Research Topics
Species | W JagustSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Age effects on atrophy rates of entorhinal cortex and hippocampusAn-Tao Du
Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurobiol Aging 27:733-40. 2006..In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials...
Central obesity and the aging brainWilliam Jagust
School of Public Health and Helen Wills Neuroscience Institute, University of California at Berkeley, 94720, USA
Arch Neurol 62:1545-8. 2005..Central adiposity as an indicator of visceral fat is linked to vascular and metabolic factors that in turn are related to cognitive decline and dementia...- Neuropathological basis of magnetic resonance images in aging and dementiaWilliam J Jagust
School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
Ann Neurol 63:72-80. 2008..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present... - Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal agingWilliam J Jagust
Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California 94720 3190, USA
J Neurosci 32:18227-33. 2012..These results show that ApoE genotype, and not aggregated fibrillar forms of Aβ, contributes to reduced glucose metabolism in aging and adds to a growing list of neural consequences of ApoE that do not appear to be related to Aβ... - Vulnerable neural systems and the borderland of brain aging and neurodegenerationWilliam Jagust
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720 3190, USA
Neuron 77:219-34. 2013..By focusing on the fundamental causes of neural system vulnerability, the prevention or treatment of a wide range of late-life neural dysfunction might be possible... - What can imaging reveal about obesity and the brain?William Jagust
School of Public Health, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
Curr Alzheimer Res 4:135-9. 2007..Application of additional imaging methods could help to establish the pathway through which obesity produces cognitive decline and dementia... - What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?W Jagust
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
Neurology 69:871-7. 2007..Few studies have compared the accuracy of [(18)F]fluorodeoxyglucose (FDG) PET to the accuracy of clinical and pathologic diagnosis in dementia patients... - Lifespan brain activity, β-amyloid, and Alzheimer's diseaseWilliam J Jagust
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA
Trends Cogn Sci 15:520-6. 2011..The aggregated findings unify observations from cellular and molecular studies with human cognitive neuroscience to reveal potential mechanisms of AD development... - Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsE C Mormino
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Brain 132:1310-23. 2009..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy... - Mapping brain beta-amyloidWilliam Jagust
School of Public Health, University of California, Berkeley, CA 94720 3190, USA
Curr Opin Neurol 22:356-61. 2009.... 
Amyloid + activation = Alzheimer's?William Jagust
Helen Wills Neuroscience Institute, University of California, Berkeley, 132 Barker Hall, Berkeley, CA 94720 3190, USA
Neuron 63:141-3. 2009....- Relationships between biomarkers in aging and dementiaW J Jagust
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94620, USA
Neurology 73:1193-9. 2009..Relationships between biomarkers and with disease severity are incompletely understood... - Dementia: finding the signals in the noiseWilliam Jagust
School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, University of California, Berkeley, CA 94720-3190, USA
Lancet Neurol 4:10-1. 2005 - The Alzheimer's Disease Neuroimaging Initiative positron emission tomography coreWilliam J Jagust
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
Alzheimers Dement 6:221-9. 2010..This is a progress report of the Alzheimer's Disease Neuroimaging Initiative (ADNI) positron emission tomography (PET) Core... - Molecular neuroimaging in Alzheimer's diseaseWilliam Jagust
School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
NeuroRx 1:206-12. 2004..Despite these unanswered questions, PET and SPECT may have application as biomarkers for AD in a number of clinical and research settings, especially in academic centers, where most of the existing studies have been done... - Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular diseaseBeth Kuczynski
Helen Wills Neuroscience Institute and the Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
Arch Neurol 65:650-5. 2008..Understanding how each disease contributes to dementia is essential from both a pathophysiologic and diagnostic perspective... - Amyloid imaging in distinguishing atypical prion disease from Alzheimer diseaseA L Boxer
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Neurology 69:283-90. 2007..To compare the in vivo uptake of two amyloid-binding PET agents, PIB and FDDNP, in human subjects with a prion protein (PrP) gene (PRNP) mutation that produces a clinical syndrome similar to Alzheimer disease (AD)... - Brain imaging evidence of preclinical Alzheimer's disease in normal agingWilliam Jagust
School of Public Health, University of California, Berkeley, USA
Ann Neurol 59:673-81. 2006..The anatomical location of these findings suggests detection of preclinical Alzheimer's disease pathology... - White matter integrity and cortical metabolic associations in aging and dementiaBeth Kuczynski
Helen Wills Neuroscience Institute, University of California at Berkeley, USA
Alzheimers Dement 6:54-62. 2010..This report investigated how regional white matter integrity (measured as fractional anisotropy [FA]) relates to brain metabolism, to unravel the complex relationship between white matter changes and brain metabolism... - Degree of discrepancy between self and other-reported everyday functioning by cognitive status: dementia, mild cognitive impairment, and healthy eldersSarah Tomaszewski Farias
Department of Neurology, School of Public Health, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
Int J Geriatr Psychiatry 20:827-34. 2005..In this study we examined whether degree of discrepancy between patient and informant-reported everyday functioning was associated with cognitive status... - Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiativeOwen Carmichael
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Arch Neurol 67:1370-8. 2010.... - The measurement of everyday cognition (ECog): scale development and psychometric propertiesSarah Tomaszewski Farias
Department of Neurology, University of California, CA 95817, USA
Neuropsychology 22:531-44. 2008..Different subtypes of MCI also showed different patterns. Results suggest the ECog shows promise as a useful tool for the measurement of general and domain-specific everyday functions in the elderly... - Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plansPaul S Aisen
Department of Neurosciences, University of California San Diego, CA, USA
Alzheimers Dement 6:239-46. 2010..The resulting data would provide valuable data on the earliest stages of AD, and support the development of interventions in these critically important populations... - Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic studyHelen Lavretsky
Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Am J Psychiatry 167:589-97. 2010.... - Requiring an amyloid-beta1-42 biomarker for prodromal Alzheimer's disease or mild cognitive impairment does not lead to more efficient clinical trialsLon S Schneider
Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Alzheimers Dement 6:367-77. 2010.... - The Alzheimer's disease neuroimaging initiativeSusanne G Mueller
Department of Radiology, University of California, San Francisco, CA, USA
Neuroimaging Clin N Am 15:869-77, xi-xii. 2005..The Alzheimer's Disease Neuroimaging Initiative will help identify clinical, neuroimaging, and biomarker outcome measures that provide the highest power for measurement of longitudinal changes and for prediction of transitions... - An inverse association of cardiovascular risk and frontal lobe glucose metabolismB Kuczynski
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
Neurology 72:738-43. 2009..To investigate associations between vascular risk profile and cerebral glucose metabolism... - SPECT perfusion imaging in the diagnosis of Alzheimer's disease: a clinical-pathologic studyW Jagust
Department of Neurology, University of California, Davis Medical Center, Sacramento 95817, USA
Neurology 56:950-6. 2001..CONCLUSIONS: In the evaluation of dementia, SPECT imaging can provide clinically useful information indicating the presence of AD in addition to the information that is obtained from clinical evaluation... - Working memory capacity predicts dopamine synthesis capacity in the human striatumRoshan Cools
Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3190, USA
J Neurosci 28:1208-12. 2008.... - Estrogen- and tamoxifen-associated effects on brain structure and functionJamie L Eberling
Department of Neurology and Center for Neuroscience, University of California, Davis, CA 95616, USA
Neuroimage 21:364-71. 2004..The ERT- group had hippocampal volumes that were intermediate to the other two groups. These findings provide physiological and anatomical evidence for neuroprotective effects of estrogen... - Enhanced cutaneous vascular response in AD subjects under donepezil therapyJonathan S Maltz
Department of Nuclear Medicine and Functional Imaging, Ernest O Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Neurobiol Aging 25:475-81. 2004..We sought to replicate these observations and further identify peripheral vascular components of AD pathology... - Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling Hispanic and non-Hispanic older adultsSarah Tomaszewski Farias
Department of Neurology, School of Medicine, University of California, Davis, USA
J Int Neuropsychol Soc 10:342-54. 2004..The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups... - A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imagingRoger Higdon
University of Washington, Seattle, USA
Stat Med 23:315-26. 2004..Methods using PLS appear to be more successful. Averaging or using VOI data may also be helpful... - Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2Oscar L Lopez
Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Arch Neurol 60:1394-9. 2003..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study... - Homocysteine and cognitive function in the Sacramento Area Latino Study on AgingJoshua W Miller
Department of Medical Pathology, School of Medicine, University of California, Davis, USA
Am J Clin Nutr 78:441-7. 2003.... - Prevalence of dementia in older latinos: the influence of type 2 diabetes mellitus, stroke and genetic factorsMary N Haan
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
J Am Geriatr Soc 51:169-77. 2003..To estimate dementia prevalence in older Mexican Americans, determine the distribution of dementia by etiology, and evaluate the contribution of type 2 diabetes mellitus, stroke, and apolipoprotein E (ApoE) genotype to dementia... - Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1Oscar L Lopez
Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Arch Neurol 60:1385-9. 2003..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study... - Brain function and cognition in a community sample of elderly LatinosWilliam J Jagust
Department of Neurology, University of California Davis Medical Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
Neurology 59:378-83. 2002..This study was designed to extend this finding to individuals selected from a population-based cohort of Mexican Americans with a wide spectrum of cognitive ability... - Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunesYuan-Yu Hsu
Department of Veterans Affairs Medical Center, Magnetic Resonance Unit, San Francisco, California, USA
Alzheimer Dis Assoc Disord 16:58-64. 2002..In conclusion, the presence of subcortical lacunes in those with AD is associated with more WM lesions and ventriculomegaly but not with cortical atrophy... - Correlates of memory function in community-dwelling elderly: the importance of white matter hyperintensitiesChristopher I Petkov
Center for Neuroscience, University of California at Davis, 95616, USA
J Int Neuropsychol Soc 10:371-81. 2004..We conclude that WMH are an important pathological substrate that affects certain memory functions in normal individuals and those with mild memory loss and discuss how tasks associated with WMH may rely upon frontal lobe function... - Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experienceNathan A Johnson
MR Research Unit, VA Medical Center, 4150 Clement St 114M San Francisco, CA 94107, USA
Radiology 234:851-9. 2005.... - Different mechanisms of episodic memory failure in mild cognitive impairmentChristine Wu Nordahl
Center for Neuroscience, University of California at Davis, Davis, CA, USA
Neuropsychologia 43:1688-97. 2005..Although both syndromes are associated with episodic memory deficits, CVD is additionally associated with working memory and executive control deficits... - White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophyAn-Tao Du
Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurobiol Aging 26:553-9. 2005..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy... - Clinical and neuropsychological features in autopsy-defined vascular dementiaBruce R Reed
Alzheimer s Disease Center, University of California, Davis 94553, USA
Clin Neuropsychol 18:63-74. 2004..A illustrative case example is included. We conclude that the profile of cognitive impairment in IVD is highly variable, but that in clinical settings neuropsychological readings may contribute to the differential diagnosis of dementia... - Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on AgingMarisa I Ramos
School of Medicine, Department of Medical Pathology, University of California, Davis, USA
Am J Clin Nutr 82:1346-52. 2005..CONCLUSION: RBC folate is directly associated with cognitive function scores and is inversely associated with dementia in elderly Latinos despite folic acid fortification... - Bilateral thalamic lesions affect recollection- and familiarity-based recognition memory judgmentsMark M Kishiyama
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94728 3190, USA
Cortex 41:778-88. 2005..The results are in agreement with models indicating that the anteromedial thalamus is important for both recollection- and familiarity-based recognition memory... - White matter changes compromise prefrontal cortex function in healthy elderly individualsChristine Wu Nordahl
University of California at Davis, Sacramento, CA 95817, USA
J Cogn Neurosci 18:418-29. 2006..These results suggest that disruption of white matter tracts, especially within the PFC, may be a mechanism for age-related changes in memory functioning... - Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imagingXiaoping Zhu
Department of Radiology, VA Medical Center, University of California, San Francisco, CA 94121, USA
Alzheimer Dis Assoc Disord 20:77-85. 2006..However, the NAA and mI changes are not correlated with each other, suggesting that they represent different processes that might help staging of AD... - Automated template-based PET region of interest analyses in the aging brainFelice T Sun
Helen Wills Neuroscience Institute, School of Public Health, University of California, 118 Barker Hall, Berkeley, CA 94720, USA
Neuroimage 34:608-17. 2007.... - FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's diseaseNorman L Foster
Center for Alzheimer s Care, Imaging and Research and Department of Neurology, University of Utah, USA
Brain 130:2616-35. 2007..FDG-PET adds important information that appropriately increases diagnostic confidence, even among experienced dementia specialists... - Effects of white matter lesions and lacunes on cortical functionBruce R Reed
University of California Davis Alzheimer s Disease Center, Martinez, CA 94553, USA
Arch Neurol 61:1545-50. 2004..Whether small-vessel disease in fact predominantly affects the frontal lobes is not well documented... - Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on AgingMary N Haan
Epidemiology Program, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
Am J Clin Nutr 85:511-7. 2007..High concentrations of homocysteine have been linked to a greater risk of Alzheimer disease, dementia, and cognitive decline... - Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular diseaseBruce R Reed
University of California, Davis, CA, USA
Brain 130:731-9. 2007.... - Cognitive impact of subcortical vascular and Alzheimer's disease pathologyHelena C Chui
Department of Neurology, University of Southern California, Los Angeles, USA
Ann Neurol 60:677-87. 2006..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype... - Imaging Interactions between Alzheimer's disease and cerebrovascular diseaseChristine C Wu
Department of Neurology, University of California-Davis, 4860 Y Street, Sacramento, CA 95616, USA
Ann N Y Acad Sci 977:403-10. 2002..In this article, we review two recent studies from our laboratory that use MRI and PET to begin to reveal the nature and mechanisms of the relationship between AD, CVD, and dementia... - Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burdenCharles DeCarli
Department of Neurology, University of California at Davis, Davis, Calif, USA
Stroke 36:50-5. 2005..Separate pathophysiologies and behavioral consequences are often attributed to these 2 classes of WMH. However, evidence to support these empirical distinctions has not been rigorously sought... - Effect of extrapyramidal signs and Lewy bodies on survival in patients with Alzheimer diseaseMary N Haan
Department of Epidemiology, University of Michigan, School of Public Health, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
Arch Neurol 59:588-93. 2002..Lewy bodies found at autopsy are not always correlated with EPSs during late life... - Hippocampal volume and retention in Alzheimer's diseaseJoel H Kramer
Department of Neurology, University of California at San Francisco, 94143, USA
J Int Neuropsychol Soc 10:639-43. 2004..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories...
Research Grants
- Neural and Biochemical Mechanisms of Cognitive AgingWilliam J Jagust; Fiscal Year: 2010..This is important both for understanding relationships between AD and normal aging, and for developing ways of optimizing brain function in aging. ..
- Amyloid Imaging in Frontotemporal Dementia and Alzheimer's DiseaseWilliam Jagust; Fiscal Year: 2009..PIB could become a diagnostic tool that is useful in diagnosing AD and FTLD during life. This will be especially important as new treatments for both disorders are developed. ..
- Molecular and Functional Imaging of Age Related Cognitive DeclineWilliam Jagust; Fiscal Year: 2009....
- Amyloid Imaging in Frontotemporal Dementia and Alzheimer's DiseaseWilliam Jagust; Fiscal Year: 2007..PIB could become a diagnostic tool that is useful in diagnosing AD and FTLD during life. This will be especially important as new treatments for both disorders are developed. ..
- Molecular and Functional Imaging of Age Related Cognitive DeclineWilliam Jagust; Fiscal Year: 2007....
- Effects of Chemotherapy on Brain FunctionWilliam J Jagust; Fiscal Year: 2010..They are also relevant to the overall mission of the NIH because of the negative impact that cognitive dysfunction has on quality of life. ..