D R Jackola

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Random outcomes of allergen-specific responses in atopic families
    D R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Exp Allergy 34:540-7. 2004
  2. ncbi request reprint Variable binding affinities for allergen suggest a 'selective competition' among immunoglobulins in atopic and non-atopic humans
    Duaine R Jackola
    The Asthma and Allergy Program, University of Minnesota Medical School, MMC 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 39:367-77. 2002
  3. ncbi request reprint Robustness into advanced age of atopy-specific mechanisms in atopy-prone families
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis 55455, USA
    J Gerontol A Biol Sci Med Sci 58:99-107. 2003
  4. ncbi request reprint Evidence for two independent distributions of serum immunoglobulin E in atopic families: cognate and non-cognate IgE
    Duaine R Jackola
    Asthma and Allergy Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hum Immunol 65:20-30. 2004
  5. ncbi request reprint Allergen skin test reaction patterns in children (</=10 years old) from atopic families suggest age-dependent changes in allergen-IgE binding in early life
    Duaine R Jackola
    Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 132:364-72. 2003
  6. pmc Random allergen-specific IgE expression in atopic families: evidence for inherited "stochastic bias" in adverse immune response development to non-infectious antigens
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Mayo Mail Code 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 44:2549-57. 2007
  7. ncbi request reprint Evidence that negative feedback between antibody concentration and affinity regulates humoral response consolidation to a non-infectious antigen in infants
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, Mayo Mail Code 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 42:19-30. 2005
  8. ncbi request reprint CD14 promoter polymorphisms in atopic families: implications for modulated allergen-specific immunoglobulin E and G1 responses
    Duaine R Jackola
    The Asthma and Allergy Program, Division of Pulmonary, Allergy and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 139:217-24. 2006
  9. ncbi request reprint Evidence of an affinity threshold for IgE-allergen binding in the percutaneous skin test reaction
    L K Pierson-Mullany
    The Asthma and Allergy Program, University of Minnesota Medical School, Minneapolis 55455, USA
    Clin Exp Allergy 32:107-16. 2002
  10. ncbi request reprint Dynamic phenotypic restructuring of the CD4 and CD8 T-cell subsets with age in healthy humans: a compartmental model analysis
    D R Jackola
    Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    Mech Ageing Dev 105:241-64. 1998

Detail Information

Publications13

  1. ncbi request reprint Random outcomes of allergen-specific responses in atopic families
    D R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Exp Allergy 34:540-7. 2004
    ..Among genetically susceptible individuals, an antigen-specific response results involving the production of allergen-specific IgE (atopy)...
  2. ncbi request reprint Variable binding affinities for allergen suggest a 'selective competition' among immunoglobulins in atopic and non-atopic humans
    Duaine R Jackola
    The Asthma and Allergy Program, University of Minnesota Medical School, MMC 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 39:367-77. 2002
    ..These results suggest that there may be a "selective competition" among isotypes for allergens that is driven by the ability to produce high affinity, allergen-specific immunoglobulins...
  3. ncbi request reprint Robustness into advanced age of atopy-specific mechanisms in atopy-prone families
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis 55455, USA
    J Gerontol A Biol Sci Med Sci 58:99-107. 2003
    ..In addition, established atopic responses may be focused in an immune system compartment either independent of or minimally influenced by T-cell activity...
  4. ncbi request reprint Evidence for two independent distributions of serum immunoglobulin E in atopic families: cognate and non-cognate IgE
    Duaine R Jackola
    Asthma and Allergy Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hum Immunol 65:20-30. 2004
    ..Elevated serum IgE is a consequence, not a predisposing cause, of allergen sensitization...
  5. ncbi request reprint Allergen skin test reaction patterns in children (</=10 years old) from atopic families suggest age-dependent changes in allergen-IgE binding in early life
    Duaine R Jackola
    Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 132:364-72. 2003
    ..Genetic studies of atopy rely upon evidence of abnormal IgE production, usually elevated total IgE or skin prick test (SPT) reactions. However, these measures may change with subject age...
  6. pmc Random allergen-specific IgE expression in atopic families: evidence for inherited "stochastic bias" in adverse immune response development to non-infectious antigens
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Mayo Mail Code 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 44:2549-57. 2007
    ..These results support a model of "stochastic bias" that "skews" an immune response to non-infectious antigens among people with an inherited predisposition for atopy...
  7. ncbi request reprint Evidence that negative feedback between antibody concentration and affinity regulates humoral response consolidation to a non-infectious antigen in infants
    Duaine R Jackola
    The Asthma and Allergy Center, University of Minnesota Medical School, Minneapolis, Mayo Mail Code 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 42:19-30. 2005
    ..A theoretical model is proposed to account for this relationship...
  8. ncbi request reprint CD14 promoter polymorphisms in atopic families: implications for modulated allergen-specific immunoglobulin E and G1 responses
    Duaine R Jackola
    The Asthma and Allergy Program, Division of Pulmonary, Allergy and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Int Arch Allergy Immunol 139:217-24. 2006
    ..We sought to determine if a single nucleotide polymorphism in the CD14 promoter region is associated with atopy in atopic families, and to assess its influence on serum levels of CD14 and allergen-specific IgE and IgG1 responses...
  9. ncbi request reprint Evidence of an affinity threshold for IgE-allergen binding in the percutaneous skin test reaction
    L K Pierson-Mullany
    The Asthma and Allergy Program, University of Minnesota Medical School, Minneapolis 55455, USA
    Clin Exp Allergy 32:107-16. 2002
    ..There is no clear correlation between IgE and other indicators of atopy such as skin prick tests (SPT)s, and physiological associations are difficult to justify in cases with detectable IgE but negative SPT results...
  10. ncbi request reprint Dynamic phenotypic restructuring of the CD4 and CD8 T-cell subsets with age in healthy humans: a compartmental model analysis
    D R Jackola
    Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    Mech Ageing Dev 105:241-64. 1998
    ....
  11. pmc Allergen-specific IgG1 provides parsimonious heritability estimates for atopy-associated immune responses to allergens
    Carol L Liebeler
    The Asthma and Allergy Program, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hum Immunol 68:113-21. 2007
    ..Moreover, atopy is an inherited deregulation of immune responses to noninfectious antigens, involving antibody isotypes other than IgE...
  12. pmc Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an "endophenotype"
    Duaine R Jackola
    The Asthma and Allergy Center, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Hum Immunol 68:839-43. 2007
    ..Allergen-specific IgG1 is a suitable "endophenotype" to be used in searches for genes associated with atopy-associated humoral immune responses to common aeroallergens...
  13. ncbi request reprint Entropy-favored human antibody binding reactions with a non-infectious antigen
    Duaine R Jackola
    The Asthma and Allergy Program, Department of Medicine, University of Minnesota Medical School, Mayo Mail Code 434, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Mol Immunol 45:1494-500. 2008
    ....