HARTMUT W JAESCHKE

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Food Chem Toxicol 55:279-89. 2013
  2. doi request reprint Caveats of using acetaminophen hepatotoxicity models for natural product testing
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 6610, USA Electronic address
    Toxicol Lett 215:40-1. 2012
  3. pmc Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Transplant Rev (Orlando) 26:103-14. 2012
  4. doi request reprint Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA
    Drug Metab Rev 44:88-106. 2012
  5. pmc Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Liver Int 32:8-20. 2012
  6. pmc Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Life Sci 88:737-45. 2011
  7. doi request reprint Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA
    J Gastroenterol Hepatol 26:173-9. 2011
  8. ncbi request reprint Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, MS 1018, Kansas City, Kansas 66160, USA
    Toxicol Sci 97:1-3. 2007
  9. pmc Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, United States
    World J Gastroenterol 16:2448-50. 2010
  10. pmc c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity
    Chieko Saito
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 246:8-17. 2010

Research Grants

  1. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
  2. Mitochondrial Dysfunction and Drug Hepatotoxicity
    Hartmut Jaeschke; Fiscal Year: 2009
  3. Mechanisms of Neutrophil-induced Liver Toxicity
    Hartmut Jaeschke; Fiscal Year: 2007
  4. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2005
  5. Mitochondrial Dysfunction and Drug Hepatotoxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. pmc Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Food Chem Toxicol 55:279-89. 2013
    ..The goal is to enable researchers to select the appropriate model and experimental conditions for testing of natural products that will yield clinically relevant results and allow valid interpretations of the pharmacological mechanisms...
  2. doi request reprint Caveats of using acetaminophen hepatotoxicity models for natural product testing
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 6610, USA Electronic address
    Toxicol Lett 215:40-1. 2012
    ..Therefore, we feel it is necessary to express our concerns regarding a recent publication by Zhao et al. (2012)...
  3. pmc Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Transplant Rev (Orlando) 26:103-14. 2012
    ....
  4. doi request reprint Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA
    Drug Metab Rev 44:88-106. 2012
    ..This review addresses the formation of oxidants and the defense mechanisms available for cells and applies this knowledge to better understand mechanisms of drug hepatotoxicity, especially acetaminophen-induced liver injury...
  5. pmc Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Liver Int 32:8-20. 2012
    ....
  6. pmc Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Life Sci 88:737-45. 2011
    ..This review should assist investigators in the optimal use of this model to test the efficacy of natural compounds and obtain reliable mechanistic information...
  7. doi request reprint Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA
    J Gastroenterol Hepatol 26:173-9. 2011
    ....
  8. ncbi request reprint Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, MS 1018, Kansas City, Kansas 66160, USA
    Toxicol Sci 97:1-3. 2007
  9. pmc Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, United States
    World J Gastroenterol 16:2448-50. 2010
    ..We would like to discuss the limitations of this experimental approach and question the conclusion based on the data presented in this manuscript and the published literature...
  10. pmc c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity
    Chieko Saito
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 246:8-17. 2010
    ....
  11. pmc Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice
    James P Luyendyk
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 250:256-62. 2011
    ....
  12. doi request reprint Oxidative stress and the pathogenesis of cholestasis
    Bryan L Copple
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Semin Liver Dis 30:195-204. 2010
    ..Furthermore, inhibition of ROS during cholestasis reduces fibrosis. Collectively, these studies suggest that ROS are important for pathologic changes that occur during cholestasis...
  13. pmc Mechanism of protection by metallothionein against acetaminophen hepatotoxicity
    Chieko Saito
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 242:182-90. 2010
    ....
  14. ncbi request reprint Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity
    Mary Lynn Bajt
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 324:8-14. 2008
    ..However, the persistent oxidant stress and peroxynitrite formation in mitochondria may eventually trigger the permeability transition pore opening and release intermembrane proteins independently of Bax...
  15. pmc Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury
    C David Williams
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Appl Pharmacol 247:169-78. 2010
    ..Thus, IL-1 signaling is irrelevant for APAP hepatotoxicity. The inflammatory cascade is a less important therapeutic target than intracellular signaling pathways to attenuate APAP-induced liver injury...
  16. pmc Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine
    Chieko Saito
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 51:246-54. 2010
    ....
  17. pmc Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation
    Ji Young Hong
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 296:G572-81. 2009
    ..The data indicate that liver cell death initiated by diquat-induced superoxide formation in vivo is mediated predominantly by oncotic necrosis and is independent of JNK activation...

Research Grants15

  1. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
    ....
  2. Mitochondrial Dysfunction and Drug Hepatotoxicity
    Hartmut Jaeschke; Fiscal Year: 2009
    ..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..
  3. Mechanisms of Neutrophil-induced Liver Toxicity
    Hartmut Jaeschke; Fiscal Year: 2007
    ....
  4. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2005
    ..abstract_text> ..
  5. Mitochondrial Dysfunction and Drug Hepatotoxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
    ..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..