Research Topics
| Joachim IxSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Fractional excretion of phosphorus modifies the association between fibroblast growth factor-23 and outcomesJulie R Dominguez
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
J Am Soc Nephrol 24:647-54. 2013..In summary, associations of FGF23 with mortality and CVD events are stronger in persons with lower FePi independent of PTH and kidney function. In such individuals, the renal tubular response to FGF23 may be suboptimal...- Test characteristics of the ankle-brachial index and ankle-brachial difference for medial arterial calcification on X-ray in type 1 diabetesJoachim H Ix
Nephrology Section, Veterans Affairs San Diego Healthcare System, University of California, San Diego, San Diego, Calif 92161, USA
J Vasc Surg 56:721-7. 2012..We hypothesized that an ABI >1.30 and ABD >75 mm Hg would have high specificity but low sensitivity for MAC on X-ray imaging... 
Fetuin-A is inversely associated with coronary artery calcification in community-living persons: the Multi-Ethnic Study of AtherosclerosisJoachim H Ix
Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
Clin Chem 58:887-95. 2012..Fetuin-A is a hepatic secretory protein that inhibits arterial calcification in vitro. The association of fetuin-A with coronary arterial calcification (CAC) in the general population is uncertain...- Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health studyJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego VA Healthcare System, San Diego, CA 92161, USA
Circulation 125:2316-22. 2012..We sought to confirm the association of fetuin-A with incident diabetes mellitus in older persons and to determine whether the association differs by age, sex, and race and among persons with cardiovascular disease (CVD)... - Influence of urine creatinine on the relationship between the albumin-to-creatinine ratio and cardiovascular eventsCaitlin E Carter
Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, USA
Clin J Am Soc Nephrol 7:595-603. 2012..Cox regression evaluated associations of spot-ACR and 24hr-UAE with CVD events by sex, weight, and age... - Interdialytic creatinine change versus predialysis creatinine as indicators of nutritional status in maintenance hemodialysisCarl P Walther
Department of Medicine, University of California San Diego, San Diego, CA, USA
Nephrol Dial Transplant 27:771-6. 2012..Predialysis creatinine levels are associated with mortality risk but may be influenced by both muscle mass and dialysis dose. This might be overcome by examining the rate of rise in creatinine between dialysis sessions... - Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fracturesBenjamin D Parker
Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA
Calcif Tissue Int 86:185-91. 2010..87). In conclusion, among community-living older women, serum OC is not associated with AAC. These findings suggest that serum OC levels may more closely reflect bone formation than vascular calcification in humans... - Equations to estimate creatinine excretion rate: the CKD epidemiology collaborationJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
Clin J Am Soc Nephrol 6:184-91. 2011..Creatinine excretion rate (CER) indicates timed urine collection accuracy. Although equations to estimate CER exist, their bias and precision are untested and none simultaneously include age, sex, race, and weight... - Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study)Joachim H Ix
Department of Medicine, University of California San Diego, USA
J Am Coll Cardiol 54:1176-84. 2009..This study sought to determine the association of chronic kidney disease (CKD) with high ankle brachial index (ABI) measurement and to compare its strength with that of CKD with a low ABI... - Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESAJoachim H Ix
Department of Medicine, Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA 92161, USA
Clin J Am Soc Nephrol 4:609-15. 2009..Higher phosphorus levels are associated with cardiovascular disease (CVD) events and mortality. Whether vascular stiffness may be responsible is unknown... - Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) studyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
J Bone Miner Res 24:514-21. 2009..Future studies should evaluate whether fetuin-A may refine fracture risk assessment in older women... - Epidemiology and diagnosis of peripheral arterial disease in patients with chronic kidney diseaseJoachim H Ix
Department of Medicine, Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA 92161, USA
Adv Chronic Kidney Dis 15:378-83. 2008..To that end, we review the epidemiology and diagnosis of atherosclerotic PAD and medical arterial calcification in patients with CKD... - Fetuin-A and change in body composition in older personsJoachim H Ix
Division of Nephrology, Department of Medicine, and Division of Preventive Medicine, University of California San Diego, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
J Clin Endocrinol Metab 94:4492-8. 2009..Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown... - Fibroblast growth factor-23 and early decrements in kidney function: the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, CA, USA
Nephrol Dial Transplant 25:993-7. 2010..The threshold of CKD or albuminuria at which FGF-23 begins to change is unknown... - A high ankle brachial index is associated with greater left ventricular mass MESA (Multi-Ethnic Study of Atherosclerosis)Joachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California 92161, USA
J Am Coll Cardiol 55:342-9. 2010..This study sought to determine the association of high ankle brachial index (ABI) measurements with left ventricular (LV) mass, and to compare its strength with that of low ABI with LV mass... - Urinary creatinine excretion rate and mortality in persons with coronary artery disease: the Heart and Soul StudyJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and VA San Diego Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
Circulation 121:1295-303. 2010..In persons with coronary artery disease, low body mass index is associated with greater mortality; however, it is uncertain whether low muscle mass is a risk factor for mortality in this setting... - Relation of sex and estrogen therapy to serum fibroblast growth factor 23, serum phosphorus, and urine phosphorus: the Heart and Soul StudyJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92161, USA
Am J Kidney Dis 58:737-45. 2011..Fibroblast growth factor 23 (FGF-23) is a hormone originating from bone that regulates urine phosphorus excretion. Whether sex or estrogen therapy is associated with different FGF-23 levels is unknown... - The associations of fetuin-A with subclinical cardiovascular disease in community-dwelling persons: the Rancho Bernardo StudyJoachim H Ix
Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
J Am Coll Cardiol 58:2372-9. 2011..The aim of this study was to determine the association of fetuin-A with subclinical cardiovascular disease (CVD) in community-living individuals... - Fetuin-A and incident diabetes mellitus in older personsJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
JAMA 300:182-8. 2008..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown... - Association of mild to moderate kidney dysfunction and coronary calcificationJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
J Am Soc Nephrol 19:579-85. 2008..These results suggest that a higher burden of CAC is unlikely to explain the association between mild to moderate kidney dysfunction and cardiovascular mortality... - Association of body mass index with peripheral arterial disease in older adults: the Cardiovascular Health StudyJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego and San Diego VA HealthCare System, San Diego, CA 92161, USA
Am J Epidemiol 174:1036-43. 2011..00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age... 
Fetuin-A is not associated with mortality in chronic kidney diseaseJ H Ix
Division of Nephrology and Hypertension, University of California San Diego, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
Kidney Int 72:1394-9. 2007..Our study shows that serum fetuin-A levels are not related to all-cause or cardiovascular mortality among persons with predominantly non-diabetic stage 3 or 4 CKD...- Cystatin C identifies chronic kidney disease patients at higher risk for complicationsCarmen A Peralta
San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
J Am Soc Nephrol 22:147-55. 2011..Cystatin C may have a role in identifying persons with CKD who have the highest risk for complications... - Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
Nephrol Dial Transplant 21:2144-51. 2006..Whether fetuin-A concentrations are also lower in the setting of mild-to-moderate chronic kidney disease (CKD) is unknown... - Genetic ancestry and lower extremity peripheral artery disease in the Multi-Ethnic Study of AtherosclerosisMatthew A Allison
Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0965, USA
Vasc Med 15:351-9. 2010.... - Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of AtherosclerosisBryan R Kestenbaum
Division of Nephrology, Department of Medicine, Harborview Medical Center, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
Kidney Int 76:991-8. 2009..Our study shows that coronary artery calcification is common in people with stage 3 disease, progresses rapidly, and may contribute to cardiovascular risk... - Racial and ethnic differences in kidney function decline among persons without chronic kidney diseaseCarmen A Peralta
Department of Medicine, University of California San Francisco, San Francisco, California 94121, USA
J Am Soc Nephrol 22:1327-34. 2011..Traditional risk factors do not explain these differences fully, highlighting the need to explore these disparities... - Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
Circulation 115:2533-9. 2007..Lower serum fetuin-A concentrations are associated with valvular calcification in persons with end-stage renal disease. Whether fetuin-A is associated with valvular calcification in other patient populations is unknown... - Obesity and change in estimated GFR among older adultsIan H De Boer
Division of Nephrology, University of Washington, Seattle, WA 98195, USA
Am J Kidney Dis 54:1043-51. 2009..Obesity assessed in midlife has been associated with chronic kidney disease... - Relation of kidney function and albuminuria with atrial fibrillation (from the Heart and Soul Study)David D McManus
Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of Massachusetts, Worcester, Massachusetts, USA
Am J Cardiol 104:1551-5. 2009..36, 95% CI 1.45 to 13.05) or eGFR(Cr) (OR 4.61, 95% CI 1.56 to 13.66). In conclusion, among outpatients with coronary artery disease, lower eGFR(cys) and higher ACR were associated with prevalent AF, independent of each other... - Kidney function and systolic blood pressure new insights from cystatin C: data from the Heart and Soul StudyCarmen A Peralta
General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, San Francisco, California 94124, USA
Am J Hypertens 19:939-46. 2006..Whether kidney function in the normal range is associated with systolic BP (SBP), diastolic BP (DBP), and pulse pressure is unclear... - Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul StudyDavid Singh
Department of Medicine, University of California, San Francisco, CA 94121, USA
Nephrol Dial Transplant 22:1087-92. 2007..In this study, we compared the relative strengths of association of cystatin C and estimated glomerular filtration rate (eGFR) with inflammatory biomarkers... - Racial differences in the association of pentraxin-3 with kidney dysfunction: the Multi-Ethnic Study of AtherosclerosisRuth Dubin
Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, CA, USA
Nephrol Dial Transplant 26:1903-8. 2011..Pentraxin-3 (PTX3), an inflammatory marker thought to be related to vascular inflammation, is elevated in advanced chronic kidney disease (CKD). Whether PTX3 is associated with mild to moderate kidney dysfunction is unknown... - Novel cardiovascular risk factors do not completely explain the higher prevalence of peripheral arterial disease among African Americans. The San Diego Population StudyJoachim H Ix
Department of Medicine, University of California, San Diego, San Diego, California 92161, USA
J Am Coll Cardiol 51:2347-54. 2008..This study was designed to determine whether novel cardiovascular disease (CVD) risk factors explain the high prevalence of peripheral arterial disease (PAD) among African Americans... - Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California at San Francisco, San Francisco, CA 94143 0532, USA
Circulation 115:173-9. 2007..Cystatin C is a novel and sensitive endogenous marker of kidney function. Whether cystatin C concentrations are associated with adverse events among ambulatory persons with CHD is unknown... - Risk factor differences for aortic versus coronary calcified atherosclerosis: the multiethnic study of atherosclerosisMichael H Criqui
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
Arterioscler Thromb Vasc Biol 30:2289-96. 2010..The goal of this study was to compare and contrast coronary artery calcium (CAC) with abdominal aortic calcium (AAC) in terms of their associations with traditional and novel cardiovascular disease (CVD) risk factors... - The ankle-brachial index and incident cardiovascular events in the MESA (Multi-Ethnic Study of Atherosclerosis)Michael H Criqui
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0607, USA
J Am Coll Cardiol 56:1506-12. 2010..The purpose of this study was to examine the association of both a low and a high ankle-brachial index (ABI) with incident cardiovascular events in a multiethnic cohort... - N-acetylcysteine for the prevention of contrast-induced nephropathy. A systematic review and meta-analysisRaymond Liu
Department of Medicine, University of California, San Francisco, CA, USA
J Gen Intern Med 20:193-200. 2005..We conducted a systematic review to determine whether administering N-acetylcysteine around the time of contrast administration reduces the risk of contrast-induced nephropathy... - Association of chronic kidney disease with clinical outcomes after coronary revascularization: the Arterial Revascularization Therapies Study (ARTS)Joachim H Ix
Department of Medicine, University of California, San Francisco, Calif, USA
Am Heart J 149:512-9. 2005..When compared with ARTS participants with normal renal function, those with CKD had substantially elevated risk of adverse clinical outcomes after coronary revascularization... - The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul StudyBenjamin D Parker
Division of Nephrologyand Hypertension, Department of Medicine, University of California San Diego, CA 92161, USA
Ann Intern Med 152:640-8. 2010..Whether circulating levels of each are associated with cardiovascular disease (CVD) events or mortality in populations without end-stage renal disease is unknown... - Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men studyJerry Meng
Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
Kidney Int 78:415-22. 2010..The mechanism responsible for the association of testosterone with serum phosphorus remains to be determined... - Serum phosphorus levels and the spectrum of ankle-brachial index in older men: the Osteoporotic Fractures in Men (MrOS) studyJerry Meng
Division of Nephrology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
Am J Epidemiol 171:909-16. 2010..These associations may explain the link between serum phosphorus levels and CVD events... - Kidney function and aortic valve and mitral annular calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)Joachim H Ix
Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
Am J Kidney Dis 50:412-20. 2007..Whether less severe kidney dysfunction is associated with AVC and MAC is uncertain... - Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143-0532, USA
J Card Fail 12:601-7. 2006..83; 95% CI 0.75 to 4.46; P = .15). CONCLUSION: Higher cystatin C concentrations are strongly associated with left ventricular hypertrophy and diastolic dysfunction in outpatients with coronary artery disease and without heart failure... - Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul StudyBenjamin D Parker
Division of Nephrology and Hypertension, Department of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
Nephrol Dial Transplant 24:2095-101. 2009..Whether mild to moderate decrements in kidney function are associated with lower serum ucMGP is unknown... - Theophylline for the prevention of radiocontrast nephropathy: a meta-analysisJoachim H Ix
Division of Nephrology, Department of Medicine Research, University of California San Francisco, San Francisco, California, USA
Nephrol Dial Transplant 19:2747-53. 2004..Whether these agents reduce the proportion of patients who experience large decrements in serum creatinine concentration, or require dialysis, is unknown... - The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul studyBenjamin D Parker
Department of Medicine, Division of Nephrology, University of California, San Diego, United States
Atherosclerosis 210:320-5. 2010..Matrix Gla protein (MGP) is an inhibitor of vascular calcification and lower levels of its precursor - uncarboxylated MGP (ucMGP) - are associated with vascular calcification in pilot studies... - Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPKJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego Veterans Affairs San Diego Healthcare System, CA 92093 0711, USA
J Am Soc Nephrol 21:406-12. 2010..Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity... - Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
Circulation 113:1760-7. 2006..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease... - Association between renal insufficiency and inducible ischemia in patients with coronary artery disease: the heart and soul studyJoachim H Ix
Department of Medicine, University of California, San Francisco, San Francisco, California 94121, USA
J Am Soc Nephrol 14:3233-8. 2003..The greater severity of atherosclerotic disease observed in patients with CRI may in part explain the association of CRI with increased cardiovascular risk among individuals with CAD... - Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosisBrent W Kinder
Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Chest 133:226-32. 2008..We hypothesized that baseline BAL fluid cell count differential (ie, elevated levels of neutrophils and eosinophils, or reduced levels of lymphocytes) would predict higher mortality among persons with IPF... - Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul StudyMichael G Shlipak
Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif, USA
Am J Med 121:50-7. 2008..The study purpose was to evaluate the ability of 6 biomarkers to improve the prediction of cardiovascular events among persons with established coronary artery disease... - Association of cystatin C with poor exercise capacity and heart rate recovery: data from the heart and soul studyDavid McManus
Cardiology Division, University of Massachusetts, Worcester, MA, USA
Am J Kidney Dis 49:365-72. 2007..We hypothesized that serum cystatin C concentration would have a stronger more linear association with cardiovascular functional status than creatinine-based measures in outpatients with established coronary heart disease (CHD)... - Utility of cystatin C measurement--precision or secretion?Joachim H Ix
Nephrol Dial Transplant 21:3614. 2006
Research Grants
- Fetuin-A and Incident Cardiovascular Disease, Fracture, and DiabetesJoachim Ix; Fiscal Year: 2009..The results of this epidemiologic study will provide novel insights into their pathogenesis and may ultimately identify novel therapeutic targets for their prevention or treatment. ..
- Fetuin-A and Incident Cardiovascular Disease, Fracture, and DiabetesJoachim H Ix; Fiscal Year: 2010..The results of this epidemiologic study will provide novel insights into their pathogenesis and may ultimately identify novel therapeutic targets for their prevention or treatment. ..