L P James

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences UAMS and Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
    Eur J Clin Pharmacol 69:851-7. 2013
  2. pmc Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
  3. ncbi Acetaminophen-induced hepatotoxicity
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Drug Metab Dispos 31:1499-506. 2003
  4. ncbi Efficacy and safety measurements of proton pump inhibitors in infants and children
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Pediatric Pharmacology Research Unit, Little Rock, Arkansas, USA
    J Pediatr Gastroenterol Nutr 37:S46-51. 2003
  5. ncbi Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression
    Laura P James
    Department of Paediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Basic Clin Pharmacol Toxicol 97:8-14. 2005
  6. ncbi Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse
    Laura P James
    Department of Pediatrics, Univerisity of Arkansas for Medical Sciences, Little Rock, AR, USA
    Biochem Biophys Res Commun 309:857-63. 2003
  7. ncbi Cytokines and toxicity in acetaminophen overdose
    Laura P James
    Department of Pediatrics, Section of Clinical Pharmacology and Toxicology, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    J Clin Pharmacol 45:1165-71. 2005
  8. ncbi Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation
    Laura P James
    Clinical Pharmacology Toxicology, Department of Pediatrics, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    Toxicol Sci 75:458-67. 2003
  9. ncbi Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Biochem Biophys Res Commun 343:171-6. 2006
  10. ncbi Pharmacology for the gastrointestinal tract
    Laura P James
    Section of Pediatric Pharmacology and Toxicology, Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital, Little Rock, Arkansas, USA
    Clin Perinatol 29:115-33. 2002

Collaborators

Detail Information

Publications39

  1. pmc Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences UAMS and Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
    Eur J Clin Pharmacol 69:851-7. 2013
    ..APAP protein adducts were measured in blood samples collected from fasted individuals who participated in a crossover study of APAP (80 mg/kg) comparing extended release (ER) and immediate release (IR) formulations...
  2. pmc Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
    ..The objective of this study is to describe APAP-CYS concentrations in these clinical settings as well as to further characterize the concentrations observed following acetaminophen overdose...
  3. ncbi Acetaminophen-induced hepatotoxicity
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Drug Metab Dispos 31:1499-506. 2003
    ..Other cytokines, such as IL-10, macrophage inhibitory protein-2 (MIP-2), and monocyte chemoattractant protein-1 (MCP-1), appear to be involved in hepatocyte repair and the regulation of proinflammatory cytokines...
  4. ncbi Efficacy and safety measurements of proton pump inhibitors in infants and children
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Pediatric Pharmacology Research Unit, Little Rock, Arkansas, USA
    J Pediatr Gastroenterol Nutr 37:S46-51. 2003
    ..This approach may likewise be used in the study of newer acid-lowering agents, such as proton pump inhibitors...
  5. ncbi Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression
    Laura P James
    Department of Paediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Basic Clin Pharmacol Toxicol 97:8-14. 2005
    ..Depletion of tumour necrosis factor receptor 1 has long-lasting effects on hepatocyte regeneration in acetaminophen toxicity but multiple other factors appear to orchestrate eventual recovery in these mice...
  6. ncbi Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse
    Laura P James
    Department of Pediatrics, Univerisity of Arkansas for Medical Sciences, Little Rock, AR, USA
    Biochem Biophys Res Commun 309:857-63. 2003
    ..Pretreatment of KO mice with IL-6 lowered AST and normalized PCNA staining in the IL-6 KO mice. These data suggest that IL-6 is important in hepatocyte regeneration following APAP toxicity in the mouse...
  7. ncbi Cytokines and toxicity in acetaminophen overdose
    Laura P James
    Department of Pediatrics, Section of Clinical Pharmacology and Toxicology, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    J Clin Pharmacol 45:1165-71. 2005
    ..An understanding of the role of cytokine responses in acetaminophen overdose may be relevant to the future development of new therapies for acetaminophen toxicity...
  8. ncbi Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation
    Laura P James
    Clinical Pharmacology Toxicology, Department of Pediatrics, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    Toxicol Sci 75:458-67. 2003
    ..IL-6, MIP-2, and MCP-1 appear to follow the toxicity. While it is a pre-requisite event, covalent binding per se does not appear to be a toxic event in the development of toxicity...
  9. ncbi Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Biochem Biophys Res Commun 343:171-6. 2006
    ..Thus, HIF-1alpha is induced before APAP toxicity and can occur under non-hypoxic conditions. The data suggest a role for oxidative stress in the induction of HIF-1alpha in APAP toxicity...
  10. ncbi Pharmacology for the gastrointestinal tract
    Laura P James
    Section of Pediatric Pharmacology and Toxicology, Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital, Little Rock, Arkansas, USA
    Clin Perinatol 29:115-33. 2002
    ..Further data are also needed to characterize fully the pharmacodynamics, or efficacy, of many of the commonly used drugs...
  11. pmc Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure
    Laura P James
    Section of Pediatric Pharmacology and Toxicology, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    Drug Metab Dispos 37:1779-84. 2009
    ..The persistence and specificity of APAP-protein adducts as correlates of toxicity support their use as specific biomarkers of APAP toxicity in patients with acute liver injury...
  12. ncbi Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents
    L P James
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock 72202, USA
    Clin Pharmacol Ther 70:280-6. 2001
    ..The purpose of this study was to measure serum cytokine levels in children and adolescents with acetaminophen overdose and to evaluate relationships between cytokine elevation and hepatotoxicity...
  13. ncbi Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
    Pediatrics 118:e676-81. 2006
    ..The objective of this study was to use a new assay for the detection of acetaminophen cysteine protein adducts in children with acute liver failure to determine the role of acetaminophen toxicity in acute liver failure of unknown cause...
  14. pmc Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose
    L P James
    Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
    Clin Pharmacol Ther 84:684-90. 2008
    ....
  15. ncbi Pharmacokinetics and tolerability of rabeprazole sodium in subjects aged 12 to 16 years with gastroesophageal reflux disease: an open-label, single- and multiple-dose study
    Laura James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Clin Ther 29:2082-92. 2007
    ..This study was conducted to characterize the pharmacokinetic and safety profile of rabeprazole sodium tablets in children and adolescents with gastroesophageal reflux disease (GERD)...
  16. ncbi Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Free Radic Res 37:1289-97. 2003
    ..These data indicate that superoxide from activated macrophages is not critical to the development of acetaminophen toxicity and provide further support for the role of mitochondrial oxidant stress in acetaminophen toxicity...
  17. ncbi Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses.
    L P James
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock 72202, USA
    J Clin Pharmacol 41:846-51. 2001
    ....
  18. ncbi Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Pediatric Pharmacology Research Unit Network
    L P James
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock 72202, USA
    Clin Pediatr (Phila) 40:243-8. 2001
    ..Acetaminophen-protein adducts were not detected in this cohort of 18 subjects. Based on this pilot study, the routine use of acetaminophen at therapeutic doses in ill, hospitalized children and adolescents appears safe...
  19. ncbi Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes
    Angela S Burke
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Toxicol Environ Health A 70:1936-45. 2007
    ..The data indicate that chloroform-induced cell death occurs in two phases: a metabolic phase characterized by glutathione depletion, and an oxidative phase characterized by MPT and protein nitration...
  20. ncbi Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection
    Kenneth L Muldrew
    Department of Pharmacology and Toxicology, the University of Arkansas for the Medical Sciences, Little Rock, Arkansas 72205, USA
    Drug Metab Dispos 30:446-51. 2002
    ..This assay may be useful in the diagnostic evaluation of patients with hepatotoxicity of an indeterminate etiology for which acetaminophen toxicity is suspect...
  21. pmc Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity
    Brian C Donahower
    Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Pharmacol Exp Ther 334:33-43. 2010
    ..Attenuation of sinusoidal cell endothelial dysfunction and changes in neutrophil dynamics may be operant mechanisms in the hepatoprotection mediated by hrVEGF in APAP toxicity...
  22. ncbi Predictors of outcome after acetaminophen poisoning in children and adolescents
    Laura P James
    Division of Pediatric Clincial Pharmacology, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    J Pediatr 140:522-6. 2002
    ..The goal of this study was to determine which clinical findings best identified patients at lowest risk for acetaminophen-related hepatotoxicity after an acute overdose...
  23. ncbi The pharmacokinetics of continuous infusion pralidoxime in children with organophosphate poisoning
    S Schexnayder
    University of Arkansas for Medical Sciences, Little Rock, USA
    J Toxicol Clin Toxicol 36:549-55. 1998
    ..To define the pharmacokinetics of continuous infusion pralidoxime in organophosphate-poisoned children...
  24. ncbi Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network
    G L Kearns
    Department of Pediatrics, University of Missouri Kansas City, MO, USA
    Pediatr Infect Dis J 19:833-9. 2000
    ..Pleconaril phamacokinetics was evaluated in 16 neonates (16.4 +/- 8.7 days postnatal age) with suspected enteroviral infection...
  25. ncbi Correlation of MCP1 with toxicity in acetaminophen overdose
    Laura P James
    Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, USA
    J Ark Med Soc 100:424-5. 2004
  26. pmc Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase
    Rakhee Agarwal
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Pharmacol Exp Ther 337:110-6. 2011
    ..APAP-MnSOD adducts were not detected. Treatment of recombinant MnSOD with NAPQI did not produce APAP protein adducts. The data indicate that MnSOD inactivation by nitration is an early event in APAP-induced hepatic toxicity...
  27. doi Coma in a 20-month-old child from an ingestion of a toy containing 1,4-butanediol, a precursor of gamma-hydroxybutyrate
    Laura A Ortmann
    Section of Critical Care Medicine, Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital, 800 Marshall St, Slot 512 12, Little Rock, AR 72202, USA
    Pediatr Emerg Care 25:758-60. 2009
    ..Health care providers should suspect the possibility of a toxic component when a presumed nontoxic object causes unusual symptoms...
  28. ncbi Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition
    Jack A Hinson
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Drug Metab Rev 36:805-22. 2004
    ....
  29. ncbi Single dose pharmacokinetics of linezolid in infants and children
    G L Kearns
    Department of Pediatrics, University of Missouri Kansas City, USA
    Pediatr Infect Dis J 19:1178-84. 2000
    ..The safety and pharmacokinetics of intravenously administered linezolid were evaluated in children and adolescents to examine the potential for developmental dependence on its disposition characteristics...
  30. ncbi Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity
    Brian Donahower
    Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Physiol Gastrointest Liver Physiol 291:G102-9. 2006
    ..These data indicate that endogenous VEGF is critically important to the process of hepatocyte regeneration in APAP-induced hepatotoxicity in the mouse...
  31. doi Metabolomics: integration of a new "omics" with clinical pharmacology
    L P James
    1 Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA 2 Clinical Pharmacology and Toxicology Section, Arkansas Children s Hospital, Little Rock, Arkansas, USA
    Clin Pharmacol Ther 94:547-51. 2013
    ..As such, the complexity of human biology afforded by metabolomics can complement genomic approaches, ultimately moving the discipline of clinical pharmacology closer to full implementation of personalized medicine. ..
  32. ncbi Ontogeny of dextromethorphan O- and N-demethylation in the first year of life
    M J Blake
    Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children s Mercy Hospitals and Clinics, Kansas City, Missouri, USA
    Clin Pharmacol Ther 81:510-6. 2007
    ..In contrast, DM N-demethylation developed significantly more slowly over the first year of life. Genotype and the temporal acquisition of drug biotransformation are critical determinants of a drug response in infants...
  33. ncbi Phenothiazine, butyrophenone, and other psychotropic medication poisonings in children and adolescents
    L P James
    Department of Pediatrics, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock 72202, USA
    J Toxicol Clin Toxicol 38:615-23. 2000
    ..To describe the presentation, epidemiology, management, and outcome of phenothiazine and butyrophenone ingestions in children requiring hospitalization...
  34. ncbi Sympathomimetic drug use in adolescents presenting to a pediatric emergency department with chest pain
    L P James
    University of Arkansas for Medical Sciences, Little Rock, USA
    J Toxicol Clin Toxicol 36:321-8. 1998
    ..Drug use has been associated with chest pain in adults presenting for emergency care. The association of drug use and chest pain in adolescents presenting to a pediatric emergency department has not been evaluated...
  35. ncbi Methamphetamine exposure presenting as caustic ingestions in children
    Karen Farst
    Department of Pediatrics, Section of Children at Risk, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, AR 72202, USA
    Ann Emerg Med 49:341-3. 2007
    ..We present the first reported cases of children harmed by ingesting caustic substances used in the production of methamphetamine in the home...
  36. ncbi Famotidine disposition in children and adolescents with chronic renal insufficiency
    Holly D Maples
    University of Arkansas for Medical Sciences, Arkansas Children s Hospital, Little Rock, Arkansas, USA
    J Clin Pharmacol 43:7-14. 2003
    ..6% Clnr) (p < 0.05). It was concluded that the pharmacokinetics of famotidine are significantly altered in children with chronic renal insufficiency; accordingly, dosing should be based on glomerular filtration rate (i.e., Clcr)...
  37. ncbi Measurement of serum acetaminophen-protein adducts in patients with acute liver failure
    Timothy J Davern
    University of California at San Francisco, San Francisco, California, USA corrected
    Gastroenterology 130:687-94. 2006
    ..Measurement of serum adducts might improve diagnostic accuracy in acute liver failure (ALF) patients...
  38. ncbi Pharmacokinetics of famotidine in infants
    Larissa A Wenning
    Merck Research Laboratories, West Point, Pennslyvania, USA
    Clin Pharmacokinet 44:395-406. 2005
    ..Little is currently known about the pharmacokinetics of famotidine in infants aged between 1 month and 1 year, a period when renal function is maturing...
  39. ncbi Omeprazole disposition in children following single-dose administration
    Gregory L Kearns
    Departments of Pediatrics and Pharmacology, University of Missouri, Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri, USA
    J Clin Pharmacol 43:840-8. 2003
    ..No association between age and CL/F, t1/2, or lambda z was observed. The range of t1/2 values for omeprazole was similar to those reported in adults (1-1.5 h)...

Research Grants12

  1. NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
    Laura James; Fiscal Year: 2004
    ..abstract_text> ..
  2. Identification of new mechanistic biomarkers of adverse responses to acetaminophe
    Laura P James; Fiscal Year: 2010
    ..This new knowledge will increase our understanding of how acetaminophen may cause liver injury and how some patients may be at greater risk for liver injury. ..
  3. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2009
    ..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
  4. Identification of new mechanistic biomarkers of adverse responses to acetaminophe
    Laura James; Fiscal Year: 2009
    ..This new knowledge will increase our understanding of how acetaminophen may cause liver injury and how some patients may be at greater risk for liver injury. ..
  5. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura James; Fiscal Year: 2007
    ..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..
  6. Evaluation of a Biomarker for Acetaminophen Toxicity
    Laura James; Fiscal Year: 2005
    ..The data generated from this study will lead to enhanced recognition of APAP hepatotoxicity, thus allowing for better identification of "at risk" populations and the creation of prevention strategies. ..
  7. HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
    Laura P James; Fiscal Year: 2010
    ..A better understanding of the recovery processes of the liver will lead to the development of new treatments for acute liver failure. ..