Mamta K Jain
Affiliation: University of Texas Southwestern Medical Center
- Pegylated interferon fractal pharmacokinetics: individualized dosing for hepatitis C virus infectionMamta K Jain
UT Southwestern Medical Center, Department of Internal Medicine, Dallas, TX, USA
Antimicrob Agents Chemother 57:1115-20. 2013..Optimizing dose to patient weight and PEGIFN AUC in the first week offers a solution to improve SVR and to potentially shorten duration of therapy...
- Change in fibrosis score as a predictor of mortality among HIV-infected patients with viral hepatitisMamta K Jain
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9113, USA
AIDS Patient Care STDS 26:73-80. 2012..Further studies are needed in a prospective cohort to evaluate the predictive value of monitoring changes in fibrosis scores over time to predict mortality in patients with viral hepatitis...
- Changes in mortality related to human immunodeficiency virus infection: comparative analysis of inpatient deaths in 1995 and in 1999-2000Mamta K Jain
Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
Clin Infect Dis 36:1030-8. 2003..AIDS-defining illnesses continue to be a major cause of mortality in the HAART era in populations where access to care and adherence to HAART is limited...
- Role of ribavirin in HCV treatment response: now and in the futureMamta K Jain
UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9113, USA
Expert Opin Pharmacother 11:673-83. 2010..Higher serum concentrations of ribavirin are associated with higher response rates but also higher rates of hemolytic anemia which is a dose limiting side effect. Alternatives to current therapy are under clinical evaluation...
- Pegylated interferon and ribavirin promote early evolution of nonstructural 5A protein in individuals with hepatitis C who demonstrate a response to treatmentMamta K Jain
Department of Internal Medicine, University of Texas Southwestern Medical Center, 4323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Infect Dis 200:866-76. 2009..We evaluated the influence of HCV therapy on changes in the nonstructural 5A (NS5A) protein...
- Biliary parasites: diagnostic and therapeutic strategiesNiraj Khandelwal
Mamta K Jain, MD, MPH Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9113, USA
Curr Treat Options Gastroenterol 11:85-95. 2008..However, oral treatment is inexpensive and effective for most of these parasites and can prevent untoward consequences. Primary and alternative treatments are available and are reviewed in this article...
- Hepatitis C is associated with type 2 diabetes mellitus in HIV-infected persons without traditional risk factorsM K Jain
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
HIV Med 8:491-7. 2007..We evaluated the effect of HCV on risk of DM in relation to traditional risk factors such as age, body mass index (BMI) and family history of DM in an HIV-infected population...
- Drug-induced liver injury associated with HIV medicationsMamta K Jain
University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9113, USA
Clin Liver Dis 11:615-39, vii-viii. 2007..This article reviews the different HIV drug classes, incidence of elevated liver enzyme values by class and by individual drug, risk factors, specific toxicities, and possible mechanisms of injury...
- Aminotransferase elevation in HIV/hepatitis B virus co-infected patients treated with two active hepatitis B virus drugsMamta K Jain
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
AIDS Patient Care STDS 20:817-22. 2006..Distinguishing clearly between drug-related hepatotoxicity and hepatitis reactivation may be difficult but is important as their clinical management differs...
- Treatment of hepatitis B with lamivudine and tenofovir in HIV/HBV-coinfected patients: factors associated with responseM K Jain
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
J Viral Hepat 14:176-82. 2007..More patients infected with HBV genotype A responded than the non-A patients, regardless of therapeutic regimen, compliance or prior HIV therapy...
- Do HIV care providers appropriately manage hepatitis B in coinfected patients treated with antiretroviral therapy?Mamta K Jain
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
Clin Infect Dis 44:996-1000. 2007..The common occurrence of hepatitis B virus (HBV) infection in patients who carry the human immunodeficiency virus (HIV) demands that both viruses be recognized, evaluated, and treated when appropriate...
- A single nucleotide polymorphism in IL28B affects viral evolution of hepatitis C quasispecies after pegylated interferon and ribavirin therapyHeJun Yuan
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390 9113, USA
J Med Virol 84:1913-9. 2012....
- Hepatitis B virus genotype G: prevalence and impact in patients co-infected with human immunodeficiency virusDoan Y Dao
Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
J Med Virol 83:1551-8. 2011..Further studies are needed to understand why this genotype occurs more frequently and what impact it has on liver disease progression in patients with HBV/HIV...
- Patient perspectives on hepatitis C and its treatmentCarol S North
aThe VA North Texas Health Care System Departments of bPsychiatry cSurgery, Division of Emergency Medicine dDepartment of Internal Medicine, Division of Infectious Diseases, The University of Texas Southwestern Medical Center eThe University of Texas Southwestern Medical Center, Graduate School of Biomedical Sciences, Dallas, Texas fThe University of Alabama School of Social Work, Tuscaloosa, Alabama gDepartment of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Eur J Gastroenterol Hepatol 26:74-81. 2014..Much of the research to date on barriers to treatment for patients with hepatitis C has approached the problem from either the perspective of the medical provider or the healthcare system...
- An empirical study of alcohol consumption by patients considering HCV treatmentCarol S North
VA North Texas Health Care System and the University of Texas Southwestern Medical Center, Departments of Psychiatry and Surgery Division of Emergency Medicine, Dallas, TX, USA
Am J Drug Alcohol Abuse 40:484-9. 2014..Alcohol accelerates the course of hepatitis C (HCV) infection and liver damage. Little is known about recency of alcohol use among patients with HCV...
- Evaluation and treatment of the patient coinfected with hepatitis B and HIVEllen Kitchell
Department of Internal Medicine, Division of Infectious Diseases, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Curr HIV/AIDS Rep 5:103-11. 2008..Improved ability to obtain long-term HBV DNA suppression and avoid resistance will translate into improved survival in this population...
- Hepatitis C treatment and SVR: the gap between clinical trials and real-world treatment aspirationsCarol S North
the VA North Texas Health Care System, Dallas, TX, USA
Gen Hosp Psychiatry 35:122-8. 2013..This review was undertaken to summarize recent experience in the treatment of HCV in clinical settings, examining the course of patients through the stages of treatment and barriers to treatment encountered...
- Presentation, treatment, and clinical outcomes of patients with hepatocellular carcinoma, with and without human immunodeficiency virus infectionAdam C Yopp
Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Clin Gastroenterol Hepatol 10:1284-90. 2012..We compared the clinical presentation, treatment, and survival of patients with HCC, with and without HIV infection...
- Host-based ribavirin resistance influences hepatitis C virus replication and treatment responseKristie D Ibarra
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9048, USA
J Virol 85:7273-83. 2011..Our results uncovered a novel form of antiviral drug resistance and suggest that host-based RBV resistance develops in HCV patients undergoing therapy and that maintenance of RBV uptake may contribute to rapid viral clearance...
- Micro-RNA-122 levels in acute liver failure and chronic hepatitis CPerry H Dubin
Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas Doris Duke Foundation, New York, New York
J Med Virol 86:1507-14. 2014..Eradication of HCV was associated with decreased miR-122 but not hgDNA. An additional mechanism besides hepatic injury may be active in chronic-HCV to explain the exaggerated circulating levels of miR-122 observed...
- Entecavir can select for M184V of HIV-1: a case of an HIV/hepatitis B (HBV) naïve patient treated for chronic HBVMamta K Jain
AIDS 21:2365-6. 2007
- A randomized study of antiviral medication switch at lower- versus higher-switch thresholds: AIDS Clinical Trials Group Study A5115Sharon A Riddler
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Antivir Ther 12:531-41. 2007..Clinical stability has been observed with continued antiretroviral therapy (ART) in the setting of partial virological suppression. The optimal time to switch treatment in patients with low but detectable HIV-1 RNA is not known...
- Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infectionsDavid A Kosub
Seattle Biomedical Research Institute, 307 Westlake Ave N, Seattle, WA 98109, USA
J Virol 82:1155-65. 2008..The SIV(+) sooty mangabey natural hosts, which do not proceed to clinical AIDS, provide evidence that gammadelta T-cell dysfunction occurs in HIV(+) patients and may contribute to HIV disease progression...
- Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: a U.S.-Canadian multicenter studyNorbert Brau
Bronx Veterans Affairs VA Medical Center, Infectious Disease Section 111F, 130 West Kingsbridge Road, Bronx, NY 10468, USA
J Hepatol 47:527-37. 2007..HIV-infected patients now live longer and often have complications of liver disease, especially with hepatitis B or C virus coinfection. Limited data are available on those with hepatocellular carcinoma (HCC)...
- U.T. SOUTHWESTERN ADULT AIDS CLINICAL TRIALS UNITMamta Jain; Fiscal Year: 2008..abstract_text> ..