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Species | Peyton JacobSummaryAffiliation: University of California Country: USA Publications
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Publications
Simultaneous determination of mecamylamine, nicotine, and cotinine in plasma by gas chromatography-mass spectrometryP Jacob
Department of Medicine and Drug Dependence Research Center, Langley Porter Psychiatric Institute, University of California, San Francisco 94110, USA
J Pharm Biomed Anal 23:653-61. 2000..Limits of quantitation for mecamylamine, nicotine and cotinine are 2, 1 and 2 ng/ml, respectively...- Determination of ephedra alkaloid and caffeine concentrations in dietary supplements and biological fluidsPeyton Jacob
University of California, San Francisco, Department of Medicine, Division of Clinical Pharmacology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, 3rd Floor, San Francisco, California 94110, USA
J Anal Toxicol 28:152-9. 2004..Using this method, low nanogram-per-milliliter concentrations of ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine, methylephedrine, methylpseudoephedrine, and caffeine can be quantitated in a 12-min LC-MS-MS run... - Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapyPeyton Jacob
Division of Clinical Pharmacology, San Francisco General Hospital Medical Center, Department of Medicine, University of California, San Francisco, San Francisco, California 94110, USA
Cancer Epidemiol Biomarkers Prev 11:1668-73. 2002..Anabasine and anatabine concentrations in urine can be used to validate abstinence or measure the extent of tobacco use in persons undergoing nicotine replacement therapy... - Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometryPeyton Jacob
Division of Clinical Pharmacology, San Francisco General Hospital Medical Center, University of California, 94110, USA
Anal Chem 74:5290-6. 2002..Precision (coefficient of variation) ranged from 1.9 to 9.7%, and accuracy ranged from 97 to 103% of expected values for controls prepared by spiking sulfatase-treated urine with MHPG sulfate... 
Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patientsS Jean Hsieh
Department of Medicine, Pulmonary and Critical Care Division, University of California, San Francisco, CA, USA
Crit Care Med 39:40-5. 2011....- Progressive commercial cigarette yield reduction: biochemical exposure and behavioral assessmentNeal L Benowitz
Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California at San Francisco, San Francisco, CA 94143 1220, USA
Cancer Epidemiol Biomarkers Prev 18:876-83. 2009..We examined the effects of gradual reduction of nicotine yield in commercial cigarettes on smoking behavior, with an assessment of nicotine intake and exposure to tobacco smoke toxins... - CYP2A6 genotype and the metabolism and disposition kinetics of nicotineNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, San Francisco 94143 1220, USA
Clin Pharmacol Ther 80:457-67. 2006..Our objective was to determine the relationship between variant CYP2A6 genotypes and the disposition and metabolism of nicotine administered intravenously... - Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearanceJanne Hukkanen
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco 94143-1220, USA
Clin Pharmacol Ther 80:522-30. 2006..However, other compounds metabolized by CYP2A6, as well as other drugs excreted via renal clearance mechanisms similar to those of nicotine, may be susceptible to significant pharmacokinetic grapefruit juice interactions... - Racial differences in the relationship between number of cigarettes smoked and nicotine and carcinogen exposureNeal L Benowitz
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 1220, USA
Nicotine Tob Res 13:772-83. 2011..We studied the relationship between cigarettes per day (CPD) and biomarkers of nicotine and carcinogen exposure in Black and White smokers... - Comparison of urine cotinine and the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and their ratio to discriminate active from passive smokingMaciej Lukasz Goniewicz
Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, Box 1220, San Francisco, CA 94143 1220, USA
Nicotine Tob Res 13:202-8. 2011..The aim of the study was to determine optimal cutoff points to discriminate active versus passive smokers and to compare sensitivity and specificity for the use of cotinine, NNAL, and the ratio of the NNAL/cotinine in urine... - Urine cotinine underestimates exposure to the tobacco-derived lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in passive compared with active smokersNeal Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 1220, USA
Cancer Epidemiol Biomarkers Prev 19:2795-800. 2010.... - Urine menthol as a biomarker of mentholated cigarette smokingNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, Department of Medicine, University of California, San Francisco, California 94143 1220, USA
Cancer Epidemiol Biomarkers Prev 19:3013-9. 2010..We measured urine menthol concentrations in relation to biomarkers of exposure to nicotine and tobacco carcinogens... - Exposure and kinetics of polycyclic aromatic hydrocarbons (PAHs) in cigarette smokersGideon St Helen
Center for Tobacco Control Research and Education, University of California, San Francisco, California, USA
Chem Res Toxicol 25:952-64. 2012..Characterization of hydroxyfluorene and 2-naphthol metabolites in urine may improve the characterization of PAHs from tobacco smoke and related disease risks among smokers and nonsmokers... 
Cocaethylene formation following ethanol and cocaine administration by different routesEllen D Herbst
San Francisco Dept of Veterans Affairs Medical Center and Department of Psychiatry, University of California, San Francisco, CA 94121, USA
Exp Clin Psychopharmacol 19:95-104. 2011..Administration of cocaine by different routes alters the amount of cocaethylene formed through hepatic first-pass effects. Increased cardiovascular and subjective effects might explain the toxicity and popularity of the combined drugs...- Nicotine, carbon monoxide, and carcinogen exposure after a single use of a water pipePeyton Jacob
Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, Building 100, San Francisco, CA 94110, USA
Cancer Epidemiol Biomarkers Prev 20:2345-53. 2011..Many perceive water pipe smoking to be less hazardous than cigarette smoking. We studied systemic absorption of nicotine, carbon monoxide, and carcinogens from one water pipe smoking session... - Carcinogen exposure during short-term switching from regular to "light" cigarettesNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California at San Francisco, Box 1220, San Francisco, CA 94143 1220, USA
Cancer Epidemiol Biomarkers Prev 14:1376-83. 2005.... - Human pharmacology of the methamphetamine stereoisomersJohn Mendelson
Addiction Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, St Luke s Hospital, San Francisco, CA 94110, USA
Clin Pharmacol Ther 80:403-20. 2006..To help predict the consequences of precursor regulation, we compared the pharmacokinetics and pharmacodynamics of the methamphetamine (INN, metamfetamine) stereoisomers... - Short-term metabolic and hemodynamic effects of ephedra and guarana combinationsChristine A Haller
Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA
Clin Pharmacol Ther 77:560-71. 2005..We sought to determine whether repeated dosing and multi-ingredient formulations contribute to the adverse effects of these supplements... - Concentrations of ephedra alkaloids and caffeine in commercial dietary supplementsChristine A Haller
University of California, San Francisco, Department of Medicine, Division of Clinical Pharmacology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, 3rd Floor, San Francisco, California 94110, USA
J Anal Toxicol 28:145-51. 2004..We conclude that product inconsistency is common among some commercially available dietary supplements that contain ephedra alkaloids and caffeine... - Reproducibility of the nicotine metabolite ratio in cigarette smokersGideon St Helen
Center for Tobacco Control Research and Education, University of California, San Francisco, San Francisco, CA 94143, USA
Cancer Epidemiol Biomarkers Prev 21:1105-14. 2012.... - Smoking behavior and exposure to tobacco toxicants during 6 months of smoking progressively reduced nicotine content cigarettesNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, San Francisco General Hospital Medical Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 1220, USA
Cancer Epidemiol Biomarkers Prev 21:761-9. 2012..We conducted a trial of progressive nicotine content tapering over 6 months to determine the effects on smoking behaviors and biomarkers of tobacco smoke exposure and cardiovascular effects... - Estimation of nicotine dose after low-level exposure using plasma and urine nicotine metabolitesNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, Box 1220, San Francisco, CA 94143 1220, USA
Cancer Epidemiol Biomarkers Prev 19:1160-6. 2010..We sought to determine the optimal plasma and urine nicotine metabolites, alone or in combination, to estimate the systemic dose of nicotine after low-level exposure... - Enhanced stimulant and metabolic effects of combined ephedrine and caffeineChristine A Haller
Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA
Clin Pharmacol Ther 75:259-73. 2004..We sought to determine whether ephedrine and caffeine have clinically significant pharmacologic interactions that explain these toxicities... - Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement useChristine A Haller
Division of Clinical Pharmacology, San Francisco General Hospital, University of California, 94143, USA
Clin Pharmacol Ther 71:421-32. 2002..We assessed the pharmacokinetics and pharmacodynamics of a dietary supplement that contains these herbal stimulants... - Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigaretteNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, Department of Medicine, University of California, San Francisco, CA 94143 1220, USA
Cancer Epidemiol Biomarkers Prev 16:2479-85. 2007..This study examined whether gradual reduction in nicotine exposure increases exposure to tobacco smoke toxins... - Elimination kinetics of the tobacco-specific biomarker and lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanolMaciej L Goniewicz
Department of Medicine, University of California, San Francisco, USA
Cancer Epidemiol Biomarkers Prev 18:3421-5. 2009.... - Hemodynamic effects of ephedra-free weight-loss supplements in humansChristine A Haller
Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, 94143, USA
Am J Med 118:998-1003. 2005..aurantium alone, because an eightfold higher dose of synephrine (Advantra Z) had no effect on blood pressure, but may be attributable to caffeine and other stimulants in the multi-component formulation... - Determination of the nicotine metabolites cotinine and trans-3'-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatography-tandem mass spectrometry: biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2Peyton Jacob
Department of Medicine, San Francisco General Hospital Medical Center, 1001 Potrero Avenue, University of California, San Francisco, UCSF Box 1220, San Francisco, CA 94143 1220, USA
J Chromatogr B Analyt Technol Biomed Life Sci 879:267-76. 2011..Concentrations of both metabolites in urine of non-smokers with different levels of secondhand smoke exposure are presented... - Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometryPeyton Jacob
Division of Clinical Pharmacology, University of California, San Francisco, UCSF Box 1220, San Francisco, California 94143 1220, USA
Anal Chem 80:8115-21. 2008..The lower limit of quantitation is 0.25 pg/mL for 5-mL urine specimens. Applications to studies of people with a range of different SHS exposure levels is described... - Mentholated cigarette smoking inhibits nicotine metabolismNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, Box 1220, San Francisco, CA 94143 1220, USA
J Pharmacol Exp Ther 310:1208-15. 2004..Our finding of impaired metabolism of nicotine while mentholated cigarette smoking suggests that mentholated cigarette smoking enhances systemic nicotine exposure... - Female sex and oral contraceptive use accelerate nicotine metabolismNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, University of California, San Francisco, San Francisco 94143 1220, USA
Clin Pharmacol Ther 79:480-8. 2006..This study tested the hypothesis that women metabolize nicotine more rapidly than men and that, among women, oral contraceptive users metabolize nicotine more rapidly than nonusers of oral contraceptives... - Nicotine metabolite ratio as a predictor of cigarette consumptionNeal L Benowitz
Department of Medicine, University of California San Francisco, San Francisco, CA 94143 1220, USA
Nicotine Tob Res 5:621-4. 2003..This finding supports the hypothesis that the rate of nicotine metabolism is a determinant of the level of cigarette consumption and supports the use of the 3-HC:cotinine ratio as a noninvasive marker of nicotine metabolism... - Prevalence of smoking assessed biochemically in an urban public hospital: a rationale for routine cotinine screeningNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, University of California San Francisco, San Francisco, CA 94143 1220, USA
Am J Epidemiol 170:885-91. 2009.... - Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolismNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, San Francisco General Hospital Medical Center, University of California, San Francisco, CA 94143 1220, USA
Clin Pharmacol Ther 74:468-74. 2003.... - Metabolism and disposition kinetics of nicotineJanne Hukkanen
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco Genreral Hospital Medical Center, and the Department of Medicine, University of California, San Francisco, Box 1220, San Francisco, CA 94143-1220, USA
Pharmacol Rev 57:79-115. 2005..Due to the significance of the CYP2A6 enzyme in nicotine clearance, special emphasis is given to the effects and population distributions of CYP2A6 alleles and the regulation of CYP2A6 enzyme... - Exposure to nicotine and carcinogens among Southwestern Alaskan Native cigarette smokers and smokeless tobacco usersNeal L Benowitz
University of California, San Francisco, CA, USA
Cancer Epidemiol Biomarkers Prev 21:934-42. 2012..To investigate possible mechanisms of increased cancer risk we studied levels of nicotine and tobacco-specific nitrosamines (TSNA) in tobacco products and biomarkers of tobacco toxicant exposure in Southwestern AN people... - Urine nicotine metabolite concentrations in relation to plasma cotinine during low-level nicotine exposureNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, San Francisco General Hospital Medical Center, University of California, San Francisco, Box 1220, San Francisco, CA 94143 1220, USA
Nicotine Tob Res 11:954-60. 2009.... - Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditionsChristine A Haller
Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA, USA
Br J Clin Pharmacol 65:833-40. 2008..The effect of exercise on the pharmacokinetics and pharmacodynamics of stimulant herbals is unknown... - Nicotine intake and dose response when smoking reduced-nicotine content cigarettesNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, Department of Medicine, University of California, San Francisco 94143 1220, USA
Clin Pharmacol Ther 80:703-14. 2006..As a first step in evaluating this strategy, we studied smokers smoking cigarettes containing tobacco with differing nicotine content... - The clinical pharmacology of intranasal l-methamphetamineJohn E Mendelson
Addiction Pharmacology Research Laboratory, The California Pacific Medical Center Research Institute, St Luke s Hospital, 7th Floor, 3555 Cesar Chavez Street, San Francisco, CA 94110, USA
BMC Clin Pharmacol 8:4. 2008..We studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant... - GHB urine concentrations after single-dose administration in humansChristine Haller
Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, California, USA
J Anal Toxicol 30:360-4. 2006..We conclude that the detection time for GHB in urine may be shorter than the previously reported 12-h window in some people taking therapeutic doses of GHB... - Cardiovascular effects of nasal and transdermal nicotine and cigarette smokingNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, San Francisco, USA. nbeno@ itsa.ucsf.edu
Hypertension 39:1107-12. 2002..We conclude that, at recommended doses, TDN and NNS have fewer effects on biomarkers of cardiovascular risk than does cigarette smoking... - Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activityDelia Dempsey
Department of Medicine, Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, University of California, 94143-1220, USA
Clin Pharmacol Ther 76:64-72. 2004.... - Racial differences in the relationship between tobacco dependence and nicotine and carcinogen exposureGideon St Helen
Center for Tobacco Control Research and Education, University of California, San Francisco, CA 94143 1220, USA
Addiction 108:607-17. 2013..To investigate the relationships between tobacco dependence, biomarkers of nicotine and carcinogen exposure and biomarkers of nicotine and carcinogen exposure per cigarette in back and white smokers... - Determination of phenolic metabolites of polycyclic aromatic hydrocarbons in human urine as their pentafluorobenzyl ether derivatives using liquid chromatography-tandem mass spectrometryPeyton Jacob
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, Department of Medicine, University of California, San Francisco, San Francisco, California 94110, USA
Anal Chem 79:587-98. 2007..01 to 0.5 ng/mL. Stable isotope-labeled internal standards were synthesized or obtained commercially. Data on urinary excretion of several PAH metabolites in urine of smokers and nonsmokers are presented... - Attitudes and practices of hookah smokers in the San Francisco Bay AreaBilaal Ahmed
School of Public Health, University of California, Berkeley, CA, USA
J Psychoactive Drugs 43:146-52. 2011..More definitive studies conveying the possible harm of hookah smoking are necessary to serve as a basis for health education programs and policy changes towards this potentially harmful activity... - Accelerated metabolism of nicotine and cotinine in pregnant smokersDelia Dempsey
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, California 94143-1220, USA
J Pharmacol Exp Ther 301:594-8. 2002..Lower cotinine levels observed during pregnancy do not necessarily reflect less smoke exposure, and cut-off levels used to classify nonsmokers, passive smokers, and active smokers need to be established for pregnancy... - Nicotine metabolism in pregnant and nonpregnant rabbitsPiotr Tutka
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, 1550 4th Street, San Francisco, CA 94143, USA
Nicotine Tob Res 10:1385-90. 2008..However, a molecular understanding of these effects is essential for prediction of the pharmacological and toxicological consequences of smoking during pregnancy... - Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady stateNeal L Benowitz
Department of Medicine, Bioengineering and Therapeutic Sciences, Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, California 94143 1220, USA
Pharmacogenet Genomics 23:135-41. 2013..Bupropion, an antidepressant and smoking cessation medication, is metabolized to hydroxybupropion (HB), an active metabolite, primarily by CYP2B6... - Longer term exposure to secondhand smoke and health outcomes in COPD: impact of urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanolMark D Eisner
Department of Medicine, University of California, San Francisco, 350 Parnassus Avenue, Suite 609, San Francisco, CA 94117, USA
Nicotine Tob Res 11:945-53. 2009..Secondhand smoke (SHS) contains respiratory irritants and has the potential to adversely affect adults with chronic obstructive pulmonary disease (COPD), but few studies have evaluated the impact of SHS on COPD... - Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-AmericansNeal L Benowitz
Division of Clinical Pharmacology, Department of Medicine, University of California, San Francisco, USA
J Natl Cancer Inst 94:108-15. 2002..We compared the rate of nicotine metabolism and the intake of nicotine per cigarette smoked among smokers of different ethnicities... - Urine toxicology samples in cocaine treatment trials: how many need to be tested?Kevin L Delucchi
Department of Psychiatry, University of California, San Francisco 94143 0984, USA
J Addict Dis 21:17-26. 2002..50 and approximately 20% disagreement among samples using cutoff values in place of quantitative levels. Both samples, however, supported similar conclusions about group-level behavior... - Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolismHuijun Z Ring
Center for Health Sciences, SRI International, Menlo Park, CA, USA
Pharmacogenet Genomics 17:1007-15. 2007..We investigated the influence of genetic variation in another potential nicotine-metabolizing enzyme, CYP2B6, and its interaction with CYP2A6, on the metabolism of nicotine... - Secondhand smoke exposure in Mexican discothequesEduardo Lazcano-Ponce
Center for Research in Population Health, National Institute of Public Health, Cuernavaca, Morelos, Mexico
Nicotine Tob Res 9:1021-6. 2007..These findings support the need to prohibit smoking in discotheques to protect nonsmokers' health... - Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influenceGary E Swan
Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
Pharmacogenet Genomics 15:115-25. 2005..These results suggest the involvement of additional genetic factors (e.g. uncharacterized or novel CYP2A6 alleles as well as other genes in the metabolic pathway) that remain to be identified... - Vitamin C supplementation decreases oxidative stress biomarker f2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smokeMarion Dietrich
School of Public Health, University of California Berkeley, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Nutr Cancer 45:176-84. 2003..Daily AO supplementation (especially with vitamin C) decreases this oxidative stress biomarker in passive smokers. This finding might be of importance for the prevention of ETS-associated adverse health effects in nonsmokers... - Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urineIrina Stepanov
The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 16:1382-6. 2007..53; P = 0.005). The results of this study provide essential validation data for the use of toenail biomarkers in investigations of the role of chronic tobacco smoke exposure in human cancer... - Genetic and environmental sources of variation in heart rate response to infused nicotine in twinsGary E Swan
Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
Cancer Epidemiol Biomarkers Prev 16:1057-64. 2007..The contribution from genetic sources to heart rate response characteristics should be investigated further as a potential endophenotype for use in genetic studies of nicotine dependence... - Pharmacogenetics of nicotine metabolism in twins: methods and proceduresGary E Swan
Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
Twin Res 7:435-48. 2004.... - Caffeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressureMatthew D Vukovich
Applied Physiology Laboratory, Department Health, Physical Education, and Recreation, South Dakota State University, Brookings, South Dakota 57007, USA
Clin Exp Pharmacol Physiol 32:47-53. 2005..5. Caffeine and herbal ephedra, at doses of 150 mg and 20 mg (ephedrine), respectively, result in a significant elevation in REE, HR and BP. Although significant, the increase in energy expenditure is negligible in terms of weight loss... - Effect of pregnancy on a measure of FMO3 activityJanne Hukkanen
Br J Clin Pharmacol 60:224-6. 2005