BETHANY ANN JANOWSKI

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Minireview: Switching on progesterone receptor expression with duplex RNA
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75205, USA
    Mol Endocrinol 24:2243-52. 2010
  2. ncbi request reprint Silencing gene expression by targeting chromosomal DNA with antigene peptide nucleic acids and duplex RNAs
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9041, USA
    Nat Protoc 1:436-43. 2006
  3. ncbi request reprint Activating gene expression in mammalian cells with promoter-targeted duplex RNAs
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Chem Biol 3:166-73. 2007
  4. ncbi request reprint Involvement of AGO1 and AGO2 in mammalian transcriptional silencing
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Nat Struct Mol Biol 13:787-92. 2006
  5. ncbi request reprint Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Chem Biol 1:210-5. 2005
  6. pmc Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms
    Daniel B Hardy
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 22:1812-24. 2008
  7. pmc Antisense transcripts are targets for activating small RNAs
    Jacob C Schwartz
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Nat Struct Mol Biol 15:842-8. 2008
  8. ncbi request reprint Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression
    Daniel B Hardy
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 20:2724-33. 2006
  9. ncbi request reprint Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Chem Biol 1:216-22. 2005
  10. pmc The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP
    Bethany A Janowski
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:12675-80. 2002

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Minireview: Switching on progesterone receptor expression with duplex RNA
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75205, USA
    Mol Endocrinol 24:2243-52. 2010
    ..The ability of small RNAs to alter transcription provides a new layer of potential regulation for gene expression...
  2. ncbi request reprint Silencing gene expression by targeting chromosomal DNA with antigene peptide nucleic acids and duplex RNAs
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9041, USA
    Nat Protoc 1:436-43. 2006
    ..This protocol can also be used to silence expression with PNAs or siRNAs that target mRNA. From preparation of oligomers to analysis of data, experiments with agPNAs and agRNAs require approximately 14 d and 9 d, respectively...
  3. ncbi request reprint Activating gene expression in mammalian cells with promoter-targeted duplex RNAs
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Chem Biol 3:166-73. 2007
    ..These data show that, like proteins, hormones and small molecules, small duplex RNAs interact at promoters and can activate or repress gene expression...
  4. ncbi request reprint Involvement of AGO1 and AGO2 in mammalian transcriptional silencing
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Nat Struct Mol Biol 13:787-92. 2006
    ..Our data indicate key linkages and important mechanistic distinctions between transcriptional and post-transcriptional silencing pathways in mammalian cells...
  5. ncbi request reprint Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Chem Biol 1:210-5. 2005
    ..agPNAs provide a general approach for controlling transcription initiation and a distinct option for target validation and therapeutic development...
  6. pmc Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms
    Daniel B Hardy
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 22:1812-24. 2008
    ..Collectively, these findings suggest that PR plays an important antiinflammatory role in breast cancer cells via ligand-dependent and ligand-independent mechanisms...
  7. pmc Antisense transcripts are targets for activating small RNAs
    Jacob C Schwartz
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Nat Struct Mol Biol 15:842-8. 2008
    ..Our data demonstrate that antisense transcripts have a central role in recognition of the PR promoter by both activating and inhibitory agRNAs...
  8. ncbi request reprint Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression
    Daniel B Hardy
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 20:2724-33. 2006
    ..Based on these findings, we propose that PR may inhibit NF-kappaB activation of COX-2 gene expression and uterine contractility via ligand-dependent and ligand-independent mechanisms...
  9. ncbi request reprint Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs
    Bethany A Janowski
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Chem Biol 1:216-22. 2005
    ..Potent inhibition of multiple genes suggests that agRNAs may represent a natural mechanism for controlling transcription, may complement siRNAs and miRNAs that target mRNA, and will be valuable agents for silencing gene expression...
  10. pmc The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP
    Bethany A Janowski
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:12675-80. 2002
    ..Taken together, these data suggest that INSIG-1 plays a critical role in regulating cholesterol concentrations in the cell...
  11. ncbi request reprint Recognition of chromosomal DNA by PNAs
    Kunihiro Kaihatsu
    Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 USA
    Chem Biol 11:749-58. 2004
    ..Peptide nucleic acid (PNA) is a nonionic DNA/RNA mimic that possesses outstanding potential for recognition of duplex DNA. Here we describe properties of PNAs and the challenges for their development as robust antigene agents...
  12. doi request reprint Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini
    Xuan Yue
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Chem Biol 6:621-9. 2010
    ..These results extend the potential for small RNAs to regulate transcription to target sequences beyond the 3' termini of mRNA...

Research Grants2

  1. Molecular Switches: Regulatory RNAs Targeting Nuclear Hormone Receptor Promoters
    BETHANY ANN JANOWSKI; Fiscal Year: 2010
    ..Exploring the capability of RNA to specifically increase expression of a target gene will encourage new approaches in the treatment of disease and in developing therapeutic leads. ..