Joachim H Ix

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California at San Francisco, San Francisco, CA 94143 0532, USA
    Circulation 115:173-9. 2007
  2. pmc Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Circulation 115:2533-9. 2007
  3. ncbi request reprint Guidelines for disorders of mineral metabolism and secondary hyperparathyroidism should not yet be modified
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, CA 94143 0532, USA
    Nat Clin Pract Nephrol 2:337-9. 2006
  4. pmc Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Nephrol Dial Transplant 21:2144-51. 2006
  5. pmc Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Circulation 113:1760-7. 2006
  6. pmc Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis
    Bryan R Kestenbaum
    Division of Nephrology, Department of Medicine, Harborview Medical Center, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Kidney Int 76:991-8. 2009
  7. pmc Chronic kidney disease, insulin resistance, and incident diabetes in older adults
    Hien Pham
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, 98195, USA
    Clin J Am Soc Nephrol 7:588-94. 2012
  8. pmc Obesity and change in estimated GFR among older adults
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Am J Kidney Dis 54:1043-51. 2009
  9. pmc Parathyroid hormone and arterial dysfunction in the multi-ethnic study of atherosclerosis
    Cortney Bosworth
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Endocrinol (Oxf) 79:429-36. 2013
  10. pmc Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego VA Healthcare System, San Diego, CA 92161, USA
    Circulation 125:2316-22. 2012

Detail Information

Publications79

  1. pmc Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California at San Francisco, San Francisco, CA 94143 0532, USA
    Circulation 115:173-9. 2007
    ..Cystatin C is a novel and sensitive endogenous marker of kidney function. Whether cystatin C concentrations are associated with adverse events among ambulatory persons with CHD is unknown...
  2. pmc Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Circulation 115:2533-9. 2007
    ..Lower serum fetuin-A concentrations are associated with valvular calcification in persons with end-stage renal disease. Whether fetuin-A is associated with valvular calcification in other patient populations is unknown...
  3. ncbi request reprint Guidelines for disorders of mineral metabolism and secondary hyperparathyroidism should not yet be modified
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, CA 94143 0532, USA
    Nat Clin Pract Nephrol 2:337-9. 2006
    ..The focus should be on evaluating the effects of alternative strategies on survival, as well as clinical manifestations of cardiovascular and bone disease...
  4. pmc Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Nephrol Dial Transplant 21:2144-51. 2006
    ..Whether fetuin-A concentrations are also lower in the setting of mild-to-moderate chronic kidney disease (CKD) is unknown...
  5. pmc Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Circulation 113:1760-7. 2006
    ..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease...
  6. pmc Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis
    Bryan R Kestenbaum
    Division of Nephrology, Department of Medicine, Harborview Medical Center, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Kidney Int 76:991-8. 2009
    ..Our study shows that coronary artery calcification is common in people with stage 3 disease, progresses rapidly, and may contribute to cardiovascular risk...
  7. pmc Chronic kidney disease, insulin resistance, and incident diabetes in older adults
    Hien Pham
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, 98195, USA
    Clin J Am Soc Nephrol 7:588-94. 2012
    ..Insulin resistance is a complication of advanced CKD. Insulin resistance is less well characterized in earlier stages of CKD. The response of the pancreatic β cell, effects on glucose tolerance, and risk of diabetes are not clear...
  8. pmc Obesity and change in estimated GFR among older adults
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Am J Kidney Dis 54:1043-51. 2009
    ..Obesity assessed in midlife has been associated with chronic kidney disease...
  9. pmc Parathyroid hormone and arterial dysfunction in the multi-ethnic study of atherosclerosis
    Cortney Bosworth
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Endocrinol (Oxf) 79:429-36. 2013
    ..Impaired arterial function is a potential mechanism for these associations. We tested whether serum PTH concentration is associated with measures of arterial function...
  10. pmc Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego VA Healthcare System, San Diego, CA 92161, USA
    Circulation 125:2316-22. 2012
    ..We sought to confirm the association of fetuin-A with incident diabetes mellitus in older persons and to determine whether the association differs by age, sex, and race and among persons with cardiovascular disease (CVD)...
  11. pmc Insulin resistance and incident peripheral artery disease in the Cardiovascular Health Study
    Kathryn A Britton
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 17:85-93. 2012
    ..15-4.58). As expected, further adjustment for potential mediators led to some attenuation of effect estimates. In conclusion, insulin resistance is associated with a higher risk of PAD in older adults...
  12. pmc Influence of urine creatinine concentrations on the relation of albumin-creatinine ratio with cardiovascular disease events: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Caitlin E Carter
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, CA
    Am J Kidney Dis 62:722-9. 2013
    ..Whether low urine creatinine concentration in the denominator of the ACR contributes to the association of ACR with CVD is uncertain...
  13. pmc Total and high-molecular-weight adiponectin and risk of coronary heart disease and ischemic stroke in older adults
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Clin Endocrinol Metab 98:255-63. 2013
    ..Whether this relates to different proportions of high-molecular-weight (HMW) adiponectin is unknown...
  14. pmc Fetuin-A and change in body composition in older persons
    Joachim H Ix
    Division of Nephrology, Department of Medicine, and Division of Preventive Medicine, University of California San Diego, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Clin Endocrinol Metab 94:4492-8. 2009
    ..Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown...
  15. pmc The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study
    Benjamin D Parker
    Division of Nephrologyand Hypertension, Department of Medicine, University of California San Diego, CA 92161, USA
    Ann Intern Med 152:640-8. 2010
    ..Whether circulating levels of each are associated with cardiovascular disease (CVD) events or mortality in populations without end-stage renal disease is unknown...
  16. pmc Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study)
    Joachim H Ix
    Department of Medicine, University of California San Diego, USA
    J Am Coll Cardiol 54:1176-84. 2009
    ..This study sought to determine the association of chronic kidney disease (CKD) with high ankle brachial index (ABI) measurement and to compare its strength with that of CKD with a low ABI...
  17. ncbi request reprint Sex differences in the prevalence and clinical outcomes of subclinical peripheral artery disease in the Health, Aging, and Body Composition (Health ABC) study
    Jade S Hiramoto
    Department of Surgery, University of California, San Francisco, CA
    Vascular 22:142-8. 2014
    ..33, 1.44-7.70) and incident stroke (2.45, 1.38-4.35) only in women. Subclinical PAD was strongly associated with adverse CV events in both women and men, but women had a higher prevalence of subclinical PAD. ..
  18. ncbi request reprint Calcium density of coronary artery plaque and risk of incident cardiovascular events
    Michael H Criqui
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla2Department of Medicine, University of California, San Diego, La Jolla
    JAMA 311:271-8. 2014
    ..The standard CAC score is the Agatston, which is weighted upward for greater calcium density. However, some data suggest increased plaque calcium density may be protective for CVD...
  19. pmc Adiposity and incident heart failure in older adults: the cardiovascular health study
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:1936-41. 2012
    ..09 (95% CI: 0.99-1.21)). In conclusion, a higher WC is associated with an increased risk of HF independent of BMI in community-living older men and women...
  20. pmc Subclinical cardiac abnormalities and kidney function decline: the multi-ethnic study of atherosclerosis
    Meyeon Park
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94121, USA
    Clin J Am Soc Nephrol 7:1137-44. 2012
    ..Whether subclinical abnormalities of cardiac structure are associated with faster kidney function decline is not known. The association between cardiac concentricity and kidney function decline was evaluated...
  21. pmc Risk factor differences for aortic versus coronary calcified atherosclerosis: the multiethnic study of atherosclerosis
    Michael H Criqui
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
    Arterioscler Thromb Vasc Biol 30:2289-96. 2010
    ..The goal of this study was to compare and contrast coronary artery calcium (CAC) with abdominal aortic calcium (AAC) in terms of their associations with traditional and novel cardiovascular disease (CVD) risk factors...
  22. pmc Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures
    Benjamin D Parker
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA
    Calcif Tissue Int 86:185-91. 2010
    ..87). In conclusion, among community-living older women, serum OC is not associated with AAC. These findings suggest that serum OC levels may more closely reflect bone formation than vascular calcification in humans...
  23. pmc Relation of kidney function and albuminuria with atrial fibrillation (from the Heart and Soul Study)
    David D McManus
    Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of Massachusetts, Worcester, Massachusetts, USA
    Am J Cardiol 104:1551-5. 2009
    ..36, 95% CI 1.45 to 13.05) or eGFR(Cr) (OR 4.61, 95% CI 1.56 to 13.66). In conclusion, among outpatients with coronary artery disease, lower eGFR(cys) and higher ACR were associated with prevalent AF, independent of each other...
  24. pmc Fatty acid-binding protein 4 and incident heart failure: the Cardiovascular Health Study
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, and Boston Veterans Affairs Healthcare System, Boston, MA 02120, USA
    Eur J Heart Fail 15:394-9. 2013
    ..To examine the association of plasma fatty acid-binding protein 4 (FABP4) with incident heart failure...
  25. pmc Association of pulse pressure, arterial elasticity, and endothelial function with kidney function decline among adults with estimated GFR >60 mL/min/1.73 m(2): the Multi-Ethnic Study of Atherosclerosis (MESA)
    Carmen A Peralta
    San Francisco VA Medical Center, San Francisco, CA University of California, San Francisco, CA 94121, USA
    Am J Kidney Dis 59:41-9. 2012
    ..The association of subclinical vascular disease and early declines in kidney function has not been well studied...
  26. pmc Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study
    David Singh
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Nephrol Dial Transplant 22:1087-92. 2007
    ..In this study, we compared the relative strengths of association of cystatin C and estimated glomerular filtration rate (eGFR) with inflammatory biomarkers...
  27. pmc The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study
    Benjamin D Parker
    Department of Medicine, Division of Nephrology, University of California, San Diego, United States
    Atherosclerosis 210:320-5. 2010
    ..Matrix Gla protein (MGP) is an inhibitor of vascular calcification and lower levels of its precursor - uncarboxylated MGP (ucMGP) - are associated with vascular calcification in pilot studies...
  28. pmc Influence of urine creatinine on the relationship between the albumin-to-creatinine ratio and cardiovascular events
    Caitlin E Carter
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, USA
    Clin J Am Soc Nephrol 7:595-603. 2012
    ....
  29. pmc Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Epidemiol 173:10-25. 2011
    ..Whether these differences translate to better risk prediction will require meta-analytical approaches, as will determination of prognostic cutpoints...
  30. pmc Fibroblast growth factor-23 and early decrements in kidney function: the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Nephrol Dial Transplant 25:993-7. 2010
    ..The threshold of CKD or albuminuria at which FGF-23 begins to change is unknown...
  31. ncbi request reprint Racial differences in the association of serum 25-hydroxyvitamin D concentration with coronary heart disease events
    Cassianne Robinson-Cohen
    Department of Medicine, Kidney Research Institute, University of Washington, Seattle 98104, USA
    JAMA 310:179-88. 2013
    ..This association has not been rigorously evaluated in other races or ethnicities, in which the distributions of 25(OH)D concentration and possibly other aspects of 25(OH)D metabolism differ...
  32. pmc Relationships between serum and urine phosphorus with all-cause and cardiovascular mortality: the Osteoporotic Fractures in Men (MrOS) Study
    Julie R Dominguez
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92161, USA
    Am J Kidney Dis 61:555-63. 2013
    ..Whether urine phosphorus-creatinine ratio (a marker of intestinal absorption) or urine fractional excretion of phosphorus (FEPi; a marker of urinary phosphorus handling) is associated with risk of mortality or CVD is uncertain...
  33. pmc Plasma fatty acid-binding protein 4, nonesterified fatty acids, and incident diabetes in older adults
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:1701-7. 2012
    ..To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults...
  34. pmc Interdialytic creatinine change versus predialysis creatinine as indicators of nutritional status in maintenance hemodialysis
    Carl P Walther
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    Nephrol Dial Transplant 27:771-6. 2012
    ..Predialysis creatinine levels are associated with mortality risk but may be influenced by both muscle mass and dialysis dose. This might be overcome by examining the rate of rise in creatinine between dialysis sessions...
  35. pmc Nonesterified fatty acids and risk of sudden cardiac death in older adults
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Boston Veterans Affairs Healthcare System, Boston, MA 02120, USA
    Circ Arrhythm Electrophysiol 5:273-8. 2012
    ..Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death...
  36. pmc Plasma neutrophil gelatinase-associated lipocalin is independently associated with cardiovascular disease and mortality in community-dwelling older adults: The Rancho Bernardo Study
    Lori B Daniels
    Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, California 92037 7411, USA
    J Am Coll Cardiol 59:1101-9. 2012
    ..The purpose of this study was to determine the association between neutrophil gelatinase-associated lipocalin (NGAL) levels and cardiovascular and all-cause mortality in community-dwelling older adults...
  37. pmc Kidney function and systolic blood pressure new insights from cystatin C: data from the Heart and Soul Study
    Carmen A Peralta
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, San Francisco, California 94124, USA
    Am J Hypertens 19:939-46. 2006
    ..Whether kidney function in the normal range is associated with systolic BP (SBP), diastolic BP (DBP), and pulse pressure is unclear...
  38. pmc Serum phosphorus levels and the spectrum of ankle-brachial index in older men: the Osteoporotic Fractures in Men (MrOS) study
    Jerry Meng
    Division of Nephrology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Am J Epidemiol 171:909-16. 2010
    ..These associations may explain the link between serum phosphorus levels and CVD events...
  39. pmc Urinary creatinine excretion rate and mortality in persons with coronary artery disease: the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and VA San Diego Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    Circulation 121:1295-303. 2010
    ..In persons with coronary artery disease, low body mass index is associated with greater mortality; however, it is uncertain whether low muscle mass is a risk factor for mortality in this setting...
  40. pmc Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA
    Joachim H Ix
    Department of Medicine, Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA 92161, USA
    Clin J Am Soc Nephrol 4:609-15. 2009
    ..Higher phosphorus levels are associated with cardiovascular disease (CVD) events and mortality. Whether vascular stiffness may be responsible is unknown...
  41. pmc Urine calcium excretion, cardiovascular events, and mortality in outpatients with stable coronary artery disease (from the Heart and Soul study)
    Christine C Welles
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Cardiol 110:1729-34. 2012
    ..On the contrary, greater UCaE is associated with a modestly lower rate of MI. These findings suggest that greater systemic calcium absorption does not confer CV harm in outpatients with prevalent CHD...
  42. pmc Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    J Card Fail 12:601-7. 2006
    ..We evaluate whether cystatin C is associated with left ventricular hypertrophy, diastolic dysfunction, and systolic dysfunction among 818 outpatients with coronary artery disease who were free of clinical heart failure...
  43. ncbi request reprint Estimated albumin excretion rate versus urine albumin-creatinine ratio for the assessment of albuminuria: a diagnostic test study from the Prevention of Renal and Vascular Endstage Disease (PREVEND) Study
    Joseph A Abdelmalek
    Division of Nephrology, Department of Medicine, University of California, San Diego, CA Veterans Affairs San Diego Healthcare System, San Diego, CA Electronic address
    Am J Kidney Dis 63:415-21. 2014
    ..We hypothesized that calculating estimated AER (eAER) using spot ACR and estimated creatinine excretion rate (eCER) may improve albuminuria assessment...
  44. pmc Association between kidney function and telomere length: the heart and soul study
    Nisha Bansal
    Department of Medicine, University of California, San Francisco, USA
    Am J Nephrol 36:405-11. 2012
    ..Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening...
  45. pmc Kidney function and progression of coronary artery calcium in community-dwelling older adults (from the Rancho Bernardo Study)
    Simerjot Kaur Jassal
    Division of General Internal Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Am J Cardiol 110:1425-33. 2012
    ..In the elderly, kidney function and CAC may not progress together...
  46. pmc Inflammation and coagulation markers and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jade S Hiramoto
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Am J Kidney Dis 60:225-32. 2012
    ..The strength and direction of the associations between inflammation and coagulation biomarkers with kidney disease onset and progression remain unclear, especially in a population-based setting...
  47. pmc Test characteristics of the ankle-brachial index and ankle-brachial difference for medial arterial calcification on X-ray in type 1 diabetes
    Joachim H Ix
    Nephrology Section, Veterans Affairs San Diego Healthcare System, University of California, San Diego, San Diego, Calif 92161, USA
    J Vasc Surg 56:721-7. 2012
    ..We hypothesized that an ABI >1.30 and ABD >75 mm Hg would have high specificity but low sensitivity for MAC on X-ray imaging...
  48. pmc Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: data from the Heart and Soul Study
    Ruth Dubin
    University of California, San Francisco, USA
    Am Heart J 163:274-9. 2012
    ..Whether PTX3 is independently associated with adverse events among persons with stable coronary heart disease (CHD), independently of CRP, and whether kidney dysfunction influences these associations are not known...
  49. pmc Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    J Bone Miner Res 24:514-21. 2009
    ..Future studies should evaluate whether fetuin-A may refine fracture risk assessment in older women...
  50. pmc Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study
    Michael G Shlipak
    Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif, USA
    Am J Med 121:50-7. 2008
    ..The study purpose was to evaluate the ability of 6 biomarkers to improve the prediction of cardiovascular events among persons with established coronary artery disease...
  51. pmc Fetuin-A and incident diabetes mellitus in older persons
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    JAMA 300:182-8. 2008
    ..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown...
  52. pmc Relation of sex and estrogen therapy to serum fibroblast growth factor 23, serum phosphorus, and urine phosphorus: the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92161, USA
    Am J Kidney Dis 58:737-45. 2011
    ..Fibroblast growth factor 23 (FGF-23) is a hormone originating from bone that regulates urine phosphorus excretion. Whether sex or estrogen therapy is associated with different FGF-23 levels is unknown...
  53. pmc Fractional excretion of phosphorus modifies the association between fibroblast growth factor-23 and outcomes
    Julie R Dominguez
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
    J Am Soc Nephrol 24:647-54. 2013
    ..In summary, associations of FGF23 with mortality and CVD events are stronger in persons with lower FePi independent of PTH and kidney function. In such individuals, the renal tubular response to FGF23 may be suboptimal...
  54. pmc Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    J Ren Nutr 22:480-9. 2012
    ..Accordingly, we hypothesized that excess intake of these foods accounts for a relationship between lower socioeconomic status and higher serum phosphorus concentration...
  55. pmc Relationship of urine dopamine with phosphorus homeostasis in humans: the heart and soul study
    Nisha Bansal
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Nephrol 35:483-90. 2012
    ..Whether urine DA is associated with phosphorus homeostasis in humans is uncertain...
  56. pmc Bone mineral density and fracture risk in older individuals with CKD
    Robert H Yenchek
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin J Am Soc Nephrol 7:1130-6. 2012
    ..We assessed whether BMD is associated with fractures in participants with and without CKD in the Health, Aging, and Body Composition study, a prospective study of well functioning older individuals...
  57. pmc Association of mild to moderate kidney dysfunction and coronary calcification
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
    J Am Soc Nephrol 19:579-85. 2008
    ..These results suggest that a higher burden of CAC is unlikely to explain the association between mild to moderate kidney dysfunction and cardiovascular mortality...
  58. pmc The ankle-brachial index and incident cardiovascular events in the MESA (Multi-Ethnic Study of Atherosclerosis)
    Michael H Criqui
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0607, USA
    J Am Coll Cardiol 56:1506-12. 2010
    ..The purpose of this study was to examine the association of both a low and a high ankle-brachial index (ABI) with incident cardiovascular events in a multiethnic cohort...
  59. pmc Renal artery calcification and mortality among clinically asymptomatic adults
    Dena E Rifkin
    Division of Preventive Medicine, University of California, San Diego School of Medicine, San Diego, California 92161, USA
    J Am Coll Cardiol 60:1079-85. 2012
    ..The goal of this study was to assess the associations between renal artery calcification (RAC) and mortality in a healthy outpatient cohort with no known cardiovascular disease (CVD)...
  60. pmc Associations between coronary calcification on chest radiographs and mortality in hemodialysis patients
    Joseph A Abdelmalek
    Division of Nephrology, Department of Medicine, University of California San Diego, CA 92161, USA
    Am J Kidney Dis 60:990-7. 2012
    ..We determined the prevalence of CAC and AAC visible on plain chest radiographs and their associations with mortality in our dialysis population...
  61. pmc Total and high-molecular-weight adiponectin and risk of incident diabetes in older people
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    Diabetes Care 35:415-23. 2012
    ..To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults...
  62. ncbi request reprint Kidney function and aortic valve and mitral annular calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Am J Kidney Dis 50:412-20. 2007
    ..Whether less severe kidney dysfunction is associated with AVC and MAC is uncertain...
  63. pmc Family history of peripheral artery disease is associated with prevalence and severity of peripheral artery disease: the San Diego population study
    Christina L Wassel
    Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0965, USA
    J Am Coll Cardiol 58:1386-92. 2011
    ..The purpose of this study was to determine the association of family history of peripheral artery disease (PAD) with PAD prevalence and severity...
  64. pmc A high ankle brachial index is associated with greater left ventricular mass MESA (Multi-Ethnic Study of Atherosclerosis)
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California 92161, USA
    J Am Coll Cardiol 55:342-9. 2010
    ..This study sought to determine the association of high ankle brachial index (ABI) measurements with left ventricular (LV) mass, and to compare its strength with that of low ABI with LV mass...
  65. pmc Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men study
    Jerry Meng
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 78:415-22. 2010
    ..The mechanism responsible for the association of testosterone with serum phosphorus remains to be determined...
  66. ncbi request reprint Association of chronic kidney disease with clinical outcomes after coronary revascularization: the Arterial Revascularization Therapies Study (ARTS)
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, Calif, USA
    Am Heart J 149:512-9. 2005
    ..In the Arterial Revascularization Therapies Study (ARTS), we compared long-term clinical outcomes after CABG or PCI with multivessel stenting in patients with CKD...
  67. pmc Relation of body mass index to urinary creatinine excretion rate in patients with coronary heart disease
    Nisha Bansal
    Department of Medicine, University of California, San Francisco, USA
    Am J Cardiol 108:179-84. 2011
    ..In conclusion, low muscle mass and low BMI are each associated with greater all-cause mortality, but low muscle mass does not appear to explain why CHD patients with low BMIs have worse prognosis...
  68. doi request reprint Epidemiology and diagnosis of peripheral arterial disease in patients with chronic kidney disease
    Joachim H Ix
    Department of Medicine, Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA 92161, USA
    Adv Chronic Kidney Dis 15:378-83. 2008
    ..To that end, we review the epidemiology and diagnosis of atherosclerotic PAD and medical arterial calcification in patients with CKD...
  69. ncbi request reprint Novel cardiovascular risk factors do not completely explain the higher prevalence of peripheral arterial disease among African Americans. The San Diego Population Study
    Joachim H Ix
    Department of Medicine, University of California, San Diego, San Diego, California 92161, USA
    J Am Coll Cardiol 51:2347-54. 2008
    ..This study was designed to determine whether novel cardiovascular disease (CVD) risk factors explain the high prevalence of peripheral arterial disease (PAD) among African Americans...
  70. pmc Equations to estimate creatinine excretion rate: the CKD epidemiology collaboration
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
    Clin J Am Soc Nephrol 6:184-91. 2011
    ..Creatinine excretion rate (CER) indicates timed urine collection accuracy. Although equations to estimate CER exist, their bias and precision are untested and none simultaneously include age, sex, race, and weight...
  71. ncbi request reprint Theophylline for the prevention of radiocontrast nephropathy: a meta-analysis
    Joachim H Ix
    Division of Nephrology, Department of Medicine Research, University of California San Francisco, San Francisco, California, USA
    Nephrol Dial Transplant 19:2747-53. 2004
    ..We conducted a meta-analysis of published randomized controlled trials to determine if the pre-procedural administration of theophylline or aminophylline prevents radiocontrast-induced declines in kidney function...
  72. pmc Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study
    Benjamin D Parker
    Division of Nephrology and Hypertension, Department of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
    Nephrol Dial Transplant 24:2095-101. 2009
    ..Whether mild to moderate decrements in kidney function are associated with lower serum ucMGP is unknown...
  73. doi request reprint Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego Veterans Affairs San Diego Healthcare System, CA 92093 0711, USA
    J Am Soc Nephrol 21:406-12. 2010
    ..Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity...
  74. pmc Extremes of an aromatase index predict increased 25-year risk of cardiovascular mortality in older women
    Gail A Laughlin
    Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Clin Endocrinol (Oxf) 77:391-8. 2012
    ..Peripheral conversion of androgens to oestrogens via aromatase is the primary source of oestrogen in postmenopausal women and may play a role in cardiovascular health...
  75. pmc Association between renal insufficiency and inducible ischemia in patients with coronary artery disease: the heart and soul study
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, San Francisco, California 94121, USA
    J Am Soc Nephrol 14:3233-8. 2003
    ..The greater severity of atherosclerotic disease observed in patients with CRI may in part explain the association of CRI with increased cardiovascular risk among individuals with CAD...
  76. ncbi request reprint Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosis
    Brent W Kinder
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Chest 133:226-32. 2008
    ..We hypothesized that baseline BAL fluid cell count differential (ie, elevated levels of neutrophils and eosinophils, or reduced levels of lymphocytes) would predict higher mortality among persons with IPF...
  77. pmc Association of body mass index with peripheral arterial disease in older adults: the Cardiovascular Health Study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego and San Diego VA HealthCare System, San Diego, CA 92161, USA
    Am J Epidemiol 174:1036-43. 2011
    ..00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age...
  78. pmc Association of cystatin C with poor exercise capacity and heart rate recovery: data from the heart and soul study
    David McManus
    Cardiology Division, University of Massachusetts, Worcester, MA, USA
    Am J Kidney Dis 49:365-72. 2007
    ..We hypothesized that serum cystatin C concentration would have a stronger more linear association with cardiovascular functional status than creatinine-based measures in outpatients with established coronary heart disease (CHD)...
  79. ncbi request reprint Utility of cystatin C measurement--precision or secretion?
    Joachim H Ix
    Nephrol Dial Transplant 21:3614. 2006