Research Topics
Genomes and GenesSpecies | YUH JANSummaryAffiliation: University of California Country: USA Publications
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Publications
Variations on the Notch pathway in neural developmentNicholas J Justice
Department of Physiology and Biochemistry, Howard Hughes Medical Institute, Box 0725, UCSF, San Francisco, California 94143 0725, USA
Curr Opin Neurobiol 12:64-70. 2002..These regulatory mechanisms, along with many others, affect how Notch signaling activity influences cell fate determination...- Retrospective: Seymour Benzer (1921-2007)Yuh-Nung Jan
Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California, San Francisco, CA 94143, USA
Science 319:45. 2008 
Branching out: mechanisms of dendritic arborizationYuh Nung Jan
Howard Hughes Medical Institute, Department of Physiology, University of California, 1550 4th Street, San Francisco 94158, USA
Nat Rev Neurosci 11:316-28. 2010..Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders...- The Notch regulator Numb links the Notch and TCR signaling pathwaysAna C Anderson
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
J Immunol 174:890-7. 2005..Together our data suggest that Notch and TCR signals may be integrated at the cell membrane, and that Numb may be an important adapter in this process... - hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphologyAdrian W Moore
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143, USA
Science 297:1355-8. 2002..Moreover, hamlet expression induced in MD neurons undergoing dendrite outgrowth drastically reduces arbor branching... - Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic nicheChay T Kuo
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143, USA
Cell 127:1253-64. 2006..Our results show a self-repair mechanism in the mammalian brain and may have implications for both niche plasticity in other areas of stem cell biology and the therapeutic use of neural stem cells in neurodegenerative diseases... - A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channelsChen Gu
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0725, USA
Science 301:646-9. 2003..Moreover, T1 mutations eliminating Kvbeta association compromised axonal targeting, but not surface expression, of CD4-T1 fusion proteins. Thus, proper association of Kvbeta with the Kv1 T1 domain is essential for axonal targeting... - Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesisHua Shun Li
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 40:1105-18. 2003..Further, these double mutant mice provide an unprecedented viable animal model for severe brain malformations due to defects in neural progenitor cells... - Yuh-Nung JanYuh Nung Jan
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 533 Parnassus Avenue, 94143-0725, USA
Curr Biol 13:R378-9. 2003 - Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendritesJay Z Parrish
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
Genes Dev 20:820-35. 2006..Thus, multiple genetic programs operate to calibrate dendritic coverage, to coordinate the elaboration of primary versus secondary branches, and to lay out these dendritic branches in the proper orientation... - The control of dendrite developmentYuh Nung Jan
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
Neuron 40:229-42. 2003..In contrast, the control of dendrite development is still much less well understood. However, recent progress has begun to shed light on the molecular mechanisms that orchestrate dendrite growth, arborization, and guidance... - Evolving potassium channels by means of yeast selection reveals structural elements important for selectivityDelphine Bichet
Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143-0725, USA
Proc Natl Acad Sci U S A 101:4441-6. 2004..Some of these suppressors also affected channel gating (channel open time and opening frequency determined in single-channel analyses), revealing intriguing interplay between ion permeation and channel gating... - A fluorescent probe designed for studying protein conformational changeBruce E Cohen
Howard Hughes Medical Institute and Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143 0725, USA
Proc Natl Acad Sci U S A 102:965-70. 2005..The spectral characteristics of APM can also report subtle differences between aqueous positions in purified preparations of the beta2 adrenergic receptor... - The coiled-coil protein shrub controls neuronal morphogenesis in DrosophilaNeal T Sweeney
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
Curr Biol 16:1006-11. 2006..Our findings demonstrate that the novel coiled-coil protein Shrub functions in the endosomal pathway and plays an essential role in neuronal morphogenesis... - Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborizationEric J Huang
Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA
Genes Dev 19:138-51. 2005..Taken together, our data provide evidence for previously unidentified functions of Numb and Numblike in sensory axon arborization by regulating Notch1 via the endocytic-lysosomal pathways... - Probing protein electrostatics with a synthetic fluorescent amino acidBruce E Cohen
Howard Hughes Medical Institute and Departments of Physiology and Biochemistry, University of California San Francisco, San Francisco, CA 94143, USA
Science 296:1700-3. 2002..Steady-state and time-resolved fluorescence measurements of Aladan residues at different buried and exposed sites in the B1 domain of protein G suggest that its interior is polar and heterogeneous... - Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neuronsWesley B Grueber
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Room U226, San Francisco, CA 94143, USA
Cell 112:805-18. 2003..Thus, different levels of a homeoprotein can regulate distinct patterns of dendrite branching... - Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecificationAdrian W Moore
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, CA 94143, USA
Genes Dev 18:623-8. 2004..The fate-determining signals NOTCH and PAX2 act at multiple stages of lineage elaboration and HAMLET acts to modulate their activity in a branch-specific manner... - Tiling of the Drosophila epidermis by multidendritic sensory neuronsWesley B Grueber
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 0725, USA
Development 129:2867-78. 2002..Together, our data suggest that widespread tiling of the larval body wall involves interactions between growing dendritic processes and as yet unidentified signals that allow avoidance by like dendrites... - Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neuronsBing Ye
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 0725, USA
Curr Biol 14:314-21. 2004..This work serves as an entry point for future studies of dendritic translational control of dendrite morphogenesis... - The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neuronsMichael D Kim
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
Genes Dev 20:2806-19. 2006..These findings suggest that one evolutionarily conserved role for Ahr in neuronal development concerns the diversification of dendrite morphology... - Growing dendrites and axons differ in their reliance on the secretory pathwayBing Ye
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143, USA
Cell 130:717-29. 2007..The distinct dependence between dendritic and axonal growth on the secretory pathway helps to establish different morphology of dendrites and axons... - Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organizationPeter Soba
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, Rock Hall, 1550 4th Street, San Francisco, CA 94143, USA
Neuron 54:403-16. 2007.... - Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphologyWesley B Grueber
Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
Development 134:55-64. 2007.... - The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and DeltaEric C Lai
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
Development 132:2319-32. 2005..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development... - Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fieldsJay Z Parrish
Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA
Annu Rev Neurosci 30:399-423. 2007..In this review, we summarize our current understanding of the cellular and molecular mechanisms that regulate dendritic field formation and influence the shaping of dendritic arbors... - Visualizing the breaking of symmetryBing Ye
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 1550 4th Street, 94143, USA
Dev Cell 10:411-2. 2006..Although several models have been proposed, few studies have provided clues about polarization events in real time. Using time-lapse imaging, a recent study described visualizing symmetry-breaking events during this process... - The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neuronsJay Z Parrish
Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
Neuron 63:788-802. 2009..This signaling between epithelial cells and neurons receiving sensory input from the body wall synchronizes their growth to ensure proper dendritic coverage of the receptive field... - Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axonsMichael E Rothenberg
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143, USA
Neuron 39:779-91. 2003..Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance... - Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heartDzwokai Ma
Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
Neuron 33:715-29. 2002..3 subunit potently inhibits plasma membrane expression by diverting the heterotetrameric channels to lysosomes. Such rich trafficking behaviors provide a mechanism for dynamic regulation of GIRK channel density in the plasma membrane... - ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase CKeli Hu
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 38:417-32. 2003..Likewise, in hippocampal CA1 neurons under metabolic stress, PKC-mediated, dynamin-dependent K(ATP) channel internalization can also act as a brake to dampen the rapid decline of excitability due to K(ATP) activation... - Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruningChay T Kuo
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California 94143, USA
Neuron 51:283-90. 2006..Thus, in addition to uncovering E2/E3 ubiquitinating enzymes for dendrite pruning, this study provides a mechanistic link between UPS and the apoptotic machinery in regulating neuronal process remodeling... - Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsionWesley B Grueber
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California San Francisco, 533 Parnassus Avenue, Room U226, San Francisco, CA 94143, USA
Curr Biol 13:618-26. 2003..By contrast, dendrites of class I and class II neurons do not completely tile the body wall, but they nevertheless occupy nonoverlapping territories... - The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenanceKazuo Emoto
Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California San Francisco, San Francisco, California 94143 0725, USA
Nature 443:210-3. 2006.... - K+ channel selectivity depends on kinetic as well as thermodynamic factorsMichael Grabe
Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143
Proc Natl Acad Sci U S A 103:14361-6. 2006.... - Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivityDelphine Bichet
Departments of Physiology and Biochemistry and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143
Proc Natl Acad Sci U S A 103:14355-60. 2006..Our results indicate that interactions between permeant ions and the channel cavity can influence ion selectivity and channel block by means of an electrostatic effect... - Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendritesKimberly F Raab-Graham
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94158, USA
Science 314:144-8. 2006..1 synthesis in dendrites upon inhibition of mTOR or the N-methyl-d-aspartate (NMDA) glutamate receptor. Thus, synaptic excitation may cause local suppression of dendritic Kv1 channels by reducing their local synthesis... - The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targetingChen Gu
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, San Francisco, California 94143, USA
Neuron 52:803-16. 2006..In addition, we found that Kvbeta2 associates with KIF3/kinesin II as well. Indeed, Kv1 channels rely on both KIF3/kinesin II and EB1 for their axonal targeting... - Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvaeWei Song
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 104:5199-204. 2007..These findings reveal that MD sensory neuron input is a necessary component in the neural circuitry that generates larval locomotion... - Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendritesJay Z Parrish
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
Genes Dev 21:956-72. 2007..We further show genetic interactions and association between PcG proteins and the tumor suppressor kinase Warts (Wts), providing evidence for their cooperation in multiple developmental processes including dendrite maintenance... - Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1)Song Hai Shi
Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California, 1550 Fourth Street, San Francisco, CA 94143 0725, USA
Proc Natl Acad Sci U S A 101:13341-5. 2004..Together with its orthologues in other species, Dasm1 defines a family of molecules likely involved specifically in dendrite arborization... - Dynein is required for polarized dendritic transport and uniform microtubule orientation in axonsYi Zheng
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Nat Cell Biol 10:1172-80. 2008..These data suggest that dynein is required for the distinguishing properties of the axon and dendrites: without dynein, dendritic organelles and proteins enter the axon and the axonal microtubules are no longer uniform in polarity... - The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levelsJill Wildonger
Department of Physiology and Department of Biochemistry, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
Genes Dev 22:2447-53. 2008..Thus, in addition to the kinase LKB1, the Tsc1-Tsc2 complex, acting through TORC1, also modulates SAD to regulate axon formation... - Control of the postmating behavioral switch in Drosophila females by internal sensory neuronsChung Hui Yang
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 61:519-26. 2009..Our results uncover a neuronal mechanism by which sex peptide exerts its control over reproductive behaviors in Drosophila females... - Structure prediction for the down state of a potassium channel voltage sensorMichael Grabe
Department of Physiology, Howard Hughes Medical Institute
Nature 445:550-3. 2007..2 structure suggests that the VSDs undergo large rearrangements during gating, whereas the S4 segment remains positioned between the central pore and the remainder of the VSD in both states... - Dendritic development: lessons from Drosophila and related branchesWesley B Grueber
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Box 0725, San Francisco CA 94143, USA
Curr Opin Neurobiol 14:74-82. 2004..Here, we review some recent advances in our understanding of dendritic development in insects, focusing primarily on insights that have been gained from studies of Drosophila... - The cadherin superfamily and dendrite developmentBing Ye
Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California-San Francisco, San Francisco, CA 94143-0725, USA
Trends Cell Biol 15:64-7. 2005..Recent work in mammals by Shima et al., and earlier work in Drosophila by Gao et al. and Sweeney et al. have determined the presence of a non-classic, seven-pass transmembrane cadherin in this process... - NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotectionYu Fung Lin
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94143 0725, USA
Proc Natl Acad Sci U S A 101:7799-804. 2004..Thus, neuroprotection caused by NO released during the short episode of sublethal ischemia may be mediated partly by K(ATP) stimulation... - The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channelHelen C Lai
Graduate Group in Biophysics, University of California, San Francisco, San Francisco, California 94143, USA
Neuron 47:395-406. 2005.... - Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signalingChay T Kuo
Howard Hughes Medical Institute and Department of Physiology, University of California, 1550 Fourth Street, Room GD484E, San Francisco, CA 94143 0725, USA
Proc Natl Acad Sci U S A 102:15230-5. 2005..These results demonstrate that, in response to environmental changes, certain neurons have cell-intrinsic abilities to completely lose their dendrites but keep their axons and subsequently regrow their dendritic arbors... - Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neuronsKazuo Emoto
Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California San Francisco, 1550 4th Street, San Francisco, CA 94143, USA
Cell 119:245-56. 2004..Thus, the Trc/Fry signaling pathway plays a key role in patterning dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching... - The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblastsClaudia Petritsch
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 4:273-81. 2003..Our studies demonstrate that a class VI myosin is necessary for basal protein targeting and spindle orientation in neuroblasts... - Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineageNicholas Justice
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0725, USA
Curr Biol 13:778-83. 2003..These findings uncover a previously unknown function of Lgl in the inhibition of Notch and reveal different modes of action by which Lgl can influence cell fate in the neuroblast and SOP lineages... - Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domainsHee Jung Chung
Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143
Proc Natl Acad Sci U S A 103:8870-5. 2006..We further show that several BFNC mutations of KCNQ2 and KCNQ3 disrupt surface expression or polarized surface distribution of KCNQ channels, thereby revealing impaired targeting of KCNQ channels to axonal surfaces as a BFNC etiology... - Identification of yeast proteins necessary for cell-surface function of a potassium channelFriederike A Haass
Department of Physiology, Neuroscience Graduate Program, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:18079-84. 2007..The seven yeast proteins identified in our screen likely impact Kir-channel functional expression at the level of vesicle budding from the ER and/or the local lipid environment at the plasma membrane... - A quantitative assessment of models for voltage-dependent gating of ion channelsMichael Grabe
Howard Hughes Medical Institute and Department of Physiology and Biochemistry, University of California, San Francisco, CA 94143-0725, USA
Proc Natl Acad Sci U S A 101:17640-5. 2004.... - salvador--The persistence of proliferationMichael E Rothenberg
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, 533 Parnassus Avenue, 94143, San Francisco, CA, USA
Cancer Cell 2:171-3. 2002.... - Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctionsRobin M Shaw
Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143, USA
Cell 128:547-60. 2007..These findings support an unanticipated mechanism for protein delivery to points of cell-cell contact... - Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channelsHee Jung Chung
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 106:629-34. 2009.... - G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiationHee Jung Chung
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 106:635-40. 2009..Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity... - APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polaritySong Hai Shi
Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California at San Francisco, 1550 4th Street, San Francisco, CA 94143 0725, USA
Curr Biol 14:2025-32. 2004.... - Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosisHsiu Hsiang Lee
Howard Hughes Medical Institute, Department of Physiology, Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:6363-8. 2009..Our study thus implicates Ik2 and Kat-60L1 in dendrite severing that involves local microtubule disassembly... - The secretory pathway and neuron polarizationBing Ye
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 26:10631-2. 2006 - Tetralogy of fallot and other congenital heart defects in Hey2 mutant miceJena Donovan
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
Curr Biol 12:1605-10. 2002..These results establish Hey2 as an important regulator of cardiac morphogenesis and suggest a role for Hey2 in mediating or modulating Notch signaling in the developing heart... - Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblastsQin Shen
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
Development 129:4843-53. 2002..These data indicate Numb has an important role in generating asymmetric cell divisions and diverse cell fates during mouse cortical development... - Progenitor cell maintenance requires numb and numblike during mouse neurogenesisPetur H Petersen
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
Nature 419:929-34. 2002..Our findings show that a shared molecular mechanism, with mouse Numb and Nbl as key components, governs the self-renewal of all neural progenitor cells, regardless of their lineage or regional identities... - Asymmetric cell divisionFabrice Roegiers
Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Ave, San Francisco, California, 94122, USA
Curr Opin Cell Biol 16:195-205. 2004..In vertebrates, analysis of dividing neural progenitor cells by in vivo imaging has raised questions about the role of asymmetric cell divisions during neurogenesis... - Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biologyFengwei Yu
Howard Hughes Medical Institute and Departments of Physiology, Biochemistry, and Biophysics, University of California, Rock Hall, 1550 Fourth Street, San Francisco, California 94143, USA
Neuron 51:13-20. 2006..We also discuss issues of progenitor proliferation and differentiation associated with asymmetric cell division and their broader implications for stem cell biology... - Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organsFabrice Roegiers
Howard Hughes Medical Institute and Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, CA 94143 0725, USA
Mol Biol Cell 16:3480-7. 2005..This study identifies a hitherto unreported role for Lgl as a regulator of Sanpodo during asymmetric cell division in the adult PNS... - Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epitheliaSalim Abdelilah-Seyfried
Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
Development 130:1927-35. 2003.... - A lethal giant kinase in cell polarityNicholas J Justice
Nat Cell Biol 5:273-4. 2003 - Comparing genomic expression patterns across species identifies shared transcriptional profile in agingSteven A McCarroll
Program in Neuroscience, University of California, San Francisco, California 94143, USA
Nat Genet 36:197-204. 2004..Using this approach to search databases of gene expression data, we found conserved transcriptional signatures in larval development, embryogenesis, gametogenesis and mRNA degradation... - Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibitionCindy Shen Huang
Howard Hughes Medical Institute and Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143, USA
Cell 123:105-18. 2005.... - An obligatory role of mind bomb-1 in notch signaling of mammalian developmentBon Kyoung Koo
Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
PLoS ONE 2:e1221. 2007..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...
Research Grants
- GENETIC DISSECTION OF DENDRITE DEVELOPMENTYUH JAN; Fiscal Year: 2009..The Core programs identified from this work will contribute to the understanding and eventual treatment of human neurological diseases many of which have pathology in dendrites. ..
- Molecular Mechanisms of dendrite development in mammaliaYUH JAN; Fiscal Year: 2007..The Core programs identified from this work will contribute to the understanding and eventual treatment of human neurological diseases many of which have pathology in dendrites. ..
- GENETIC DISSECTION OF DENDRITE DEVELOPMENTYUH JAN; Fiscal Year: 2007..The Core programs identified from this work will contribute to the understanding and eventual treatment of human neurological diseases many of which have pathology in dendrites. ..
- GENETIC DISSECTION OF DENDRITE DEVELOPMENTYUH JAN; Fiscal Year: 2004..The Core programs identified from this work should help unravel the molecular control of dendrite development in mammals and contribute to the understanding and eventual treatment of neurological diseases in Human. ..
- Molecular mechanisms of dendrite development in mammalian CNSYuh Nung Jan; Fiscal Year: 2010..Given that dendrite defects are the likely cause of many mental disorders such as autism, this project could contribute to the diagnosis and possible treatment in the future. ..