ANDREI IVANOVICH IVANOV

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Structure and regulation of intestinal epithelial tight junctions: current concepts and unanswered questions
    Andrei I Ivanov
    Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Adv Exp Med Biol 763:132-48. 2012
  2. pmc Cytoskeletal regulation of epithelial barrier function during inflammation
    Andrei I Ivanov
    Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester, Rochester, New York, USA
    Am J Pathol 177:512-24. 2010
  3. pmc Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium
    Andrei I Ivanov
    Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Box 646, Rochester, NY 14642, USA
    Am J Pathol 176:134-45. 2010
  4. pmc Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility
    Andrei I Ivanov
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    BMC Cell Biol 10:36. 2009
  5. ncbi Actin motors that drive formation and disassembly of epithelial apical junctions
    Andrei I Ivanov
    Division Gastroenterology and Hepatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Front Biosci 13:6662-81. 2008
  6. doi Myosin II regulates the shape of three-dimensional intestinal epithelial cysts
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Cell Sci 121:1803-14. 2008
  7. pmc Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:2636-50. 2005
  8. ncbi c-Jun N-terminal kinase mediates disassembly of apical junctions in model intestinal epithelia
    Nayden G Naydenov
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Cell Cycle 8:2110-21. 2009
  9. pmc A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 2:e658. 2007
  10. pmc Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Mol Biol Cell 15:2639-51. 2004

Collaborators

Detail Information

Publications29

  1. ncbi Structure and regulation of intestinal epithelial tight junctions: current concepts and unanswered questions
    Andrei I Ivanov
    Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Adv Exp Med Biol 763:132-48. 2012
    ..The chapter outlines our current understanding of TJ structure and dynamics and highlights several unresolved questions regarding regulation of this junctional complex under normal conditions and in gastroenterological diseases...
  2. pmc Cytoskeletal regulation of epithelial barrier function during inflammation
    Andrei I Ivanov
    Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester, Rochester, New York, USA
    Am J Pathol 177:512-24. 2010
    ..Finally, we highlight signaling pathways induced by inflammatory mediators that regulate reorganization of actin filaments and junctional disassembly in mucosal epithelia...
  3. pmc Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium
    Andrei I Ivanov
    Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Box 646, Rochester, NY 14642, USA
    Am J Pathol 176:134-45. 2010
    ..We conclude that Scribble is an important regulator of TJ functions and plasticity in the intestinal epithelium. Down-regulation of Scribble may mediate mucosal barrier breakdown during intestinal inflammation...
  4. pmc Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility
    Andrei I Ivanov
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    BMC Cell Biol 10:36. 2009
    ..In the present study we investigate mechanisms by which PKC activation induces disassembly of tight junctions (TJs) and adherens junctions (AJs) in a model pancreatic epithelium...
  5. ncbi Actin motors that drive formation and disassembly of epithelial apical junctions
    Andrei I Ivanov
    Division Gastroenterology and Hepatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Front Biosci 13:6662-81. 2008
    ..The review focuses on the roles of these actin motors in the establishment, maintenance and disassembly of epithelial TJ and AJ during tissue morphogenesis and in pathology...
  6. doi Myosin II regulates the shape of three-dimensional intestinal epithelial cysts
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Cell Sci 121:1803-14. 2008
    ..We conclude that myosin II regulates the spherical shape of epithelial cysts by controlling actin polymerization at the cyst surface...
  7. pmc Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:2636-50. 2005
    ....
  8. ncbi c-Jun N-terminal kinase mediates disassembly of apical junctions in model intestinal epithelia
    Nayden G Naydenov
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Cell Cycle 8:2110-21. 2009
    ..Taken together, our findings suggest a novel role for JNK in the signaling pathway that links ROCK and F-actin remodeling during disassembly of epithelial junctions...
  9. pmc A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 2:e658. 2007
    ..These findings provide the first direct non-pharmacological evidence of myosin II-dependent regulation of AJC dynamics in mammalian epithelia and highlight a unique role of NMMIIA in junctional biogenesis...
  10. pmc Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Mol Biol Cell 15:2639-51. 2004
    ..Mechanisms of such reorganization involve cofilin-1-dependent depolymerization and Arp2/3-assisted repolymerization of actin filaments as well as myosin IIA-mediated contraction...
  11. pmc Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane
    Markus Utech
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:5040-52. 2005
    ..These results, for the first time, suggest that IFN-gamma induces endocytosis of epithelial TJ proteins via RhoA/ROCK-mediated, myosin II-dependent formation of VACs...
  12. pmc Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Mol Biol Cell 15:176-88. 2004
    ..Such mechanisms may mediate the disruption of intercellular contacts during normal tissue remodeling and in pathology...
  13. pmc Microtubules regulate disassembly of epithelial apical junctions
    Andrei I Ivanov
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    BMC Cell Biol 7:12. 2006
    ..In the present study, we investigated the role of microtubules in disassembly of the AJC in intestinal epithelial cells using a model of extracellular calcium depletion...
  14. pmc Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signaling
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 170:951-66. 2007
    ..These findings suggest that annexin 2 plays a role in targeting Rho to cellular membranes, thereby modulating Rho-related signaling events regulating cytoskeletal reorganization during epithelial cell migration...
  15. pmc Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions
    Stanislav N Samarin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 18:3429-39. 2007
    ..Thus, our findings demonstrate a central role of the GEF-H1/Rho/ROCK-II signaling pathway in the disassembly of AJC in epithelial cells...
  16. pmc Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells
    Elena V Vassilieva
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Whitehead Research Building, 615 Michael Street, Atlanta, Georgia 30322, USA
    Biochem Biophys Res Commun 379:460-5. 2009
    ..Our data suggest that flotillin-1 regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells...
  17. ncbi The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Whitehead Research Building, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Novartis Found Symp 263:115-24; discussion 124-32, 211-8. 2004
    ..A better understanding of the mechanisms of junctional internalization and recycling will likely provide new insights into the mechanisms of altered barrier function in IBD...
  18. pmc Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells
    Stanislav N Samarin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 391:394-400. 2010
    ..Thus, our findings provide the first evidence that Coronin 1C negatively regulates epithelial cell migration via FAK-mediated inhibition of cell-matrix adhesion...
  19. ncbi Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers
    Andrei I Ivanov
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Room 115, 615 Michael Street, Atlanta, GA 30322, USA
    Bioessays 27:356-65. 2005
    ..Potential biological roles for AJC endocytosis in maintaining functional apical junctions, reversible opening of epithelial barrier and disruption of intercellular adhesion are also discussed...
  20. pmc Lipid rafts mediate internalization of beta1-integrin in migrating intestinal epithelial cells
    Elena V Vassilieva
    Dept of Pathology and Laboratory Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 295:G965-76. 2008
    ..Such endocytosis is likely to be important for disassembly of integrin-based cell-matrix adhesions and therefore in regulating IEC migration and wound closure...
  21. pmc Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 174:436-48. 2009
    ..These observations indicate multiple functions for NM IIA, which, along with the regulation of the F-actin cytoskeleton and cell-matrix adhesions, involve previously unrecognized control of intracellular signaling and protein expression...
  22. ncbi Interferon-gamma inhibits T84 epithelial cell migration by redirecting transcytosis of beta1 integrin from the migrating leading edge
    Qiao Tong
    Epithelial Pathology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 175:4030-8. 2005
    ....
  23. ncbi Exocytosis and endocytosis. Preface
    Andrei I Ivanov
    Department of Medicine, Gastroenterology and Hepatology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Methods Mol Biol 440:v-vi. 2008
  24. ncbi Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
    Matthias Bruewer
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    FASEB J 19:923-33. 2005
    ..These results for the first time suggest that IFN-gamma produces a leaky epithelial barrier by inducing macropinoytosis of TJ proteins...
  25. doi Pharmacological inhibition of endocytic pathways: is it specific enough to be useful?
    Andrei I Ivanov
    Department of Medicine, Gastroenterology and Hepatology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Methods Mol Biol 440:15-33. 2008
    ..The most and the least-selective inhibitors of each major endocytic pathway are highlighted...
  26. ncbi Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 179:8112-21. 2007
    ..Taken together, theses results support a novel role for FPR stimulation in enhancing intestinal epithelial cell restitution through PI3K-dependent activation of Rac1 and Cdc42...
  27. ncbi Putative dual role of ephrin-Eph receptor interactions in inflammation
    Andrei I Ivanov
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    IUBMB Life 58:389-94. 2006
    ..Taking into consideration the abundance of ephrins and Eph receptors in tissues and the robustness of their signaling effects, the proposed involvement is likely to be substantial and may constitute a novel therapeutic target...
  28. ncbi Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats
    Andrei I Ivanov
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital, Phoenix, Arizona 85013, USA
    Physiol Genomics 21:152-60. 2005
    ....
  29. ncbi Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever
    Andrei I Ivanov
    Trauma Research and Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 284:R698-706. 2003
    ..By increasing the blood-brain gradient of PGE(2), this mechanism likely facilitates penetration of PGE(2) into the brain and prevents its elimination from the brain...

Research Grants2

  1. Actin dynamics and regulation of epithelial barrier in intestinal inflammation
    ANDREI IVANOVICH IVANOV; Fiscal Year: 2010
    ..This may result in decreased morbidity and mortality of a large cohort of patients with inflammatory disorders. ..
  2. Junctional exocytosis and breakdown of the intestinal barrier in inflammation
    ANDREI IVANOVICH IVANOV; Fiscal Year: 2010
    ..This may result in decreased morbidity and mortality of a large cohort of patients with inflammatory disorders. ..