Yvonne M W Janssen-Heininger

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation
    Jos L J Van Der Velden
    Dept of Pathology, Univ of Vermont Health Sciences Research Facility, Rm 216A Burlington, VT 05405
    Am J Physiol Lung Cell Mol Physiol 306:L866-75. 2014
  2. pmc Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas
    Vikas Anathy
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Cell Biol 184:241-52. 2009
  3. pmc Emerging mechanisms of glutathione-dependent chemistry in biology and disease
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 114:1962-8. 2013
  4. pmc Induction of a mesenchymal expression program in lung epithelial cells by wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1)
    Jos L J Van Der Velden
    Department of Pathology, Health Sciences Research Facility, Room 216A, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 47:306-14. 2012
  5. pmc SPLUNC1 regulation in airway epithelial cells: role of Toll-like receptor 2 signaling
    Hong Wei Chu
    Department of Medicine, National Jewish Health, and the University of Colorado Denver, Denver, CO, USA
    Respir Res 11:155. 2010
  6. pmc Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Proc Am Thorac Soc 6:249-55. 2009
  7. pmc Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Ann N Y Acad Sci 1203:23-8. 2010
  8. pmc SOD inactivation in asthma: bad or no news?
    Yvonne Janssen-Heininger
    Department of Pathology, University of Vermont, Health Sciences Research Facility, 216A, 149 Beaumont Avenue, Burlington VT 05405, USA
    Am J Pathol 166:649-52. 2005
  9. pmc Redox-based regulation of signal transduction: principles, pitfalls, and promises
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 45:1-17. 2008
  10. pmc Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation
    John F Alcorn
    Department of Pathology, Univ of Vermont, HSRF Bldg, Rm 216A, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 298:L57-66. 2010

Research Grants

  1. REGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 1999
  2. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2009
  3. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne Janssen Heininger; Fiscal Year: 2009
  4. Redox-based Fas signaling in allergic airway disease
    Yvonne Janssen Heininger; Fiscal Year: 2009
  5. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne M W Janssen Heininger; Fiscal Year: 2010
  6. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen Heininger; Fiscal Year: 2010
  7. Redox-based Fas signaling in allergic airway disease
    Yvonne Janssen Heininger; Fiscal Year: 2009
  8. Redox-based Fas signaling in allergic airway disease
    Yvonne M W Janssen Heininger; Fiscal Year: 2010
  9. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2007
  10. REGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2000

Collaborators

Detail Information

Publications46

  1. pmc Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation
    Jos L J Van Der Velden
    Dept of Pathology, Univ of Vermont Health Sciences Research Facility, Rm 216A Burlington, VT 05405
    Am J Physiol Lung Cell Mol Physiol 306:L866-75. 2014
    ..Overexpression of let-7g in lung epithelial cells reversed the HDM-induced increases in α-SMA. Collectively, these findings demonstrate an important requirement for JNK1 in promoting HDM-induced fibrotic airway remodeling. ..
  2. pmc Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas
    Vikas Anathy
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Cell Biol 184:241-52. 2009
    ..As a result, death-inducing signaling complex formation is also increased, and subsequent activation of caspase-8 and -3 is augmented. These results define a novel redox-based mechanism to propagate Fas-dependent apoptosis...
  3. pmc Emerging mechanisms of glutathione-dependent chemistry in biology and disease
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 114:1962-8. 2013
    ..We will also cover newly developed methodology to detect S-glutathionylation in situ, which will enable further discovery into the role of S-glutathionylation in biology and disease...
  4. pmc Induction of a mesenchymal expression program in lung epithelial cells by wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1)
    Jos L J Van Der Velden
    Department of Pathology, Health Sciences Research Facility, Room 216A, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 47:306-14. 2012
    ..These data show that the activation of the Wnt signaling pathway is capable of inducing an EMT program in lung epithelial cells through β-catenin, and that this process is controlled by JNK1...
  5. pmc SPLUNC1 regulation in airway epithelial cells: role of Toll-like receptor 2 signaling
    Hong Wei Chu
    Department of Medicine, National Jewish Health, and the University of Colorado Denver, Denver, CO, USA
    Respir Res 11:155. 2010
    ..However, the mechanisms underlying SPLUNC1 regulation remain unknown. In the current study, we investigated if SPLUNC1 production following Mp infection is regulated through Toll-like receptor 2 (TLR2) signaling...
  6. pmc Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Proc Am Thorac Soc 6:249-55. 2009
    ....
  7. pmc Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Ann N Y Acad Sci 1203:23-8. 2010
    ..This manuscript will discuss evidence that S-glutathionylation regulates death receptor induced apoptosis, and the potential implications for cysteine oxidations in the pathogenesis of in fibrotic lung disease...
  8. pmc SOD inactivation in asthma: bad or no news?
    Yvonne Janssen-Heininger
    Department of Pathology, University of Vermont, Health Sciences Research Facility, 216A, 149 Beaumont Avenue, Burlington VT 05405, USA
    Am J Pathol 166:649-52. 2005
  9. pmc Redox-based regulation of signal transduction: principles, pitfalls, and promises
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 45:1-17. 2008
    ..We also attempt to highlight some of the current pitfalls and the approaches needed to advance this important area of biochemical and biomedical research...
  10. pmc Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation
    John F Alcorn
    Department of Pathology, Univ of Vermont, HSRF Bldg, Rm 216A, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 298:L57-66. 2010
    ....
  11. pmc Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease
    Sidra M Hoffman
    Departments of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Am J Physiol Lung Cell Mol Physiol 303:L528-38. 2012
    ..These results demonstrate that the Glrx1/S-glutathionylation redox status in mice is a critical regulator of AHR, suggesting that avenues to increase S-glutathionylation of specific target proteins may be beneficial to attenuate AHR...
  12. pmc Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling
    Jane E Tully
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405
    J Immunol 191:5811-21. 2013
    ....
  13. pmc Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injury
    Jennifer L Ather
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 43:443-51. 2010
    ....
  14. pmc Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling
    Scott W Aesif
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 51:1249-57. 2011
    ..Collectively, this study demonstrates that the Glrx1 gene is positively regulated by NF-κB and suggests a feed-forward mechanism to promote NF-κB signaling by decreasing S-glutathionylation...
  15. pmc Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration
    Karina Ckless
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Immunol 181:4255-64. 2008
    ..These results suggest that inhibition of arginase activity enhanced a variety of parameters relevant to allergic airways disease, possibly by altering NO homeostasis...
  16. pmc Cooperation between classical and alternative NF-κB pathways regulates proinflammatory responses in epithelial cells
    Jane E Tully
    Health Sciences Research Facility, Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 47:497-508. 2012
    ..These results demonstrate that the coordinated activation of both NF-κB pathways regulates the magnitude and nature of proinflammatory responses in lung epithelial cells...
  17. pmc Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation
    Scott W Aesif
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 44:491-9. 2011
    ....
  18. ncbi request reprint A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation
    Matthew E Poynter
    Vermont Lung Center and Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 170:6257-65. 2003
    ....
  19. pmc Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta
    Niki L Reynaert
    Department of Pathology and Chemistry, University of Vermont, Burlington, 05405, USA
    Proc Natl Acad Sci U S A 103:13086-91. 2006
    ..Collectively, these findings demonstrate the physiological relevance of the S-glutathionylation-GRX redox module in controlling the magnitude of activation of the NF-kappaB pathway...
  20. pmc c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis
    John F Alcorn
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 40:422-32. 2009
    ..Collectively, these findings demonstrate an important requirement for JNK1 in promoting collagen deposition in multiple models of fibrosis...
  21. ncbi request reprint Nitric oxide and redox signaling in allergic airway inflammation
    Niki L Reynaert
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Antioxid Redox Signal 7:129-43. 2005
    ..Lastly, difficulties in studying NO signaling and possible therapeutic uses for NO will be highlighted...
  22. pmc In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization
    Scott W Aesif
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Pathol 175:36-45. 2009
    ....
  23. pmc Catalase overexpression fails to attenuate allergic airways disease in the mouse
    Niki L Reynaert
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Immunol 178:3814-21. 2007
    ....
  24. pmc Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness
    Cristen Pantano
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Respir Crit Care Med 177:959-69. 2008
    ..Previous studies demonstrated that inhibition of NF-kappaB in airway epithelium causes attenuation of allergic inflammation...
  25. pmc Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1
    John F Alcorn
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Cell Sci 121:1036-45. 2008
    ..In aggregate, these results illuminate the novel role of airway epithelial-dependent JNK1 activation in EMT...
  26. ncbi request reprint Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Respir Crit Care Med 166:S9-S16. 2002
    ..A review of these pathways, their modes of action, and their importance in executing oxidative stress responses in lung epithelial cells are discussed...
  27. pmc NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness
    Matthew E Poynter
    Vermont Lung Center and the Department of Medicine, Division of Pulmonary and Critical Care, University of Vermont, Burlington, VT 05405, USA
    J Immunol 173:7003-9. 2004
    ....
  28. pmc Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells
    Elle C Roberson
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 46:573-81. 2012
    ..Proc Am Thorac Soc 2004;1:115-120) and idiopathic pulmonary fibrosis (Umeda Y, et al. Int Med 2010;49:2333-2336)...
  29. pmc Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation
    Niki L Reynaert
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 101:8945-50. 2004
    ..Collectively, our findings demonstrate that IKKbeta is an important target for the redox regulation of NF-kappaB by endogenous or exogenous NO, providing an additional mechanism for its antiinflammatory properties...
  30. pmc Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease
    John F Alcorn
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Respir Crit Care Med 176:974-82. 2007
    ..The cytokine transforming growth factor (TGF)-beta has been shown to have a central role in asthma pathogenesis and in mouse models of allergic airway disease...
  31. pmc Nonphagocytic oxidase 1 causes death in lung epithelial cells via a TNF-RI-JNK signaling axis
    Cristen Pantano
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, HSRF 216A, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 36:473-9. 2007
    ..Collectively, these studies suggest a mechanism by which ROS produced in lung epithelial cells activate JNK and cause cell death using TNF-RI and the TRAF2-ASK1 signaling axis...
  32. ncbi request reprint Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway
    Cristen Pantano
    Department of Pathology, University of Vermont College of Medicine, Burlington, 05405, USA
    Antioxid Redox Signal 8:1791-806. 2006
    ..The crosstalk of NF-kappaB with other signaling pathways is therefore critical for cellular fate, notably survival or cell death under oxidative conditions, and will also be reviewed...
  33. pmc Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis
    Vikas Anathy
    Department of Pathology, University of Vermont, Burlington, Vermont, USA
    Mol Cell Biol 32:3464-78. 2012
    ..Collectively, these findings illuminate a regulatory switch, a ligand-initiated oxidative processing of latent Fas, that controls the strength of apoptosis...
  34. pmc c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3
    Jos L J van der Velden
    Department of Pathology, Health Sciences Research Facility, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 44:571-81. 2011
    ....
  35. pmc Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen
    Jennifer L Ather
    Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, 05405, USA
    Am J Respir Cell Mol Biol 44:631-8. 2011
    ....
  36. ncbi request reprint In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization
    Niki L Reynaert
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Biochim Biophys Acta 1760:380-7. 2006
    ....
  37. pmc Dual oxidase-1 is required for airway epithelial cell migration and bronchiolar reepithelialization after injury
    Stefan H Gorissen
    Department of Pathology, College of Medicine, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 48:337-45. 2013
    ....
  38. pmc Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense
    Jos van der Velden
    Department of Pathology, University of Vermont, Burlington, Vermont, United States of America
    PLoS ONE 7:e34638. 2012
    ..These data identify JNK1 as an important signaling molecule in host defense and demonstrate a pathogen specific role in disease. Manipulation of the JNK1 pathway may represent a novel therapeutic target in pneumonia...
  39. pmc Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death
    Vikas Anathy
    Department of Pathology, University of Vermont College of Medicine, Burlington, 05405, USA
    Antioxid Redox Signal 16:496-505. 2012
    ..Apoptosis can be triggered by a wide variety of stimuli, including death receptor ligands, environmental agents, and cytotoxic drugs. Apoptosis has also been implicated in the etiology of many human diseases...
  40. pmc Protocols for the detection of s-glutathionylated and s-nitrosylated proteins in situ
    Scott W Aesif
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Methods Enzymol 474:289-96. 2010
    ..These techniques can be applied in situ to elucidate which compartments in tissues are affected in diseased states whose underlying pathologies are thought to represent a redox imbalance...
  41. pmc Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation
    Matthew E Poynter
    Vermont Lung Center and Department of Pathology, University of Vermont, Burlington 05405, USA
    Am J Pathol 160:1325-34. 2002
    ..These studies strengthen the potential importance of the bronchiolar epithelial cell as a source of production of NF-kappaB-dependent mediators that play a role in asthma...
  42. ncbi request reprint Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent manner
    Brian McElhinney
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Leukoc Biol 74:897-907. 2003
    ..Our findings demonstrate that catalytically active EPO is capable of causing significant damage to lung epithelial cells in vitro and that this involves the activation of JNK...
  43. pmc Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways
    Nicholas H Heintz
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    Am J Respir Cell Mol Biol 42:133-9. 2010
    ..An understanding of the pathogenic features of asbestos fibers and dysregulation of signaling pathways allows strategies for the prevention and therapy of asbestos-related diseases...
  44. ncbi request reprint In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation
    Karina Ckless
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Nitric Oxide 11:216-27. 2004
    ....
  45. doi request reprint Hydrogen peroxide as a damage signal in tissue injury and inflammation: murderer, mediator, or messenger?
    Albert van Der Vliet
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont, 05405
    J Cell Biochem 115:427-35. 2014
    ....
  46. pmc Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism
    Karina Ckless
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 36:645-53. 2007
    ....

Research Grants23

  1. REGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 1999
    ..Combined approaches in specific aims 1-4 will lead to a better understanding of the role of NF- kappaB in pulmonary disease associated with exposure to ROS/RNS and may provide strategies for therapeutic intervention. ..
  2. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..These approaches will provide critical insights into the physiological relevance of GRX1-controlled redox regulation of NF-KB in airways. ..
  3. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..Completion of this project will provide new insights into the process of lung stiffening, and may lead to the development of new therapeutics to limit lung stiffening, and also potentially reverse this process. ..
  4. Redox-based Fas signaling in allergic airway disease
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..Completion of this project will provide new insights into the process of lung stiffening, and may lead to the development of new therapeutics to limit lung stiffening, and also potentially reverse this process. ..
  5. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne M W Janssen Heininger; Fiscal Year: 2010
    ..These approaches will provide critical insights into the physiological relevance of GRX1-controlled redox regulation of NF-KB in airways. ..
  6. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen Heininger; Fiscal Year: 2010
    ..Completion of this project will provide new insights into the process of lung stiffening, and may lead to the development of new therapeutics to limit lung stiffening, and also potentially reverse this process. ..
  7. Redox-based Fas signaling in allergic airway disease
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..These approaches are crucial in defining critical oxidant targets and epithelial signaling events crucial to the patho-physiology of allergic airways disease. ..
  8. Redox-based Fas signaling in allergic airway disease
    Yvonne M W Janssen Heininger; Fiscal Year: 2010
    ..Completion of this project will provide new insights into the process of lung stiffening, and may lead to the development of new therapeutics to limit lung stiffening, and also potentially reverse this process. ..
  9. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2007
    ..These approaches will provide critical insights into the physiological relevance of GRX1-controlled redox regulation of NF-?B in airways. ..
  10. REGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2000
    ..Combined approaches in specific aims 1-4 will lead to a better understanding of the role of NF- kappaB in pulmonary disease associated with exposure to ROS/RNS and may provide strategies for therapeutic intervention. ..
  11. REGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2001
    ..Combined approaches in specific aims 1-4 will lead to a better understanding of the role of NF- kappaB in pulmonary disease associated with exposure to ROS/RNS and may provide strategies for therapeutic intervention. ..
  12. REGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2002
    ..Combined approaches in specific aims 1-4 will lead to a better understanding of the role of NF- kappaB in pulmonary disease associated with exposure to ROS/RNS and may provide strategies for therapeutic intervention. ..
  13. Regulation of NF-kB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2003
    ..abstract_text> ..
  14. Redox-based Fas signaling in allergic airway disease
    Yvonne Janssen Heininger; Fiscal Year: 2006
    ..These approaches are crucial in defining critical oxidant targets and epithelial signaling events crucial to the patho-physiology of allergic airways disease. ..
  15. Redox-based Fas signaling in allergic airway disease
    Yvonne Janssen Heininger; Fiscal Year: 2007
    ..These approaches are crucial in defining critical oxidant targets and epithelial signaling events crucial to the patho-physiology of allergic airways disease. ..
  16. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne M W Janssen Heininger; Fiscal Year: 2011
    ..These approaches will provide critical insights into the physiological relevance of GRX1-controlled redox regulation of NF-KB in airways. ..