David D Ivy

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Long-term outcomes in children with pulmonary arterial hypertension treated with bosentan in real-world clinical settings
    D Dunbar Ivy
    University of Colorado Denver Health Sciences Center, Children s Hospital, USA
    Am J Cardiol 106:1332-8. 2010
  2. pmc Transition of stable pediatric patients with pulmonary arterial hypertension from intravenous epoprostenol to intravenous treprostinil
    D Dunbar Ivy
    The Children s Hospital, Denver, Colorado, USA
    Am J Cardiol 99:696-8. 2007
  3. pmc Weaning and discontinuation of epoprostenol in children with idiopathic pulmonary arterial hypertension receiving concomitant bosentan
    D Dunbar Ivy
    Pediatric Cardiology, Pediatric Pulmonary Hypertension Program, Pediatric Heart Lung Center, Department of Pediatrics, The Children s Hospital, University of Colorado, Denver 80218, USA
    Am J Cardiol 93:943-6. 2004
  4. pmc Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension
    D Dunbar Ivy
    The Pulmonary Hypertension Program and Pediatric Heart Lung Center, Department of Pediatrics, The University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80045, USA
    J Am Coll Cardiol 51:161-9. 2008
  5. pmc Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension
    D Dunbar Ivy
    Section of Pediatric Cardiology, University of Colorado School of Medicine and Children s Hospital, Denver 80218, USA
    Circulation 111:2988-96. 2005
  6. pmc Prostacyclin in the intensive care setting
    D Dunbar Ivy
    Department of Pediatrics, University of Colorado Denver School of Medicine, The Children s Hospital, Aurora, CO, USA
    Pediatr Crit Care Med 11:S41-5. 2010
  7. pmc Closed-hub systems with protected connections and the reduction of risk of catheter-related bloodstream infection in pediatric patients receiving intravenous prostanoid therapy for pulmonary hypertension
    D Dunbar Ivy
    University of Colorado Denver School of Medicine, The Children s Hospital, Aurora, 80045, USA
    Infect Control Hosp Epidemiol 30:823-9. 2009
  8. pmc Long-term outcome of palliation with internal pulmonary artery bands after primary heart transplantation for hypoplastic left heart syndrome
    Shelley D Miyamoto
    Department of Pediatric Cardiology, University of Colorado Denver Health Sciences Center and The Children s Hospital, Aurora, CO 80045, USA
    Pediatr Cardiol 30:419-25. 2009
  9. pmc Implications of incising the ventricular septum in double outlet right ventricle and in the Ross-Konno operation
    Steven P Goldberg
    The Children s Hospital Heart Institute, Denver, CO, USA
    Eur J Cardiothorac Surg 35:589-93; discussion 593. 2009
  10. ncbi Mechanical limitation of pulmonary blood flow facilitates heart transplantation in older infants with hypoplastic left heart syndrome
    Max B Mitchell
    Division of Cardiothoracic Surgery, University of Colorado Health Sciences Center and The Children s Hospital, Denver, CO, USA
    Eur J Cardiothorac Surg 23:735-42. 2003

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc Long-term outcomes in children with pulmonary arterial hypertension treated with bosentan in real-world clinical settings
    D Dunbar Ivy
    University of Colorado Denver Health Sciences Center, Children s Hospital, USA
    Am J Cardiol 106:1332-8. 2010
    ..In conclusion, outcome in children with PAH managed with current treatment regimens appears favorable. However, despite current therapy options, disease progression remains a concern...
  2. pmc Transition of stable pediatric patients with pulmonary arterial hypertension from intravenous epoprostenol to intravenous treprostinil
    D Dunbar Ivy
    The Children s Hospital, Denver, Colorado, USA
    Am J Cardiol 99:696-8. 2007
    ..In conclusion, treprostinil provides an alternative therapy in children with PAH, with fewer side effects. However, evaluation regarding rates of infection requires further exploration...
  3. pmc Weaning and discontinuation of epoprostenol in children with idiopathic pulmonary arterial hypertension receiving concomitant bosentan
    D Dunbar Ivy
    Pediatric Cardiology, Pediatric Pulmonary Hypertension Program, Pediatric Heart Lung Center, Department of Pediatrics, The Children s Hospital, University of Colorado, Denver 80218, USA
    Am J Cardiol 93:943-6. 2004
    ..In 3 children with normal or near-normal pulmonary artery pressure on epoprostenol, the addition of bosentan allowed discontinuation of epoprostenol and stabilization of hemodynamics for up to 1 year...
  4. pmc Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension
    D Dunbar Ivy
    The Pulmonary Hypertension Program and Pediatric Heart Lung Center, Department of Pediatrics, The University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80045, USA
    J Am Coll Cardiol 51:161-9. 2008
    ..This study investigated the short- and long-term outcome of children with pulmonary arterial hypertension (PAH) treated with inhaled iloprost...
  5. pmc Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension
    D Dunbar Ivy
    Section of Pediatric Cardiology, University of Colorado School of Medicine and Children s Hospital, Denver 80218, USA
    Circulation 111:2988-96. 2005
    ..Herein, we determined and thereafter showed that exposure of ET(B) receptor-deficient rats to the endothelial toxin monocrotaline (MCT) leads to the development of neointimal lesions that share hallmarks of human PAH...
  6. pmc Prostacyclin in the intensive care setting
    D Dunbar Ivy
    Department of Pediatrics, University of Colorado Denver School of Medicine, The Children s Hospital, Aurora, CO, USA
    Pediatr Crit Care Med 11:S41-5. 2010
    ..Currently, there are no universal recommendations for dosing delivery of inhaled prostanoids to intubated patients in the intensive care unit setting...
  7. pmc Closed-hub systems with protected connections and the reduction of risk of catheter-related bloodstream infection in pediatric patients receiving intravenous prostanoid therapy for pulmonary hypertension
    D Dunbar Ivy
    University of Colorado Denver School of Medicine, The Children s Hospital, Aurora, 80045, USA
    Infect Control Hosp Epidemiol 30:823-9. 2009
    ..Prevention of CR-BSI during long-term use of indwelling central venous catheters is important...
  8. pmc Long-term outcome of palliation with internal pulmonary artery bands after primary heart transplantation for hypoplastic left heart syndrome
    Shelley D Miyamoto
    Department of Pediatric Cardiology, University of Colorado Denver Health Sciences Center and The Children s Hospital, Aurora, CO 80045, USA
    Pediatr Cardiol 30:419-25. 2009
    ..Transcatheter placement of internal pulmonary artery bands for HLHS offers protection of the pulmonary vascular bed while preserving pulmonary artery architecture and growth with good long-term outcome...
  9. pmc Implications of incising the ventricular septum in double outlet right ventricle and in the Ross-Konno operation
    Steven P Goldberg
    The Children s Hospital Heart Institute, Denver, CO, USA
    Eur J Cardiothorac Surg 35:589-93; discussion 593. 2009
    ..This retrospective study evaluates the risk of a ventricular septal incision in patients undergoing double outlet right ventricle (DORV) repair and Ross-Konno procedure...
  10. ncbi Mechanical limitation of pulmonary blood flow facilitates heart transplantation in older infants with hypoplastic left heart syndrome
    Max B Mitchell
    Division of Cardiothoracic Surgery, University of Colorado Health Sciences Center and The Children s Hospital, Denver, CO, USA
    Eur J Cardiothorac Surg 23:735-42. 2003
    ..Our objective was to assess the impact of bilateral pulmonary artery banding (PAB) on the operative courses of HLHS infants transplanted at ages older than 4 months...
  11. pmc Noninvasive methods for determining pulmonary vascular function in children with pulmonary arterial hypertension: application of a mechanical oscillator model
    Kendall S Hunter
    Center for Bioengineering, University of Colorado Health Science Center, Denver, CO 80045, USA
    Congenit Heart Dis 3:106-16. 2008
    ..Here, we investigate such a model's utility as a noninvasive predictor of total right heart afterload and right heart function...
  12. pmc Outcomes of reparative and transplantation strategies for multilevel left heart obstructions with mitral stenosis
    Sunil P Malhotra
    The Children s Hospital Heart Institute, Children s Hospital, Denver, Colorado, USA
    Ann Thorac Surg 86:1305-9; discussion 1310. 2008
    ..This study reviews our experience with reconstructive and transplantation approaches for Shone's complex...
  13. pmc Application of a microstructural constitutive model of the pulmonary artery to patient-specific studies: validation and effect of orthotropy
    Yanhang Zhang
    Department of Aerospace and Mechanical Engineering, Boston University, Boston, MA 02215, USA
    J Biomech Eng 129:193-201. 2007
    ..This initial study also puts forward important questions that need to be considered before combining the microstructural model with complex patient-specific vascular geometries...
  14. ncbi Simulations of congenital septal defect closure and reactivity testing in patient-specific models of the pediatric pulmonary vasculature: A 3D numerical study with fluid-structure interaction
    Kendall S Hunter
    Department of Pediatric Cardiology, University of Colorado Health Sciences Center, 1056 E 19th Ave, Denver, CO 80218, USA
    J Biomech Eng 128:564-72. 2006
    ..This new patient-specific technique provides much greater detail regarding the function of the pulmonary circuit than can be obtained with current medical imaging methods alone, and holds promise for enabling surgical planning...
  15. ncbi Effects of long-term bosentan in children with pulmonary arterial hypertension
    Erika Berman Rosenzweig
    Division of Pediatric Cardiology, New York Presbyterian Hospital, New York, New York 10032, USA
    J Am Coll Cardiol 46:697-704. 2005
    ..This study investigated the long-term outcome of children with pulmonary arterial hypertension (PAH) treated with bosentan therapy, with or without concomitant prostanoid therapy...
  16. ncbi Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats
    D Dunbar Ivy
    Section of Pediatric Cardiology, Pediatric Heart Lung Center, University of Colorado School of Medicine, 1056 E 19th Ave, Denver, CO 80218, USA
    Am J Physiol Lung Cell Mol Physiol 282:L703-12. 2002
    ..These findings suggest that the ET(B) receptor plays a protective role in the pulmonary hypertensive response to chronic hypoxia...
  17. pmc Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension
    Kendall S Hunter
    Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Am Heart J 155:166-74. 2008
    ....
  18. ncbi Pulmonary vascular effects of inhaled nitric oxide and oxygen tension in bronchopulmonary dysplasia
    Peter M Mourani
    Division of Critical Care, The Pediatric Heart Lung Center, Department of Pediatrics, The Children s Hospital, Denver, Colorado 80218, USA
    Am J Respir Crit Care Med 170:1006-13. 2004
    ..We conclude that hyperoxia plus iNO causes marked pulmonary vasodilatation in older patients with BPD, suggesting that heightened pulmonary vascular tone contributes to pulmonary vascular disease in BPD...
  19. ncbi Endothelin B receptor blockade attenuates pulmonary vasodilation in oxygen-ventilated fetal lambs
    D Dunbar Ivy
    Pediatric Heart Lung Center, Section of Cardiology, University of Colorado School of Medicine and The Children s Hospital, Denver, CO 80218, USA
    Biol Neonate 86:155-9. 2004
    ..However, whether activation of ETB receptors contributes to the fall in pulmonary vascular tone at birth is unknown...
  20. ncbi Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia
    Cynthia L Hartsfield
    Div of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Health Sciences Center, 4200 East Ninth Ave, B 133, Denver, CO 80262, USA
    Am J Physiol Heart Circ Physiol 287:H2009-15. 2004
    ....
  21. ncbi Extraction of pulmonary vascular compliance, pulmonary vascular resistance, and right ventricular work from single-pressure and Doppler flow measurements in children with pulmonary hypertension: a new method for evaluating reactivity: in vitro and clinica
    Craig E Weinberg
    Department of Mechanical Engineering, University of Colorado, Boulder, USA
    Circulation 110:2609-17. 2004
    ..Here we report the utility of pulsed-wave (PW) Doppler-measured instantaneous flow and pressure measurements for estimation of input impedance and VP and use this method to develop a novel parameter: reactivity in compliance...
  22. ncbi Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic hernia
    John P Kinsella
    Department of Pediatrics, Divisions of Neonatology, Cardiology, and Pulmonary and Critical Care Medicine, The Children s Hospital and the University of Colorado School of Medicine, Denver, Colorado 80218 1088, USA
    J Pediatr 142:397-401. 2003
    ....
  23. ncbi Inhaled Nitric Oxide as a Preoperative Test (INOP Test I): the INOP Test Study Group
    David T Balzer
    St Louis Children s Hospital, St Louis, MO, USA
    Circulation 106:I76-81. 2002
    ....
  24. ncbi Utility of cardiopulmonary stress testing in assessing disease severity in children with pulmonary arterial hypertension
    Anji T Yetman
    Pediatric Pulmonary Hypertension Program, Children s Hospital Heart Institute, Department of Pediatrics, The University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Cardiol 95:697-9. 2005
    ..6, p = 0.006). Exercise testing can be performed safely in this group of patients and can yield valuable clinical information...
  25. ncbi Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertension
    D Dunbar Ivy
    Section of Cardiology, Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine and CChildren s Hospital, Denver, Colorado 80218 1088, USA
    Am J Cardiol 92:886-90. 2003
    ..In 2 patients, NO delivered in the home using this pulsing system was well tolerated for up to 2 years. The long-term safety, efficacy, and acceptability of NO delivered in the home remains to be studied...
  26. ncbi Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus
    Vivek Balasubramaniam
    Pediatric Heart Lung Center and Section of Pediatric Pulmonary Medicine, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 284:L826-33. 2003
    ..We speculate that PDGF signaling contributes to structural vascular remodeling in perinatal PH and that selective PDGF inhibition may provide a novel therapeutic strategy for the treatment of chronic PH...
  27. ncbi Longitudinal motion of the atrioventricular annuli in children: reference values, growth related changes, and effects of right ventricular volume and pressure overload
    Orlando X Arce
    University of Colorado Health Sciences Center, The Children s Hospital, 1056 E 19th Avenue, Denver, CO 80218, USA
    J Am Soc Echocardiogr 15:906-16. 2002
    ..In patients with PPH, %displacement and ascent velocities were blunted. Our results demonstrate the utility of this technique to assess annular dynamics in pediatric patients...
  28. ncbi Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression
    Todd Carpenter
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Circ Res 93:456-63. 2003
    ....
  29. pmc Clinical utility of echocardiography for the diagnosis and management of pulmonary vascular disease in young children with chronic lung disease
    Peter M Mourani
    Division of Critical Care, Children s Hospital and University of Colorado Denver School of Medicine, Denver, Colorado 80045, USA
    Pediatrics 121:317-25. 2008
    ..The goal was to determine the clinical utility of Doppler echocardiography in predicting the presence and severity of pulmonary hypertension in patients with chronic lung disease who subsequently underwent cardiac catheterization...
  30. ncbi Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase
    Karen A Fagan
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 287:L656-64. 2004
    ..In conclusion, Rho/Rho-kinase activation is important in the effects of both acute and chronic hypoxia on the pulmonary circulation of mice, possibly by contributing to both vasoconstriction and vascular remodeling...
  31. pmc Portopulmonary hypertension in pediatric patients
    Adria A Condino
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pathology, The Children s Hospital, University of Colorado Health Sciences Center, Denver, CO, USA
    J Pediatr 147:20-6. 2005
    ..To investigate the clinical presentation, manifestations, and response to therapy of portopulmonary hypertension (PPHTN) in pediatric patients...
  32. pmc Noninvasive Doppler tissue measurement of pulmonary artery compliance in children with pulmonary hypertension
    Karrie Dyer
    Department of Pediatrics, Division of Pediatric Cardiology, University of Colorado Health Sciences Center, The Children s Hospital, Denver, Colorado 80218, USA
    J Am Soc Echocardiogr 19:403-12. 2006
    ..Here, we develop and validate a noninvasive method to measure pulmonary artery (PA) compliance using ultrasound color M-mode (CMM) Doppler tissue imaging (DTI)...
  33. ncbi Endothelin-B receptor overexpression prevents hypoxic pulmonary hypertension in cirrhotic rats
    Masatoshi Imamura
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 128:580S-581S. 2005
  34. ncbi Oxygen tension modulates the expression of pulmonary vascular BKCa channel alpha- and beta-subunits
    Ernesto Resnik
    Univ of Minnesota, Minneapolis, MN 55455, USA
    Am J Physiol Lung Cell Mol Physiol 290:L761-L768. 2006
    ..Together, these results suggest that oxygen tension modulates BK(Ca) channel subunit mRNA expression, and the regulation is, at least in part, at the transcriptional level...
  35. ncbi Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation
    Masatoshi Imamura
    Cardiovascular Pulmonary Research Laboratory, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Appl Physiol 98:739-47. 2005
    ..Understanding these interactions may provide important information for the prevention and treatment of pulmonary hypertension...
  36. ncbi Pulmonary vasodilator therapy in congenital diaphragmatic hernia: acute, late, and chronic pulmonary hypertension
    John P Kinsella
    Department of Pediatrics, Division of Neonatology, The Children s Hospital and the University of Colorado School of Medicine, Denver, CO 80218 1088, USA
    Semin Perinatol 29:123-8. 2005
    ..We will also review the role of currently available pulmonary vasoactive drugs in the management of pulmonary hypertension in this population...

Research Grants1

  1. ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATION
    DAVID IVY; Fiscal Year: 2002
    ..Research presentations along with graduate level courses in molecular biology, and the clinical ambiance of the Univ of CO SOM in the area of pulmonary hypertension enhance career development. ..