Ramaswamy K Iyer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Cloning and characterization of human agmatinase
    Ramaswamy K Iyer
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1732, USA
    Mol Genet Metab 75:209-18. 2002
  2. pmc Mouse model for human arginase deficiency
    Ramaswamy K Iyer
    Department of Pathology and Laboratory Medicine and the Mental Retardation Research Center, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
    Mol Cell Biol 22:4491-8. 2002
  3. ncbi request reprint Polyamine homeostasis in arginase knockout mice
    Joshua L Deignan
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Am J Physiol Cell Physiol 293:C1296-301. 2007
  4. ncbi request reprint Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia
    Joshua L Deignan
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    Mol Genet Metab 93:172-8. 2008
  5. ncbi request reprint Ornithine deficiency in the arginase double knockout mouse
    Joshua L Deignan
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mol Genet Metab 89:87-96. 2006
  6. ncbi request reprint Widespread expression of arginase I in mouse tissues. Biochemical and physiological implications
    Hong Yu
    Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1732, USA
    J Histochem Cytochem 51:1151-60. 2003
  7. ncbi request reprint Arginase expression in mouse embryonic development
    Hong Yu
    Mental Retardation Research Center, UCLA, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Mech Dev 115:151-5. 2002
  8. ncbi request reprint Expression of the liver form of arginase in erythrocytes
    Phillip S Kim
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, 10833 Le Conte Avenue, 90095 1732, USA
    Mol Genet Metab 76:100-10. 2002
  9. ncbi request reprint Arginases I and II: do their functions overlap?
    Stephen D Cederbaum
    Department of Psychiatry, David Geffen School of Medicine at the University of California, Los Angeles, USA
    Mol Genet Metab 81:S38-44. 2004
  10. pmc A novel method for creating artificial mutant samples for performance evaluation and quality control in clinical molecular genetics
    Michael Jarvis
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095 1732, USA
    J Mol Diagn 7:247-51. 2005

Collaborators

  • H Yu
  • Wayne W Grody
  • Stephen Cederbaum
  • Stephen I Goodman
  • Anthony E Pegg
  • Lisa Shantz
  • Joshua L Deignan
  • Justin C Livesay
  • William E O'Brien
  • Sara G Becker-Catania
  • Michael Jarvis
  • Phillip S Kim
  • Alain P Gobert
  • Bart Marescau
  • Peter P De Deyn
  • Yawei Yang
  • Teresa L Gregory
  • Chia Ling Gau
  • Paul K Yoo
  • Jean de Vellis
  • Laurina O Williams
  • Walter W Noll
  • Kirk Thomas
  • Milhan Telatar
  • Robert A Casero
  • Denice K Tai
  • Jean Luc Boucher
  • Keith T Wilson
  • Ardeshir Karimi
  • Rita M Kern
  • Yulan Cheng
  • Jamie C Newton
  • Jian Ying Wang
  • Kan V Lu

Detail Information

Publications12

  1. ncbi request reprint Cloning and characterization of human agmatinase
    Ramaswamy K Iyer
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1732, USA
    Mol Genet Metab 75:209-18. 2002
    ..It has 56% similarity to E. coli agmatinase and 42% similarity to human arginases I and II and shares highly conserved substrate-binding domains with these well-characterized enzymes...
  2. pmc Mouse model for human arginase deficiency
    Ramaswamy K Iyer
    Department of Pathology and Laboratory Medicine and the Mental Retardation Research Center, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
    Mol Cell Biol 22:4491-8. 2002
    ....
  3. ncbi request reprint Polyamine homeostasis in arginase knockout mice
    Joshua L Deignan
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Am J Physiol Cell Physiol 293:C1296-301. 2007
    ..These results suggest that endogenous arginase-derived ornithine may not directly contribute to polyamine homeostasis in mice. Alternate sources such as diet may provide sufficient polyamines for maintenance in mammalian tissues...
  4. ncbi request reprint Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia
    Joshua L Deignan
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    Mol Genet Metab 93:172-8. 2008
    ....
  5. ncbi request reprint Ornithine deficiency in the arginase double knockout mouse
    Joshua L Deignan
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mol Genet Metab 89:87-96. 2006
    ..Although most human AI-deficient patients have no symptomatic hyperammonemia at birth, it is possible that clinically significant ornithine deficiency is already present...
  6. ncbi request reprint Widespread expression of arginase I in mouse tissues. Biochemical and physiological implications
    Hong Yu
    Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1732, USA
    J Histochem Cytochem 51:1151-60. 2003
    ....
  7. ncbi request reprint Arginase expression in mouse embryonic development
    Hong Yu
    Mental Retardation Research Center, UCLA, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Mech Dev 115:151-5. 2002
    ..The strong AI expression in the peripheral nervous system suggests that the pathogenesis of the neurological retardation in AI deficiency may be conditioned by AI deficiency in the nervous system during embryonic development...
  8. ncbi request reprint Expression of the liver form of arginase in erythrocytes
    Phillip S Kim
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, 10833 Le Conte Avenue, 90095 1732, USA
    Mol Genet Metab 76:100-10. 2002
    ....
  9. ncbi request reprint Arginases I and II: do their functions overlap?
    Stephen D Cederbaum
    Department of Psychiatry, David Geffen School of Medicine at the University of California, Los Angeles, USA
    Mol Genet Metab 81:S38-44. 2004
    ..Finally, prenatal diagnosis appears to be possible as was predicted, but never proven, some years ago...
  10. pmc A novel method for creating artificial mutant samples for performance evaluation and quality control in clinical molecular genetics
    Michael Jarvis
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095 1732, USA
    J Mol Diagn 7:247-51. 2005
    ....
  11. ncbi request reprint Loss of arginase I results in increased proliferation of neural stem cells
    Sara G Becker-Catania
    Edward Hines Jr Veterans Administration Hospital, Hines, Illinois, USA
    J Neurosci Res 84:735-46. 2006
    ..The consequence of these changes may contribute to the differential phenotypes of KO vs. WT cells. It appears that AI may play an important and unanticipated role in growth and development of NSCs...
  12. ncbi request reprint Helicobacter pylori induces macrophage apoptosis by activation of arginase II
    Alain P Gobert
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
    J Immunol 168:4692-700. 2002
    ..pylori gastritis tissues, indicating the likely in vivo relevance of our findings. Therefore, we describe arginase- and ODC-dependent macrophage apoptosis, which implicates polyamines in the pathophysiology of H. pylori infection...