Ramaswamy K Iyer
Affiliation: University of California
- Cloning and characterization of human agmatinaseRamaswamy K Iyer
Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1732, USA
Mol Genet Metab 75:209-18. 2002..It has 56% similarity to E. coli agmatinase and 42% similarity to human arginases I and II and shares highly conserved substrate-binding domains with these well-characterized enzymes...
- Mouse model for human arginase deficiencyRamaswamy K Iyer
Department of Pathology and Laboratory Medicine and the Mental Retardation Research Center, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
Mol Cell Biol 22:4491-8. 2002....
- Polyamine homeostasis in arginase knockout miceJoshua L Deignan
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
Am J Physiol Cell Physiol 293:C1296-301. 2007..These results suggest that endogenous arginase-derived ornithine may not directly contribute to polyamine homeostasis in mice. Alternate sources such as diet may provide sufficient polyamines for maintenance in mammalian tissues...
- Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemiaJoshua L Deignan
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
Mol Genet Metab 93:172-8. 2008....
- Ornithine deficiency in the arginase double knockout mouseJoshua L Deignan
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Mol Genet Metab 89:87-96. 2006..Although most human AI-deficient patients have no symptomatic hyperammonemia at birth, it is possible that clinically significant ornithine deficiency is already present...
- Widespread expression of arginase I in mouse tissues. Biochemical and physiological implicationsHong Yu
Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1732, USA
J Histochem Cytochem 51:1151-60. 2003....
- Arginase expression in mouse embryonic developmentHong Yu
Mental Retardation Research Center, UCLA, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
Mech Dev 115:151-5. 2002..The strong AI expression in the peripheral nervous system suggests that the pathogenesis of the neurological retardation in AI deficiency may be conditioned by AI deficiency in the nervous system during embryonic development...
- Expression of the liver form of arginase in erythrocytesPhillip S Kim
Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, 10833 Le Conte Avenue, 90095 1732, USA
Mol Genet Metab 76:100-10. 2002....
- Arginases I and II: do their functions overlap?Stephen D Cederbaum
Department of Psychiatry, David Geffen School of Medicine at the University of California, Los Angeles, USA
Mol Genet Metab 81:S38-44. 2004..Finally, prenatal diagnosis appears to be possible as was predicted, but never proven, some years ago...
- A novel method for creating artificial mutant samples for performance evaluation and quality control in clinical molecular geneticsMichael Jarvis
Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095-1732, USA
J Mol Diagn 7:247-51. 2005....
- Loss of arginase I results in increased proliferation of neural stem cellsSara G Becker-Catania
Edward Hines Jr Veterans Administration Hospital, Hines, Illinois, USA
J Neurosci Res 84:735-46. 2006..The consequence of these changes may contribute to the differential phenotypes of KO vs. WT cells. It appears that AI may play an important and unanticipated role in growth and development of NSCs...
- Helicobacter pylori induces macrophage apoptosis by activation of arginase IIAlain P Gobert
Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
J Immunol 168:4692-700. 2002..pylori gastritis tissues, indicating the likely in vivo relevance of our findings. Therefore, we describe arginase- and ODC-dependent macrophage apoptosis, which implicates polyamines in the pathophysiology of H. pylori infection...