Research Topics
| Jonathon S JahrSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC)Jonathan S Jahr
Department of Anesthesiology, University of California Los Angeles, School of Medicine, USA
Can J Anaesth 49:243-8. 2002..Cambridge, MA, USA); hemoglobin glutamer-250 (bovine; Hemopure, Biopure Corp, Cambridge, MA, USA), and hemoglobin-raffimer, (human; Hemolink, Hemosol, Inc., Toronto, Ontario, Canada)...- Lactate measurement interference by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure, and Hemolink)Jonathan S Jahr
Department of Anesthesiology, David Geffen School of Medicine at UCLA, PO Box 951778, Los Angeles, CA 90095 1778, USA
Anesth Analg 100:431-6. 2005..Therefore, caution must be exercised when interpreting lactate results when a HBOC is present in plasma... - Blood substitutes as pharmacotherapies in clinical practiceJonathan S Jahr
Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Curr Opin Anaesthesiol 20:325-30. 2007..Research in this field offers an important view into the future of transfusion medicine in the operating room, as well as in trauma and combat arenas... 
Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia modelJonathan S Jahr
Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Am J Ther 15:98-101. 2008..This study aimed to verify the technique in a canine hypovolemia model with varying concentrations of infused HBOC...- Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current productsJonathan S Jahr
David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Los Angeles, CA 90095, USA
Curr Drug Discov Technol 9:158-65. 2012..As a new generation HBOC, zero-linked hemoglobin polymer may begin to address the issues presented by the first two generations of HBOCs, and may hold promise as a universally applicable HBOC... - Safety and efficacy of intravenous acetaminophen in the elderly after major orthopedic surgery: subset data analysis from 3, randomized, placebo-controlled trialsJonathan S Jahr
Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Am J Ther 19:66-75. 2012..A review of the literature similarly demonstrates the efficacy and safety of IV acetaminophen used for postoperative analgesia after joint replacement... - Does OxyVita, a new-generation hemoglobin-based oxygen carrier, or oxyglobin acutely interfere with coagulation compared with normal saline or 6% hetastarch? An ex vivo thromboelastography studyJonathan S Jahr
Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Cardiothorac Vasc Anesth 22:34-9. 2008..Because hetastarches have deleterious effects on coagulation that increase with molecular weight (MWt), risk of coagulopathy associated with a high MWt hemoglobin-based oxygen carrier (HBOC) was studied... - HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation)Jonathan S Jahr
David Geffen School of Medicine at UCLA, UCLA Department of Anesthesiology, CHS 56 122, Box 951778, Los Angeles, CA 90095 1778, USA
Expert Opin Biol Ther 8:1425-33. 2008.... - Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter studyJonathan S Jahr
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7403, USA
Am J Ther 17:140-7. 2010..Further controlled studies are needed to establish definitively the effects that HBOC-201 has on platelet function in patients... - Intravenous acetaminophenJonathan S Jahr
Department of Anesthesiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 3304, Los Angeles, CA 90095 7403, USA
Anesthesiol Clin 28:619-45. 2010..This review summarizes recent clinical trial experiences with intravenous acetaminophen for the treatment of postoperative pain and fever in adult and pediatric subjects... - PolyHeme. Northfield LaboratoriesJonathon S Jahr
David Geffen School of Medicine at UCLA, Department of Anesthesiology, Box 951778, Los Angeles, CA 90095, USA
IDrugs 7:478-82. 2004..Northfield is developing PolyHeme, a solution of polymerized hemoglobin, as a potential blood substitute for use following surgery and trauma... - Blood substitutes and oxygen therapeutics: an overview and current statusJonathan S Jahr
Department of Anesthesiology, University of California at Los Angeles, Los Angeles, CA 90095 1778, USA
Am J Ther 9:437-43. 2002.... - Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testingJonathan S Jahr
Department of Anesthesiology, University of California Los Angeles, Los Angeles, California 90095 1770, USA
Am J Ther 9:431-6. 2002..Mechanical detection methods (fibrometer, STA, CS-190) and the MDA-180 method were less affected by increasing levels of HBOC-201 than optical detection devices for all test parameters... - Reversal of neuromuscular block with a selective relaxant-binding agent: sugammadexWendy H P Ren
Department of Anesthesiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095, USA
Am J Ther 16:295-9. 2009..Sugammadex may be considered the ideal reversal agent and the first drug in its class, which will likely change the practice of anesthesia and clinical neuromuscular pharmacology... - HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgeryJonathan S Jahr
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Trauma 64:1484-97. 2008..The ability of hemoglobin based oxygen carrier-201 (HBOC-201) to safely reduce and/or eliminate perioperative transfusion was studied in orthopedic surgery patients... - Does methemoglobin from oxidized hemoglobin-based oxygen carrier (hemoglobin Glutamer-200) interfere with lactate measurement (YSI 2700 SELECT Biochemistry Analyzer)?Stephen L Osgood
Department of Anesthesiology, David Geffen School of Medicine at UCLA, PO Box 951778, Los Angeles, CA 90095 1778, USA
Anesth Analg 100:437-9. 2005..When interpreting lactate concentrations from a patient with a HBOC present in plasma, underestimation of true lactate levels may occur unrelated to methemoglobin concentrations... - Does Hextend impair coagulation compared to 6% hetastarch? An ex vivo thromboelastography studyDavid L Weeks
Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Am J Ther 15:225-30. 2008..Substitution of lactated Ringer's for NS in 6% hetastarch appears to offer no advantage in avoiding hemostatic compromise in an in vitro model... - Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusionJonathan S Jahr
Department of Anesthesiology, University of California Los Angeles, 90095, USA
Am J Ther 10:21-8. 2003..79 for i-STAT system). Systemic oxygen uptake values based on CO-Oximeter and Corning 170 blood gas analyzer data showed 75% accuracy; i-STAT system accuracy was 63% for control samples and 50% for samples after HBOC infusion... - Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram modelMojgan Moallempour
Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Cardiothorac Vasc Anesth 23:41-7. 2009..The risk of coagulopathy after different dilutions of HBOC-200 with low and high methemoglobin concentrations was studied... - Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrationsAhsanul K Khan
Department of Anesthesiology, Charles R Drew University of Medicine and Science, King Drew Medical Center, Los Angeles, California, USA
Anesth Analg 96:1813-20, table of contents. 2003..HBOCs may be useful in patients with gunshot wounds... - Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholineChingmuh Lee
Department of Anesthesiology, David Geffen School of Medicine at University of California Los Angeles, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Anesthesiology 110:1020-5. 2009..This study compared time to sugammadex reversal of profound rocuronium-induced neuromuscular block with time to spontaneous recovery from succinylcholine... - Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgeryRaymond S Sinatra
Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Anesthesiology 102:822-31. 2005..Propacetamol has been available in many European countries for more than 20 yr... - The novel HemoCu plasma/low hemoglobin system accurately measures small concentrations of three different hemoglobin-based oxygen carriers in plasma: hemoglobin glutamer-200 (bovine) (Oxyglobin), hemoglobin glutamer-250 (bovine) (Hemopure), and hemoglobinFedor Lurie
Department of Surgery, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
Anesth Analg 95:870-3, table of contents. 2002..IMPLICATIONS: This study evaluated a new bedside blood-measuring device for low levels and found that it rapidly measured low levels accurately for three blood substitutes... - Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trialJerrold H Levy
Emory University Hospital, Atlanta, GA, USA
J Thorac Cardiovasc Surg 124:35-42. 2002..In a third of cases, HBOC-201 eliminated the need for red blood cell transfusion, although substantial doses were needed to produce this modest degree of blood conservation... - Blood substitute resuscitation as a treatment modality for moderate hypovolemiaAnthony T W Cheung
Department of Medical Pathology, University of California, Davis School of Medicine, Sacramento, California 95817, USA
Artif Cells Blood Substit Immobil Biotechnol 32:189-207. 2004.... - Changes in circulating blood and plasma volume after hemoglobin-based oxygen carrier infusion and additional infusion of colloid solutionsFedor Lurie
Department of Surgery, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
Am J Ther 9:425-30. 2002..The magnitude of this difference was lower than expected based on in vitro colloid osmotic pressure measurements... - Arterial oxygenation and oxygen delivery after hemoglobin-based oxygen carrier infusion in canine hypovolemic shock: a dose-response studyBernd Driessen
School of Veterinary Medicine, Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA, USA
Crit Care Med 31:1771-9. 2003..CONCLUSIONS: In hemorrhagic shock, Hb-200 infusion may not improve oxygen delivery more than hetastarch, likely due to hemodilution caused by its high colloid oncotic pressure, but may facilitate diffusive oxygen transport to tissues... - Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutesAnthony T Cheung
Department of Pathology and Laboratory Medicine, UCD Medical Center, Sacramento, CA 95817, USA
Clin Hemorheol Microcirc 34:325-34. 2006..However, only shed blood resuscitation restored oxygenation level close to pre-hemorrhagic values. All 12 dogs survived resuscitation treatments despite differences in oxygen-carrying capability between groups... - Comparison of treatment modalities for hemorrhagic shockAnthony T W Cheung
Department of Medical Pathology and Laboratory Medicine, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
Artif Cells Blood Substit Immobil Biotechnol 35:173-90. 2007..Vasopressin treatment resulted in inadvertent detrimental outcome without the intended benefit... - Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock modelBernd Driessen
University of Pennsylvania, School of Veterinary Medicine, Department of Clinical Studies, Section of Critical Care, New Bolton Center, Kennett Square, PA, USA
Crit Care Med 35:2101-9. 2007.... - Validity of arterial and mixed venous oxygen saturation measurements in a canine hemorrhage model after resuscitation with varying concentrations of hemoglobin-based oxygen carrierFedor Lurie
John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
Anesth Analg 96:46-50, table of contents. 2003..IMPLICATIONS: This study evaluated oxygen saturation monitors in a canine model of acute blood loss and resuscitation with a blood substitute and found that these may interfere with the monitors' results in a dose-dependent way... - A revolution in transfusion medication in the last decadeEdward T Crosby
Am J Ther 9:370. 2002 - Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometryFuyu Guan
School of Veterinary Medicine, Department of Clinical Studies, University of Pennsylvania, New Bolton Center Campus, Kennett Square, Pennsylvania 19348, USA
Anal Chem 76:5127-35. 2004..OXY was detected and quantified in equine plasma up to 24 h following administration of a very low dose of OXY (32.5 g in 2 x 125 mL per horse), and its presence in equine plasma was confirmed up to 12 h postadministration...