Research Topics
Genomes and Genes
| Patricia H JanakSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrosePatricia H Janak
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Alcohol 30:1-7. 2003....- Dynamics of neural coding in the accumbens during extinction and reinstatement of rewarded behaviorPatricia H Janak
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
Behav Brain Res 154:125-35. 2004.... 
GDNF is a fast-acting potent inhibitor of alcohol consumption and relapseSebastien Carnicella
The Ernest Gallo Research Center and Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Proc Natl Acad Sci U S A 105:8114-9. 2008..Together, these results suggest that GDNF, via activation of the MAPK pathway, is a fast-acting selective agent to reduce the motivation to consume and seek alcohol...- Endogenous BDNF in the dorsolateral striatum gates alcohol drinkingJerome Jeanblanc
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 29:13494-502. 2009..Importantly, our results suggest that an endogenous signaling pathway within the same brain region that mediates drug-taking behavior also plays a critical role in gating the level of ethanol intake... - The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumptionJerome Jeanblanc
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 26:1457-64. 2006.... - Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens coreNadia Chaudhri
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street Suite 200, Emeryville, CA 94608, USA
Eur J Neurosci 28:2288-98. 2008..In contrast, the shell may normally inhibit incorrect behavioral responses... - Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factorSebastien Carnicella
The Gallo Research Center, University of California, San Francisco, Emeryville, California, USA
Biol Psychiatry 66:146-53. 2009..We recently showed that GDNF in the ventral tegmental area (VTA) reduces the motivation to consume alcohol. We therefore set out to determine whether cabergoline administration decreases alcohol-drinking and -seeking behaviors via GDNF... - Context-induced relapse of conditioned behavioral responding to ethanol cues in ratsNadia Chaudhri
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
Biol Psychiatry 64:203-10. 2008..The environmental context in which drug-conditioned cues are encountered could modulate the capacity of such cues to trigger relapse in abstinent addicts. We explored this hypothesis using a behavioral animal model... - General and outcome-specific forms of Pavlovian-instrumental transfer: the effect of shifts in motivational state and inactivation of the ventral tegmental areaLaura H Corbit
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
Eur J Neurosci 26:3141-9. 2007.... - Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behaviorJun Wang
Ernest Gallo Research Center, Emeryville, California 94608, USA
J Neurosci 27:3593-602. 2007.... - Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumptionDao-Yao He
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 25:619-28. 2005..These findings highlight the importance of GDNF as a new target for drug development for alcoholism that may mimic the effect of ibogaine against alcohol consumption but avoid the negative side effects... 
Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intakeMarian L Logrip
Ernest Gallo Research Center, Emeryville, CA 94608, USA
FASEB J 22:2393-404. 2008..Taken together, these results demonstrate that BDNF regulates ethanol intake by initiation of MAP kinase signaling and the ensuing production of downstream gene products, including Pdyn...- The nucleus accumbens core and shell are critical for the expression, but not the consolidation, of Pavlovian conditioned approachCory A Blaiss
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
Behav Brain Res 200:22-32. 2009.... - GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinenceSebastien Carnicella
The Ernest Gallo Research Center, University of California San Francisco, Emeryville, CA 94608, USA
Alcohol Clin Exp Res 33:1012-24. 2009..In this study, we set out to assess the contribution of endogenous GDNF or its receptor GFRalpha1 to the regulation of ethanol-related behaviors... - Posterior dorsomedial striatum is critical for both selective instrumental and Pavlovian reward learningLaura H Corbit
Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street Suite 200, Emeryville, CA 94698, USA
Eur J Neurosci 31:1312-21. 2010..Finally, we demonstrate that both S-O and R-O associations are required for selective Pavlovian-instrumental transfer... - Escalating ethanol intake is associated with altered corticostriatal BDNF expressionMarian L Logrip
The Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurochem 109:1459-68. 2009..These results suggest that the persistence of altered BDNF signaling may contribute to the inflexibility of addictive behaviors... - Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in ratsNadia Chaudhri
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street Suite 200, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 207:303-14. 2009..Rodent models of drug self-administration have been adapted to reveal the capacity of contexts to trigger drug seeking, thereby enabling neurobiological investigations of this effect... - Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seekingNadia Chaudhri
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
Neuropsychopharmacology 35:783-91. 2010..These data highlight an important role for the core in cue-induced ethanol-seeking, and suggest that the shell is required to mediate the influence of contexts on conditioned ethanol-seeking... - The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviorsSami Ben Hamida
Ernest Gallo Research Center and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 32:15849-58. 2012..Together, these results position H-Ras as a central molecular mediator of alcohol's actions within the mesolimbic system and put forward the potential value of the enzyme as a novel target to treat alcohol use disorders... - Alpha4 subunit-containing GABAA receptors in the accumbens shell contribute to the reinforcing effects of alcoholMridula Rewal
Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Emeryville, CA 94608, USA
Addict Biol 17:309-21. 2012..Possible pharmacological and non-pharmacological explanations for these effects are considered... - Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcoholMridula Rewal
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 29:543-9. 2009..These results indicate that the GABA(A) receptor alpha4 subunit in the NAc shell mediates alcohol intake... - Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intakeHong Nie
Ernest Gallo Clinic and Research Center, University of California, Emeryville, CA 94608, USA
Proc Natl Acad Sci U S A 108:4459-64. 2011..These results provide strong evidence that extrasynaptic δ-subunit-containing GABA(A) receptors in the medial shell of the NAc are critical for the reinforcing effects of oral ethanol... - Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approachCory A Blaiss
Neuroscience Graduate Program, Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
Neurobiol Learn Mem 87:644-58. 2007..This suggests that the consolidation of PCA can be modulated in a manner comparable to other types of learned associations, but once learned, the memory appears to be relatively robust and stable... - Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neuronsJiasheng Zhang
Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Nat Neurosci 10:77-86. 2007..These data underscore the importance of the TGFbeta-Smad-HIPK2 pathway in the survival of DA neurons and its potential as a therapeutic target for promoting DA neuron survival during neurodegeneration... - Nucleus accumbens AGS3 expression drives ethanol seeking through G betagammaM Scott Bowers
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Proc Natl Acad Sci U S A 105:12533-8. 2008..AGS3 up-regulation during abstinence may be a key determinant of the transition from social consumption to compulsion-like seeking during relapse... - Ethanol-associated cues produce general pavlovian-instrumental transferLaura H Corbit
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
Alcohol Clin Exp Res 31:766-74. 2007..Therefore, understanding the mechanisms through which such stimuli trigger ethanol seeking is of interest in the study and treatment of alcoholism... - A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administrationCostanza Burattini
University of California, San Francisco, USA
Addict Biol 13:70-9. 2008.... - Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatumLaura H Corbit
Ernest Gallo Clinic and Research Center, University of California at San Francisco, San Francisco, California, USA
Biol Psychiatry 72:389-95. 2012.... - Ethanol operant self-administration in rats is regulated by adenosine A2 receptorsMaria Pia Arolfo
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
Alcohol Clin Exp Res 28:1308-16. 2004..Here we tested this hypothesis. Because adenosine A2 and dopamine D2 receptors are coexpressed in neurons of the NAc, we compared the effects of A2 blockade with those of D2 receptor blockade... - RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addictionNancy N H McGough
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 24:10542-52. 2004..Taken together, these findings suggest that RACK1 and BDNF are part of a regulatory pathway that opposes adaptations that lead to the development of alcohol addiction... - Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in ratsM Scott Bowers
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 195:397-406. 2007..Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator used for the treatment of alcoholism, but its potential efficacy in the treatment of psychostimulant addiction has not been explored... - Similar neural activity during fear and disgust in the rat basolateral amygdalaSteven J Shabel
Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America
PLoS ONE 6:e27797. 2011.... - Blockade of ethanol reward by the kappa opioid receptor agonist U50,488HMarian L Logrip
The Ernest Gallo Research Center, Suite 200, Emeryville, CA 94608, USA
Alcohol 43:359-65. 2009..Taken together, these data indicate that the KOR/dynorphin system may acutely regulate ethanol intake via inhibition of the rewarding properties of ethanol... - Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learningKay M Tye
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
Nature 453:1253-7. 2008..These findings provide evidence of a connection between LA synaptic plasticity and cue-reward learning, potentially representing a key mechanism underlying goal-directed behaviour... - Methylphenidate facilitates learning-induced amygdala plasticityKay M Tye
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California, USA
Nat Neurosci 13:475-81. 2010..These findings reveal critical and distinct roles for dopamine receptor subtypes in mediating methylphenidate-induced enhancements of neural transmission and learning performance... - Compound stimulus presentation and the norepinephrine reuptake inhibitor atomoxetine enhance long-term extinction of cocaine-seeking behaviorPatricia H Janak
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA
Neuropsychopharmacology 37:975-85. 2012..These data may have important implications for understanding the biological basis of extinction learning, as well as for improving the outcome of extinction-based therapies... - Amygdala neural encoding of the absence of reward during extinctionKay M Tye
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
J Neurosci 30:116-25. 2010..Because BLA neural correlates reflect the omission of an expected reward, these neuronal populations may contribute to the expression of behavior during extinction... - Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypesLacey L Sahuque
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 186:122-32. 2006..CONCLUSIONS: CRF1 receptors in the BNST mediate the anxiogenic-like effects of CRF in this region, whereas both CRF1 and CRF2 receptor subtypes mediate the conditioned aversive effects of this peptide within the BNST... - Inactivation of the lateral but not medial dorsal striatum eliminates the excitatory impact of Pavlovian stimuli on instrumental respondingLaura H Corbit
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
J Neurosci 27:13977-81. 2007..These findings identify new roles for the dorsal striatum in mediating the incentive effects of reward-predictive stimuli on behavioral actions made to obtain reward... - BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNFPatricia H Janak
Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
Alcohol Clin Exp Res 30:214-21. 2006..Dr. Pandey showed that amygdalar BDNF regulates alcohol's anxiolytic effects and preference. Finally, Dr. Janak presented evidence that increases in the expression of GDNF in the midbrain reduce alcohol self-administration in rats... - Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in ratsHong Nie
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 168:222-8. 2003..In contrast, conditioned stimuli reinstate previously extinguished ethanol- and sucrose-seeking behavior, indicating that the mechanisms that subserve cue-induced reinstatement do not depend upon the nature of the positive reinforcer... - The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanismM Foster Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
Mol Pharmacol 67:349-55. 2005..Our data indicate that mGluR5 is coupled to PKCepsilon via a PI3K-dependent pathway and that PKCepsilon is required for the ability of the mGluR5 antagonist MPEP to reduce ethanol consumption... - Alcohol seeking in C57BL/6 mice induced by conditioned cues and contexts in the extinction-reinstatement modelMargaret T Tsiang
Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
Alcohol 38:81-8. 2006.... - Dissociable roles of the medial prefrontal cortex and nucleus accumbens core in goal-directed actions for differential reward magnitudeT Michael Gill
Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Emeryville, CA 94608, USA
Cereb Cortex 20:2884-99. 2010.... - Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousalSteven J Shabel
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
Proc Natl Acad Sci U S A 106:15031-6. 2009..Together, our results suggest that a substantial proportion of neuronal circuits within the amygdala can contribute to both appetitive and aversive emotional arousal... - BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesisJerome Jeanblanc
Gallo Research Center, University of California, San Francisco, Emeryville, CA, 94608, USA
Eur J Neurosci 37:607-12. 2013..Together, our results show that BDNF attenuates ethanol drinking via activation of the MAPK pathway in a protein synthesis-dependent manner within the DLS... - Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned rewardRami Yaka
Ernst Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville 94608, USA
Alcohol Clin Exp Res 27:1736-42. 2003.... - GDNF and addictionDorit Ron
Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, USA
Rev Neurosci 16:277-85. 2005..We also provide evidence to suggest that therapies that activate GDNF signaling may be useful for the treatment of drug and alcohol addiction... - Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in miceAndrew J McGeehan
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 174:266-73. 2004.... - Amygdala neurons differentially encode motivation and reinforcementKay M Tye
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 27:3937-45. 2007..These data demonstrate that separate populations of cue-responsive neurons in the BLA encode the motivating or reinforcing properties of a cue previously associated with a reward... - Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid miceJana P Lim
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco Emeryville, California 94608
Brain Behav 2:22-31. 2012..All lines developed CPP for ethanol. Our findings indicate that it may not be necessary to backcross hybrids to an inbred B6 background to study many ethanol-related behaviors in gene-targeted mice... - Deepened extinction following compound stimulus presentation: noradrenergic modulationPatricia H Janak
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
Learn Mem 18:1-10. 2011..These results have important implications for models of relapse to drug seeking and the development of extinction-based therapies... - betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumptionLina Yao
Ernest Gallo Clinic and Research Center, San Francisco, CA 94110, USA
Cell 109:733-43. 2002..We propose that synergy of D2 and A2 confers ethanol hypersensitivity and that betagamma dimers are required for voluntary drinking... - Post-training and post-reactivation administration of amphetamine enhances morphine conditioned place preferenceCory A Blaiss
Neuroscience Graduate Program, Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, 94608, USA
Behav Brain Res 171:329-37. 2006..Our results suggest that amphetamine enhances the consolidation of morphine CPP and that morphine CPP exhibits a temporally limited period of post-reactivation lability during which the memory can be modulated... - Context is a trigger for relapse to alcoholIsabella Zironi
Department of Human and General Physiology, University of Bologna, via San Donato 19 2, 40127 Bologna, Italy
Behav Brain Res 167:150-5. 2006..This animal model may be useful to study the neural mechanisms underlying relapse induced by ethanol-associated contexts in humans... - Neuroactive steroids and ethanolRobert H Purdy
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Alcohol Clin Exp Res 29:1292-8. 2005