SANDRA JAMES

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi A mathematical model of glutathione metabolism
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 5:8. 2008
  2. ncbi The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study
    Daniel A Rossignol
    International Child Development Resource Center, 3800 West Eau Gallie Blvd, Suite 105, Melbourne, FL 32934, USA
    BMC Pediatr 7:36. 2007
  3. ncbi Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 1120 Marshall St, Little Rock, AR 72202, USA
    FASEB J 23:2374-83. 2009
  4. ncbi Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism
    S Jill James
    Department of Pediatrics and Biostatistics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Am J Clin Nutr 89:425-30. 2009
  5. ncbi Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Autism Dev Disord 38:1966-75. 2008
  6. ncbi Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 133:3740S-3747S. 2003
  7. ncbi Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Am J Med Genet B Neuropsychiatr Genet 141:947-56. 2006
  8. ncbi Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Am J Clin Nutr 80:1611-7. 2004
  9. ncbi Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors
    S J James
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Neurotoxicology 26:1-8. 2005
  10. ncbi A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1209-20. 2010

Research Grants

  1. Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility
    SANDRA JILL JAMES; Fiscal Year: 2010
  2. Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility
    SANDRA JAMES; Fiscal Year: 2007

Collaborators

Detail Information

Publications10

  1. ncbi A mathematical model of glutathione metabolism
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 5:8. 2008
    ..Deficits in glutathione have been implicated in aging and a host of diseases including Alzheimer's disease, Parkinson's disease, cardiovascular disease, cancer, Down syndrome and autism...
  2. ncbi The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study
    Daniel A Rossignol
    International Child Development Resource Center, 3800 West Eau Gallie Blvd, Suite 105, Melbourne, FL 32934, USA
    BMC Pediatr 7:36. 2007
    ..Changes in markers of oxidative stress and inflammation were measured. The children were evaluated to determine clinical effects and safety...
  3. ncbi Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 1120 Marshall St, Little Rock, AR 72202, USA
    FASEB J 23:2374-83. 2009
    ..These results suggest that the autism LCLs exhibit a reduced glutathione reserve capacity in both cytosol and mitochondria that may compromise antioxidant defense and detoxification capacity under prooxidant conditions...
  4. ncbi Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism
    S Jill James
    Department of Pediatrics and Biostatistics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Am J Clin Nutr 89:425-30. 2009
    ..Metabolic abnormalities and targeted treatment trials have been reported for several neurobehavioral disorders but are relatively understudied in autism...
  5. ncbi Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Autism Dev Disord 38:1966-75. 2008
    ..Studies are underway to determine whether the abnormal profile in parents reflects linked genetic polymorphisms in these pathways or whether it simply reflects the chronic stress of coping with an autistic child...
  6. ncbi Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 133:3740S-3747S. 2003
    ..These insights in an experimental model are consistent with the possibility that DNA lesions may be a necessary prerequisite for the disruption of normal DNA methylation patterns in preneoplastic and neoplastic cells...
  7. ncbi Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Am J Med Genet B Neuropsychiatr Genet 141:947-56. 2006
    ..We propose that an increased vulnerability to oxidative stress (endogenous or environmental) may contribute to the development and clinical manifestations of autism...
  8. ncbi Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Am J Clin Nutr 80:1611-7. 2004
    ..Although abnormal metabolism of methionine and homocysteine has been associated with other neurologic diseases, these pathways have not been evaluated in persons with autism...
  9. ncbi Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors
    S J James
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Neurotoxicology 26:1-8. 2005
    ..The potential protective effect of GSH or NAC against mercury toxicity warrants further research as possible adjunct therapy to individuals still receiving Thimerosal-containing vaccinations...
  10. ncbi A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1209-20. 2010
    ..Together, these results suggest that the maternal genetics/epigenetics may influence fetal predisposition to autism...

Research Grants5

  1. Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility
    SANDRA JILL JAMES; Fiscal Year: 2010
    ....
  2. Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility
    SANDRA JAMES; Fiscal Year: 2007
    ....