Elizabeth T Jacobs

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma
    Elizabeth Jacobs
    Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, Arizona Cancer Center, University of Arizona, P O Box 245024, Tucson, AZ 85724 5024, USA
    J Carcinog 10:3. 2011
  2. pmc Correlates of 25-hydroxyvitamin D and breast cancer stage in the Women's Healthy Eating and Living Study
    Elizabeth T Jacobs
    Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona 85724 5024, USA
    Nutr Cancer 65:188-94. 2013
  3. ncbi request reprint Selenium and colorectal adenoma: results of a pooled analysis
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, P O Box 245024, Tucson, AZ 85724 5024, USA
    J Natl Cancer Inst 96:1669-75. 2004
  4. pmc Association between body size and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, Arizona 85724 5024, USA
    Clin Gastroenterol Hepatol 5:982-90. 2007
  5. ncbi request reprint Diet, gender, and colorectal neoplasia
    Elizabeth T Jacobs
    Mel and Enid Zuckerman Arizona College of Public Health, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    J Clin Gastroenterol 41:731-46. 2007
  6. pmc Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    J Steroid Biochem Mol Biol 103:752-6. 2007
  7. doi request reprint Plasma insulin-like growth factor I is inversely associated with colorectal adenoma recurrence: a novel hypothesis
    Elizabeth T Jacobs
    Arizona Cancer Center, Arizona College of Public Health, University of Arizona P O Box 245024, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 17:300-5. 2008
  8. ncbi request reprint Vitamin D insufficiency in southern Arizona
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Am J Clin Nutr 87:608-13. 2008
  9. pmc Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, USA
    Carcinogenesis 31:1412-6. 2010
  10. ncbi request reprint Fiber, sex, and colorectal adenoma: results of a pooled analysis
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Am J Clin Nutr 83:343-9. 2006

Detail Information

Publications41

  1. pmc Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma
    Elizabeth Jacobs
    Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, Arizona Cancer Center, University of Arizona, P O Box 245024, Tucson, AZ 85724 5024, USA
    J Carcinog 10:3. 2011
    ..Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia...
  2. pmc Correlates of 25-hydroxyvitamin D and breast cancer stage in the Women's Healthy Eating and Living Study
    Elizabeth T Jacobs
    Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona 85724 5024, USA
    Nutr Cancer 65:188-94. 2013
    ..59), compared to Stage I. This study confirms previous work regarding the correlates of 25(OH)D concentrations but does not provide support for an association between vitamin D status and breast cancer stage...
  3. ncbi request reprint Selenium and colorectal adenoma: results of a pooled analysis
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, P O Box 245024, Tucson, AZ 85724 5024, USA
    J Natl Cancer Inst 96:1669-75. 2004
    ..Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association...
  4. pmc Association between body size and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, Arizona 85724 5024, USA
    Clin Gastroenterol Hepatol 5:982-90. 2007
    ..Therefore, we sought to evaluate the effect of anthropometric measures of obesity on adenoma after polypectomy...
  5. ncbi request reprint Diet, gender, and colorectal neoplasia
    Elizabeth T Jacobs
    Mel and Enid Zuckerman Arizona College of Public Health, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    J Clin Gastroenterol 41:731-46. 2007
    ..However, this observation may be influenced by the differential effects in women by menopausal status. Further research on sex-specific dietary effects is warranted...
  6. pmc Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    J Steroid Biochem Mol Biol 103:752-6. 2007
    ..In summary, the results of this study show a moderate, nonsignificant inverse association between serum 25(OH)D levels and reduced risk for colorectal adenoma recurrence, particularly among women...
  7. doi request reprint Plasma insulin-like growth factor I is inversely associated with colorectal adenoma recurrence: a novel hypothesis
    Elizabeth T Jacobs
    Arizona Cancer Center, Arizona College of Public Health, University of Arizona P O Box 245024, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 17:300-5. 2008
    ..02) than for nonadvanced recurrence (P(trend) = 0.10). These results suggest that, once an adenoma is removed, higher IGF-I levels reduce the odds of the formation of new lesions in the colorectum...
  8. ncbi request reprint Vitamin D insufficiency in southern Arizona
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Am J Clin Nutr 87:608-13. 2008
    ..Vitamin D deficiency or insufficiency has been observed among populations in the northern United States. However, data on the prevalence of vitamin D deficiency in areas of high sun exposure, such as Arizona, are limited...
  9. pmc Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, USA
    Carcinogenesis 31:1412-6. 2010
    ..29-0.96). These results provide support that RXRA SNPs rs7861779 and rs12004589 and CASR SNP rs1801726 may be important markers for colorectal neoplasia. Further work is needed to elucidate their role in the carcinogenic pathway...
  10. ncbi request reprint Fiber, sex, and colorectal adenoma: results of a pooled analysis
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Am J Clin Nutr 83:343-9. 2006
    ..Evidence for an association between dietary fiber and colorectal neoplasia has been equivocal, and some data suggest that there may be sex differences in response to fiber...
  11. pmc Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL) Study
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson AZ, USA
    Am J Clin Nutr 93:108-17. 2011
    ..There is a paucity of research evaluating the relation between vitamin D and recurrence of breast cancer after treatment...
  12. ncbi request reprint Plasma levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and the risk of prostate cancer
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tuscon 85724 5024, USA
    J Steroid Biochem Mol Biol 89:533-7. 2004
    ....
  13. ncbi request reprint Dietary change in an intervention trial of wheat bran fiber and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Ann Epidemiol 14:280-6. 2004
    ..The objectives of this study were to determine whether participants in the Wheat Bran Fiber (WBF) trial exhibited changes in diet over time, and whether these changes were differential by assigned treatment group...
  14. ncbi request reprint Baseline dietary fiber intake and colorectal adenoma recurrence in the wheat bran fiber randomized trial
    Elizabeth T Jacobs
    Arizona Cancer Center and Nutritional Sciences Interdisciplinary Program, University of Arizona, Tucson 85716, USA
    J Natl Cancer Inst 94:1620-5. 2002
    ..Therefore, we examined whether baseline fiber intake affected colorectal adenoma recurrence or modified the effect of treatment group in the WBF trial participants...
  15. pmc Association between body mass index and colorectal neoplasia at follow-up colonoscopy: a pooling study
    Elizabeth T Jacobs
    Arizona Cancer Center, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724 5024, USA
    Am J Epidemiol 169:657-66. 2009
    ..Our results provide further support for the association between BMI and metachronous colorectal adenomas, particularly among men, thereby indicating that body size may affect colorectal carcinogenesis at comparatively early stages...
  16. ncbi request reprint Meat intake, preparation methods, mutagens and colorectal adenoma recurrence
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Carcinogenesis 28:2019-27. 2007
    ..07-2.82) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (OR = 1.68; 95% CI = 1.03-2.75). Our results support a meat mutagen exposure hypothesis as a potential mechanism for recurrence of clinically significant adenomatous polyps...
  17. doi request reprint Gender modifies the effect of ursodeoxycholic acid in a randomized controlled trial in colorectal adenoma patients
    Patricia A Thompson
    Arizona Cancer Center, 1515 North Campbell Avenue, P O Box 245024, Tucson, AZ 85724, USA
    Cancer Prev Res (Phila) 2:1023-30. 2009
    ..We re-evaluated the effect of UDCA in men and women separately, based on sex-specific differences in bile acid metabolism and suspected variation in etiologic factors contributing to colorectal cancer risk...
  18. ncbi request reprint Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Gastroenterology 131:1706-16. 2006
    ..We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status...
  19. pmc Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence
    Jan B Egan
    Arizona Cancer Center, University of Arizona and Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona 85724 5024, USA
    Cancer Res 70:1496-504. 2010
    ..Our results indicate that allelic variation in RXRA affects metachronous colorectal neoplasia, perhaps of particular importance in the development of proximal lesions...
  20. pmc A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Gastroenterology 136:832-41. 2009
    ..Limited data exist regarding the actual risk of developing advanced adenomas and cancer after polypectomy or the factors that determine risk...
  21. ncbi request reprint Intake of supplemental and total fiber and risk of colorectal adenoma recurrence in the wheat bran fiber trial
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 87516, USA
    Cancer Epidemiol Biomarkers Prev 11:906-14. 2002
    ....
  22. pmc Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia
    Elizabeth A Hibler
    Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 21:368-75. 2012
    ..This study evaluated associations between polymorphic variation in the Gc-globulin (GC) and calcium-sensing receptor (CASR) and odds for metachronous colorectal neoplasia and vitamin D metabolite concentrations...
  23. pmc Components of metabolic syndrome and metachronous colorectal neoplasia
    Erin L Ashbeck
    Arizona Cancer Center, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 18:1134-43. 2009
    ..The consistent association between obesity and colorectal cancer is thought to be explained by metabolic disturbances common, but not exclusive, to the obese...
  24. pmc Physical activity as a determinant of fecal bile acid levels
    Betsy C Wertheim
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 18:1591-8. 2009
    ..However, this effect may be limited to individuals with lower triglyceride levels...
  25. ncbi request reprint Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrence
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Int J Cancer 119:1440-6. 2006
    ..Our finding, suggesting that multivitamins or supplemental folate only benefit individuals with lower plasma folate concentrations, should be taken into consideration when designing and interpreting results of intervention studies...
  26. pmc Association between circulating concentrations of 25(OH)D and colorectal adenoma: a pooled analysis
    Elizabeth T Jacobs
    University of Arizona Cancer Center, University of Arizona, Tucson, Arizona Division of Epidemiology, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona
    Int J Cancer 133:2980-8. 2013
    ..91 (0.71-1.17) and 0.95 (0.73-1.24; p-trend = 0.85). These findings support the concept that the relationship between vitamin D and colorectal neoplasia may vary by stage of adenoma development...
  27. pmc Vitamin D status and breast cancer in Saudi Arabian women: case-control study
    Fatimah M Yousef
    Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA
    Am J Clin Nutr 98:105-10. 2013
    ..Data regarding the vitamin D status of Saudi Arabian women and its relation to breast cancer risk are lacking...
  28. pmc Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells
    Jan B Egan
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 49:337-52. 2010
    ..Collectively, these findings strengthen evidence favoring a direct effect on the Wnt-signaling molecule beta-catenin as one anti-cancer target of 1,25D-VDR action in the colorectum...
  29. pmc Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics
    Janine G Einspahr
    Department of Medicine, Arizona Cancer Center, P O Box 245024, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 15:1443-50. 2006
    ....
  30. doi request reprint Presence of a TA haplotype in the APC gene containing the common 1822 polymorphism and colorectal adenoma
    Jan B Egan
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Cancer Res 68:6006-13. 2008
    ..01-0.80) when compared with the common CC-AA diplotype (codons 486 and 1822, respectively). Our findings support an important role for germ-line allele sequence in the APC gene and individual risk of metachronous adenomatous polyps...
  31. pmc CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells
    Elizabeth T Jacobs
    University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Cancer Res 73:2563-73. 2013
    ..A comprehensive understanding of 1,25D metabolism may allow for a more personalized approach toward treating vitamin D-related disorders and evaluating risk for carcinogenesis...
  32. pmc Associations between Vitamin D-Binding Protein Isotypes, Circulating 25(OH)D Levels, and Vitamin D Metabolite Uptake in Colon Cancer Cells
    Elizabeth A Hibler
    University of Arizona, 1515 N Campbell Ave, Cancer Center, Tucson, AZ 85724
    Cancer Prev Res (Phila) 7:426-34. 2014
    ..Overall, these results may help identify populations at risk for cancer and potential recipients of targeted chemoprevention. Cancer Prev Res; 7(4); 426-34. ©2014 AACR. ..
  33. doi request reprint Primary care physician compliance with colorectal cancer screening guidelines
    Jesse N Nodora
    Arizona Cancer Center, University of Arizona, PO Box 245024, Tucson, AZ 85724, USA
    Cancer Causes Control 22:1277-87. 2011
    ..To assess self-reported compliance to colorectal cancer (CRC) screening guidelines among primary care physicians (PCPs) and to assess physician and practice characteristics associated with reported compliance...
  34. pmc Vitamin D: marker or mechanism of action?
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, P O Box 245024, 1515 N Campbell Ave, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 20:585-90. 2011
    ..To further the field of vitamin D and cancer prevention, future studies will need to bridge the gap between the epidemiology and molecular biology of vitamin D activity in carcinogenesis...
  35. ncbi request reprint Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma
    Elizabeth A Hibler
    University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, 85724 5024, USA
    Cancer Causes Control 25:809-17. 2014
    ....
  36. ncbi request reprint Perceptions of personal belief vaccine exemption policy: a survey of Arizona vaccine providers
    Steven D Haenchen
    Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295N Martin Avenue, Tucson, AZ 85724, United States Electronic address
    Vaccine 32:3630-5. 2014
    ....
  37. doi request reprint Correlates of high vaccination exemption rates among kindergartens
    Michael S Birnbaum
    Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA
    Vaccine 31:750-6. 2013
    ..The present study was designed to characterize Arizona schools with high rates of permanent PBE among kindergartners, and to determine the degree to which they aggregate across the state...
  38. ncbi request reprint Studies into the anticancer effects of selenomethionine against human colon cancer
    Mark A Nelson
    Department of Pathology, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Ann N Y Acad Sci 1059:26-32. 2005
    ..In addition, we discuss preclinical mechanistic studies that provide insights into the biochemical and molecular bases for the anticancer effects of selenomethionine...
  39. ncbi request reprint Research and public health implications of the intricate relationship between calcium and vitamin D in the prevention of colorectal neoplasia
    Elizabeth T Jacobs
    J Natl Cancer Inst 95:1736-7. 2003
  40. ncbi request reprint Calcium supplementation and prevention of colorectal neoplasia: lessons from clinical trials
    Maria Elena Martinez
    J Natl Cancer Inst 99:99-100. 2007
  41. ncbi request reprint Vitamin D activity and colorectal neoplasia: a pathway approach to epidemiologic studies
    Elizabeth T Jacobs
    Cancer Epidemiol Biomarkers Prev 14:2061-3. 2005

Research Grants7

  1. VDR Variants, Nutrient Intakes, and Adenoma Recurrence
    Elizabeth Jacobs; Fiscal Year: 2007
    ..The resources at the ACC, coursework, and practical experience will be combined in a program designed to assist me in pursuing a successful career in translational cancer prevention research. ..
  2. Serum 25(OH)D, Vitamin D Intake, and Breast Cancer Recurrence in the WHEL Study
    Elizabeth Jacobs; Fiscal Year: 2009
    ....
  3. Serum 25(OH)D, Vitamin D Intake, and Breast Cancer Recurrence in the WHEL Study
    Elizabeth T Jacobs; Fiscal Year: 2010
    ....
  4. Fiber and Colorectal Adenomas: A Pooling Project
    Elizabeth Jacobs; Fiscal Year: 2005
    ..If it is found that certain groups may receive greater benefit from fiber, then public health recommendations can be made which target these groups and prevent the recurrence of colorectal adenomas. ..
  5. Vitamin D Status, Genetic Variation in Vitamin D Signaling and Metabolism, and Ri
    Peter W Jurutka; Fiscal Year: 2010
    ....