Chaim Jacob

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Development of Systemic Lupus Erythematosus in NZM 2328 Mice in the Absence of any Single BAFF Receptor
    Chaim O Jacob
    University of Southern California Keck School of Medicine, Los Angeles
    Arthritis Rheum 65:1043-54. 2013
  2. ncbi Genetics of rheumatoid arthritis: an impressionist perspective
    Noam Jacob
    Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue HMR 703, Los Angeles, CA 90033, USA
    Rheum Dis Clin North Am 38:243-57. 2012
  3. ncbi Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase
    Chaim O Jacob
    The Lupus Genetic Group, Department of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 109:E59-67. 2012
  4. ncbi Function2Gene: a gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge
    Don L Armstrong
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    BMC Bioinformatics 9:311. 2008
  5. ncbi Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Arthritis Rheum 56:4164-73. 2007
  6. ncbi Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
    Chaim O Jacob
    The Lupus Genetic Group, Department of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:6256-61. 2009
  7. ncbi Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
  8. ncbi Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF
    Chaim O Jacob
    Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Immunol 177:2671-80. 2006
  9. ncbi A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    Dehuang Guo
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, Georgia 30912, USA
    Nat Genet 36:837-41. 2004
  10. ncbi Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90089, USA
    J Immunol 171:1564-71. 2003

Research Grants

  1. Cytokine mechanisms in systemic lupus erythematosus
    Chaim Jacob; Fiscal Year: 2007
  2. A new direction in studing sex hormone involovement in *
    Chaim Jacob; Fiscal Year: 2003
  3. GENETICS OF CHILDHOOD ONSET SLE
    Chaim Jacob; Fiscal Year: 2003
  4. Elucidation of novel gene variants predisposing to childhood and adult-onset SLE
    Chaim O Jacob; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi Development of Systemic Lupus Erythematosus in NZM 2328 Mice in the Absence of any Single BAFF Receptor
    Chaim O Jacob
    University of Southern California Keck School of Medicine, Los Angeles
    Arthritis Rheum 65:1043-54. 2013
    ..To determine the necessity for any individual BAFF receptor in the development of systemic lupus erythematosus (SLE)...
  2. ncbi Genetics of rheumatoid arthritis: an impressionist perspective
    Noam Jacob
    Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue HMR 703, Los Angeles, CA 90033, USA
    Rheum Dis Clin North Am 38:243-57. 2012
    ..This review evaluates critically the recent literature on the genetic contribution to RA and assesses the methodology used to identify these risk alleles...
  3. ncbi Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase
    Chaim O Jacob
    The Lupus Genetic Group, Department of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 109:E59-67. 2012
    ..Our study completes the chain of evidence from genetic association to specific molecular function...
  4. ncbi Function2Gene: a gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge
    Don L Armstrong
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    BMC Bioinformatics 9:311. 2008
    ..SNPs have been used to identify genetic components which are associated with a disease. Unfortunately, many studies using these methods suffer from low reproducibility due to lack of power...
  5. ncbi Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Arthritis Rheum 56:4164-73. 2007
    ....
  6. ncbi Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
    Chaim O Jacob
    The Lupus Genetic Group, Department of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:6256-61. 2009
    ..This demonstration of an X chromosome gene as a disease susceptibility factor in human SLE raises the possibility that the gender difference in SLE may in part be attributed to sex chromosome genes...
  7. ncbi Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  8. ncbi Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF
    Chaim O Jacob
    Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Immunol 177:2671-80. 2006
    ..These observations may have profound ramifications for the use of BAFF antagonists in human SLE and related diseases...
  9. ncbi A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    Dehuang Guo
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, Georgia 30912, USA
    Nat Genet 36:837-41. 2004
    ..5 times greater NF kappa B transcriptional activity and approximately 2 times greater expression of IL12B, an NF kappa B-dependent gene. These findings suggest a new pathway that may be implicated in the pathogenesis of T1D...
  10. ncbi Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90089, USA
    J Immunol 171:1564-71. 2003
    ..Furthermore, these results also question the apparent equation of the effect of Stat deficiency with loss of secretion or response to particular cytokines...

Research Grants12

  1. Cytokine mechanisms in systemic lupus erythematosus
    Chaim Jacob; Fiscal Year: 2007
    ..These studies should lead to better understanding of a number of characteristics of SLE and may lead to identification of new targets for therapy. ..
  2. A new direction in studing sex hormone involovement in *
    Chaim Jacob; Fiscal Year: 2003
    ..Stanczyk) and biochemistry of steroid hormones (Dr. Roberts). The project proposed represents a clear and distinct departure from the PI's and the other investigators ongoing research. ..
  3. GENETICS OF CHILDHOOD ONSET SLE
    Chaim Jacob; Fiscal Year: 2003
    ..They further state that this is a multi-center application from some of the largest pediatric lupus clinics in the country and, therefore, represents a major and unique resource for the study of the genetics of childhood-onset SLE. ..
  4. Elucidation of novel gene variants predisposing to childhood and adult-onset SLE
    Chaim O Jacob; Fiscal Year: 2010
    ....