John A Jane

..The authors have evaluated multiple objective surrogate markers of resident performance and quality of training to determine the impact of the 80-hour workweek...

..The purpose of this study was to report the outcomes of the endoscopic transsphenoidal approach for adults with craniopharyngiomas in whom the goal was gross-total resection...

..The purpose of this study is to report the outcomes after transsphenoidal surgery in a consecutive series of pediatric patients with craniopharyngiomas treated at a single institution with the goal of gross-total resection (GTR)...

..Furthermore, the relevance of the rate of cortisol drop immediately after surgery has not been investigated...

..Despite the growing application of endoscopic transsphenoidal surgery (ETSS), outcomes for GH adenomas are not clearly defined...

..This article discusses the history of the endoscope, the pivotal technological advances, and the key figures in the burgeoning field of endoneurosurgery...

..Less invasive modalities, such as endoscopic transsphenoidal surgery, specific chemotherapeutic drugs, and stereotactic radiosurgery, show promise as adjuvant treatment modalities...

..This study details long-term clinical and radiographic outcomes following single-level posterior cervical foraminotomy for degenerative disc or osteophyte disease...

..This paper examines a single-surgeon experience with single-level ACDF without use of plates or hard collars in patients with degenerative spondylosis in whom allograft was used as the fusion material...

..The MR imaging, CT scanning, and fluoroscopic stereotaxy modalities all have unique advantages as well as specific limitations...

..In this study, the authors evaluated outcomes following GKS of nonfunctioning pituitary macroadenomas and assessed predictors of tumor control, neurological deficits, and delayed hypopituitarism...

..Specifically, in this review the history of endoscopy and its application in endonasal neurosurgery are presented...

..The authors examine the indications for and outcomes following decompressive craniectomy in a single-center pediatric patient population with traumatic brain injury (TBI)...

..The management strategies and outcomes in pediatric patients with elevated intracranial pressure (ICP) following severe traumatic brain injury (TBI) are examined in this study...

..We studied the use of an ePTFE dural substitute (GORE Preclude MVP, W.L. Gore & Associates, Flagstaff, Arizona, USA), as a method for obtaining reliable reconstruction of the sellar dura...

..In addition, the authors describe the use of electrophysiological guidance to identify an "autonomous placode" in the untethering of the cord in STCS...

..The authors describe their current endoscopic technique and elucidate the advantages and disadvantages of the pure endoscopic adenomectomy compared with the standard microscopic approach...

..These tumors can still be extremely difficult to manage, however, and can cause significant morbidity to the patient, both from tumor mass effect and secondary to hormonal imbalances...

..Recently, case reports have described efficacy of temozolomide for the treatment of aggressive pituitary tumors...

..Meticulous attention to detail, particularly with respect to reconstruction and closure of the sellar floor, is necessary for its effective application...

..Less invasive modalities such as endoscopic transsphenoidal surgery, and stereotactic radiosurgery have shown promise as primary and adjuvant treatment modalities, respectively...

..Therapy is generally supportive in nature but may require surgery for pathological diagnosis and treatment of mass effect...

..Furthermore, this study identifies two unique corticotroph tumor populations which differ in their expression of COUP-TFI, the presence of which occurs more frequently in macroadenomas...

..Other less invasive treatments include intracavitary therapy and debulking followed by radiation therapy or stereotactic radiosurgery. Overall, the management of these tumors requires a multidisciplinary approach...

..Single suture craniosynostoses were long considered a benign condition with little risk of complications. In many cases, parents may forego surgical correction because of the inherent risks of surgical intervention...

..Here we present the use of a novel fixative (1,4-benzoquinone) for immunoflourescence staining of neurospheres...

..This chapter aims to review the pathogenesis, symptomatologic manifestations, radiographic, morphologic and histopathological characteristics, treatment strategies and outcomes in the cysts of Rathke's cleft...

..Radiosurgery is an effective treatment option in patients with persistent Cushing disease. When a target cannot be found on MR imaging, one can target the entire sellar region with radiosurgery...

..The aim of this review was to detail the characteristics and management of pediatric cervical spine injury...

..This retrospective analysis presents a comprehensive examination of spinal fusion, functional outcomes, and pain relief in a growing elderly population in which a BMP was used...

..The technique may be appropriate for evaluating responses to therapies aimed at preventing secondary ischemia and for assessing regional perfusion abnormalities...

..The relationships between high Ki-67 LIs and tumor recurrence, invasiveness, and growth velocity in pituitary adenomas are reviewed...

..Observation with aggressive correction of coagulopathy is a reasonable treatment choice for hemophilic patients presenting with SEH and a stable neurological examination...

..If papilledema is present, spinal cord imaging should be performed when lumbar puncture discloses unexplained protein elevation and in cases that lack clinical features typical of idiopathic intracranial hypertension...

..The utility and limitations of common intraoperative aides including video fluoroscopy, frameless stereotaxy, ultrasound, and magnetic resonance imaging are reviewed...

..His legendary sessions with neurosurgical residents resulted in his recognition as one of the world's leading fiber tract dissectors. His gentle, engaging manner has been documented in several media formats...

..Although the effectiveness of medical management has improved and some children may be treated with antimicrobial therapy alone, surgical evaluation remains an important component of the treatment algorithm for most pediatric patients...

..The deletion of lp was demonstrated by FISH analysis; lq, 19p, and 19q were intact. This appears to be the first reported case of a primary diffuse leptomeningeal oligodendroglioma in which a lp deletion was identified...

..The authors report the second known case of an intramedullary spinal cord metastatic lesion arising from primary bladder carcinoma...

..Practice with transsphenoidal surgery, however, is less well represented and tends to be clustered at several active centers. The implications for neurosurgical education are significant...