YUH JAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Variations on the Notch pathway in neural development
    Nicholas J Justice
    Department of Physiology and Biochemistry, Howard Hughes Medical Institute, Box 0725, UCSF, San Francisco, California 94143 0725, USA
    Curr Opin Neurobiol 12:64-70. 2002
  2. doi request reprint Retrospective: Seymour Benzer (1921-2007)
    Yuh Nung Jan
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California, San Francisco, CA 94143, USA
    Science 319:45. 2008
  3. pmc Branching out: mechanisms of dendritic arborization
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California, 1550 4th Street, San Francisco 94158, USA
    Nat Rev Neurosci 11:316-28. 2010
  4. ncbi request reprint The Notch regulator Numb links the Notch and TCR signaling pathways
    Ana C Anderson
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 174:890-7. 2005
  5. ncbi request reprint hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology
    Adrian W Moore
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143, USA
    Science 297:1355-8. 2002
  6. pmc Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche
    Chay T Kuo
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143, USA
    Cell 127:1253-64. 2006
  7. ncbi request reprint A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels
    Chen Gu
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0725, USA
    Science 301:646-9. 2003
  8. ncbi request reprint Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis
    Hua Shun Li
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:1105-18. 2003
  9. ncbi request reprint Yuh-Nung Jan
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 533 Parnassus Avenue, 94143 0725, USA
    Curr Biol 13:R378-9. 2003
  10. pmc Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites
    Jay Z Parrish
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    Genes Dev 20:820-35. 2006

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Variations on the Notch pathway in neural development
    Nicholas J Justice
    Department of Physiology and Biochemistry, Howard Hughes Medical Institute, Box 0725, UCSF, San Francisco, California 94143 0725, USA
    Curr Opin Neurobiol 12:64-70. 2002
    ..These regulatory mechanisms, along with many others, affect how Notch signaling activity influences cell fate determination...
  2. doi request reprint Retrospective: Seymour Benzer (1921-2007)
    Yuh Nung Jan
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California, San Francisco, CA 94143, USA
    Science 319:45. 2008
  3. pmc Branching out: mechanisms of dendritic arborization
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California, 1550 4th Street, San Francisco 94158, USA
    Nat Rev Neurosci 11:316-28. 2010
    ..Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders...
  4. ncbi request reprint The Notch regulator Numb links the Notch and TCR signaling pathways
    Ana C Anderson
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 174:890-7. 2005
    ..Together our data suggest that Notch and TCR signals may be integrated at the cell membrane, and that Numb may be an important adapter in this process...
  5. ncbi request reprint hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology
    Adrian W Moore
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143, USA
    Science 297:1355-8. 2002
    ..Moreover, hamlet expression induced in MD neurons undergoing dendrite outgrowth drastically reduces arbor branching...
  6. pmc Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche
    Chay T Kuo
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143, USA
    Cell 127:1253-64. 2006
    ..Our results show a self-repair mechanism in the mammalian brain and may have implications for both niche plasticity in other areas of stem cell biology and the therapeutic use of neural stem cells in neurodegenerative diseases...
  7. ncbi request reprint A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels
    Chen Gu
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0725, USA
    Science 301:646-9. 2003
    ..Moreover, T1 mutations eliminating Kvbeta association compromised axonal targeting, but not surface expression, of CD4-T1 fusion proteins. Thus, proper association of Kvbeta with the Kv1 T1 domain is essential for axonal targeting...
  8. ncbi request reprint Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis
    Hua Shun Li
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:1105-18. 2003
    ..Further, these double mutant mice provide an unprecedented viable animal model for severe brain malformations due to defects in neural progenitor cells...
  9. ncbi request reprint Yuh-Nung Jan
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 533 Parnassus Avenue, 94143 0725, USA
    Curr Biol 13:R378-9. 2003
  10. pmc Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites
    Jay Z Parrish
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    Genes Dev 20:820-35. 2006
    ..Thus, multiple genetic programs operate to calibrate dendritic coverage, to coordinate the elaboration of primary versus secondary branches, and to lay out these dendritic branches in the proper orientation...
  11. ncbi request reprint The control of dendrite development
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 40:229-42. 2003
    ..In contrast, the control of dendrite development is still much less well understood. However, recent progress has begun to shed light on the molecular mechanisms that orchestrate dendrite growth, arborization, and guidance...
  12. pmc Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity
    Delphine Bichet
    Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 101:4441-6. 2004
    ..Some of these suppressors also affected channel gating (channel open time and opening frequency determined in single-channel analyses), revealing intriguing interplay between ion permeation and channel gating...
  13. pmc A fluorescent probe designed for studying protein conformational change
    Bruce E Cohen
    Howard Hughes Medical Institute and Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 102:965-70. 2005
    ..The spectral characteristics of APM can also report subtle differences between aqueous positions in purified preparations of the beta2 adrenergic receptor...
  14. ncbi request reprint The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila
    Neal T Sweeney
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    Curr Biol 16:1006-11. 2006
    ..Our findings demonstrate that the novel coiled-coil protein Shrub functions in the endosomal pathway and plays an essential role in neuronal morphogenesis...
  15. pmc Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
    Eric J Huang
    Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA
    Genes Dev 19:138-51. 2005
    ..Taken together, our data provide evidence for previously unidentified functions of Numb and Numblike in sensory axon arborization by regulating Notch1 via the endocytic-lysosomal pathways...
  16. ncbi request reprint Probing protein electrostatics with a synthetic fluorescent amino acid
    Bruce E Cohen
    Howard Hughes Medical Institute and Departments of Physiology and Biochemistry, University of California San Francisco, San Francisco, CA 94143, USA
    Science 296:1700-3. 2002
    ..Steady-state and time-resolved fluorescence measurements of Aladan residues at different buried and exposed sites in the B1 domain of protein G suggest that its interior is polar and heterogeneous...
  17. ncbi request reprint Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons
    Wesley B Grueber
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Room U226, San Francisco, CA 94143, USA
    Cell 112:805-18. 2003
    ..Thus, different levels of a homeoprotein can regulate distinct patterns of dendrite branching...
  18. pmc Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification
    Adrian W Moore
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, CA 94143, USA
    Genes Dev 18:623-8. 2004
    ..The fate-determining signals NOTCH and PAX2 act at multiple stages of lineage elaboration and HAMLET acts to modulate their activity in a branch-specific manner...
  19. ncbi request reprint Tiling of the Drosophila epidermis by multidendritic sensory neurons
    Wesley B Grueber
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 0725, USA
    Development 129:2867-78. 2002
    ..Together, our data suggest that widespread tiling of the larval body wall involves interactions between growing dendritic processes and as yet unidentified signals that allow avoidance by like dendrites...
  20. ncbi request reprint Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons
    Bing Ye
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 0725, USA
    Curr Biol 14:314-21. 2004
    ..This work serves as an entry point for future studies of dendritic translational control of dendrite morphogenesis...
  21. pmc The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons
    Michael D Kim
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 20:2806-19. 2006
    ..These findings suggest that one evolutionarily conserved role for Ahr in neuronal development concerns the diversification of dendrite morphology...
  22. pmc Growing dendrites and axons differ in their reliance on the secretory pathway
    Bing Ye
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143, USA
    Cell 130:717-29. 2007
    ..The distinct dependence between dendritic and axonal growth on the secretory pathway helps to establish different morphology of dendrites and axons...
  23. pmc Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization
    Peter Soba
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, Rock Hall, 1550 4th Street, San Francisco, CA 94143, USA
    Neuron 54:403-16. 2007
    ....
  24. ncbi request reprint Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology
    Wesley B Grueber
    Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
    Development 134:55-64. 2007
    ....
  25. ncbi request reprint The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
    Eric C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 132:2319-32. 2005
    ..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development...
  26. ncbi request reprint Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields
    Jay Z Parrish
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA
    Annu Rev Neurosci 30:399-423. 2007
    ..In this review, we summarize our current understanding of the cellular and molecular mechanisms that regulate dendritic field formation and influence the shaping of dendritic arbors...
  27. ncbi request reprint Visualizing the breaking of symmetry
    Bing Ye
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 1550 4th Street, 94143, USA
    Dev Cell 10:411-2. 2006
    ..Although several models have been proposed, few studies have provided clues about polarization events in real time. Using time-lapse imaging, a recent study described visualizing symmetry-breaking events during this process...
  28. pmc The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons
    Jay Z Parrish
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 63:788-802. 2009
    ..This signaling between epithelial cells and neurons receiving sensory input from the body wall synchronizes their growth to ensure proper dendritic coverage of the receptive field...
  29. ncbi request reprint Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons
    Michael E Rothenberg
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuron 39:779-91. 2003
    ..Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance...
  30. ncbi request reprint Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart
    Dzwokai Ma
    Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Neuron 33:715-29. 2002
    ..3 subunit potently inhibits plasma membrane expression by diverting the heterotetrameric channels to lysosomes. Such rich trafficking behaviors provide a mechanism for dynamic regulation of GIRK channel density in the plasma membrane...
  31. ncbi request reprint ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C
    Keli Hu
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 38:417-32. 2003
    ..Likewise, in hippocampal CA1 neurons under metabolic stress, PKC-mediated, dynamin-dependent K(ATP) channel internalization can also act as a brake to dampen the rapid decline of excitability due to K(ATP) activation...
  32. ncbi request reprint Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning
    Chay T Kuo
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 51:283-90. 2006
    ..Thus, in addition to uncovering E2/E3 ubiquitinating enzymes for dendrite pruning, this study provides a mechanistic link between UPS and the apoptotic machinery in regulating neuronal process remodeling...
  33. ncbi request reprint Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion
    Wesley B Grueber
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California San Francisco, 533 Parnassus Avenue, Room U226, San Francisco, CA 94143, USA
    Curr Biol 13:618-26. 2003
    ..By contrast, dendrites of class I and class II neurons do not completely tile the body wall, but they nevertheless occupy nonoverlapping territories...
  34. ncbi request reprint The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance
    Kazuo Emoto
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California San Francisco, San Francisco, California 94143 0725, USA
    Nature 443:210-3. 2006
    ....
  35. pmc K+ channel selectivity depends on kinetic as well as thermodynamic factors
    Michael Grabe
    Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 103:14361-6. 2006
    ....
  36. pmc Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity
    Delphine Bichet
    Departments of Physiology and Biochemistry and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 103:14355-60. 2006
    ..Our results indicate that interactions between permeant ions and the channel cavity can influence ion selectivity and channel block by means of an electrostatic effect...
  37. ncbi request reprint Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites
    Kimberly F Raab-Graham
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94158, USA
    Science 314:144-8. 2006
    ..1 synthesis in dendrites upon inhibition of mTOR or the N-methyl-d-aspartate (NMDA) glutamate receptor. Thus, synaptic excitation may cause local suppression of dendritic Kv1 channels by reducing their local synthesis...
  38. ncbi request reprint The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting
    Chen Gu
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:803-16. 2006
    ..In addition, we found that Kvbeta2 associates with KIF3/kinesin II as well. Indeed, Kv1 channels rely on both KIF3/kinesin II and EB1 for their axonal targeting...
  39. pmc Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae
    Wei Song
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:5199-204. 2007
    ..These findings reveal that MD sensory neuron input is a necessary component in the neural circuitry that generates larval locomotion...
  40. pmc Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites
    Jay Z Parrish
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 21:956-72. 2007
    ..We further show genetic interactions and association between PcG proteins and the tumor suppressor kinase Warts (Wts), providing evidence for their cooperation in multiple developmental processes including dendrite maintenance...
  41. pmc Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1)
    Song Hai Shi
    Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California, 1550 Fourth Street, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 101:13341-5. 2004
    ..Together with its orthologues in other species, Dasm1 defines a family of molecules likely involved specifically in dendrite arborization...
  42. pmc Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons
    Yi Zheng
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Nat Cell Biol 10:1172-80. 2008
    ..These data suggest that dynein is required for the distinguishing properties of the axon and dendrites: without dynein, dendritic organelles and proteins enter the axon and the axonal microtubules are no longer uniform in polarity...
  43. pmc The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels
    Jill Wildonger
    Department of Physiology and Department of Biochemistry, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 22:2447-53. 2008
    ..Thus, in addition to the kinase LKB1, the Tsc1-Tsc2 complex, acting through TORC1, also modulates SAD to regulate axon formation...
  44. pmc Control of the postmating behavioral switch in Drosophila females by internal sensory neurons
    Chung Hui Yang
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 61:519-26. 2009
    ..Our results uncover a neuronal mechanism by which sex peptide exerts its control over reproductive behaviors in Drosophila females...
  45. ncbi request reprint Structure prediction for the down state of a potassium channel voltage sensor
    Michael Grabe
    Department of Physiology, Howard Hughes Medical Institute
    Nature 445:550-3. 2007
    ..2 structure suggests that the VSDs undergo large rearrangements during gating, whereas the S4 segment remains positioned between the central pore and the remainder of the VSD in both states...
  46. ncbi request reprint Dendritic development: lessons from Drosophila and related branches
    Wesley B Grueber
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Box 0725, San Francisco CA 94143, USA
    Curr Opin Neurobiol 14:74-82. 2004
    ..Here, we review some recent advances in our understanding of dendritic development in insects, focusing primarily on insights that have been gained from studies of Drosophila...
  47. ncbi request reprint The cadherin superfamily and dendrite development
    Bing Ye
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143 0725, USA
    Trends Cell Biol 15:64-7. 2005
    ..Recent work in mammals by Shima et al., and earlier work in Drosophila by Gao et al. and Sweeney et al. have determined the presence of a non-classic, seven-pass transmembrane cadherin in this process...
  48. pmc NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection
    Yu Fung Lin
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 101:7799-804. 2004
    ..Thus, neuroprotection caused by NO released during the short episode of sublethal ischemia may be mediated partly by K(ATP) stimulation...
  49. ncbi request reprint The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel
    Helen C Lai
    Graduate Group in Biophysics, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 47:395-406. 2005
    ....
  50. pmc Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling
    Chay T Kuo
    Howard Hughes Medical Institute and Department of Physiology, University of California, 1550 Fourth Street, Room GD484E, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 102:15230-5. 2005
    ..These results demonstrate that, in response to environmental changes, certain neurons have cell-intrinsic abilities to completely lose their dendrites but keep their axons and subsequently regrow their dendritic arbors...
  51. ncbi request reprint Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons
    Kazuo Emoto
    Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California San Francisco, 1550 4th Street, San Francisco, CA 94143, USA
    Cell 119:245-56. 2004
    ..Thus, the Trc/Fry signaling pathway plays a key role in patterning dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching...
  52. ncbi request reprint The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts
    Claudia Petritsch
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 4:273-81. 2003
    ..Our studies demonstrate that a class VI myosin is necessary for basal protein targeting and spindle orientation in neuroblasts...
  53. ncbi request reprint Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage
    Nicholas Justice
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0725, USA
    Curr Biol 13:778-83. 2003
    ..These findings uncover a previously unknown function of Lgl in the inhibition of Notch and reveal different modes of action by which Lgl can influence cell fate in the neuroblast and SOP lineages...
  54. pmc Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains
    Hee Jung Chung
    Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 103:8870-5. 2006
    ..We further show that several BFNC mutations of KCNQ2 and KCNQ3 disrupt surface expression or polarized surface distribution of KCNQ channels, thereby revealing impaired targeting of KCNQ channels to axonal surfaces as a BFNC etiology...
  55. pmc Identification of yeast proteins necessary for cell-surface function of a potassium channel
    Friederike A Haass
    Department of Physiology, Neuroscience Graduate Program, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:18079-84. 2007
    ..The seven yeast proteins identified in our screen likely impact Kir-channel functional expression at the level of vesicle budding from the ER and/or the local lipid environment at the plasma membrane...
  56. pmc A quantitative assessment of models for voltage-dependent gating of ion channels
    Michael Grabe
    Howard Hughes Medical Institute and Department of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 101:17640-5. 2004
    ....
  57. ncbi request reprint salvador--The persistence of proliferation
    Michael E Rothenberg
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, 533 Parnassus Avenue, 94143, San Francisco, CA, USA
    Cancer Cell 2:171-3. 2002
    ....
  58. pmc Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions
    Robin M Shaw
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Cell 128:547-60. 2007
    ..These findings support an unanticipated mechanism for protein delivery to points of cell-cell contact...
  59. pmc Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels
    Hee Jung Chung
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 106:629-34. 2009
    ....
  60. pmc G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation
    Hee Jung Chung
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 106:635-40. 2009
    ..Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity...
  61. ncbi request reprint APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity
    Song Hai Shi
    Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California at San Francisco, 1550 4th Street, San Francisco, CA 94143 0725, USA
    Curr Biol 14:2025-32. 2004
    ....
  62. pmc Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis
    Hsiu Hsiang Lee
    Howard Hughes Medical Institute, Department of Physiology, Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:6363-8. 2009
    ..Our study thus implicates Ik2 and Kat-60L1 in dendrite severing that involves local microtubule disassembly...
  63. ncbi request reprint The secretory pathway and neuron polarization
    Bing Ye
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:10631-2. 2006
  64. ncbi request reprint Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice
    Jena Donovan
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Curr Biol 12:1605-10. 2002
    ..These results establish Hey2 as an important regulator of cardiac morphogenesis and suggest a role for Hey2 in mediating or modulating Notch signaling in the developing heart...
  65. ncbi request reprint Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts
    Qin Shen
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Development 129:4843-53. 2002
    ..These data indicate Numb has an important role in generating asymmetric cell divisions and diverse cell fates during mouse cortical development...
  66. ncbi request reprint Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
    Petur H Petersen
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 419:929-34. 2002
    ..Our findings show that a shared molecular mechanism, with mouse Numb and Nbl as key components, governs the self-renewal of all neural progenitor cells, regardless of their lineage or regional identities...
  67. ncbi request reprint Asymmetric cell division
    Fabrice Roegiers
    Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Ave, San Francisco, California, 94122, USA
    Curr Opin Cell Biol 16:195-205. 2004
    ..In vertebrates, analysis of dividing neural progenitor cells by in vivo imaging has raised questions about the role of asymmetric cell divisions during neurogenesis...
  68. ncbi request reprint Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology
    Fengwei Yu
    Howard Hughes Medical Institute and Departments of Physiology, Biochemistry, and Biophysics, University of California, Rock Hall, 1550 Fourth Street, San Francisco, California 94143, USA
    Neuron 51:13-20. 2006
    ..We also discuss issues of progenitor proliferation and differentiation associated with asymmetric cell division and their broader implications for stem cell biology...
  69. pmc Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs
    Fabrice Roegiers
    Howard Hughes Medical Institute and Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, CA 94143 0725, USA
    Mol Biol Cell 16:3480-7. 2005
    ..This study identifies a hitherto unreported role for Lgl as a regulator of Sanpodo during asymmetric cell division in the adult PNS...
  70. ncbi request reprint Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia
    Salim Abdelilah-Seyfried
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Development 130:1927-35. 2003
    ....
  71. ncbi request reprint A lethal giant kinase in cell polarity
    Nicholas J Justice
    Nat Cell Biol 5:273-4. 2003
  72. ncbi request reprint Comparing genomic expression patterns across species identifies shared transcriptional profile in aging
    Steven A McCarroll
    Program in Neuroscience, University of California, San Francisco, California 94143, USA
    Nat Genet 36:197-204. 2004
    ..Using this approach to search databases of gene expression data, we found conserved transcriptional signatures in larval development, embryogenesis, gametogenesis and mRNA degradation...
  73. ncbi request reprint Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition
    Cindy Shen Huang
    Howard Hughes Medical Institute and Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143, USA
    Cell 123:105-18. 2005
    ....
  74. pmc An obligatory role of mind bomb-1 in notch signaling of mammalian development
    Bon Kyoung Koo
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
    PLoS ONE 2:e1221. 2007
    ..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...

Research Grants16

  1. GENETIC DISSECTION OF DENDRITE DEVELOPMENT
    YUH JAN; Fiscal Year: 2009
    ..The Core programs identified from this work will contribute to the understanding and eventual treatment of human neurological diseases many of which have pathology in dendrites. ..
  2. Molecular Mechanisms of dendrite development in mammalia
    YUH JAN; Fiscal Year: 2007
    ..The Core programs identified from this work will contribute to the understanding and eventual treatment of human neurological diseases many of which have pathology in dendrites. ..
  3. GENETIC DISSECTION OF DENDRITE DEVELOPMENT
    YUH JAN; Fiscal Year: 2007
    ..The Core programs identified from this work will contribute to the understanding and eventual treatment of human neurological diseases many of which have pathology in dendrites. ..
  4. GENETIC DISSECTION OF DENDRITE DEVELOPMENT
    YUH JAN; Fiscal Year: 2004
    ..The Core programs identified from this work should help unravel the molecular control of dendrite development in mammals and contribute to the understanding and eventual treatment of neurological diseases in Human. ..
  5. Molecular mechanisms of dendrite development in mammalian CNS
    Yuh Nung Jan; Fiscal Year: 2010
    ..Given that dendrite defects are the likely cause of many mental disorders such as autism, this project could contribute to the diagnosis and possible treatment in the future. ..