Mark W Jacobson
Affiliation: University of California
- Asymmetries in global-local processing ability in elderly people with the apolipoprotein e-epsilon4 alleleMark W Jacobson
Veterans Affairs San Diego Healthcare System, Research Service, and University of California, San Diego School of Medicine, Department of Psychiatry, CA 92161, USA
Neuropsychology 19:822-9. 2005..These findings build on previous studies identifying subgroups of elderly people at greater risk for AD who often demonstrate increased cognitive asymmetries relative to groups without significant risk factors...
- The emergence of cognitive discrepancies in preclinical Alzheimer's disease: a six-year case studyMark W Jacobson
Veterans Affairs San Diego Healthcare System, Department 151B, 3350 La Jolla Village Dr, San Diego, CA 92151, USA
Neurocase 15:278-93. 2009..The present case provides intriguing evidence that cognitive-discrepancy measures could improve our ability to detect subtle changes in cognition at the earliest, preclinical stages of AD...
- Do neuropsychological tests detect preclinical Alzheimer's disease: individual-test versus cognitive-discrepancy score analysesMark W Jacobson
Department of Veterans Affairs Medical Center, San Diego, California 92161, USA
Neuropsychology 16:132-9. 2002..The PCAD group also had a higher frequency of asymmetric cognitive profiles relative to a normative group...
- Cognitive phenotypes, brain morphometry and the detection of cognitive decline in preclinical ADMark W Jacobson
Veterans Affairs San Diego Healthcare System, San Diego, CA 92151, USA
Behav Neurol 21:29-37. 2009..We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia...
- Asymmetry in auditory and spatial attention span in normal elderly genetically at risk for Alzheimer's diseaseMark W Jacobson
Department of Veterans Affairs Medical Center, San Diego, CA 92161, USA
J Clin Exp Neuropsychol 27:240-53. 2005....
- Heterogeneity in verbal memory: a marker of preclinical Alzheimer's disease?Spencer R Wetter
Veterans Affairs San Diego Healthcare System, California, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:503-15. 2006..Implications of these findings for the detection of a preclinical phase of AD are discussed...
- Identifying the "source" of recognition memory deficits in patients with Huntington's disease or Alzheimer's disease: evidence from the CVLT-IIEric M Fine
Psychology Service 116B Delis Lab, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
J Clin Exp Neuropsychol 30:463-70. 2008..Implications of these findings on the differentiation of the memory disorders associated with HD and AD are discussed...
- Comparison of the traditional recall-based versus a new list-based method for computing semantic clustering on the California Verbal Learning Test: evidence from Alzheimer's diseaseDean C Delis
Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
Clin Neuropsychol 24:70-9. 2010..Logistic regression and score distribution analyses indicated that the new list-based method enhances the detection of differences in semantic-clustering ability between the groups...
- Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's diseaseYu Ling Chang
Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Drive Suite C101, La Jolla, CA 92037, USA
Neuropsychologia 48:1237-47. 2010..Overall, our results highlight the importance of including learning measures in addition to retention measures when making a diagnosis of MCI and for predicting clinical outcome...
- Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normal-functioning elderly individuals: a longitudinal studyEric M Fine
Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
Am J Geriatr Psychiatry 16:366-74. 2008....
- Level of executive function influences verbal memory in amnestic mild cognitive impairment and predicts prefrontal and posterior cingulate thicknessYu Ling Chang
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA
Cereb Cortex 20:1305-13. 2010..Overall, these results demonstrate the importance of evaluating executive function in individuals with MCI to predict involvement of brain areas beyond the mesial temporal lobe...
- Difficulty modifying a sustained motor response in prodromal Huntington's diseaseLaura Mickes
Department of Psychology, University of California, San Diego, La Jolla, CA 92093 0109, USA
J Clin Exp Neuropsychol 35:35-40. 2013..Our results show that motor slowing is evident prior to the clinical diagnosis of Huntington's disease and may reflect difficulty in modifying a sustained motor program...
- Temporal order memory deficits prior to clinical diagnosis in Huntington's diseaseEva Pirogovsky
SDSU UCSD Joint Doctoral Program in Clinical Psychology, San Diego, California 92120, USA
J Int Neuropsychol Soc 15:662-70. 2009..Therefore, temporal order memory declines with increased temporal interference in pre-HD close to estimated diagnosis of HD...
- Cognitive and functional decline in Huntington's disease: dementia criteria revisitedGuerry M Peavy
Department of Neurosciences, University of California, San Diego, California, USA
Mov Disord 25:1163-9. 2010....
- Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adultsSpencer R Wetter
Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
J Clin Exp Neuropsychol 27:943-52. 2005..The association between these subtle executive-function deficits and the overall cognitive functioning of at-risk individuals provides further evidence of their utility as a possible preclinical marker of AD...
- Recall discriminability: utility of a new CVLT-II measure in the differential diagnosis of dementiaDean C Delis
Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
J Int Neuropsychol Soc 11:708-15. 2005..Implications of these results for clinical practice and theories of memory disorder in dementia are discussed...
- Structural neuroimaging in the detection and prognosis of pre-clinical and early ADChristine Fennema-Notestine
Deptartment of Psychiatry, University of California San Diego, San Diego, CA, USA
Behav Neurol 21:3-12. 2009....
- The influence of chronic stress on dementia-related diagnostic change in older adultsGuerry M Peavy
Department of Neurosciences, University of California, San Diego, CA, USA
Alzheimer Dis Assoc Disord 26:260-6. 2012..These findings could facilitate the identification of interventional strategies to reduce the risk of decline at different stages of susceptibility...
- Neuropsychological contributions to the early identification of Alzheimer's diseaseMark W Bondi
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Neuropsychol Rev 18:73-90. 2008..Finally, we provide a critical examination of the clinical concept of Mild Cognitive Impairment and offer suggestions for an increased focus on the impact of cerebrovascular disease (CVD) and CVD risk during the prodromal period of AD...
- Effects of chronic stress on memory decline in cognitively normal and mildly impaired older adultsGuerry M Peavy
UCSD Shiley Marcos Alzheimer s Disease Research Center, University of California San Diego, 8950 Villa La Jolla Drive, La Jolla, CA 92037, USA
Am J Psychiatry 166:1384-91. 2009..The authors sought to determine the prospective association between subjective and objective measures of chronic stress and rate of memory decline in cognitively normal and mildly impaired older adults...
- Functional interactions of HIV-infection and methamphetamine dependence during motor programmingSarah L Archibald
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
Psychiatry Res 202:46-52. 2012..Thus, HIV and METH dependence, perhaps through their effects on dopaminergic systems, may have opposing functional effects on neural circuits involved in motor programming...
- Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease: verbal versus design fluencyWes S Houston
University of Iowa, Department of Neurology, Division of Cognitive Neuroscience, Iowa City, Iowa 52242 1053, USA
J Int Neuropsychol Soc 11:863-70. 2005..e., fluency plus switching) may serve as a useful preclinical marker of AD...