J A James

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Lupus and Epstein-Barr
    Judith A James
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Curr Opin Rheumatol 24:383-8. 2012
  2. ncbi request reprint A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in mice
    J A James
    College of Medicine, University of Oklahoma Health Sciences Center and U S Department of Veteran s Affairs Medical Center, Oklahoma City 73104, USA
    J Immunol 160:502-8. 1998
  3. ncbi request reprint Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus
    J A James
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Lupus 16:401-9. 2007
  4. ncbi request reprint Epstein-Barr virus and systemic lupus erythematosus
    Judith A James
    Arthritis and Immunology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Curr Opin Rheumatol 18:462-7. 2006
  5. ncbi request reprint Role of viruses in systemic lupus erythematosus and Sjögren syndrome
    J A James
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Curr Opin Rheumatol 13:370-6. 2001
  6. ncbi request reprint Immunization with peptides from 60 kDa Ro in diverse mouse strains
    R H Scofield
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center and the Department of Veterans Affairs Medical Center, Oklahoma City, OK 73105, USA
    Scand J Immunol 56:477-83. 2002
  7. ncbi request reprint Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE
    M T McClain
    Oklahoma Research Foundation, Oklahoma City, OK 73114, USA
    Scand J Immunol 56:399-407. 2002
  8. doi request reprint Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans
    J A Kelly
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 9:187-94. 2008
  9. pmc Evaluation of C1q genomic region in minority racial groups of lupus
    B Namjou
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 10:517-24. 2009
  10. pmc A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus
    S Wang
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Genes Immun 13:380-7. 2012

Detail Information

Publications72

  1. pmc Lupus and Epstein-Barr
    Judith A James
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Curr Opin Rheumatol 24:383-8. 2012
    ....
  2. ncbi request reprint A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in mice
    J A James
    College of Medicine, University of Oklahoma Health Sciences Center and U S Department of Veteran s Affairs Medical Center, Oklahoma City 73104, USA
    J Immunol 160:502-8. 1998
    ..These results present a new murine model of B cell epitope spreading and lupus autoimmunity induced by peptide immunization that is strain specific and not apparently dependent upon the loci at H-2...
  3. ncbi request reprint Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus
    J A James
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Lupus 16:401-9. 2007
    ..A prospective, blinded trial testing the capacity of hydroxychloroquine to delay or prevent SLE in high risk populations is warranted...
  4. ncbi request reprint Epstein-Barr virus and systemic lupus erythematosus
    Judith A James
    Arthritis and Immunology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Curr Opin Rheumatol 18:462-7. 2006
    ..Although many genetic and environmental factors are associated, this review will focus on the evolving evidence for key Epstein-Barr virus specific roles...
  5. ncbi request reprint Role of viruses in systemic lupus erythematosus and Sjögren syndrome
    J A James
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Curr Opin Rheumatol 13:370-6. 2001
    ..Although the understanding of this field is still incomplete, significant advances are being made...
  6. ncbi request reprint Immunization with peptides from 60 kDa Ro in diverse mouse strains
    R H Scofield
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center and the Department of Veterans Affairs Medical Center, Oklahoma City, OK 73105, USA
    Scand J Immunol 56:477-83. 2002
    ..Furthermore, these data suggest that genetic variation is important with regard to responding towards short peptide immunization by epitope spreading...
  7. ncbi request reprint Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE
    M T McClain
    Oklahoma Research Foundation, Oklahoma City, OK 73114, USA
    Scand J Immunol 56:399-407. 2002
    ..These results demonstrate that loss of tolerance to select single, small antigenic structures can begin a cascade which virtually recreates, at the epitope level, the humoral autoimmune specificity seen in human SLE...
  8. doi request reprint Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans
    J A Kelly
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 9:187-94. 2008
    ..We conclude that genetic variants of IRF5 associate with SLE in multiple populations, providing evidence that IRF5 is likely to be a crucial component in SLE pathogenesis among multiple ethnic groups...
  9. pmc Evaluation of C1q genomic region in minority racial groups of lupus
    B Namjou
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 10:517-24. 2009
    ..Further studies with higher SNP densities in this region and other complement components are necessary to elucidate the complex genetics and phenotypic interactions between complement components and SLE...
  10. pmc A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus
    S Wang
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Genes Immun 13:380-7. 2012
    ..0004) and UBCH7 protein expression (P=0.0068). The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression...
  11. ncbi request reprint The curiously suspicious: a role for Epstein-Barr virus in lupus
    J B Harley
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Lupus 15:768-77. 2006
    ....
  12. pmc Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
    C P Lin
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 13:232-8. 2012
    ..This study provides the first investigation of MYH9 in LN in non-Africans and of APOL1 in LN in any population, and presents novel insight into the potential role of MYH9 in LN in EAs...
  13. doi request reprint Patients with familial and sporadic onset SLE have similar clinical profiles but vary profoundly by race
    A L Sestak
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Lupus 17:1004-9. 2008
    ..4x10(-13)), proteinuria (P = 4 x 10(-12)) and anti-Sm (P = 1.7 x 10(-12)) than AA or HI. We, therefore, conclude that familial and sporadic onset patients may be treated similarly with respect to clinical and genetic studies...
  14. ncbi request reprint Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'
    K M Kaufman
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Biochem Biophys Res Commun 285:1206-12. 2001
    ..These results are consistent with the possibility that generation of anti-Sm autoantibodies in a subset of lupus patients is due to abnormal processing and expression of an aORF SmB/B' message, by an as yet unidentified mechanism...
  15. pmc Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments
    Brian D Poole
    Arthritis and Immunology Program, Lou Kerr Chair in Biomedical Research, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Autoimmun 31:362-71. 2008
    ..This similarity, as well as the prevalence of autoimmunity after immunization with these peptides, identifies PPPGRRP as a strong candidate for molecular mimicry in SLE etiology...
  16. ncbi request reprint Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus
    M R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Scand J Immunol 54:211-9. 2001
    ..In addition, the data are consistent with increases in anti-dsDNA levels contributing to the onset of clinical illness in some patients with SLE...
  17. ncbi request reprint Rapid clinical progression to diagnosis among African-American men with systemic lupus erythematosus
    M R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Lupus 12:99-106. 2003
    ..African-American men progress from initial clinical manifestations to SLE diagnosis more rapidly than other ethnic or gender groups...
  18. pmc Genetic associations of LYN with systemic lupus erythematosus
    R Lu
    Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Genes Immun 10:397-403. 2009
    ..These results support an association of LYN with European-derived individuals with SLE, especially within autoantibody or clinical subsets...
  19. pmc Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population
    L Guo
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 10:531-8. 2009
    ..Our results suggest that BANK1 polymorphisms alter immune system development and function to increase the risk for developing lupus...
  20. pmc Epitope specificity of myeloperoxidase antibodies: identification of candidate human immunodominant epitopes
    B F Bruner
    Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Clin Exp Immunol 164:330-6. 2011
    ..These results provide major common human anti-MPO immunodominant antigenic targets which can be used to examine further the potential pathogenic mechanisms for these autoantibodies...
  21. ncbi request reprint Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
    Micah T McClain
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Med 11:85-9. 2005
    ....
  22. pmc Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus
    Ryan Webb
    Oklahoma Medical Research Foundation, and University of Oklahoma Health Sciences Center, Oklahoma City, USA
    Arthritis Rheum 60:1076-84. 2009
    ....
  23. doi request reprint A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
    Swapan K Nath
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:152-4. 2008
    ..0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development...
  24. pmc Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees
    K L Moser
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 95:14869-74. 1998
    ..0). Our results are consistent with the presumed complexity of genetic susceptibility to SLE and illustrate racial origin is likely to influence the specific nature of these genetic effects...
  25. ncbi request reprint The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3)
    A I Quintero-Del-Rio
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 3:S57-62. 2002
    ..Of the significant genetic linkages with SLE described herein, those at 10q22.3 in the EA pedigrees (SLEN1) and at 2q34-35 in the AA pedigrees (SLEN2) have not been previously described...
  26. ncbi request reprint The role of Epstein-Barr virus in systemic lupus erythematosus
    M T McClain
    Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Front Biosci 6:E137-47. 2001
    ..This work reviews these historical papers in the context of new results and presents a hypothetical role for this virus as an etiological environmental trigger for SLE...
  27. ncbi request reprint Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus
    Kenneth M Kaufman
    Oklahoma Medical Research Foundation, and Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma 73104, USA
    Arthritis Rheum 54:2533-40. 2006
    ..The aim of this study was to evaluate this polymorphism in patients with familial SLE and in those with sporadic SLE...
  28. ncbi request reprint Peptide mimics of a major lupus epitope of SmB/B'
    Kenneth M Kaufman
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Ann N Y Acad Sci 987:215-29. 2003
    ..Interestingly, one of the peptide motifs that mimicked the SmB' epitope is identical to a peptide sequence found in the Epstein-Barr virus major DNA binding protein...
  29. pmc Early targets of nuclear RNP humoral autoimmunity in human systemic lupus erythematosus
    Brian D Poole
    Oklahoma Medical Research Foundation, and University of Oklahoma Health Sciences Center, Oklahoma City, and Brigham Young University, Provo, Utah, USA
    Arthritis Rheum 60:848-59. 2009
    ....
  30. ncbi request reprint Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    Melissa R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    N Engl J Med 349:1526-33. 2003
    ..We investigated the onset and progression of autoantibody development before the clinical diagnosis...
  31. pmc Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations
    J S Bates
    Oklahoma Medical Research Foundation, Arthritis and Immunology Research Program, Oklahoma City, OK 73104, USA
    Genes Immun 10:470-7. 2009
    ....
  32. ncbi request reprint Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse
    R H Scofield
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Department of Veterans Affairs Medical Center, and WK Warren Medical Research Institute, Oklahoma City 73104, USA
    Arthritis Rheum 42:1017-24. 1999
    ..The purpose of this study was to determine the ability of several different peptides from 60-kd Ro to induce expansion of the immune response to the Ro/La RNP particle...
  33. ncbi request reprint Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure
    J A James
    University of Oklahoma Health Sciences Center, Oklahoma City, USA
    Arthritis Rheum 44:1122-6. 2001
    ..CONCLUSION: These new data from adults, along with the many suggestive features of EBV infection, are consistent with the contribution of this infection to the etiology of SLE...
  34. ncbi request reprint Epstein-Barr virus infection induces lupus autoimmunity
    John B Harley
    Departments of Medicineand Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Bull NYU Hosp Jt Dis 64:45-50. 2006
    ..In aggregate, these results are consistent with an immune response against Epstein-Barr virus being important in at least some patients for the initiation of lupus autoimmunity...
  35. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  36. pmc Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response
    Micah T McClain
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, and Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 101:3551-6. 2004
    ....
  37. ncbi request reprint Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
    A H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA
    Ann Rheum Dis 67:458-61. 2008
    ..The reported effect of IL-21 on B-cell differentiation into plasma cells and its effect on dendritic cell maturation and T-cell responses make IL-21 an attractive candidate gene for SLE...
  38. ncbi request reprint Genome scan stratified by the presence of anti-double-stranded DNA (dsDNA) autoantibody in pedigrees multiplex for systemic lupus erythematosus (SLE) establishes linkages at 19p13.2 (SLED1) and 18q21.1 (SLED2)
    B Namjou
    Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, OK 73104, USA
    Genes Immun 3:S35-41. 2002
    ..These findings show SLE to be a richly complicated disease phenotype that is now ripe for important new discovery through a genetic approach...
  39. pmc Common variants within MECP2 confer risk of systemic lupus erythematosus
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    PLoS ONE 3:e1727. 2008
    ..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE...
  40. pmc Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)
    Shizhong Han
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Hum Mol Genet 18:1171-80. 2009
    ..Taken together along with our earlier findings, these results demonstrate that the coding variant, rs1143679, best explains the ITGAM-SLE association, especially in European- and African-derived populations, but not in Asian populations...
  41. pmc Antibody quantity versus quality after influenza vaccination
    Jingqi Feng
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126 0901, USA
    Vaccine 27:6358-62. 2009
    ..We propose an index consisting of rank order of antibody level plus antibody avidity, both measured against native virus, plus hemagglutination-inhibition antibody titer, as a useful measure of immunity against influenza...
  42. pmc ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry
    Xana Kim-Howard
    Genetic Epidemiology Unit, Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Ann Rheum Dis 69:1329-32. 2010
    ..It was hypothesised that the coding variant (R77H), rs1143679, within ITGAM could predict specific clinical manifestations associated with systemic lupus erythematosus (SLE)...
  43. pmc Male-only systemic lupus
    Rachna Aggarwal
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Rheumatol 37:1480-7. 2010
    ..Systemic lupus erythematosus (SLE) is more common among women than men, a ratio of about 10 to 1. We undertook this study to describe familial male SLE within a large familial SLE cohort...
  44. pmc High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups
    Bahram Namjou
    Oklahoma Medical Research Foundation, Oklahoma City, USA
    Arthritis Rheum 60:1085-95. 2009
    ..STAT-1 and STAT-4 are transcription factors that play key roles in the interferon and Th1 signaling pathways, making them attractive candidates for involvement in SLE susceptibility...
  45. ncbi request reprint Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1
    Micah T McClain
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Med Virol 70:253-7. 2003
    ..Patients with recent clinical infectious mononucleosis temporarily recognize a unique cross-reactive epitope of EBNA-1 not bound by antibodies from non-infectious mononucleosis EBV-positive sera or those with a distant history of IM...
  46. ncbi request reprint Overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus
    James N George
    Hematology Oncology Section, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    South Med J 100:512-4. 2007
  47. ncbi request reprint Systemic lupus erythematosus (SLE) and chromosome 16: confirmation of linkage to 16q12-13 and evidence for genetic heterogeneity
    Swapan K Nath
    Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Eur J Hum Genet 12:668-72. 2004
    ..Therefore, independent published reports, together with our initial linkage with Hispanics and followed by significant evidence from group-2, provide a strong and confirmed evidence for an SLE susceptibility locus at 16q12-13...
  48. ncbi request reprint Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading
    R Hal Scofield
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 38:719-28. 2005
    ..These data may suggest a hitherto unappreciated mechanism by which oxidative stress facilitates epitope spreading in SLE...
  49. ncbi request reprint Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens
    Micah T McClain
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 168:2054-62. 2002
    ....
  50. pmc Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides
    Latisha D Heinlen
    Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    J Mol Med (Berl) 88:719-27. 2010
    ..Our findings provide evidence that antibodies against ribosomal P frequently develop before clinical SLE diagnosis and are more broadly reactive than previously thought by targeting regions outside of the C terminus...
  51. pmc Fine specificity mapping of autoantigens targeted by anti-centromere autoantibodies
    Yasmin Akbarali
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    J Autoimmun 27:272-80. 2006
    ..This epitope mapping study identifies key antigenic targets of the anti-centromere response and establishes that the majority of the responses depend on key amino-terminal residues...
  52. pmc Influenza vaccination can induce new-onset anticardiolipins but not β2-glycoprotein-I antibodies among patients with systemic lupus erythematosus
    E S Vista
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Lupus 21:168-74. 2012
    ..Controversy exists as to whether vaccination triggers the development of antiphospholipid antibodies (aPL) in patients with systemic lupus erythematosus (SLE)...
  53. pmc Anti-neutrophil cytoplasmic antibodies target sequential functional proteinase 3 epitopes in the sera of patients with Wegener’s granulomatosis
    B F Bruner
    Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
    Clin Exp Immunol 162:262-70. 2010
    ..c-ANCA targets both unique and previously known sequential PR3 peptides. This information may prove useful in understanding anti-PR3-mediated disease pathogenesis in systemic vasculitides...
  54. pmc Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort
    B Namjou
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 12:270-9. 2011
    ..99E-13, OR=5.2, 95% CI=3.18-8.56). Our data confirm and expand previous reports and provide additional support for the involvement of TREX1 in lupus pathogenesis...
  55. pmc A polymorphism within IL21R confers risk for systemic lupus erythematosus
    Ryan Webb
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Arthritis Rheum 60:2402-7. 2009
    ..The aim of this study was to examine the genetic association between single-nucleotide polymorphisms (SNPs) within IL21R and SLE...
  56. ncbi request reprint Humoral antigenic targets of the ribosomal P0 lupus autoantigen are not limited to the carboxyl region
    Benjamin F Bruner
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Ann N Y Acad Sci 1051:390-403. 2005
    ..This study confirms that the P22 ribosomal peptide is commonly targeted in SLE and accounts for a variable percentage of the anti-ribosomal P response. Additional anti-ribosomal P humoral epitopes are described...
  57. pmc Select human anthrax protective antigen epitope-specific antibodies provide protection from lethal toxin challenge
    Sherry R Crowe
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Infect Dis 202:251-60. 2010
    ..Identification of these antigenic regions has important implications for vaccine design and the development of directed immunotherapeutics...
  58. ncbi request reprint Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms
    Latisha D Heinlen
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Arthritis Rheum 56:2344-51. 2007
    ..The aim of this study was to identify patterns that distinguish early clinical events in SLE and to assess whether the presence of associated autoantibodies precedes the fulfillment of clinical criteria...
  59. ncbi request reprint The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus
    Micah T McClain
    Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Arthritis Rheum 50:1226-32. 2004
    ..To determine whether antiphospholipid antibodies (aPL) occur before the diagnosis of systemic lupus erythematosus (SLE) and before initial clotting events, and whether their presence early in the disease course influences clinical outcome...
  60. ncbi request reprint An altered immune response to Epstein-Barr nuclear antigen 1 in pediatric systemic lupus erythematosus
    Micah T McClain
    Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Arthritis Rheum 54:360-8. 2006
    ..We undertook this study to further test whether the humoral immune response to EBNA-1 is a risk factor for pediatric SLE...
  61. ncbi request reprint Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus
    Brian D Poole
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma, OK 73104, USA
    Autoimmunity 39:63-70. 2006
    ..This paper reviews some of the current literature supporting roles for EBV exposure and epitope spreading in SLE...
  62. pmc Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction
    Shizhong Han
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 3:e0001757. 2008
    ..Our data suggest SPP1 is associated with SLE, and this association is especially stronger in males. To our knowledge, this report serves as the first association of a specific autosomal gene with human male lupus...
  63. ncbi request reprint Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3
    Bahram Namjou
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Arthritis Rheum 46:2937-45. 2002
    ..If this proved to be true, we would then use the increased genetic homogeneity to more easily reveal genetic linkage...
  64. pmc The major neutralizing antibody responses to recombinant anthrax lethal and edema factors are directed to non-cross-reactive epitopes
    Melissa L Nguyen
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Infect Immun 77:4714-23. 2009
    ..This work increases understanding of the immunogenicity of EF and LF and offers perspective for the development of new strategies for vaccination against anthrax...
  65. ncbi request reprint Primary Sjogren's syndrome: current and prospective therapies
    Aikaterini Thanou-Stavraki
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Semin Arthritis Rheum 37:273-92. 2008
    ..To summarize data on existing and experimental therapies for primary Sjogren's syndrome (pSS), referring both to sicca syndrome and to other systemic disease manifestations...
  66. pmc Sequential B-cell epitopes of Bacillus anthracis lethal factor bind lethal toxin-neutralizing antibodies
    Melissa L Nguyen
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Infect Immun 77:162-9. 2009
    ..This study paves the way for a more effective anthrax vaccine by identifying discontinuous peptide epitopes of LF...
  67. pmc Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expression
    Stephen M Jackson
    Molecular Immunogenetics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 113:3999-4007. 2009
    ..Application of this RB:RO system should advance our understanding of normal B-cell development and facilitate the isolation of more discrete B-cell populations with potentially different propensities in disease pathogenesis...
  68. ncbi request reprint Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Mol Recognit 15:163-70. 2002
    ..These findings suggest that the structure of the U1A protein may be different when not part of the U1snRNP...
  69. pmc Autoimmunity as a result of escape from RNA surveillance
    Michael P Bachmann
    Institute of Immunology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    J Immunol 177:1698-707. 2006
    ..Consequently, escape of mutant La mRNA from RNA control can have two effects: it 1) results in the expression of an immunogenic (neo)epitope, and 2) predisposes to autoimmunity...
  70. doi request reprint Autoantibody prevalence and lupus characteristics in a unique African American population
    Diane L Kamen
    Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Arthritis Rheum 58:1237-47. 2008
    ..Because of the unique homogeneous nature of the Gullah, we sought to define the genetic and environmental factors contributing to systemic lupus erythematosus (SLE) in this population...
  71. ncbi request reprint Update in rheumatoid arthritis therapy
    Xana R Kim-Howard
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Okla City, OK 73104, USA
    J Okla State Med Assoc 98:53-62. 2005
    ..Developing therapeutics will be briefly discussed...
  72. ncbi request reprint Anti-Ro and anti-nRNP response in unaffected family members of SLE patients
    Latisha D Heinlen
    Lupus 12:335-7. 2003