Thomas Jansson

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches
    Thomas Jansson
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Clin Sci (Lond) 113:1-13. 2007
  2. ncbi request reprint The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease
    Thomas Jansson
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    Curr Vasc Pharmacol 7:521-33. 2009
  3. ncbi request reprint IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a review
    T Jansson
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, PO Box 670526, Cincinnati, OH 45267, USA
    Placenta 27:S91-7. 2006
  4. ncbi request reprint Placental transport and metabolism in fetal overgrowth -- a workshop report
    T Jansson
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, OH 45267, USA
    Placenta 27:S109-13. 2006
  5. pmc Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies
    Nina Jansson
    Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    J Clin Endocrinol Metab 98:105-13. 2013
  6. pmc Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth
    Fredrick J Rosario
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Physiol 590:1495-509. 2012
  7. pmc Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4
    Susanne Lager
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA
    J Lipid Res 54:725-33. 2013
  8. pmc Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells
    Fredrick J Rosario
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Physiol 591:609-25. 2013
  9. doi request reprint Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters
    Fredrick J Rosario
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Endocrinology 152:1119-29. 2011
  10. pmc Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells
    Helen N Jones
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:1161-70. 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches
    Thomas Jansson
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Clin Sci (Lond) 113:1-13. 2007
    ....
  2. ncbi request reprint The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease
    Thomas Jansson
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    Curr Vasc Pharmacol 7:521-33. 2009
    ....
  3. ncbi request reprint IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a review
    T Jansson
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, PO Box 670526, Cincinnati, OH 45267, USA
    Placenta 27:S91-7. 2006
    ..Preliminary evidence suggests that placental mammalian target of rapamycin, a protein kinase regulating protein translation and transcription in response to nutrient stimuli, may be involved in placental nutrient sensing...
  4. ncbi request reprint Placental transport and metabolism in fetal overgrowth -- a workshop report
    T Jansson
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, OH 45267, USA
    Placenta 27:S109-13. 2006
    ....
  5. pmc Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies
    Nina Jansson
    Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    J Clin Endocrinol Metab 98:105-13. 2013
    ..Babies of obese women are often large at birth, which is associated with perinatal complications and metabolic syndrome later in life. The mechanisms linking maternal obesity to fetal overgrowth are largely unknown...
  6. pmc Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth
    Fredrick J Rosario
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Physiol 590:1495-509. 2012
    ..We have identified a novel physiological mechanism by which the endocrine functions of maternal adipose tissue influence fetal growth...
  7. pmc Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4
    Susanne Lager
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA
    J Lipid Res 54:725-33. 2013
    ..Our data suggest that maternal fatty acids can increase placental nutrient transport via TLR4, thereby potentially affecting fetal growth...
  8. pmc Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells
    Fredrick J Rosario
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Physiol 591:609-25. 2013
    ....
  9. doi request reprint Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters
    Fredrick J Rosario
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Endocrinology 152:1119-29. 2011
    ..We speculate that maternal endocrine and metabolic control of placental nutrient transport reduces fetal growth in response to protein restriction...
  10. pmc Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells
    Helen N Jones
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:1161-70. 2010
    ..We hypothesized that adiponectin regulates placental amino acid transport...
  11. pmc High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice
    Helen N Jones
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati OH 45267, USA
    FASEB J 23:271-8. 2009
    ..These data suggest that up-regulation of specific placental nutrient transporter isoforms constitute a mechanism linking maternal high-fat diet and obesity to fetal overgrowth...
  12. doi request reprint Effect of 30% nutrient restriction in the first half of gestation on maternal and fetal baboon serum amino acid concentrations
    Thomas J McDonald
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Sciences Center, San Antonio, TX 78229, USA
    Br J Nutr 109:1382-8. 2013
    ..We speculate that these adaptive mechanisms may fail later in gestation when fetal nutrient demands increase rapidly, resulting in IUGR...
  13. pmc Fetal serum folate concentrations and placental folate transport in obese women
    Margaret F Carter
    Division of Maternal Fetal Medicine, University of Texas Health Science Center at San Antonio, Department of Obstetrics and Gynecology, San Antonio, TX 78229, USA
    Am J Obstet Gynecol 205:83.e17-25. 2011
    ..We hypothesized that fetal folate serum concentrations are lower and placental folate transport is impaired in pregnancies of obese women...
  14. ncbi request reprint Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes
    Thomas Jansson
    Department of Physiology and Pharmacology, The Perinatal Center, Goteborg University, Box 432, S 405 30 Goteborg, Sweden
    Diabetes 51:2214-9. 2002
    ..The increased MVM leucine uptake in the GDM/LGA group may contribute to accelerated fetal growth in these patients...
  15. ncbi request reprint [Pregnancy complications can impair placental transport systems. Aberrant fetal growth, for example in diabetes, is only now beginning to be understood]
    Thomas Jansson
    Institutionen för fysiologi och farmakologi, Sahlgrenska akademin, Göteborgs Universitet
    Lakartidningen 100:2508-11. 2003
    ....
  16. pmc Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport
    Anette Ericsson
    Perinatal Center, Institute of Neuroscience and Physiology, Gothenburg University, Box 432, S 405 30 Gothenburg, Sweden
    J Physiol 581:1323-32. 2007
    ..We speculate that maternal metabolism in early pregnancy represents a key environmental cue to which the placenta responds in order to match fetal growth rate with the available resources of the mother...
  17. ncbi request reprint Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency
    Anne Liese Magnusson-Olsson
    Perinatal Center, Institute of Neuroscience and Physiology, Goteborg University, Box 432, S 405 30 Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 293:E24-30. 2007
    ..This regulatory mechanism may serve to counteract an excessive delivery of FFA to the fetus in conditions where maternal TG levels are markedly increased...
  18. pmc Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet
    Nina Jansson
    Perinatal Center, Institute of Neuroscience and Physiology, Goteborg University, Sweden
    J Physiol 576:935-46. 2006
    ..Reduced maternal levels of insulin, leptin and IGF-1 may link maternal protein malnutrition to reduced fetal growth by down-regulation of key placental amino acid transporters...
  19. ncbi request reprint Placental phenotypes of intrauterine growth
    Colin P Sibley
    Division of Human Development, Acadamic Unit of Child Health, The Medical School, University of Manchester, St Mary s Hospital, Manchester M13 OJH, UK
    Pediatr Res 58:827-32. 2005
    ....
  20. ncbi request reprint Effects of blockade of the endothelin receptor A and inhibition of nitric oxide synthesis on uteroplacental and renal blood flow in awake pregnant rats
    Gunilla Ajne
    Department of Obstetrics and Gynecology, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden
    Am J Obstet Gynecol 192:295-301. 2005
    ..The aim of this study was to evaluate the role of the ETA receptor and nitric oxide (NO) in the regulation of uteroplacental and renal blood flow in pregnant rats...
  21. ncbi request reprint Placental lactate transporter activity and expression in intrauterine growth restriction
    Paul Settle
    Division of Human Development, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    J Soc Gynecol Investig 13:357-63. 2006
    ..In addition, we examine the expression of monocarboxylate transporters (MCT1 and MCT4)...
  22. ncbi request reprint Interleukin-6 in the maternal circulation reaches the rat fetus in mid-gestation
    Jovanna Dahlgren
    Goteborg Pediatric Growth Research Center, Institute for the Health of Women and Children, Queen Silvia Childrens Hospital, Goteborg, Sweden
    Pediatr Res 60:147-51. 2006
    ..Maternally derived IL-6 may directly induce fetal injury but also stimulate the release of fetal stress hormones resulting in stimuli or insults in neuroendocrine structures and hormonal axes which might lead to disease at adult age...
  23. pmc Maternal taurine supplementation in the late pregnant rat stimulates postnatal growth and induces obesity and insulin resistance in adult offspring
    Karin Hultman
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Goteborg University, Sweden
    J Physiol 579:823-33. 2007
    ..This effect was particularly evident in females. These data suggest that fetal taurine availability is an important determinant for postnatal growth, insulin sensitivity and fat accumulation...
  24. ncbi request reprint Maternal hormones linking maternal body mass index and dietary intake to birth weight
    Nina Jansson
    Perinatal Center, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Am J Clin Nutr 87:1743-9. 2008
    ..The mechanisms underlying increased fetal growth remain to be established...
  25. pmc Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth
    Sara Roos
    Perinatal Center, Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, PO Box 432, SE 405 30 Gothenburg, Sweden
    J Physiol 582:449-59. 2007
    ..We propose that mTOR functions as a placental nutrient sensor, matching fetal growth with maternal nutrient availability by regulating placental nutrient transport...