. 2010
  9. ncbi request reprint Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    Jorge J Palop
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 55:697-711. 2007
  10. pmc Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists
    Talia N Lerner
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:2160-4. 2010

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Physiology and pharmacology of striatal neurons
    Anatol C Kreitzer
    Gladstone Institute of Neurological Disease and Departments of Physiology and Neurology, University of California, San Francisco, California 94158, USA
    Annu Rev Neurosci 32:127-47. 2009
    ..This review examines the cellular physiology and modulation of striatal neurons that give rise to their unique properties and function...
  2. pmc Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
    Alexxai V Kravitz
    Gladstone Institute of Neurological Disease, 1650 Owens St, San Francisco, California 94158, USA
    Nature 466:622-6. 2010
    ....
  3. ncbi request reprint Reassessing models of Basal Ganglia function and dysfunction
    Alexandra B Nelson
    The Gladstone Institutes, San Francisco, California 94158 email
    Annu Rev Neurosci 37:117-35. 2014
    ....
  4. pmc Distinct roles for direct and indirect pathway striatal neurons in reinforcement
    Alexxai V Kravitz
    Gladstone Institute of Neurological Disease, University of California San Francisco, San Francisco, CA, USA
    Nat Neurosci 15:816-8. 2012
    ....
  5. pmc Investigating striatal function through cell-type-specific manipulations
    A C Kreitzer
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuroscience 198:19-26. 2011
    ..Recently, application of new methodologies for perturbing activity and signaling in different cell types in vivo has begun to allow direct tests of the causal roles of striatal neurons in behavior...
  6. pmc ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons
    Jin A Lee
    Department of Biotechnology, College of Life Science and Nanotechnology, Hannam University, Dajeon 305 811, Korea
    Mol Brain 4:37. 2011
    ..Many mammalian ESCRT proteins have multiple isoforms but their precise functions remain largely unknown, especially in human neurons...
  7. pmc Striatal plasticity and basal ganglia circuit function
    Anatol C Kreitzer
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 60:543-54. 2008
    ..Here, we review current understanding of synaptic plasticity in the striatum and its role in the physiology and pathophysiology of basal ganglia function...
  8. pmc Distinct roles of GABAergic interneurons in the regulation of striatal output pathways
    Aryn H Gittis
    Gladstone Institute of Neurological Disease, Department of Physiology, and Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:2223-34. 2010
    ..Surprisingly, we find that FS interneurons preferentially target direct-pathway MSNs over indirect-pathway MSNs, suggesting a potential mechanism for rapid pathway-specific regulation of striatal output pathways...
  9. ncbi request reprint Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    Jorge J Palop
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 55:697-711. 2007
    ..Aberrant increases in network excitability and compensatory inhibitory mechanisms in the hippocampus may contribute to Abeta-induced neurological deficits in hAPP mice and, possibly, also in humans with AD...
  10. pmc Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists
    Talia N Lerner
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:2160-4. 2010
    ..Together, these data outline a molecular mechanism by which A(2A) antagonists reduce excitatory synaptic drive on the indirect pathway through CB(1) receptor signaling, thus leading to increased psychomotor activation...
  11. pmc Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor
    Karen L Ring
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Cell Stem Cell 11:100-9. 2012
    ..Thus, self-renewable and multipotent iNSCs without tumorigenic potential can be generated directly from fibroblasts by reprogramming...

Research Grants3

  1. Neuron- and Circuit-Specific Mechanisms and Adaptations Regulating Striatal Funct
    Anatol C Kreitzer; Fiscal Year: 2010
    ..The long- term goal is to develop a framework for the development of novel therapies for treating movement disorders involving the striatum. ..
  2. Mechanisms of Long-Term Depression in the Striatum
    Anatol Kreitzer; Fiscal Year: 2005
    ..These studies will provide a framework for understanding how long-term changes in synaptic strength in the striatum are related to such health issues as addiction and neurodegenerative disease. ..
  3. Neuron- and Circuit-Specific Mechanisms and Adaptations Regulating Striatal Funct
    Anatol Kreitzer; Fiscal Year: 2009
    ..The long- term goal is to develop a framework for the development of novel therapies for treating movement disorders involving the striatum. ..