Monica M Jablonski

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 10:577-87. 2004
  2. pmc Age-related decline in VIP-positive parasympathetic nerve fibers in the human submacular choroid
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Invest Ophthalmol Vis Sci 48:479-85. 2007
  3. ncbi An ENU-induced mutation in Rs1h causes disruption of retinal structure and function
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center and Tennessee Mouse Genome Consortium, Memphis, TN, USA
    Mol Vis 11:569-81. 2005
  4. ncbi The intact Xenopus laevis eye rudiment: a quasi-in vivo system for the study of retinal development and degenerations
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, 956 Court Avenue, Suite D228, Memphis, TN 38163, USA
    Adv Exp Med Biol 533:189-96. 2003
  5. pmc Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains
    Shankar Swaminathan
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, USA
    Pigment Cell Melanoma Res 26:487-98. 2013
  6. pmc Cellular retinol binding protein 1 modulates photoreceptor outer segment folding in the isolated eye
    Xiaofei Wang
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Dev Neurobiol 70:623-35. 2010
  7. ncbi The Tennessee Mouse Genome Consortium: identification of ocular mutants
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Vis Neurosci 22:595-604. 2005
  8. pmc In search of the identity of the XAP-1 antigen: a protein localized to cone outer segments
    Suba Nookala
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Invest Ophthalmol Vis Sci 51:2736-43. 2010
  9. pmc Complex interactions of Tyrp1 in the eye
    Hong Lu
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 17:2455-68. 2011
  10. pmc Innate immune network in the retina activated by optic nerve crush
    Justin P Templeton
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA
    Invest Ophthalmol Vis Sci 54:2599-606. 2013

Research Grants

  1. Proteomic Analysis of the Retina
    MONICA JABLONSKI; Fiscal Year: 2007

Collaborators

Detail Information

Publications31

  1. ncbi The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 10:577-87. 2004
    ..We also have fine-mapped the mutation, ldis1 (lens disrupter 1), and have evaluated positional candidate genes...
  2. pmc Age-related decline in VIP-positive parasympathetic nerve fibers in the human submacular choroid
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Invest Ophthalmol Vis Sci 48:479-85. 2007
    ..The current study was conducted to examine the possibility that an age-related loss of these fibers might occur in the submacular choroid in humans, and thus contribute to a decline in ChBF...
  3. ncbi An ENU-induced mutation in Rs1h causes disruption of retinal structure and function
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center and Tennessee Mouse Genome Consortium, Memphis, TN, USA
    Mol Vis 11:569-81. 2005
    ..Herein we present its retinal phenotype and genetic basis...
  4. ncbi The intact Xenopus laevis eye rudiment: a quasi-in vivo system for the study of retinal development and degenerations
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, 956 Court Avenue, Suite D228, Memphis, TN 38163, USA
    Adv Exp Med Biol 533:189-96. 2003
  5. pmc Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains
    Shankar Swaminathan
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, USA
    Pigment Cell Melanoma Res 26:487-98. 2013
    ..Our model accounted for 71-88% of the explained variance of the TID phenotype across the age bins. These results demonstrate that along with Tyrp1 and Gpnmb, Oca2, Myo5a, Prkcz, and Zbtb20 modulate the TID in an age-dependent manner. ..
  6. pmc Cellular retinol binding protein 1 modulates photoreceptor outer segment folding in the isolated eye
    Xiaofei Wang
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Dev Neurobiol 70:623-35. 2010
    ....
  7. ncbi The Tennessee Mouse Genome Consortium: identification of ocular mutants
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Vis Neurosci 22:595-604. 2005
    ..Mice from each of these pedigrees of mutant mice are available for distribution to researchers for independent study...
  8. pmc In search of the identity of the XAP-1 antigen: a protein localized to cone outer segments
    Suba Nookala
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Invest Ophthalmol Vis Sci 51:2736-43. 2010
    ..To determine the identity of the XAP-1 antigen. The XAP-1 antibody has been used by many investigators and is recognized as an index of photoreceptor outer segment maturity, yet its antigen remains unknown...
  9. pmc Complex interactions of Tyrp1 in the eye
    Hong Lu
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 17:2455-68. 2011
    ....
  10. pmc Innate immune network in the retina activated by optic nerve crush
    Justin P Templeton
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA
    Invest Ophthalmol Vis Sci 54:2599-606. 2013
    ..We have used transcriptome profiling in the mouse to identify a network of genes involved in innate immunity that is present in the normal retina and that is activated by optic nerve crush (ONC)...
  11. ncbi Clinical and functional findings in choroideremia due to complete deletion of the CHM gene
    Marco Mura
    Retinal Degeneration and Ophthalmic Genetics Service, Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Ave, Ste 731, Memphis, TN 38163, USA
    Arch Ophthalmol 125:1107-13. 2007
    ..To report the clinical, functional, and in vivo microanatomic characteristics of a family with choroideremia with a deletion of the entire gene that encodes for the Rab escort protein 1 (CHM)...
  12. pmc Proteomic analysis of the retina: removal of RPE alters outer segment assembly and retinal protein expression
    Xiaofei Wang
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Glia 57:380-92. 2009
    ....
  13. ncbi An unusual X-linked retinoschisis phenotype and biochemical characterization of the W112C RS1 mutation
    Alessandro Iannaccone
    Hamilton Eye Institute, Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Avenue, Suite 731, Memphis, TN 38163, USA
    Vision Res 46:3845-52. 2006
    ....
  14. ncbi Permissive glycan support of photoreceptor outer segment assembly occurs via a non-metabolic mechanism
    Xiaofei Wang
    Retinal Degeneration Research Center, Department of Ophthalmology, The University of Tennessee, Memphis, TN, USA
    Mol Vis 9:701-9. 2003
    ..The present study was undertaken to determine if permissive glycan-mediated support of photoreceptor outer segment assembly occurred via a non-metabolic mechanism and if the phenomenon was reversible...
  15. pmc Early transposable element insertion in intron 9 of the Hsf4 gene results in autosomal recessive cataracts in lop11 and ldis1 mice
    Elijah Talamas
    Department of Ophthalmology, Eye Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Genomics 88:44-51. 2006
    ..In humans, mutations in HSF4 have been associated with both autosomal dominant and recessive cataracts. The lop11 mouse is an excellent resource for evaluating the role of Hsf4 in transparency of the lens...
  16. ncbi Downregulation of a unique photoreceptor protein correlates with improper outer segment assembly
    Amira Wohabrebbi
    Department of Ophthalmology, the Retinal Degeneration Research Center, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci Res 67:298-308. 2002
    ....
  17. pmc Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene
    Amy C Martin
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Invest Ophthalmol Vis Sci 45:3387-96. 2004
    ..The present work addressed the pathogenesis of PHPV in a mouse model that replicates many aspects of the human disease...
  18. pmc Genetic pathways regulating glutamate levels in retinal Müller cells
    Monica M Jablonski
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neurochem Res 36:594-603. 2011
    ....
  19. pmc Novel endogenous glycan therapy for retinal diseases: safety, in vitro stability, ocular pharmacokinetic modeling, and biodistribution
    Shankar Swaminathan
    Department of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, 930 Madison Avenue, Suite 731, Memphis, Tennessee, 38163, USA
    AAPS J 16:311-23. 2014
    ..NA3 was stable at 37°C in vitreous over a minimum of 6 days, while it degraded rapidly in plasma. Collectively, these results document that NA3 shows a good safety profile and favorable ocular pharmacokinetics. ..
  20. pmc Mice with targeted genetic reduction of GABA(A) receptor alpha1 subunits display performance differences in Morris water maze tasks
    Raymond B Berry
    Department of Psychology, The University of Memphis, Memphis, TN 38152, USA
    Neurobiol Learn Mem 90:580-3. 2008
    ..These results suggested that normal performance of the spatial and nonspatial water maze tasks may be dependent upon a natural alpha1 subunit array...
  21. ncbi Clinical evidence of decreased olfaction in Bardet-Biedl syndrome caused by a deletion in the BBS4 gene
    Alessandro Iannaccone
    Hamilton Eye Institute, Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Am J Med Genet A 132:343-6. 2005
    ..This finding broadens the spectrum of clinical manifestations associated with BBS, confirms the role of BBS4 in olfaction, and lends support to the hypothesis that ciliary dysfunction is an important aspect of BBS pathogenesis...
  22. ncbi Synthesis, characterization and in vitro studies of celecoxib-loaded poly(ortho ester) nanoparticles targeted for intraocular drug delivery
    Mallika Palamoor
    Department of Ophthalmology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA Electronic address
    Colloids Surf B Biointerfaces 112:474-82. 2013
    ..These features have the potential to decrease the number of intraocular injections required to treat chronic eye diseases. ..
  23. ncbi Novel topical ophthalmic formulations for management of glaucoma
    Mohammed M Ibrahim
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Avenue, Suite 731, Memphis, Tennessee, 38163, USA
    Pharm Res 30:2818-31. 2013
    ....
  24. ncbi Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration
    Vidyullatha Vasireddy
    Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA
    Invest Ophthalmol Vis Sci 47:4558-68. 2006
    ..To develop and characterize a heterozygous knock-in mouse model carrying the 5-bp deletion in Elovl4 (E_mut+/-) and to study the pathology underlying Stargardt-like macular degeneration (STGD3)...
  25. ncbi Atrophic macular degeneration mutations in ELOVL4 result in the intracellular misrouting of the protein
    Rajesh Ambasudhan
    Kellogg Eye Center, Ophthalmology, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Genomics 83:615-25. 2004
    ..Our observations suggest that the consequences of defective protein trafficking could underlie the molecular mechanism associated with degeneration of the macula in the patients with adMD/STGD3...
  26. ncbi An engineered 800 kilobase deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina
    Ekaterina Semenova
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Hum Mol Genet 12:1301-12. 2003
    ..We suggest that the increase in severity may reflect an interaction between Uchl3 and Lmo7 in the ubiquitin-mediated protein degradation pathway...
  27. ncbi Electroretinographic abnormalities in parents of patients with Leber congenital amaurosis who have heterozygous GUCY2D mutations
    Robert K Koenekoop
    McGill Ocular Genetics Laboratory, Montreal Children s Hospital, McGill University, Montreal, Quebec, Canada
    Arch Ophthalmol 120:1325-30. 2002
    ..In the future, LCA may become treatable by gene and/or pharmacological intervention, and these therapies will likely be gene specific, giving major significance to rapid gene identification and gene-phenotype studies...
  28. ncbi Increasing evidence for syndromic phenotypes associated with RPGR mutations
    Alessandro Iannaccone
    Am J Ophthalmol 137:785-6; author reply 786. 2004
  29. ncbi Stargardt-like macular dystrophy protein ELOVL4 exerts a dominant negative effect by recruiting wild-type protein into aggresomes
    Vidyullatha Vasireddy
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA
    Mol Vis 11:665-76. 2005
    ..To understand the disease mechanism underlying STGD3 we studied the intracellular trafficking of the wild-type and a 5 bp deletion mutant of ELOVL4...
  30. ncbi CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion
    Md Nawajes A Mandal
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
    Invest Ophthalmol Vis Sci 47:5505-13. 2006
    ..The purpose of this study was to characterize the spatial and temporal expression of the mouse Ctrp5 gene, determine tissue and subcellular localization, and study the effect of the S163R mutation...
  31. ncbi Spatial and temporal expression of MFRP and its interaction with CTRP5
    Md Nawajes A Mandal
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
    Invest Ophthalmol Vis Sci 47:5514-21. 2006
    ..The purpose of this study was to characterize the spatial and temporal expression of the mouse Mfrp gene, determine tissue and subcellular localization of MFRP protein, and study its interaction with CTRP5...

Research Grants1

  1. Proteomic Analysis of the Retina
    MONICA JABLONSKI; Fiscal Year: 2007
    ..These studies will also generate the framework for future project periods in which the precise molecular mechanisms and detailed pathways that control photoreceptor outer segment assembly will be determined. ..