Jonathon S Jahr

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC)
    Jonathan S Jahr
    Department of Anesthesiology, University of California Los Angeles, School of Medicine, USA
    Can J Anaesth 49:243-8. 2002
  2. ncbi request reprint Lactate measurement interference by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure, and Hemolink)
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, PO Box 951778, Los Angeles, CA 90095 1778, USA
    Anesth Analg 100:431-6. 2005
  3. ncbi request reprint Blood substitutes as pharmacotherapies in clinical practice
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Opin Anaesthesiol 20:325-30. 2007
  4. doi request reprint Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Am J Ther 15:98-101. 2008
  5. doi request reprint Intravenous acetaminophen: a review of pharmacoeconomic science for perioperative use
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095, USA
    Am J Ther 20:189-99. 2013
  6. ncbi request reprint Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products
    Jonathan S Jahr
    David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Los Angeles, CA 90095, USA
    Curr Drug Discov Technol 9:158-65. 2012
  7. doi request reprint Safety and efficacy of intravenous acetaminophen in the elderly after major orthopedic surgery: subset data analysis from 3, randomized, placebo-controlled trials
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Ther 19:66-75. 2012
  8. doi request reprint Does OxyVita, a new-generation hemoglobin-based oxygen carrier, or oxyglobin acutely interfere with coagulation compared with normal saline or 6% hetastarch? An ex vivo thromboelastography study
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Cardiothorac Vasc Anesth 22:34-9. 2008
  9. ncbi request reprint HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation)
    Jonathan S Jahr
    David Geffen School of Medicine at UCLA, UCLA Department of Anesthesiology, CHS 56 122, Box 951778, Los Angeles, CA 90095 1778, USA
    Expert Opin Biol Ther 8:1425-33. 2008
  10. doi request reprint Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study
    Jonathan S Jahr
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7403, USA
    Am J Ther 17:140-7. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC)
    Jonathan S Jahr
    Department of Anesthesiology, University of California Los Angeles, School of Medicine, USA
    Can J Anaesth 49:243-8. 2002
    ..Cambridge, MA, USA); hemoglobin glutamer-250 (bovine; Hemopure, Biopure Corp, Cambridge, MA, USA), and hemoglobin-raffimer, (human; Hemolink, Hemosol, Inc., Toronto, Ontario, Canada)...
  2. ncbi request reprint Lactate measurement interference by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure, and Hemolink)
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, PO Box 951778, Los Angeles, CA 90095 1778, USA
    Anesth Analg 100:431-6. 2005
    ..Therefore, caution must be exercised when interpreting lactate results when a HBOC is present in plasma...
  3. ncbi request reprint Blood substitutes as pharmacotherapies in clinical practice
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Opin Anaesthesiol 20:325-30. 2007
    ..Research in this field offers an important view into the future of transfusion medicine in the operating room, as well as in trauma and combat arenas...
  4. doi request reprint Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Am J Ther 15:98-101. 2008
    ..This study aimed to verify the technique in a canine hypovolemia model with varying concentrations of infused HBOC...
  5. doi request reprint Intravenous acetaminophen: a review of pharmacoeconomic science for perioperative use
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095, USA
    Am J Ther 20:189-99. 2013
    ..While IV acetaminophen adds to drug costs, the body of evidence indicates this drug has the potential to improve outcomes and hospital efficiency...
  6. ncbi request reprint Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products
    Jonathan S Jahr
    David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Los Angeles, CA 90095, USA
    Curr Drug Discov Technol 9:158-65. 2012
    ..As a new generation HBOC, zero-linked hemoglobin polymer may begin to address the issues presented by the first two generations of HBOCs, and may hold promise as a universally applicable HBOC...
  7. doi request reprint Safety and efficacy of intravenous acetaminophen in the elderly after major orthopedic surgery: subset data analysis from 3, randomized, placebo-controlled trials
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Ther 19:66-75. 2012
    ..A review of the literature similarly demonstrates the efficacy and safety of IV acetaminophen used for postoperative analgesia after joint replacement...
  8. doi request reprint Does OxyVita, a new-generation hemoglobin-based oxygen carrier, or oxyglobin acutely interfere with coagulation compared with normal saline or 6% hetastarch? An ex vivo thromboelastography study
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Cardiothorac Vasc Anesth 22:34-9. 2008
    ..Because hetastarches have deleterious effects on coagulation that increase with molecular weight (MWt), risk of coagulopathy associated with a high MWt hemoglobin-based oxygen carrier (HBOC) was studied...
  9. ncbi request reprint HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation)
    Jonathan S Jahr
    David Geffen School of Medicine at UCLA, UCLA Department of Anesthesiology, CHS 56 122, Box 951778, Los Angeles, CA 90095 1778, USA
    Expert Opin Biol Ther 8:1425-33. 2008
    ....
  10. doi request reprint Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study
    Jonathan S Jahr
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7403, USA
    Am J Ther 17:140-7. 2010
    ..Further controlled studies are needed to establish definitively the effects that HBOC-201 has on platelet function in patients...
  11. doi request reprint Intravenous acetaminophen
    Jonathan S Jahr
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 3304, Los Angeles, CA 90095 7403, USA
    Anesthesiol Clin 28:619-45. 2010
    ..This review summarizes recent clinical trial experiences with intravenous acetaminophen for the treatment of postoperative pain and fever in adult and pediatric subjects...
  12. ncbi request reprint PolyHeme. Northfield Laboratories
    Jonathon S Jahr
    David Geffen School of Medicine at UCLA, Department of Anesthesiology, Box 951778, Los Angeles, CA 90095, USA
    IDrugs 7:478-82. 2004
    ..Northfield is developing PolyHeme, a solution of polymerized hemoglobin, as a potential blood substitute for use following surgery and trauma...
  13. ncbi request reprint Blood substitutes and oxygen therapeutics: an overview and current status
    Jonathan S Jahr
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, CA 90095 1778, USA
    Am J Ther 9:437-43. 2002
    ....
  14. ncbi request reprint Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing
    Jonathan S Jahr
    Department of Anesthesiology, University of California Los Angeles, Los Angeles, California 90095 1770, USA
    Am J Ther 9:431-6. 2002
    ..Mechanical detection methods (fibrometer, STA, CS-190) and the MDA-180 method were less affected by increasing levels of HBOC-201 than optical detection devices for all test parameters...
  15. doi request reprint HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery
    Jonathan S Jahr
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Trauma 64:1484-97. 2008
    ..The ability of hemoglobin based oxygen carrier-201 (HBOC-201) to safely reduce and/or eliminate perioperative transfusion was studied in orthopedic surgery patients...
  16. doi request reprint Reversal of neuromuscular block with a selective relaxant-binding agent: sugammadex
    Wendy H P Ren
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095, USA
    Am J Ther 16:295-9. 2009
    ..Sugammadex may be considered the ideal reversal agent and the first drug in its class, which will likely change the practice of anesthesia and clinical neuromuscular pharmacology...
  17. ncbi request reprint Does methemoglobin from oxidized hemoglobin-based oxygen carrier (hemoglobin Glutamer-200) interfere with lactate measurement (YSI 2700 SELECT Biochemistry Analyzer)?
    Stephen L Osgood
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, PO Box 951778, Los Angeles, CA 90095 1778, USA
    Anesth Analg 100:437-9. 2005
    ..When interpreting lactate concentrations from a patient with a HBOC present in plasma, underestimation of true lactate levels may occur unrelated to methemoglobin concentrations...
  18. ncbi request reprint Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusion
    Jonathan S Jahr
    Department of Anesthesiology, University of California Los Angeles, 90095, USA
    Am J Ther 10:21-8. 2003
    ..79 for i-STAT system). Systemic oxygen uptake values based on CO-Oximeter and Corning 170 blood gas analyzer data showed 75% accuracy; i-STAT system accuracy was 63% for control samples and 50% for samples after HBOC infusion...
  19. doi request reprint Does Hextend impair coagulation compared to 6% hetastarch? An ex vivo thromboelastography study
    David L Weeks
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Ther 15:225-30. 2008
    ..Substitution of lactated Ringer's for NS in 6% hetastarch appears to offer no advantage in avoiding hemostatic compromise in an in vitro model...
  20. ncbi request reprint Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrations
    Ahsanul K Khan
    Department of Anesthesiology, Charles R Drew University of Medicine and Science, King Drew Medical Center, Los Angeles, California, USA
    Anesth Analg 96:1813-20, table of contents. 2003
    ..HBOCs may be useful in patients with gunshot wounds...
  21. doi request reprint Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine
    Chingmuh Lee
    Department of Anesthesiology, David Geffen School of Medicine at University of California Los Angeles, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Anesthesiology 110:1020-5. 2009
    ..This study compared time to sugammadex reversal of profound rocuronium-induced neuromuscular block with time to spontaneous recovery from succinylcholine...
  22. doi request reprint Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model
    Mojgan Moallempour
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Cardiothorac Vasc Anesth 23:41-7. 2009
    ..The risk of coagulopathy after different dilutions of HBOC-200 with low and high methemoglobin concentrations was studied...
  23. ncbi request reprint Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery
    Raymond S Sinatra
    Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Anesthesiology 102:822-31. 2005
    ..Propacetamol has been available in many European countries for more than 20 yr...
  24. ncbi request reprint Changes in circulating blood and plasma volume after hemoglobin-based oxygen carrier infusion and additional infusion of colloid solutions
    Fedor Lurie
    Department of Surgery, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Am J Ther 9:425-30. 2002
    ..The magnitude of this difference was lower than expected based on in vitro colloid osmotic pressure measurements...
  25. ncbi request reprint Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial
    Jerrold H Levy
    Emory University Hospital, Atlanta, GA, USA
    J Thorac Cardiovasc Surg 124:35-42. 2002
    ..This study examined the hypothesis that a hemoglobin-based oxygen-carrying solution can serve as an initial alternative to red blood cell transfusion...
  26. ncbi request reprint Blood substitute resuscitation as a treatment modality for moderate hypovolemia
    Anthony T W Cheung
    Department of Medical Pathology, University of California, Davis School of Medicine, Sacramento, California 95817, USA
    Artif Cells Blood Substit Immobil Biotechnol 32:189-207. 2004
    ....
  27. ncbi request reprint The novel HemoCu plasma/low hemoglobin system accurately measures small concentrations of three different hemoglobin-based oxygen carriers in plasma: hemoglobin glutamer-200 (bovine) (Oxyglobin), hemoglobin glutamer-250 (bovine) (Hemopure), and hemoglobin
    Fedor Lurie
    Department of Surgery, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Anesth Analg 95:870-3, table of contents. 2002
    ..The HemoCue Plasma/Low Hemoglobin System is a reliable instrument for detecting and measuring small concentrations of three different HBOCs in plasma...
  28. ncbi request reprint Validity of arterial and mixed venous oxygen saturation measurements in a canine hemorrhage model after resuscitation with varying concentrations of hemoglobin-based oxygen carrier
    Fedor Lurie
    John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
    Anesth Analg 96:46-50, table of contents. 2003
    ..We conclude that the administration of this oxygen therapeutic may interfere with the values of some monitors...
  29. ncbi request reprint Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model
    Bernd Driessen
    University of Pennsylvania, School of Veterinary Medicine, Department of Clinical Studies, Section of Critical Care, New Bolton Center, Kennett Square, PA, USA
    Crit Care Med 35:2101-9. 2007
    ....
  30. ncbi request reprint Comparison of treatment modalities for hemorrhagic shock
    Anthony T W Cheung
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
    Artif Cells Blood Substit Immobil Biotechnol 35:173-90. 2007
    ..Vasopressin treatment resulted in inadvertent detrimental outcome without the intended benefit...
  31. ncbi request reprint Arterial oxygenation and oxygen delivery after hemoglobin-based oxygen carrier infusion in canine hypovolemic shock: a dose-response study
    Bernd Driessen
    School of Veterinary Medicine, Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA, USA
    Crit Care Med 31:1771-9. 2003
    ....
  32. ncbi request reprint Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes
    Anthony T Cheung
    Department of Pathology and Laboratory Medicine, UCD Medical Center, Sacramento, CA 95817, USA
    Clin Hemorheol Microcirc 34:325-34. 2006
    ..However, only shed blood resuscitation restored oxygenation level close to pre-hemorrhagic values. All 12 dogs survived resuscitation treatments despite differences in oxygen-carrying capability between groups...
  33. ncbi request reprint A revolution in transfusion medication in the last decade
    Edward T Crosby
    Am J Ther 9:370. 2002
  34. ncbi request reprint Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry
    Fuyu Guan
    School of Veterinary Medicine, Department of Clinical Studies, University of Pennsylvania, New Bolton Center Campus, Kennett Square, Pennsylvania 19348, USA
    Anal Chem 76:5127-35. 2004
    ..OXY was detected and quantified in equine plasma up to 24 h following administration of a very low dose of OXY (32.5 g in 2 x 125 mL per horse), and its presence in equine plasma was confirmed up to 12 h postadministration...