Patricia H Janak

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Dynamics of neural coding in the accumbens during extinction and reinstatement of rewarded behavior
    Patricia H Janak
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    Behav Brain Res 154:125-35. 2004
  2. ncbi request reprint Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose
    Patricia H Janak
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Alcohol 30:1-7. 2003
  3. pmc GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse
    Sebastien Carnicella
    The Ernest Gallo Research Center and Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 105:8114-9. 2008
  4. pmc Endogenous BDNF in the dorsolateral striatum gates alcohol drinking
    Jerome Jeanblanc
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 29:13494-502. 2009
  5. pmc Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core
    Nadia Chaudhri
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street Suite 200, Emeryville, CA 94608, USA
    Eur J Neurosci 28:2288-98. 2008
  6. ncbi request reprint The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption
    Jerome Jeanblanc
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 26:1457-64. 2006
  7. pmc Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor
    Sebastien Carnicella
    The Gallo Research Center, University of California, San Francisco, Emeryville, California, USA
    Biol Psychiatry 66:146-53. 2009
  8. pmc Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse
    Segev Barak
    The Ernest Gallo Research Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
    Nat Neurosci 16:1111-7. 2013
  9. pmc Context-induced relapse of conditioned behavioral responding to ethanol cues in rats
    Nadia Chaudhri
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
    Biol Psychiatry 64:203-10. 2008
  10. ncbi request reprint Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior
    Jun Wang
    Ernest Gallo Research Center, Emeryville, California 94608, USA
    J Neurosci 27:3593-602. 2007

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Dynamics of neural coding in the accumbens during extinction and reinstatement of rewarded behavior
    Patricia H Janak
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    Behav Brain Res 154:125-35. 2004
    ....
  2. ncbi request reprint Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose
    Patricia H Janak
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Alcohol 30:1-7. 2003
    ....
  3. pmc GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse
    Sebastien Carnicella
    The Ernest Gallo Research Center and Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 105:8114-9. 2008
    ..Together, these results suggest that GDNF, via activation of the MAPK pathway, is a fast-acting selective agent to reduce the motivation to consume and seek alcohol...
  4. pmc Endogenous BDNF in the dorsolateral striatum gates alcohol drinking
    Jerome Jeanblanc
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 29:13494-502. 2009
    ..Importantly, our results suggest that an endogenous signaling pathway within the same brain region that mediates drug-taking behavior also plays a critical role in gating the level of ethanol intake...
  5. pmc Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core
    Nadia Chaudhri
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street Suite 200, Emeryville, CA 94608, USA
    Eur J Neurosci 28:2288-98. 2008
    ..In contrast, the shell may normally inhibit incorrect behavioral responses...
  6. ncbi request reprint The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption
    Jerome Jeanblanc
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 26:1457-64. 2006
    ....
  7. pmc Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor
    Sebastien Carnicella
    The Gallo Research Center, University of California, San Francisco, Emeryville, California, USA
    Biol Psychiatry 66:146-53. 2009
    ..We recently showed that GDNF in the ventral tegmental area (VTA) reduces the motivation to consume alcohol. We therefore set out to determine whether cabergoline administration decreases alcohol-drinking and -seeking behaviors via GDNF...
  8. pmc Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse
    Segev Barak
    The Ernest Gallo Research Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
    Nat Neurosci 16:1111-7. 2013
    ..Our findings provide evidence that the mTORC1 pathway and its downstream substrates are crucial in alcohol-related memory reconsolidation and highlight this pathway as a therapeutic target to prevent relapse. ..
  9. pmc Context-induced relapse of conditioned behavioral responding to ethanol cues in rats
    Nadia Chaudhri
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
    Biol Psychiatry 64:203-10. 2008
    ..The environmental context in which drug-conditioned cues are encountered could modulate the capacity of such cues to trigger relapse in abstinent addicts. We explored this hypothesis using a behavioral animal model...
  10. ncbi request reprint Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior
    Jun Wang
    Ernest Gallo Research Center, Emeryville, California 94608, USA
    J Neurosci 27:3593-602. 2007
    ....
  11. ncbi request reprint General and outcome-specific forms of Pavlovian-instrumental transfer: the effect of shifts in motivational state and inactivation of the ventral tegmental area
    Laura H Corbit
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Eur J Neurosci 26:3141-9. 2007
    ....
  12. pmc Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption
    Dao Yao He
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 25:619-28. 2005
    ..These findings highlight the importance of GDNF as a new target for drug development for alcoholism that may mimic the effect of ibogaine against alcohol consumption but avoid the negative side effects...
  13. ncbi request reprint Safety encoding in the basal amygdala
    Susan Sangha
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
    J Neurosci 33:3744-51. 2013
    ..These data demonstrate the presence of neurons in the basal amygdala that are selectively responsive to Safety Cues. Furthermore, these data suggest that safety and reward learning use overlapping mechanisms in the basal amygdala...
  14. pmc GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence
    Sebastien Carnicella
    The Ernest Gallo Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    Alcohol Clin Exp Res 33:1012-24. 2009
    ..In this study, we set out to assess the contribution of endogenous GDNF or its receptor GFRalpha1 to the regulation of ethanol-related behaviors...
  15. doi request reprint Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake
    Marian L Logrip
    Ernest Gallo Research Center, Emeryville, CA 94608, USA
    FASEB J 22:2393-404. 2008
    ..Taken together, these results demonstrate that BDNF regulates ethanol intake by initiation of MAP kinase signaling and the ensuing production of downstream gene products, including Pdyn...
  16. doi request reprint The nucleus accumbens core and shell are critical for the expression, but not the consolidation, of Pavlovian conditioned approach
    Cory A Blaiss
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Behav Brain Res 200:22-32. 2009
    ....
  17. pmc Posterior dorsomedial striatum is critical for both selective instrumental and Pavlovian reward learning
    Laura H Corbit
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street Suite 200, Emeryville, CA 94698, USA
    Eur J Neurosci 31:1312-21. 2010
    ..Finally, we demonstrate that both S-O and R-O associations are required for selective Pavlovian-instrumental transfer...
  18. pmc Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking
    Nadia Chaudhri
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Neuropsychopharmacology 35:783-91. 2010
    ..These data highlight an important role for the core in cue-induced ethanol-seeking, and suggest that the shell is required to mediate the influence of contexts on conditioned ethanol-seeking...
  19. pmc Escalating ethanol intake is associated with altered corticostriatal BDNF expression
    Marian L Logrip
    The Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurochem 109:1459-68. 2009
    ..These results suggest that the persistence of altered BDNF signaling may contribute to the inflexibility of addictive behaviors...
  20. pmc Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats
    Nadia Chaudhri
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 207:303-14. 2009
    ..Rodent models of drug self-administration have been adapted to reveal the capacity of contexts to trigger drug seeking, thereby enabling neurobiological investigations of this effect...
  21. pmc The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors
    Sami Ben Hamida
    Ernest Gallo Research Center and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 32:15849-58. 2012
    ..Together, these results position H-Ras as a central molecular mediator of alcohol's actions within the mesolimbic system and put forward the potential value of the enzyme as a novel target to treat alcohol use disorders...
  22. pmc Alpha4 subunit-containing GABAA receptors in the accumbens shell contribute to the reinforcing effects of alcohol
    Mridula Rewal
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Emeryville, CA 94608, USA
    Addict Biol 17:309-21. 2012
    ..Possible pharmacological and non-pharmacological explanations for these effects are considered...
  23. pmc Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol
    Mridula Rewal
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 29:543-9. 2009
    ..These results indicate that the GABA(A) receptor alpha4 subunit in the NAc shell mediates alcohol intake...
  24. pmc Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Neurosci 10:77-86. 2007
    ..These data underscore the importance of the TGFbeta-Smad-HIPK2 pathway in the survival of DA neurons and its potential as a therapeutic target for promoting DA neuron survival during neurodegeneration...
  25. pmc Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake
    Hong Nie
    Ernest Gallo Clinic and Research Center, University of California, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 108:4459-64. 2011
    ..These results provide strong evidence that extrasynaptic δ-subunit-containing GABA(A) receptors in the medial shell of the NAc are critical for the reinforcing effects of oral ethanol...
  26. pmc Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach
    Cory A Blaiss
    Neuroscience Graduate Program, Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Neurobiol Learn Mem 87:644-58. 2007
    ..This suggests that the consolidation of PCA can be modulated in a manner comparable to other types of learned associations, but once learned, the memory appears to be relatively robust and stable...
  27. pmc BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis
    Jerome Jeanblanc
    Gallo Research Center, University of California, San Francisco, Emeryville, CA, 94608, USA
    Eur J Neurosci 37:607-12. 2013
    ..Together, our results show that BDNF attenuates ethanol drinking via activation of the MAPK pathway in a protein synthesis-dependent manner within the DLS...
  28. doi request reprint A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administration
    Costanza Burattini
    University of California, San Francisco, USA
    Addict Biol 13:70-9. 2008
    ....
  29. ncbi request reprint Ethanol-associated cues produce general pavlovian-instrumental transfer
    Laura H Corbit
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    Alcohol Clin Exp Res 31:766-74. 2007
    ..Therefore, understanding the mechanisms through which such stimuli trigger ethanol seeking is of interest in the study and treatment of alcoholism...
  30. pmc Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma
    M Scott Bowers
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 105:12533-8. 2008
    ..AGS3 up-regulation during abstinence may be a key determinant of the transition from social consumption to compulsion-like seeking during relapse...
  31. doi request reprint The orbitofrontal cortex as part of a hierarchical neural system mediating choice between two good options
    Ronald Keiflin
    Ernest Gallo Clinic and Research Center, Department of Neurology, Wheeler Center for the Neurobiology of Addiction, University of California at San Francisco, San Francisco, California 94143
    J Neurosci 33:15989-98. 2013
    ..These results indicate that the representations encoded in the OFC, while not essential to the expression of outcome preference, exert hierarchical control on downstream decision-making circuits. ..
  32. pmc A causal link between prediction errors, dopamine neurons and learning
    Elizabeth E Steinberg
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    Nat Neurosci 16:966-73. 2013
    ..Our findings establish a causal role for temporally precise dopamine neuron signaling in cue-reward learning, bridging a critical gap between experimental evidence and influential theoretical frameworks. ..
  33. pmc Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum
    Laura H Corbit
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, San Francisco, California, USA
    Biol Psychiatry 72:389-95. 2012
    ....
  34. ncbi request reprint Ethanol operant self-administration in rats is regulated by adenosine A2 receptors
    Maria Pia Arolfo
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    Alcohol Clin Exp Res 28:1308-16. 2004
    ..Here we tested this hypothesis. Because adenosine A2 and dopamine D2 receptors are coexpressed in neurons of the NAc, we compared the effects of A2 blockade with those of D2 receptor blockade...
  35. ncbi request reprint Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats
    M Scott Bowers
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 195:397-406. 2007
    ..Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator used for the treatment of alcoholism, but its potential efficacy in the treatment of psychostimulant addiction has not been explored...
  36. ncbi request reprint RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction
    Nancy N H McGough
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 24:10542-52. 2004
    ..Taken together, these findings suggest that RACK1 and BDNF are part of a regulatory pathway that opposes adaptations that lead to the development of alcohol addiction...
  37. pmc Similar neural activity during fear and disgust in the rat basolateral amygdala
    Steven J Shabel
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America
    PLoS ONE 6:e27797. 2011
    ....
  38. pmc Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning
    Kay M Tye
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    Nature 453:1253-7. 2008
    ..These findings provide evidence of a connection between LA synaptic plasticity and cue-reward learning, potentially representing a key mechanism underlying goal-directed behaviour...
  39. pmc Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H
    Marian L Logrip
    The Ernest Gallo Research Center, Suite 200, Emeryville, CA 94608, USA
    Alcohol 43:359-65. 2009
    ..Taken together, these data indicate that the KOR/dynorphin system may acutely regulate ethanol intake via inhibition of the rewarding properties of ethanol...
  40. pmc Methylphenidate facilitates learning-induced amygdala plasticity
    Kay M Tye
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California, USA
    Nat Neurosci 13:475-81. 2010
    ..These findings reveal critical and distinct roles for dopamine receptor subtypes in mediating methylphenidate-induced enhancements of neural transmission and learning performance...
  41. pmc Compound stimulus presentation and the norepinephrine reuptake inhibitor atomoxetine enhance long-term extinction of cocaine-seeking behavior
    Patricia H Janak
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA
    Neuropsychopharmacology 37:975-85. 2012
    ..These data may have important implications for understanding the biological basis of extinction learning, as well as for improving the outcome of extinction-based therapies...
  42. doi request reprint Amygdala neural encoding of the absence of reward during extinction
    Kay M Tye
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
    J Neurosci 30:116-25. 2010
    ..Because BLA neural correlates reflect the omission of an expected reward, these neuronal populations may contribute to the expression of behavior during extinction...
  43. pmc Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes
    Lacey L Sahuque
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 186:122-32. 2006
    ..However, the CRF receptor subtypes within the BNST mediating these phenomena have not been established...
  44. ncbi request reprint Inactivation of the lateral but not medial dorsal striatum eliminates the excitatory impact of Pavlovian stimuli on instrumental responding
    Laura H Corbit
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
    J Neurosci 27:13977-81. 2007
    ..These findings identify new roles for the dorsal striatum in mediating the incentive effects of reward-predictive stimuli on behavioral actions made to obtain reward...
  45. pmc Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens
    Elizabeth E Steinberg
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, San Francisco, California, United States of America Graduate Program in Neuroscience, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e94771. 2014
    ....
  46. ncbi request reprint Alcohol seeking in C57BL/6 mice induced by conditioned cues and contexts in the extinction-reinstatement model
    Margaret T Tsiang
    Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Alcohol 38:81-8. 2006
    ....
  47. pmc Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousal
    Steven J Shabel
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 106:15031-6. 2009
    ..Together, our results suggest that a substantial proportion of neuronal circuits within the amygdala can contribute to both appetitive and aversive emotional arousal...
  48. doi request reprint Dissociable roles of the medial prefrontal cortex and nucleus accumbens core in goal-directed actions for differential reward magnitude
    T Michael Gill
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Emeryville, CA 94608, USA
    Cereb Cortex 20:2884-99. 2010
    ....
  49. ncbi request reprint BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF
    Patricia H Janak
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    Alcohol Clin Exp Res 30:214-21. 2006
    ..Dr. Pandey showed that amygdalar BDNF regulates alcohol's anxiolytic effects and preference. Finally, Dr. Janak presented evidence that increases in the expression of GDNF in the midbrain reduce alcohol self-administration in rats...
  50. ncbi request reprint The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism
    M Foster Olive
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    Mol Pharmacol 67:349-55. 2005
    ..Our data indicate that mGluR5 is coupled to PKCepsilon via a PI3K-dependent pathway and that PKCepsilon is required for the ability of the mGluR5 antagonist MPEP to reduce ethanol consumption...
  51. ncbi request reprint Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in rats
    Hong Nie
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 168:222-8. 2003
    ..This study compared the reinstatement of alcohol- or sucrose-seeking by conditioned stimuli and priming injections of the neuroactive steroid, allopregnanolone (ALLO)...
  52. pmc Establishing causality for dopamine in neural function and behavior with optogenetics
    Elizabeth E Steinberg
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, CA 94608, USA
    Brain Res 1511:46-64. 2013
    ..This article is part of a Special Issue entitled Optogenetics (7th BRES)...
  53. ncbi request reprint GDNF and addiction
    Dorit Ron
    Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, USA
    Rev Neurosci 16:277-85. 2005
    ..We also provide evidence to suggest that therapies that activate GDNF signaling may be useful for the treatment of drug and alcohol addiction...
  54. pmc Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward
    Rami Yaka
    Ernst Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville 94608, USA
    Alcohol Clin Exp Res 27:1736-42. 2003
    ....
  55. ncbi request reprint Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice
    Andrew J McGeehan
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 174:266-73. 2004
    ....
  56. ncbi request reprint Amygdala neurons differentially encode motivation and reinforcement
    Kay M Tye
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 27:3937-45. 2007
    ..These data demonstrate that separate populations of cue-responsive neurons in the BLA encode the motivating or reinforcing properties of a cue previously associated with a reward...
  57. pmc Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice
    Jana P Lim
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco Emeryville, California 94608
    Brain Behav 2:22-31. 2012
    ..All lines developed CPP for ethanol. Our findings indicate that it may not be necessary to backcross hybrids to an inbred B6 background to study many ethanol-related behaviors in gene-targeted mice...
  58. ncbi request reprint betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption
    Lina Yao
    Ernest Gallo Clinic and Research Center, San Francisco, CA 94110, USA
    Cell 109:733-43. 2002
    ..We propose that synergy of D2 and A2 confers ethanol hypersensitivity and that betagamma dimers are required for voluntary drinking...
  59. pmc Post-training and post-reactivation administration of amphetamine enhances morphine conditioned place preference
    Cory A Blaiss
    Neuroscience Graduate Program, Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, 94608, USA
    Behav Brain Res 171:329-37. 2006
    ..Our results suggest that amphetamine enhances the consolidation of morphine CPP and that morphine CPP exhibits a temporally limited period of post-reactivation lability during which the memory can be modulated...
  60. pmc Deepened extinction following compound stimulus presentation: noradrenergic modulation
    Patricia H Janak
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
    Learn Mem 18:1-10. 2011
    ..These results have important implications for models of relapse to drug seeking and the development of extinction-based therapies...
  61. ncbi request reprint Context is a trigger for relapse to alcohol
    Isabella Zironi
    Department of Human and General Physiology, University of Bologna, via San Donato 19 2, 40127 Bologna, Italy
    Behav Brain Res 167:150-5. 2006
    ..This animal model may be useful to study the neural mechanisms underlying relapse induced by ethanol-associated contexts in humans...
  62. ncbi request reprint Neuroactive steroids and ethanol
    Robert H Purdy
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 29:1292-8. 2005