ELAINE JACOBSON

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Optimizing the energy status of skin cells during solar radiation
    E L Jacobson
    College of Pharmacy and Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    J Photochem Photobiol B 63:141-7. 2001
  2. ncbi request reprint A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin
    Elaine L Jacobson
    Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85724, USA
    Exp Dermatol 16:490-9. 2007
  3. ncbi request reprint Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage
    Myron K Jacobson
    Department of Pharmacology and Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Niadyne Development Inc, Tucson, AZ 85724, USA
    Exp Dermatol 16:927-35. 2007
  4. ncbi request reprint Antimelanoma activity of apoptogenic carbonyl scavengers
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, USA
    J Pharmacol Exp Ther 316:805-14. 2006
  5. ncbi request reprint NAD in skin: therapeutic approaches for niacin
    Claudia A Benavente
    Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Curr Pharm Des 15:29-38. 2009
  6. ncbi request reprint 3-hydroxypyridine chromophores are endogenous sensitizers of photooxidative stress in human skin cells
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 279:30009-20. 2004
  7. ncbi request reprint Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cells
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    J Invest Dermatol 121:578-86. 2003
  8. ncbi request reprint Photosensitized growth inhibition of cultured human skin cells: mechanism and suppression of oxidative stress from solar irradiation of glycated proteins
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    J Invest Dermatol 119:489-98. 2002
  9. ncbi request reprint Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Biochem Pharmacol 63:361-73. 2002
  10. ncbi request reprint Identification of quenchers of photoexcited States as novel agents for skin photoprotection
    Georg T Wondrak
    University of Arizona, Arizona Cancer Center, 1515 North Campbell Ave, Tucson, AZ 85724, USA
    J Pharmacol Exp Ther 312:482-91. 2005

Research Grants

  1. Carbonyl scavengers for skin protection from glycation
    ELAINE JACOBSON; Fiscal Year: 2003
  2. Endogenous photosensitizers in skin carcinogenesis
    ELAINE JACOBSON; Fiscal Year: 2007
  3. Endogenous photosensitizers in skin carcinogenesis
    ELAINE JACOBSON; Fiscal Year: 2009
  4. Endogenous photosensitizers in skin carcinogenesis
    ELAINE JACOBSON; Fiscal Year: 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Optimizing the energy status of skin cells during solar radiation
    E L Jacobson
    College of Pharmacy and Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    J Photochem Photobiol B 63:141-7. 2001
    ..Identifying approaches to optimize these responses while maintaining the energy status of cells is likely to be very important in minimizing the deleterious effects of solar radiation on skin...
  2. ncbi request reprint A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin
    Elaine L Jacobson
    Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85724, USA
    Exp Dermatol 16:490-9. 2007
    ....
  3. ncbi request reprint Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage
    Myron K Jacobson
    Department of Pharmacology and Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Niadyne Development Inc, Tucson, AZ 85724, USA
    Exp Dermatol 16:927-35. 2007
    ..These results show that prior and concurrent use of MN can mitigate barrier impairment and improve the tolerability of retinoic acid therapy for facial photodamage without interfering with efficacy...
  4. ncbi request reprint Antimelanoma activity of apoptogenic carbonyl scavengers
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, USA
    J Pharmacol Exp Ther 316:805-14. 2006
    ..Our results suggest that carbonyl scavengers acting as direct molecular antagonists of RCS are promising apoptogenic prototype agents for antimelanoma drug design...
  5. ncbi request reprint NAD in skin: therapeutic approaches for niacin
    Claudia A Benavente
    Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Curr Pharm Des 15:29-38. 2009
    ..The new roles for niacin as a modulator of differentiation and photo-immune suppression and niacin status as a critical resistance factor for UV damaged skin cells are reviewed here...
  6. ncbi request reprint 3-hydroxypyridine chromophores are endogenous sensitizers of photooxidative stress in human skin cells
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 279:30009-20. 2004
    ....
  7. ncbi request reprint Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cells
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    J Invest Dermatol 121:578-86. 2003
    ..Our results support the hypothesis that extracellular matrix proteins play a functional role in skin photoaging and carcinogenesis by sensitization of photo-oxidative damage...
  8. ncbi request reprint Photosensitized growth inhibition of cultured human skin cells: mechanism and suppression of oxidative stress from solar irradiation of glycated proteins
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    J Invest Dermatol 119:489-98. 2002
    ....
  9. ncbi request reprint Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Biochem Pharmacol 63:361-73. 2002
    ..Our research qualifies alpha-amino-beta-mercapto-beta,beta-dimethyl-ethane as a promising pharmacophore for the development of related alpha-dicarbonyl scavengers as therapeutic agents to protect cells against carbonyl stress...
  10. ncbi request reprint Identification of quenchers of photoexcited States as novel agents for skin photoprotection
    Georg T Wondrak
    University of Arizona, Arizona Cancer Center, 1515 North Campbell Ave, Tucson, AZ 85724, USA
    J Pharmacol Exp Ther 312:482-91. 2005
    ..Furthermore, QPES photoprotection of reconstructed full thickness human skin exposed to solar simulated light has been demonstrated...
  11. pmc Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes
    Claudia A Benavente
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Free Radic Biol Med 44:527-37. 2008
    ..Our data support the hypothesis that glutamine is a likely alternative energy source during niacin deficiency and we suggest a model for NADPH generation important in ROS production...
  12. ncbi request reprint DNA damage by carbonyl stress in human skin cells
    Michael J Roberts
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Mutat Res 522:45-56. 2003
    ..The genotoxic potential of RCS in cultured skin cells and its suppression by a carbonyl scavenger as described in this study have implications for skin damage and carcinogenesis and its prevention by agents selective for carbonyl stress...
  13. ncbi request reprint Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ, USA
    Photochem Photobiol Sci 5:215-37. 2006
    ....
  14. ncbi request reprint Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients
    Harris Bernstein
    Department of Microbiology and Immunology, College of Public Health, University of Arizona, Tucson, AZ 85724, USA
    Ann Surg Oncol 9:505-17. 2002
    ..Abnormal areas in normal-appearing flat colonic mucosa (field defects) may predispose individuals to colon cancer. Markers of field defects would indicate cancer risk...
  15. ncbi request reprint Nuclear proteasome activation and degradation of carboxymethylated histones in human keratinocytes following glyoxal treatment
    Daniel Cervantes-Laurean
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Free Radic Biol Med 38:786-95. 2005
    ....
  16. ncbi request reprint Photosensitization of DNA damage by glycated proteins
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University, of Arizona, Tucson, AZ, USA
    Photochem Photobiol Sci 1:355-63. 2002
    ..Glycated proteins in skin may equally function as potent photosensitizers of DNA damage with implications for photoaging and photocarcinogenesis...
  17. ncbi request reprint Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)
    Ralph G Meyer
    Department of Pharmacology and Toxicology, University of Arizona College of Pharmacy, Room 4943 Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Gene 314:181-90. 2003
    ..The activity of the promoter was found to be 3.7 fold higher for TIM23 than for PARG, indicating that the two genes are expressed at different levels, although coregulation of the two genes remains an interesting possibility...
  18. ncbi request reprint Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase
    Hong Gao
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Room 3985 Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Exp Cell Res 313:984-96. 2007
    ..Our results show that a precise coordination of PARPs and PARG activities is important for normal cellular responses to DNA damage and that this coordination is defective in the absence of the PARG A domain...
  19. ncbi request reprint A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations
    Bassam M Tashtoush
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
    J Pharm Biomed Anal 43:859-64. 2007
    ..The method should also facilitate studies of the formulation compatibility and photocompatibility of tretinoin with agents that may improve its clinical tolerability...
  20. ncbi request reprint Formulation compatibility of myristyl nicotinate with drugs used to treat dermatological conditions involving an impaired skin barrier
    Bassam M Tashtoush
    Department of Pharmaceutical Technology, Faculty of Pharmacy Jordan University of Science and Technology, Irbid Jordan
    Drug Dev Ind Pharm 33:1176-82. 2007
    ..Our results suggest that the combination of myristyl nicotinate with these drugs is a feasible therapeutic development strategy...
  21. pmc UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations
    Bassam M Tashtoush
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
    Int J Pharm 352:123-8. 2008
    ..Our studies suggest that development of improved formulations and the use of effective UVA sunscreens may reduce the side effects of RA therapy...
  22. ncbi request reprint Water maze performance in young male Long-Evans rats is inversely affected by dietary intakes of niacin and may be linked to levels of the NAD+ metabolite cADPR
    Genevieve S Young
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Nutr 137:1050-7. 2007
    ..Changes in neural function related to the NAD(+) associated calcium signaling molecule, cADPR, may be the link between diet and behavior...
  23. pmc Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity
    Ralph G Meyer
    Department of Animal Biology and Mari Lowe Center for Comparative Oncology, University of Pennsylvania, Kennett Square, PA 19348, USA
    Exp Cell Res 313:2920-36. 2007
    ....
  24. ncbi request reprint Analysis and stability study of myristyl nicotinate in dermatological preparations by high-performance liquid chromatography
    Bassam M Tashtoush
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
    J Pharm Biomed Anal 43:893-9. 2007
    ..05% conversion to nicotinic acid. These methods will be effective for routine analysis of myristyl nicotinate stability in dermatological formulations...
  25. ncbi request reprint Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent
    Paul Catz
    Toxicology and Metabolism Laboratory, SRI International, 333 Ravenswood Ave Menlo Park, CA 94025, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 829:123-35. 2005
    ....

Research Grants8

  1. Carbonyl scavengers for skin protection from glycation
    ELAINE JACOBSON; Fiscal Year: 2003
    ....
  2. Endogenous photosensitizers in skin carcinogenesis
    ELAINE JACOBSON; Fiscal Year: 2007
    ..This study will validate endogenous structural skin components as novel molecular targets for chemoprevention in skin photocarcinogenesis and photoaging and lead to a new class of photoprotective agents. ..
  3. Endogenous photosensitizers in skin carcinogenesis
    ELAINE JACOBSON; Fiscal Year: 2009
    ..This study will validate endogenous structural skin components as novel molecular targets for chemoprevention in skin photocarcinogenesis and photoaging and lead to a new class of photoprotective agents. ..
  4. Endogenous photosensitizers in skin carcinogenesis
    ELAINE JACOBSON; Fiscal Year: 2009
    ..This study will validate endogenous structural skin components as novel molecular Itargets for chemoprevention in skin photocarcinogenesis and photoaging and lead to a new class of Iphotoprotective agents. ..