Affiliation: University of Southern California
Jaskoll T, Htet K, Abichaker G, Kaye F, Melnick M. CRTC1 expression during normal and abnormal salivary gland development supports a precursor cell origin for mucoepidermoid cancer. Gene Expr Patterns. 2011;11:57-63 pubmed publisher
..Moreover, the coincident expression of CRTC1 protein and cell proliferation markers in tumor-like histopathology suggests that CRTC1-mediated cell proliferation may contribute, in part, to initial tumor formation. ..
Melnick M, Deluca K, Jaskoll T. CMV-induced pathology: pathway and gene-gene interaction analysis. Exp Mol Pathol. 2014;97:154-65 pubmed publisher
..Detailed characterization of the functional architecture of the examined "cancer network" exposes the critical crosstalk and compensatory pathways that limit the efficacy of targeted anti-kinase therapies. ..
Jaskoll T, Abichaker G, Sedghizadeh P, Bringas P, Melnick M. Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev Biol. 2008;8:33 pubmed publisher
Jaskoll T, Abichaker G, Htet K, Bringas P, Morita S, Sedghizadeh P, et al
. Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars. Cells Tissues Organs. 2010;192:221-39 pubmed publisher
..Importantly, our data indicate that specific levels of Amelx and Dspp gene expression define whether mouse CMV induces enamel agenesis or hypoplasia. ..
Jaskoll T, Abichaker G, Jangaard N, Bringas P, Melnick M. Cytomegalovirus inhibition of embryonic mouse tooth development: a model of the human amelogenesis imperfecta phenocopy. Arch Oral Biol. 2008;53:405-15 pubmed publisher
Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P, et al
. Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. Dev Dyn. 2004;229:722-32 pubmed
Jaskoll T, Witcher D, Toreno L, Bringas P, Moon A, Melnick M. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004;268:457-69 pubmed
..This is as expected, though there is no synergistic effect with FGF10 + Shh peptide supplementation. These in vitro experiments model the principle that mutations have different effects in the context of different epigenotypes. ..
Jaskoll T, Abichaker G, Witcher D, Sala F, Bellusci S, Hajihosseini M, et al
. FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev Biol. 2005;5:11 pubmed