Amy J Jak

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Crosswords to computers: a critical review of popular approaches to cognitive enhancement
    Amy J Jak
    VA San Diego Healthcare System, Psychology Service and Center of Excellence for Stress and Mental Health CESAMH, 3350 La Jolla Village Dr 151B, San Diego, CA 92161, USA
    Neuropsychol Rev 23:13-26. 2013
  2. doi request reprint The impact of physical and mental activity on cognitive aging
    Amy J Jak
    Department of Psychology Service, Veteran s Affairs San Diego Healthcare System, San Diego, CA, USA
    Curr Top Behav Neurosci 10:273-91. 2012
  3. pmc Quantification of five neuropsychological approaches to defining mild cognitive impairment
    Amy J Jak
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 17:368-75. 2009
  4. pmc Assessment of Alzheimer's disease risk with functional magnetic resonance imaging: an arterial spin labeling study
    Katherine J Bangen
    Department of Psychiatry, University of California, San Diego, School of Medicine, San Diego, CA, USA
    J Alzheimers Dis 31:S59-74. 2012
  5. pmc Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment
    Lisa Delano-Wood
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Alzheimers Dis 29:589-603. 2012
  6. pmc Altered brain response for semantic knowledge in Alzheimer's disease
    Christina E Wierenga
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Neuropsychologia 49:392-404. 2011
  7. pmc Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's disease
    Daniel A Nation
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    J Alzheimers Dis 36:689-98. 2013
  8. pmc Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age
    Eero Vuoksimaa
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychologia 51:1124-31. 2013
  9. pmc Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition
    Christina E Wierenga
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, California, USA
    J Cereb Blood Flow Metab 32:1589-99. 2012
  10. pmc Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes?
    Lindsay R Clark
    San Diego State University University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Int Neuropsychol Soc 19:635-45. 2013

Detail Information

Publications30

  1. doi request reprint Crosswords to computers: a critical review of popular approaches to cognitive enhancement
    Amy J Jak
    VA San Diego Healthcare System, Psychology Service and Center of Excellence for Stress and Mental Health CESAMH, 3350 La Jolla Village Dr 151B, San Diego, CA 92161, USA
    Neuropsychol Rev 23:13-26. 2013
    ..Despite these limitations, evidence suggests that computerized cognitive training has the potential to positively impact one's sense of social connectivity and self-efficacy...
  2. doi request reprint The impact of physical and mental activity on cognitive aging
    Amy J Jak
    Department of Psychology Service, Veteran s Affairs San Diego Healthcare System, San Diego, CA, USA
    Curr Top Behav Neurosci 10:273-91. 2012
    ..Finally, we comment on the limitations of the extant literature and directions for future research, in particular the need for prospective trials of activity interventions in older adults...
  3. pmc Quantification of five neuropsychological approaches to defining mild cognitive impairment
    Amy J Jak
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 17:368-75. 2009
    ....
  4. pmc Assessment of Alzheimer's disease risk with functional magnetic resonance imaging: an arterial spin labeling study
    Katherine J Bangen
    Department of Psychiatry, University of California, San Diego, School of Medicine, San Diego, CA, USA
    J Alzheimers Dis 31:S59-74. 2012
    ..No group differences were found for BOLD response. Findings suggest that abnormal resting state CBF and CBF response to memory encoding may be early indicators of brain dysfunction in individuals at risk for developing AD...
  5. pmc Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment
    Lisa Delano-Wood
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Alzheimers Dis 29:589-603. 2012
    ..Findings implicate involvement of posterior microstructural white matter degeneration in the development of MCI-related cognitive changes and suggest that reduced FA of the PC may be a candidate neuroimaging marker of AD risk...
  6. pmc Altered brain response for semantic knowledge in Alzheimer's disease
    Christina E Wierenga
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Neuropsychologia 49:392-404. 2011
    ....
  7. pmc Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's disease
    Daniel A Nation
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    J Alzheimers Dis 36:689-98. 2013
    ..OBJECTIVe: To compare probable AD patients to mild cognitive impairment (MCI) and normal control (NC) participants on CVRi, the ratio of mean arterial pressure to rCBF...
  8. pmc Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age
    Eero Vuoksimaa
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychologia 51:1124-31. 2013
    ..e., lower levels of cognitive reserve. Our results provide support for the hypothesis that cognitive reserve moderates the relationship between brain structure and cognition in middle age, well before the onset of dementia...
  9. pmc Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition
    Christina E Wierenga
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, California, USA
    J Cereb Blood Flow Metab 32:1589-99. 2012
    ..Correlations between CBF and verbal memory suggest a differential neurovascular compensatory response in posterior and anterior cortices with cognitive decline in ɛ4 adults...
  10. pmc Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes?
    Lindsay R Clark
    San Diego State University University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Int Neuropsychol Soc 19:635-45. 2013
    ..Whether these empirically-derived MCI subtypes correspond to dissociable neuropathologic substrates and represent reliable prodromes of dementia will require additional follow-up...
  11. pmc Complex activities of daily living vary by mild cognitive impairment subtype
    Katherine J Bangen
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California San Diego, San Diego, California, USA
    J Int Neuropsychol Soc 16:630-9. 2010
    ..Results further suggest performance-based IADL assessment may have utility in distinguishing MCI subtypes...
  12. pmc Profile of hippocampal volumes and stroke risk varies by neuropsychological definition of mild cognitive impairment
    Amy J Jak
    Research Service, VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Int Neuropsychol Soc 15:890-7. 2009
    ....
  13. pmc Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normal-functioning elderly individuals: a longitudinal study
    Eric M Fine
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 16:366-74. 2008
    ....
  14. pmc Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury?
    Dawn M Schiehser
    Psychology and Research Services, VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Clin Exp Neuropsychol 33:704-14. 2011
    ....
  15. pmc Increased functional brain response during word retrieval in cognitively intact older adults at genetic risk for Alzheimer's disease
    Christina E Wierenga
    Department of Psychiatry, Veterans Affairs San Diego Healthcare System, School of Medicine, University of California, San Diego, CA 92161, USA
    Neuroimage 51:1222-33. 2010
    ..Findings are discussed in the context of possible compensatory mechanisms invoked to maintain performance in those at genetic risk for AD...
  16. pmc Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer's disease
    Daniel A Nation
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    J Alzheimers Dis 30:595-603. 2012
    ..These findings may have treatment implications since some antihypertensive medications specifically address the pulsatile component of blood pressure (e.g., renin-angiotensin system inhibitors, calcium channel blockers)...
  17. pmc Stroke risk modifies regional white matter differences in mild cognitive impairment
    Lisa Delano-Wood
    Department of Psychiatry, University of California, San Diego School of Medicine, CA, USA
    Neurobiol Aging 31:1721-31. 2010
    ..Findings demonstrate a relationship between increased vascular burden and white matter changes, and they support the possibility that posterior white matter pathology may contribute to the development of MCI-related cognitive changes...
  18. pmc Hierarchical genetic organization of human cortical surface area
    Chi Hua Chen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Science 335:1634-6. 2012
    ..We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns...
  19. pmc Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 59:1123-31. 2012
    ..To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor...
  20. pmc Heterogeneity in mild cognitive impairment: differences in neuropsychological profile and associated white matter lesion pathology
    Lisa Delano-Wood
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92161, USA
    J Int Neuropsychol Soc 15:906-14. 2009
    ..Overall, findings suggest different underlying pathologies within MCI and contribute to our understanding of MCI subtypes...
  21. pmc Neuropsychological contributions to the early identification of Alzheimer's disease
    Mark W Bondi
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychol Rev 18:73-90. 2008
    ..Finally, we provide a critical examination of the clinical concept of Mild Cognitive Impairment and offer suggestions for an increased focus on the impact of cerebrovascular disease (CVD) and CVD risk during the prodromal period of AD...
  22. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
    ..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging...
  23. pmc Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults
    Amy J Jak
    Veteran s Medical Research Foundation, San Diego, CA 92161, USA
    Dement Geriatr Cogn Disord 23:382-9. 2007
    ..Because of conflicting findings across studies, we sought to better determine the relationship between apolipoprotein E (APOE) genotype, hippocampal volume, and cognitive performance in nondemented older adults...
  24. pmc Early identification and heritability of mild cognitive impairment
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA, Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA, Psychology Service, VA San Diego Healthcare System, La Jolla, CA, USA, Computational Science Research Center, San Diego State University Claremont Graduate University, San Diego, CA, USA, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA, Department of Public Health, University of Helsinki, Helsinki, Finland, Department of Statistics, St Louis University, St Louis, MO, USA, Research Service, VA St Louis Healthcare System, St Louis, MO, USA and Department of Psychology, Boston University, Boston, MA, USA
    Int J Epidemiol 43:600-10. 2014
    ..We estimated prevalence rates, association with premorbid general cognitive ability (GCA) and heritability for different definitions of neuropsychologically defined MCI in adults in their 50s...
  25. pmc Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
    J Alzheimers Dis 26:49-60. 2011
    ..Ongoing follow-up of the VETSA sample may shed light on the potential for age- and disease-related mediation of the influence of ApoE allele status...
  26. pmc Differential age effects on cerebral blood flow and BOLD response to encoding: associations with cognition and stroke risk
    Katherine J Bangen
    San Diego State University University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120 4913, USA
    Neurobiol Aging 30:1276-87. 2009
    ..Stroke risk was associated with both CBF and BOLD response. Results suggest that aging effects on CBF and BOLD responses to encoding are dissociable and that cerebrovascular alterations contribute to findings of age-related differences...
  27. pmc Stress, exercise, and Alzheimer's disease: a neurovascular pathway
    Daniel A Nation
    University of California San Diego, School of Medicine, Department of Psychiatry, San Diego, CA, USA
    Med Hypotheses 76:847-54. 2011
    ..Greater knowledge of the molecular mechanisms behind these behavioral effects would further our understanding of the disease and lead to innovative treatment and preventive approaches...
  28. pmc Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response
    S Duke Han
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92093 0603, United States
    Neurobiol Aging 28:238-47. 2007
    ....
  29. pmc Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 53:1093-102. 2010
    ..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology...
  30. ncbi request reprint Cognitive Symptom Management and Rehabilitation Therapy (CogSMART) for veterans with traumatic brain injury: pilot randomized controlled trial
    Elizabeth W Twamley
    Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, 3350 La Jolla Village Dr 116A, San Diego, CA 92161
    J Rehabil Res Dev 51:59-70. 2014
    ..These effects, as well as smaller effects on psychiatric symptoms and ability to return to work, warrant replication in a larger trial. ..