Anil K Jain

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. ncbi request reprint Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries
    Anil K Jain
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA Electronic address
    Toxicology 320:25-33. 2014
  2. pmc 2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin
    Anil K Jain
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, 12700 East 19th Avenue, Box C238 P 15 Research 2, Aurora, CO 80045, USA
    Toxicology 282:129-38. 2011
  3. pmc Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin
    Anil K Jain
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, Aurora, CO 80045, USA
    Toxicol Lett 205:293-301. 2011
  4. pmc Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 7:e46149. 2012
  5. doi request reprint Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-κB, and AP-1 activation in RAW264.7 cells
    Chandagirikoppal V Kavitha
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado
    Mol Carcinog 53:169-80. 2014
  6. pmc Clinically-relevant cutaneous lesions by nitrogen mustard: useful biomarkers of vesicants skin injury in SKH-1 hairless and C57BL/6 mice
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 8:e67557. 2013
  7. pmc Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin
    Swetha Inturi
    Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, 12850 E Montview Blvd, Aurora, CO 80045, USA
    Toxicology 311:184-90. 2013
  8. ncbi request reprint Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045, USA
    Toxicol Appl Pharmacol 264:23-31. 2012
  9. pmc Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation
    Molly M Derry
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Cancer Prev Res (Phila) 6:625-33. 2013
  10. ncbi request reprint Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, University of Colorado at Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 72:285-95. 2014

Collaborators

  • Rajesh Agarwal
  • Chapla Agarwal
  • Uday B Kompella
  • Natalie J Serkova
  • Michael F Wempe
  • Daniel Chan
  • Neera Tewari-Singh
  • Swetha Inturi
  • Gagan Deep
  • Carl W White
  • Komal Raina
  • Manjinder Kaur
  • Sangeeta Shrotriya
  • Chandagirikoppal V Kavitha
  • David J Orlicky
  • Subhash C Gangar
  • Molly M Derry
  • Samiha Mateen
  • Kavitha C Vijendra
  • Anand Ramteke
  • Brian J Day
  • Harold Ting
  • Srirupa Roy
  • Kendra M Huber
  • Velmurugan Balaiya
  • Mallikarjuna Gu
  • Puneet Tyagi
  • David A Ammar
  • J Mark Petrash
  • Robert W Enzenauer

Detail Information

Publications17

  1. ncbi request reprint Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries
    Anil K Jain
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA Electronic address
    Toxicology 320:25-33. 2014
    ..This suggests the development of mechanism-based treatments against NM- and SM-induced skin injuries that inhibit MPO activity and attenuate MPO-derived oxidants. ..
  2. pmc 2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin
    Anil K Jain
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, 12700 East 19th Avenue, Box C238 P 15 Research 2, Aurora, CO 80045, USA
    Toxicology 282:129-38. 2011
    ....
  3. pmc Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin
    Anil K Jain
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, Aurora, CO 80045, USA
    Toxicol Lett 205:293-301. 2011
    ..This study could help in identifying countermeasures that alone or in combination, can target the unveiled pathways for reducing skin injury in humans by SM...
  4. pmc Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 7:e46149. 2012
    ..Together, these findings support further optimization of silibinin in HD skin toxicity model to develop a novel effective therapy for skin injuries by vesicants...
  5. doi request reprint Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-κB, and AP-1 activation in RAW264.7 cells
    Chandagirikoppal V Kavitha
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado
    Mol Carcinog 53:169-80. 2014
    ..Together, our findings showing that silibinin inhibits PCA cells-induced osteoclastogenesis, suggest that silibinin could be useful clinically against bone metastatic PCA...
  6. pmc Clinically-relevant cutaneous lesions by nitrogen mustard: useful biomarkers of vesicants skin injury in SKH-1 hairless and C57BL/6 mice
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 8:e67557. 2013
    ....
  7. pmc Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin
    Swetha Inturi
    Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, 12850 E Montview Blvd, Aurora, CO 80045, USA
    Toxicology 311:184-90. 2013
    ..Thus, targeting this pathway could be a novel strategy for developing countermeasures against vesicants-induced skin injury. ..
  8. ncbi request reprint Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045, USA
    Toxicol Appl Pharmacol 264:23-31. 2012
    ....
  9. pmc Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation
    Molly M Derry
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Cancer Prev Res (Phila) 6:625-33. 2013
    ....
  10. ncbi request reprint Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, University of Colorado at Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 72:285-95. 2014
    ..Results from this study demonstrate the potential therapeutic efficacy of AEOL 10150 against CEES-mediated cutaneous lesions, supporting AEOL 10150 as a medical countermeasure against SM-induced skin injuries. ..
  11. pmc Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells
    Manjinder Kaur
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Cancer Center, University of Colorado, Aurora, CO 80045, USA
    Carcinogenesis 34:1585-92. 2013
    ..Overall, BMJ exerts strong anticancer efficacy against human pancreatic carcinoma cells, both in vitro and in vivo, suggesting its clinical usefulness. ..
  12. ncbi request reprint Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice
    Anil K Jain
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Denver, Aurora, CO 80045, USA
    Exp Toxicol Pathol 66:129-38. 2014
    ....
  13. doi request reprint Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice
    Neera Tewari-Singh
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 9:e85402. 2014
    ..This study advocates the usefulness of these histopathological parameters observed due to NM exposure in screening and optimization of rescue therapies against NM and SM skin injuries. ..
  14. pmc Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells
    Samiha Mateen
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA
    Epigenetics 7:1161-72. 2012
    ..These findings are both novel and highly significant in establishing that HDACi with silibinin would be safe and effective to suppress NSCLC growth...
  15. doi request reprint SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin
    Gagan Deep
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA
    Mol Cancer 13:37. 2014
    ..Here, we examined the role of two epithelial-to-mesenchymal transition (EMT) regulators, the adherens junction protein E-cadherin and its transcriptional repressor SNAI1, in regulating the aggressiveness of PCA cells...
  16. pmc Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells
    Sangeeta Shrotriya
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA
    Carcinogenesis 33:848-58. 2012
    ....
  17. pmc Deletion of p21/Cdkn1a confers protective effect against prostate tumorigenesis in transgenic adenocarcinoma of the mouse prostate model
    Anil K Jain
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
    Cell Cycle 12:1598-604. 2013
    ....