Research Topics
| J L IzzoSummaryAffiliation: University at Buffalo Country: USA Publications
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Publications
Differences in mean and variability of heart rate and ambulatory rate-pressure product when valsartan or carvedilol is added to lisinoprilJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Erie County Medical Center, Buffalo, NY, USA
J Am Soc Hypertens 6:399-404. 2012..These effects may contribute to the outcome benefits observed with β-blocker-ACE inhibitor combinations...
Hemodynamic and central blood pressure differences between carvedilol and valsartan added to lisinopril at rest and during exercise stressJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Erie County Medical Center, Buffalo, NY 14215, USA
J Am Soc Hypertens 6:117-23. 2012..Adding V or C to an angiotensin-converting enzyme inhibitor reduced cardiac workload by different mechanisms: vasodilation and reduced central blood pressure with V and lower heart rate with C...
Prehypertension: demographics, pathophysiology, and treatmentJoseph L Izzo
State University of New York at Buffalo, Erie County Medical Center, 462 Grider Street, Buffalo, NY 14216, USA
Curr Hypertens Rep 9:264-8. 2007..Associated elevated risk conditions (prediabetes, hypercholesterolemia, microalbuminuria) may justify early use of ARB therapy (in men and in women without childbearing potential) if weight control fails...
Seasonal variation in haemodynamics and blood pressure-regulating hormonesK J Radke
Department of Medicine, Erie County Medical Center, 462 Grider Street, Buffalo, NY 14215, USA
J Hum Hypertens 24:410-6. 2010..There are dramatic counterregulatory haemodynamic and hormonal adaptations to maintain a relatively constant BP. Norepinephrine, PRA, and aldosterone have a function in mediating the changes in haemodynamics...
Comparative efficacy and safety of amlodipine/benazepril combination therapy and amlodipine monotherapy in severe hypertensionJ L Izzo
Department of Medicine, State University of New York at Buffalo, 462 Grider St, Buffalo, NY 14215, USA
J Hum Hypertens 24:403-9. 2010..We conclude that titration of amlodipine and benazepril in single-pill combinations is more effective than titration of amlodipine alone for rapid BP control in patients with severe hypertension...
Are there benefits of antihypertensive therapy beyond blood pressure lowering?Joseph L Izzo
Erie County Medical Center, State University of New York at Buffalo, 462 Grider Street, Buffalo, NY 14215, USA
Curr Hypertens Rep 12:440-7. 2010..The mandate for BP reduction remains strong in virtually all clinical situations. Because of clinical heterogeneity, however, no single drug class is preferred in all circumstances...
Combined aliskiren-amlodipine treatment for hypertension in African Americans: clinical science and management issuesJoseph L Izzo
Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 462 Grider Street, Buffalo, NY 14215, USA
Ther Adv Cardiovasc Dis 5:169-78. 2011....
Mechanisms and management of hypertensive heart disease: from left ventricular hypertrophy to heart failureJoseph L Izzo
State University of New York at Buffalo, Buffalo, NY 14215, USA
Med Clin North Am 88:1257-71. 2004....
Angiotensin-converting enzyme inhibitorsJoseph L Izzo
Erie County Medical Center and SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
J Clin Hypertens (Greenwich) 13:667-75. 2011....
Benefits of antihypertensive drugs when blood pressure is below 140/90 mmHgJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, New York, USA
Pol Arch Med Wewn 121:303-9. 2011....
Value of Angiotensin receptor blocker therapy in diabetesJoseph L Izzo
Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14215, USA
J Clin Hypertens (Greenwich) 13:290-5. 2011..Thus, ARB therapy is a highly attractive alternative for individuals at any stage of diabetes and with any pattern of complications...
Treating systolic hypertension in the very elderly with valsartan-hydrochlorothiazide vs. either monotherapy: ValVET primary resultsJoseph L Izzo
State University of New York at Buffalo, Buffalo, NY, USA
J Clin Hypertens (Greenwich) 13:722-30. 2011..Thiazide monotherapy was more effective than angiotensin receptor blocker monotherapy (by about 5 mm Hg), but greater antihypertensive efficacy was achieved by initiating treatment with combination valsartan/HCTZ in the elderly...
24-hour efficacy and safety of Triple-Combination Therapy With Olmesartan, Amlodipine, and Hydrochlorothiazide: the TRINITY ambulatory blood pressure substudyJoseph L Izzo
State University of New York at Buffalo, Buffalo, NY 14215, USA
J Clin Hypertens (Greenwich) 13:873-80. 2011..The authors conclude that the triple combination of OM 40 mg/AML 10 mg/HCTZ 25 mg demonstrated superior efficacy and sustained reductions in ABP compared with its dual-combination components...
Pet ownership, but not ace inhibitor therapy, blunts home blood pressure responses to mental stressK Allen
Division of Clinical Pharmacology, Department of Medicine, State University of New York at Buffalo, USA
Hypertension 38:815-20. 2001..9 [0.92] versus 16.1 [0.58] ng. mL(-1). h(-1)). We conclude that ACE inhibitor therapy alone lowers resting blood pressure, whereas increased social support through pet ownership lowers blood pressure response to mental stress...
Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitusB H Sung
Department of Medicine, State University of New York and CGF Millard Fillmore Hospital, Buffalo, NY, USA
Hypertension 34:83-8. 1999..A reduction in vascular resistance may be a primary hemodynamic mechanism of the manner in which troglitazone lowers BP. Insulin sensitizers may offer potential therapeutic advantage in subjects with DM with elevated BP...
Moderately obese, insulin-resistant women exhibit abnormal vascular reactivity to stressB H Sung
Department of Medicine, State University of New York, and Millard Fillmore Health System, Buffalo 14209, USA
Hypertension 30:848-53. 1997..This hyperreactivity may be a marker for future hypertension in obese, normotensive, hyperinsulinemic individuals...
Diameter, pressure and compliance relationships in dorsal hand veinsB E Shykoff
Department of Medicine, University at Buffalo, State University of New York, Buffalo, USA
Vasc Med 6:97-102. 2001..Reactivity depends on distending pressure and baseline P50. Percentage constriction is a function of initial and final P50 and of distending pressure...
Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal womenB H Sung
Department of Medicine, State University of New York and Millard Fillmore Hospital, Buffalo 14209, USA
J Hypertens 17:523-8. 1999..In the present study, we examined the role of estrogen in the blood pressure response to mental stress...
Office blood pressures, arterial compliance characteristics, and estimated cardiac loadJ L Izzo
Department of Medicine, State University of New York at Buffalo, 14209, USA
Hypertension 38:1467-70. 2001..At present, compliance-related variables provide little additional advantage over cuff BP in the office estimation of cardiac work...
Titration of HCTZ to 50 mg daily in individuals with stage 2 systolic hypertension pretreated with an angiotensin receptor blockerJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14215, USA
J Clin Hypertens (Greenwich) 9:45-8. 2007..There was a dose-dependent increase in uric acid but no acute gout attacks. OM 40/HCTZ 50 mg/d is an effective strategy for managing stage 2 systolic hypertension...
Efficacy and safety of treating stage 2 systolic hypertension with olmesartan and olmesartan/HCTZ: results of an open-label titration studyJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14215, USA
J Clin Hypertens (Greenwich) 9:36-44. 2007..The authors conclude that an OM-based regimen, with or without HCTZ in conventional doses, is effective in controlling and normalizing BP in stage 2 systolic hypertension...
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 reportAram V Chobanian
Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
JAMA 289:2560-72. 2003..Empathy builds trust and is a potent motivator. Finally, in presenting these guidelines, the committee recognizes that the responsible physician's judgment remains paramount...
Sympathoadrenal activity, catecholamines, and the pathogenesis of vasculopathic hypertensive target-organ damageJ L Izzo
Department of Medicine, State University of New York, Buffalo
Am J Hypertens 2:305S-312S. 1989..Choosing the optimal antihypertensive drugs may require considering the impact of the drugs on the sympathoadrenal system...
The role of the renin-angiotensin system in vascular health: use of ACE inhibition to improve vascular functionJ L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14209, USA
Heart Dis 2:380-3. 2000....
Hemodynamics of seasonal adaptationJ L Izzo
Department of Medicine, University of Rochester School of Medicine and Dentistry, New York
Am J Hypertens 3:405-7. 1990..Thus, in the northern US, wintertime vasoconstriction is related to increased sympathetic nervous activity and decreased cardiac output. When these reciprocal changes are proportional, blood pressure remains constant...
Antihypertensive efficacy of candesartan-lisinopril in combination vs. up-titration of lisinopril: the AMAZE trialsJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, 462 Grider Street, Buffalo, NY 14215, USA
J Clin Hypertens (Greenwich) 6:485-93. 2004..In conclusion, for hypertensive patients not controlled by lisinopril 20 mg once daily, addition of candesartan (32 mg once daily) or doubling the dose of lisinopril provides safe, additional reduction of blood pressure...
Arterial stiffness and the systolic hypertension syndromeJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, New York, USA
Curr Opin Cardiol 19:341-52. 2004..This review is intended to provide the background for a new comprehensive hemodynamic view of the syndrome of systolic or wide pulse pressure hypertension and its hallmark abnormality: increased central arterial stiffness...
Aging and arterial structure-function relationsJoseph L Izzo
State University of New York at Buffalo, Buffalo, NY 14209, USA
Adv Cardiol 44:19-34. 2007..In the microcirculation, vasoconstriction, VSM hypertrophy and rarefaction accompany and may contribute to changes in organ function...
Calcium channel blockers in hypertension. Is there still a controversy?Joseph L Izzo
Clinical Pharmacology Division, Department of Medicine, State University of New York at Buffalo, Buffalo, USA
Aging Clin Exp Res 17:1-5. 2005..Combinations of CCBs with "anti-neurohumoral" drugs such as ACE inhibitors are particularly useful to achieve sustained blood pressure control, reduce adverse effects such as edema, and improve outcomes...
Acid-suppressive therapy use associated with antihypertensive agentsS L Chow
School of Pharmacy, University at Buffalo, State University of New York, Buffalo, New York, USA
J Clin Pharmacol 41:750-6. 2001..Within the class of CCBs, there was no significant difference among the individual agents. As the clinical and economic burden may be substantial, further study is warranted...
Systolic hypertension, arterial stiffness, and vascular damage: role of the renin-angiotensin systemJ L Izzo
Department of Medicine and Clinical Pharmacology Division, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA
Blood Press Monit 5:S7-11. 2000..The pharmacologic interruption of the renin-angiotensin system may therefore confer previously unrecognized benefits on age-related vascular damage, providing special benefits in systolic hypertension...
Arterial stiffness: clinical relevance, measurement, and treatmentJ L Izzo
State University of New York at Buffalo, USA
Rev Cardiovasc Med 2:29-34, 37-40. 2001..Recent developments, however, suggest that improved clinical recognition of age-related vascular stiffening will lead to better therapy and improved outcomes for patients with hypertension...
Humoral effect of norepinephrine on renin release in humansM R Licht
Department of Medicine, University of Rochester Medical Center, New York
Am J Hypertens 2:788-91. 1989..02). This differential effect of alpha-agonists on PRA defines an important humoral effect of NE, which should be considered to be a "cardiovascular hormone."..
Clinical impact of renin-angiotensin system blockade: angiotensin-converting enzyme inhibitors vs. angiotensin receptor antagonistsJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14209, USA
J Clin Hypertens (Greenwich) 4:11-9, 31. 2002....
Your drug, my drug, or our drugs: how aggressive should we be with antihypertensive therapy?Joseph L Izzo
Erie County Medical Center and the Department of Medicine, Division of Clinical Pharmacology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14215, USA
J Clin Hypertens (Greenwich) 7:5-7. 2005..In summary, why would an astute clinician (or informed patient) be satisfied with the relatively limited effects of any single class of antihypertensive agents when better overall protection is possible?..
Pulse contour analysis and augmentation index: it's time to move beyond cuff blood pressure measurementJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, New York, USA
Am J Hypertens 18:1S-2S. 2005
ASH position paper: treatment of hypertension in patients with diabetes-an updateGeorge L Bakris
Hypertensive Diseases and Diabetes Center, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
J Clin Hypertens (Greenwich) 10:707-13; discussion 714-5. 2008..Last, an updated algorithm is provided that incorporates many of the new findings and is suggested as a starting point to achieve blood pressure goals...
Effects of cholesterol reduction on BP response to mental stress in patients with high cholesterolB H Sung
Department of Medicine, State University of New York and Millard Fillmore Health Care System, Buffalo 14209, USA
Am J Hypertens 10:592-9. 1997..Decreased BP reactivity during HMG-CoA reductase inhibitor therapy suggests that lowering cholesterol may have a role in the overall control of BP...
Hypertension in the metabolic syndrome and diabetes: pathogenesis, clinical studies, and treatmentJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14209, USA
J Clin Hypertens (Greenwich) 5:3-10. 2003....
ASH Position Paper: Dietary approaches to lower blood pressureLawrence J Appel
Department of Medicine, Division of General Internal Medicine, Johns Hopkins University, Baltimore, MD 21205 2223, USA
J Clin Hypertens (Greenwich) 11:358-68. 2009..The current challenge is designing and implementing effective clinical and public health interventions that lead to sustained dietary changes among individuals and more broadly in the general population...
Improved medical records improve hypertension management: a wake up call to payers and providersJoseph L Izzo
Department of Medicine, State University of New York at Buffalo, 14209, USA
J Clin Hypertens (Greenwich) 4:413-4. 2002
Is postural adaptation impaired by hardened arteries?Joseph L Izzo
Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14215, USA
Am J Geriatr Cardiol 14:262-4. 2005
Validity and reliability of diastolic pulse contour analysis (windkessel model) in humansTimothy S Manning
Division of Clinical Pharmacology, Department of Medicine, State University of New York at Buffalo, NY, USA
Hypertension 39:963-8. 2002..The validity and utility of Windkessel-derived variables is further diminished by the absence of between-site correlations and the common occurrence of uninterpretable values in hypertensive subjects...
Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research studyGary F Mitchell
Cardiovascular Engineering, Inc, Holliston, Mass 01746, USA
Circulation 105:2955-61. 2002....
Efficacy of the combination of amlodipine and valsartan in patients with hypertension uncontrolled with previous monotherapy: the Exforge in Failure after Single Therapy (EX-FAST) studyYves Allemann
Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Inselspital, Bern, Switzerland
J Clin Hypertens (Greenwich) 10:185-94. 2008..These results provide support for the BP-lowering benefits of complementary antihypertensive therapy with amlodipine and valsartan in patients with hypertension uncontrolled by previous monotherapy...
Determinants of elevated pulse pressure in middle-aged and older subjects with uncomplicated systolic hypertension: the role of proximal aortic diameter and the aortic pressure-flow relationshipGary F Mitchell
Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, Mass 01746, USA
Circulation 108:1592-8. 2003....
Hypertensive emergenciesMarvin Moser
Yale University School of Medicine, New Haven, CT, USA
J Clin Hypertens (Greenwich) 8:275-81. 2006..Joseph L. Izzo, Jr., Professor of Medicine at the State University of New York at Buffalo, Buffalo, NY, and Dr. John Bisognano, Associate Professor of Medicine at the University of Rochester School of Medicine, Rochester, NY...
Changes in aortic stiffness and augmentation index after acute converting enzyme or vasopeptidase inhibitionGary F Mitchell
Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
Hypertension 46:1111-7. 2005..Our findings indicate that AI is a complex surrogate marker that is inversely related to changes in proximal aortic stiffness in systolic hypertension...
Expanding the definition and classification of hypertensionThomas D Giles
Louisiana State University School of Medicine, New Orleans, LA 70112, USA
J Clin Hypertens (Greenwich) 7:505-12. 2005..We believe it would be preferable to classify all individuals as either normal or hypertensive, based on their cardiovascular evaluation, using the four categories of normal and stages 1, 2, and 3 hypertension...
Prehypertension--what is it and should it be treated?Marvin Moser
J Clin Hypertens (Greenwich) 8:812-8. 2006
First-step use of fixed-dose combination treatment in stage 2 hypertensive patients: has the time come?Michael A Weber
SUNY Downstate College of Medicine, New York, New York, USA
J Clin Hypertens (Greenwich) 9:276-84. 2007
Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureAram V Chobanian
Boston University School of Medicine, Boston, Mass, USA
Hypertension 42:1206-52. 2003..Positive experiences, trust in the clinician, and empathy improve patient motivation and satisfaction. This report serves as a guide, and the committee continues to recognize that the responsible physician's judgment remains paramount...
Aortic diameter, wall stiffness, and wave reflection in systolic hypertensionGary F Mitchell
Cardiovascular Engineering Inc, University Office Park, Bldg 2, Suite 100, 51 Sawyer Road, Waltham, MA 02453, USA
Hypertension 51:105-11. 2008..Among individuals with systolic hypertension, increased PP is primarily attributable to increased wall stiffness and reduced aortic diameter rather than premature wave reflection...
Augmentation index and central aortic stiffness in middle-aged to elderly individualsMitul Vyas
Cardiovascular Engineering, Inc, Waltham, Massachusetts 02453, USA
Am J Hypertens 20:642-7. 2007..We evaluated this hypothesis by investigating relations between AI and other direct measures of aortic stiffness...
The role of therapeutic inertia and the use of fixed-dose combination therapy in the management of hypertensionJan Basile
Ralph H. Johnson VA Medical Center, Charleston, SC, USA
J Clin Hypertens (Greenwich) 9:636-45. 2007
Plasma renin measurement in the management of hypertension: the V and R hypothesisMarvin Moser
J Clin Hypertens (Greenwich) 5:373-6. 2003
Preventing microalbuminuria in patients with diabetes: rationale and design of the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) studyHermann Haller
Nephrology Section, Hanover Medical School, Hanover, Germany
J Hypertens 24:403-8. 2006..The ROADMAP study will answer the question whether an ARB can prevent or delay the onset of microalbuminuria and whether this translates into protection against cardiovascular events and renal disease...
Graded blood pressure reduction in hypertensive outpatients associated with use of a device to assist with slow breathingWilliam J Elliot
Department of Preventive Medicine, Rush Medical College of Rush University, Rush University Medical Center, Chicago, IL 60612, USA
J Clin Hypertens (Greenwich) 6:553-9; quiz 560-1. 2004....
Pulsology rediscovered: commentary on the Conduit Artery Function Evaluation (CAFE) studySuzanne Oparil
Circulation 113:1162-3. 2006
The use of renin inhibitors in the management of hypertensionMarvin Moser
Yale University School of Medicine, New Haven, CT, USA
J Clin Hypertens (Greenwich) 9:701-5. 2007
Device-guided breathing to lower blood pressure: case report and clinical overviewWilliam J Elliott
Rush Medical College, Chicago, Illinois, USA
MedGenMed 8:23. 2006..Device-guided paced breathing may offer an effective, simple, and new nonpharmacologic option for treating high BP without additional side effects, but like all lifestyle modifications, must be practiced consistently to provide benefits...
Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and PreventiClive Rosendorff
Veterans Health Administration, USA
Circulation 115:2761-88. 2007
Stagnation and the critical need for hypertension subtypingJoseph L Izzo
J Clin Hypertens (Greenwich) 10:174-5. 2008
