Y Itzhak

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites
    Y Itzhak
    Department of Biochemistry and Molecular Biology R 629, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101, USA
    Brain Res 818:204-11. 1999
  2. ncbi request reprint Effect of melatonin on methamphetamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity and methamphetamine-induced behavioral sensitization
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101, USA
    Neuropharmacology 37:781-91. 1998
  3. ncbi request reprint Comparison between the role of the neuronal and inducible nitric oxide synthase in methamphetamine-induced neurotoxicity and sensitization
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33101, USA
    Ann N Y Acad Sci 914:104-11. 2000
  4. ncbi request reprint Modulation of the PCP/NMDA receptor complex and sigma binding sites by psychostimulants
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Neurotoxicol Teratol 16:363-8. 1994
  5. ncbi request reprint Nitric oxide (NO) synthase inhibitors abolish cocaine-induced toxicity in mice
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Neuropharmacology 32:1069-70. 1993
  6. ncbi request reprint Effect of riluzole and gabapentin on cocaine- and methamphetamine-induced behavioral sensitization in mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA
    Psychopharmacology (Berl) 151:226-33. 2000
  7. ncbi request reprint Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
    Synapse 34:305-12. 1999
  8. ncbi request reprint Cocaine-induced kindling is associated with elevated NMDA receptor binding in discrete mouse brain regions
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33101, USA
    Neuropharmacology 39:32-9. 2000
  9. ncbi request reprint Blockade of alcohol-induced locomotor sensitization and conditioned place preference in DBA mice by 7-nitroindazole
    Y Itzhak
    Department of Psychiatry and Behavioral Science R 629, Room 503, Gautier Building, University of Miami School of Medicine, Miami, FL 33101, USA
    Brain Res 858:402-7. 2000
  10. ncbi request reprint Effect of ibogaine on the various sites of the NMDA receptor complex and sigma binding sites in rat brain
    Y Itzhak
    Department of Biochemistry and Molecular Biology R 629, University of Miami School of Medicine, Florida 33101, USA
    Ann N Y Acad Sci 844:245-51. 1998

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites
    Y Itzhak
    Department of Biochemistry and Molecular Biology R 629, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101, USA
    Brain Res 818:204-11. 1999
    ....
  2. ncbi request reprint Effect of melatonin on methamphetamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity and methamphetamine-induced behavioral sensitization
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101, USA
    Neuropharmacology 37:781-91. 1998
    ....
  3. ncbi request reprint Comparison between the role of the neuronal and inducible nitric oxide synthase in methamphetamine-induced neurotoxicity and sensitization
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33101, USA
    Ann N Y Acad Sci 914:104-11. 2000
    ..The present findings indicate that nNOS(-/-) mice are more resistant to METH-induced neurotoxicity and behavioral sensitization than iNOS(-/-) mice. These results suggest a major role for nNOS rather than iNOS in the effects of METH...
  4. ncbi request reprint Modulation of the PCP/NMDA receptor complex and sigma binding sites by psychostimulants
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Neurotoxicol Teratol 16:363-8. 1994
    ..The methamphetamine-related studies insinuate a potential role of sigma-1 binding sites in psychostimulant-induced behavioral disorders...
  5. ncbi request reprint Nitric oxide (NO) synthase inhibitors abolish cocaine-induced toxicity in mice
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Neuropharmacology 32:1069-70. 1993
    ..These findings suggest a role for NO in cocaine-induced toxicity...
  6. ncbi request reprint Effect of riluzole and gabapentin on cocaine- and methamphetamine-induced behavioral sensitization in mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA
    Psychopharmacology (Berl) 151:226-33. 2000
    ..Recent studies have suggested the involvement of excitatory amino acid (EAA) and inhibitory gamma amino butyric acid (GABA) transmission in the effects of psychostimulants such as cocaine and amphetamines...
  7. ncbi request reprint Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
    Synapse 34:305-12. 1999
    ..Moreover, in contrast to nNOS deficiency, iNOS deficiency did not affect METH-induced behavioral sensitization...
  8. ncbi request reprint Cocaine-induced kindling is associated with elevated NMDA receptor binding in discrete mouse brain regions
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33101, USA
    Neuropharmacology 39:32-9. 2000
    ....
  9. ncbi request reprint Blockade of alcohol-induced locomotor sensitization and conditioned place preference in DBA mice by 7-nitroindazole
    Y Itzhak
    Department of Psychiatry and Behavioral Science R 629, Room 503, Gautier Building, University of Miami School of Medicine, Miami, FL 33101, USA
    Brain Res 858:402-7. 2000
    ..These findings support the role of NO in ethanol actions and further suggest that the nNOS system is relevant to the rewarding effects of various drugs of abuse...
  10. ncbi request reprint Effect of ibogaine on the various sites of the NMDA receptor complex and sigma binding sites in rat brain
    Y Itzhak
    Department of Biochemistry and Molecular Biology R 629, University of Miami School of Medicine, Florida 33101, USA
    Ann N Y Acad Sci 844:245-51. 1998
    ..In turn, ibogaine interaction with sigma binding sites may be associated with its adverse effects...
  11. ncbi request reprint Scopolamine inhibits cocaine-conditioned but not unconditioned stimulant effects in mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33101, USA
    Psychopharmacology (Berl) 152:216-23. 2000
    ..In animal models, cocaine cues contribute to the development of conditioned responses to the psychomotor stimulating and rewarding effects of the drug...
  12. ncbi request reprint Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood
    C Achat-Mendes
    The Neuroscience Program and Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Neuropharmacology 45:106-15. 2003
    ....
  13. ncbi request reprint Different modulation of the binding to two phencyclidine (PCP) receptor subtypes: effects of N-methyl-D-aspartate agonists and antagonists
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Neurosci Lett 104:314-9. 1989
    ..The present results indicate that the high (sigma p) and low-affinity (PCP) sites, that are distinct from the sigma h site, are affected differently by NMDA agonists and antagonists, and thus may represent different receptor domains...
  14. ncbi request reprint Effect of the neuronal nitric oxide synthase inhibitor 7-nitroindazole on methylphenidate-induced hyperlocomotion in mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA
    Behav Pharmacol 13:81-6. 2002
    ....
  15. ncbi request reprint Sigma binding sites in the brain; an emerging concept for multiple sites and their relevance for psychiatric disorders
    Y Itzhak
    Department of Biochemistry and Molecular Biology, REPSCEND Labs, University of Miami School of Medicine, FL 33101
    Life Sci 47:1073-81. 1990
    ..Revealing the existence of sigma receptor subtypes may help to elucidate their association with various psychiatric disorders...
  16. pmc Long-term memory of visually cued fear conditioning: roles of the neuronal nitric oxide synthase gene and cyclic AMP response element-binding protein
    J B Kelley
    Division of Neuroscience, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Neuroscience 174:91-103. 2011
    ..These findings suggest that visual cue-dependent LTM is impaired in nNOS KO mice, and aberrant modulation of CREB in the absence of the nNOS gene may hinder cued and contextual LTM formation...
  17. ncbi request reprint Methamphetamine-induced alteration in striatal p53 and bcl-2 expressions in mice
    S Z Imam
    Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Rd, Jefferson, AR 72079-9502, USA
    Brain Res Mol Brain Res 91:174-8. 2001
    ..These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery...
  18. ncbi request reprint Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts
    S Z Imam
    Neurochemistry Laboratory Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Ann N Y Acad Sci 939:366-80. 2001
    ..These antioxidants and decomposition catalysts may have therapeutic potential in the treatment of psychostimulant addictions...
  19. ncbi request reprint Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase
    S Z Imam
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas, USA
    J Neurochem 76:745-9. 2001
    ..The dopaminergic damage induced by METH treatment was also attenuated in nNOS-/- or SOD-Tg mice. These data further confirm that METH causes its neurotoxic effects via the production of peroxynitrite...