Y Itzhak

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi Sodium butyrate-induced histone acetylation strengthens the expression of cocaine-associated contextual memory
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL 33136, USA Division of Neuroscience, University of Miami, Miller School of Medicine, Miami, FL 33136, USA Electronic address
    Neurobiol Learn Mem 102:34-42. 2013
  2. ncbi Changes in the magnitude of drug-unconditioned stimulus during conditioning modulate cocaine-induced place preference in mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, FL 33136, USA
    Addict Biol 17:706-16. 2012
  3. ncbi Histone acetylation rescues contextual fear conditioning in nNOS KO mice and accelerates extinction of cued fear conditioning in wild type mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Neurobiol Learn Mem 97:409-17. 2012
  4. ncbi Cocaine-induced conditioned place preference in mice: induction, extinction and reinstatement by related psychostimulants
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, R 629, Gautier Building Room 503, 1011 NW 15th Street, University of Miami School of Medicine, Miami, FL 33136, USA
    Neuropsychopharmacology 26:130-4. 2002
  5. ncbi Comparison between the role of the neuronal and inducible nitric oxide synthase in methamphetamine-induced neurotoxicity and sensitization
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33101, USA
    Ann N Y Acad Sci 914:104-11. 2000
  6. ncbi Differential response of nNOS knockout mice to MDMA ("ecstasy")- and methamphetamine-induced psychomotor sensitization and neurotoxicity
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
    Ann N Y Acad Sci 1025:119-28. 2004
  7. ncbi Effect of the neuronal nitric oxide synthase inhibitor 7-nitroindazole on methylphenidate-induced hyperlocomotion in mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA
    Behav Pharmacol 13:81-6. 2002
  8. ncbi Methamphetamine and MDMA (ecstasy) neurotoxicity: 'of mice and men'
    Yossef Itzhak
    Department of Psychiatry and Behavioral Science and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    IUBMB Life 56:249-55. 2004
  9. ncbi Role of the NMDA receptor and nitric oxide in memory reconsolidation of cocaine-induced conditioned place preference in mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida, USA
    Ann N Y Acad Sci 1139:350-7. 2008
  10. ncbi Methamphetamine-induced dopaminergic neurotoxicity in mice: long-lasting sensitization to the locomotor stimulation and desensitization to the rewarding effects of methamphetamine
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences R 629, Gautier Building Room No 503, 1011 NW 15th Street, University of Miami School of Medicine, Miami, FL 33136, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1177-83. 2002

Research Grants

  1. Reconsolidation and extinction processes in the treatment of drug addiction
    Yossef Itzhak; Fiscal Year: 2010
  2. Adolescent Exposure to Psychostimulants: Role of nNOS
    Yossef Itzhak; Fiscal Year: 2007
  3. Substituted Amphetamines: NO-Dependent Mechanisms
    Yossef Itzhak; Fiscal Year: 2005

Collaborators

Detail Information

Publications49

  1. ncbi Sodium butyrate-induced histone acetylation strengthens the expression of cocaine-associated contextual memory
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL 33136, USA Division of Neuroscience, University of Miami, Miller School of Medicine, Miami, FL 33136, USA Electronic address
    Neurobiol Learn Mem 102:34-42. 2013
    ..Results suggest that regardless of the scheduling of either cocaine or NaB administration, NaB-induced histone hyperacetylation in the hippocampus may strengthen cocaine-associated contextual memory...
  2. ncbi Changes in the magnitude of drug-unconditioned stimulus during conditioning modulate cocaine-induced place preference in mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, FL 33136, USA
    Addict Biol 17:706-16. 2012
    ..Increase and decrease in cocaine dosage strengthens and weakens cocaine-associated memory, respectively. Moreover, extinction by 'tapering down' drug reward may be superior to extinction by saline...
  3. ncbi Histone acetylation rescues contextual fear conditioning in nNOS KO mice and accelerates extinction of cued fear conditioning in wild type mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Neurobiol Learn Mem 97:409-17. 2012
    ..Hence, a single administration of HDAC inhibitor may rescue NO-dependent cognitive deficits and afford a long-term accelerating effect on extinction of fear memory of WT mice...
  4. ncbi Cocaine-induced conditioned place preference in mice: induction, extinction and reinstatement by related psychostimulants
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, R 629, Gautier Building Room 503, 1011 NW 15th Street, University of Miami School of Medicine, Miami, FL 33136, USA
    Neuropsychopharmacology 26:130-4. 2002
    ..The finding that METH and MPD but not PCP reinstated and supported cocaine-induced CPP suggests that the CPP paradigm may be a useful tool for drug discrimination studies and the reinstatement of drug-seeking behavior...
  5. ncbi Comparison between the role of the neuronal and inducible nitric oxide synthase in methamphetamine-induced neurotoxicity and sensitization
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33101, USA
    Ann N Y Acad Sci 914:104-11. 2000
    ..The present findings indicate that nNOS(-/-) mice are more resistant to METH-induced neurotoxicity and behavioral sensitization than iNOS(-/-) mice. These results suggest a major role for nNOS rather than iNOS in the effects of METH...
  6. ncbi Differential response of nNOS knockout mice to MDMA ("ecstasy")- and methamphetamine-induced psychomotor sensitization and neurotoxicity
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
    Ann N Y Acad Sci 1025:119-28. 2004
    ....
  7. ncbi Effect of the neuronal nitric oxide synthase inhibitor 7-nitroindazole on methylphenidate-induced hyperlocomotion in mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA
    Behav Pharmacol 13:81-6. 2002
    ....
  8. ncbi Methamphetamine and MDMA (ecstasy) neurotoxicity: 'of mice and men'
    Yossef Itzhak
    Department of Psychiatry and Behavioral Science and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    IUBMB Life 56:249-55. 2004
    ....
  9. ncbi Role of the NMDA receptor and nitric oxide in memory reconsolidation of cocaine-induced conditioned place preference in mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida, USA
    Ann N Y Acad Sci 1139:350-7. 2008
    ....
  10. ncbi Methamphetamine-induced dopaminergic neurotoxicity in mice: long-lasting sensitization to the locomotor stimulation and desensitization to the rewarding effects of methamphetamine
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences R 629, Gautier Building Room No 503, 1011 NW 15th Street, University of Miami School of Medicine, Miami, FL 33136, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1177-83. 2002
    ..These consequences may be relevant to the psychopathology of METH abuse...
  11. ncbi Relevance of MDMA ("ecstasy")-induced neurotoxicity to long-lasting psychomotor stimulation in mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences R 629, Gautier Building Room 503, University of Miami School of Medicine, 1011 NW 15th Street, Miami, FL 33136, USA
    Psychopharmacology (Berl) 166:241-8. 2003
    ..Although many studies have focused on the mechanisms underlying MDMA-induced neurotoxicity, little is known about the subsequent long-term response to psychostimulants following exposure to a neurotoxic dose of MDMA...
  12. ncbi Fenfluramine-induced serotonergic neurotoxicity in mice: lack of neuroprotection by inhibition/ablation of nNOS
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida, USA
    J Neurochem 87:268-71. 2003
    ..These findings suggest that NO and peroxynitrite do not mediate fenfluramine-induced serotonergic neurotoxicity, and that NO is a selective mediator of amphetamines-induced dopaminergic neurotoxicity...
  13. ncbi Scopolamine inhibits cocaine-conditioned but not unconditioned stimulant effects in mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33101, USA
    Psychopharmacology (Berl) 152:216-23. 2000
    ..In animal models, cocaine cues contribute to the development of conditioned responses to the psychomotor stimulating and rewarding effects of the drug...
  14. ncbi Effect of riluzole and gabapentin on cocaine- and methamphetamine-induced behavioral sensitization in mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33136, USA
    Psychopharmacology (Berl) 151:226-33. 2000
    ..Recent studies have suggested the involvement of excitatory amino acid (EAA) and inhibitory gamma amino butyric acid (GABA) transmission in the effects of psychostimulants such as cocaine and amphetamines...
  15. ncbi Role of the nNOS gene in ethanol-induced conditioned place preference in mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Alcohol 43:285-91. 2009
    ..Hence, inhibition of nNOS may attenuate the development of maladaptive behaviors associated with alcohol exposure...
  16. ncbi Memory reconsolidation of cocaine-associated context requires nitric oxide signaling
    Yossef Itzhak
    Department of Psychiatry and Behavioral Science, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Synapse 61:1002-5. 2007
    ..Results suggest that in the absence of nNOS activity, particularly during the reconsolidation phase, LTM of cocaine-associated context is extinguished...
  17. ncbi Role of nitrergic system in behavioral and neurotoxic effects of amphetamine analogs
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, 1011 NW 15th Street Gautier 503, University of Miami School of Medicine, Miami, FL 33136, USA
    Pharmacol Ther 109:246-62. 2006
    ..These findings, and evidence supporting the role of NO in synaptic plasticity and neurotoxic insults, suggest that NO functions as a neuronal messenger and a neurotoxicant subsequent to exposure to amphetamine-like psychostimulants...
  18. ncbi Discrimination between cocaine-associated context and cue in a modified conditioned place preference paradigm: role of the nNOS gene in cue conditioning
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Int J Neuropsychopharmacol 13:171-80. 2010
    ..Hence, this modified CPP paradigm is useful for the investigation of approach behaviour for both drug-associated context and cue, and allows further investigation of mechanisms underlying cue- and context-dependent appetitive learning...
  19. ncbi Ethanol-induced behavioral sensitization in adolescent and adult mice: role of the nNOS gene
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Alcohol Clin Exp Res 32:1839-48. 2008
    ..The current study investigated the role of the nNOS gene in the development of behavioral sensitization to ethanol in adolescent and adult mice...
  20. ncbi Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites
    Y Itzhak
    Department of Biochemistry and Molecular Biology R 629, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101, USA
    Brain Res 818:204-11. 1999
    ....
  21. ncbi Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
    Synapse 34:305-12. 1999
    ..Moreover, in contrast to nNOS deficiency, iNOS deficiency did not affect METH-induced behavioral sensitization...
  22. ncbi Effect of melatonin on methamphetamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity and methamphetamine-induced behavioral sensitization
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101, USA
    Neuropharmacology 37:781-91. 1998
    ....
  23. ncbi Differential effects of amphetamines-induced neurotoxicity on appetitive and aversive Pavlovian conditioning in mice
    Cindy Achat-Mendes
    Neuroscience Program and Department of Psychiatry and Behavioral Sciences (R-629, University of Miami School of Medicine, Miami, FL 33136, USA
    Neuropsychopharmacology 30:1128-37. 2005
    ..Modulation of Pavlovian conditioning by amphetamines-induced neurotoxicity may be relevant to compulsive drug-seeking behavior in METH and MDMA abusers...
  24. ncbi Cocaine-induced kindling is associated with elevated NMDA receptor binding in discrete mouse brain regions
    Y Itzhak
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33101, USA
    Neuropharmacology 39:32-9. 2000
    ....
  25. ncbi Differential regulation of sigma and PCP receptors after chronic administration of haloperidol and phencyclidine in mice
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Florida 33101
    FASEB J 3:1868-72. 1989
    ..This phenomenon is accompanied by an up-regulation of D-2 dopamine receptors...
  26. ncbi Impairment in consolidation of learned place preference following dopaminergic neurotoxicity in mice is ameliorated by N-acetylcysteine but not D1 and D2 dopamine receptor agonists
    Cindy Achat-Mendes
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Neuropsychopharmacology 32:531-41. 2007
    ..Restoration of brain glutathione levels immediately post-training may facilitate the consolidation process...
  27. ncbi Nitric oxide (NO) synthase inhibitors abolish cocaine-induced toxicity in mice
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Neuropharmacology 32:1069-70. 1993
    ..These findings suggest a role for NO in cocaine-induced toxicity...
  28. ncbi Modulation of the PCP/NMDA receptor complex and sigma binding sites by psychostimulants
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Neurotoxicol Teratol 16:363-8. 1994
    ..The methamphetamine-related studies insinuate a potential role of sigma-1 binding sites in psychostimulant-induced behavioral disorders...
  29. ncbi Blockade of alcohol-induced locomotor sensitization and conditioned place preference in DBA mice by 7-nitroindazole
    Y Itzhak
    Department of Psychiatry and Behavioral Science R 629, Room 503, Gautier Building, University of Miami School of Medicine, Miami, FL 33101, USA
    Brain Res 858:402-7. 2000
    ..These findings support the role of NO in ethanol actions and further suggest that the nNOS system is relevant to the rewarding effects of various drugs of abuse...
  30. ncbi Inhibition of neuronal nitric oxide synthase suppresses the maintenance but not the induction of psychomotor sensitization to MDMA ('Ecstasy') and p-chloroamphetamine in mice
    Karen L Anderson
    Department of Psychiatry and Behavioral Science, University of Miami School of Medicine, Miami, FL 33136, USA
    Nitric Oxide 9:24-32. 2003
    ..b) The maintenance of psychomotor sensitization is dependent on intact nNOS activity and involves primarily dopaminergic transmission...
  31. ncbi Long-term memory of visually cued fear conditioning: roles of the neuronal nitric oxide synthase gene and cyclic AMP response element-binding protein
    J B Kelley
    Division of Neuroscience, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Neuroscience 174:91-103. 2011
    ..These findings suggest that visual cue-dependent LTM is impaired in nNOS KO mice, and aberrant modulation of CREB in the absence of the nNOS gene may hinder cued and contextual LTM formation...
  32. ncbi Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood
    C Achat-Mendes
    The Neuroscience Program and Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA
    Neuropharmacology 45:106-15. 2003
    ....
  33. ncbi Differential role of the nNOS gene in the development of behavioral sensitization to cocaine in adolescent and adult B6;129S mice
    Mara A Balda
    Neuroscience Program, University of Miami School of Medicine, Miami, FL, USA
    Psychopharmacology (Berl) 200:509-19. 2008
    ..Previous studies have suggested the involvement of neuronal nitric oxide synthase (nNOS) in the development of sensitization to psychostimulants. Ontogeny-dependent differences in the response to psychostimulants have been reported...
  34. ncbi Binding of umespirone to the sigma receptor: evidence for multiple affinity states
    Y Itzhak
    Department of Biochemistry and Molecular Biology, REPSCEND Labs, University of Miami School of Medicine, Florida 33101
    Neuropharmacology 29:181-4. 1990
    ..These findings suggest that different coupling states of the sigma receptor may be associated with the binding of umespirone and buspirone compared to the binding of haloperidol and chlorpromazine...
  35. ncbi Sigma binding sites in the brain; an emerging concept for multiple sites and their relevance for psychiatric disorders
    Y Itzhak
    Department of Biochemistry and Molecular Biology, REPSCEND Labs, University of Miami School of Medicine, FL 33101
    Life Sci 47:1073-81. 1990
    ..Revealing the existence of sigma receptor subtypes may help to elucidate their association with various psychiatric disorders...
  36. ncbi Effect of ibogaine on the various sites of the NMDA receptor complex and sigma binding sites in rat brain
    Y Itzhak
    Department of Biochemistry and Molecular Biology R 629, University of Miami School of Medicine, Florida 33101, USA
    Ann N Y Acad Sci 844:245-51. 1998
    ..In turn, ibogaine interaction with sigma binding sites may be associated with its adverse effects...
  37. ncbi Adolescent and adult responsiveness to the incentive value of cocaine reward in mice: role of neuronal nitric oxide synthase (nNOS) gene
    Mara A Balda
    Neuroscience Program, University of Miami School of Medicine, Miami, FL 33136, USA
    Neuropharmacology 51:341-9. 2006
    ..Sexual dimorphism in response to cocaine CPP emerges in adulthood; nNOS contribution to long-term plasticity is therefore sexually dimorphic and age-dependent in female but not in male subjects...
  38. ncbi Impairments in fear conditioning in mice lacking the nNOS gene
    Jonathan B Kelley
    Division of Neuroscience, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Learn Mem 16:371-8. 2009
    ..Results suggest that the nNOS gene contributes more to optimal contextual fear learning than to cued fear learning, and therefore, inhibition of the nNOS enzyme may ameliorate context-dependent fear response...
  39. ncbi Long-term memory of cocaine-associated context: disruption and reinstatement
    Jonathan B Kelley
    Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Neuroreport 18:777-80. 2007
    ..Challenge administration of cocaine reinstated place preference in all groups except the MK-801 group, suggesting that suppression of conditioned response may or may not suppress memory evoked by drug-context reexposure...
  40. ncbi Different modulation of the binding to two phencyclidine (PCP) receptor subtypes: effects of N-methyl-D-aspartate agonists and antagonists
    Y Itzhak
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Neurosci Lett 104:314-9. 1989
    ..The present results indicate that the high (sigma p) and low-affinity (PCP) sites, that are distinct from the sigma h site, are affected differently by NMDA agonists and antagonists, and thus may represent different receptor domains...
  41. ncbi Repeated administration of gamma-hydroxybutyric acid (GHB) to mice: assessment of the sedative and rewarding effects of GHB
    Yossef Itzhak
    Department of Psychiatry and Behavioral Science, University of Miami School of Medicine, Miami, Florida 33136, USA
    Ann N Y Acad Sci 965:451-60. 2002
    ..Further studies are necessary to determine the mechanism underlying the development of tolerance to GHB and the rewarding effect of the drug...
  42. ncbi Development and persistence of long-lasting behavioral sensitization to cocaine in female mice: role of the nNOS gene
    Mara A Balda
    Neuroscience Program, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB 6001 R 50, Miami, FL 33136, USA
    Neuropharmacology 56:709-15. 2009
    ..The present study suggests that long-term expression of cocaine-induced behavioral sensitization in females (adolescent and adult) is nNOS-independent, unlike our previous findings in adult males...
  43. ncbi Long-lasting behavioral sensitization to psychostimulants following p-chloroamphetamine-induced neurotoxicity in mice
    Yossef Itzhak
    Department of Psychiatry and Behavioral Sciences R 629, University of Miami School of Medicine, Miami, FL 33136
    Neuropharmacology 46:74-84. 2004
    ..These findings may be relevant to the psychopathology of amphetamines-induced neurotoxicity...
  44. ncbi The neuronal nitric oxide synthase (nNOS) gene contributes to the regulation of tyrosine hydroxylase (TH) by cocaine
    Mara A Balda
    Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Neurosci Lett 457:120-4. 2009
    ..Thus, the nitrergic system may contribute to cocaine-induced behavioral sensitization by regulating dopaminergic neurotransmission...
  45. ncbi Behavioral consequences of methamphetamine-induced neurotoxicity in mice: relevance to the psychopathology of methamphetamine addiction
    Yossef Itzhak
    Department of Psychiatry and Behavioral Science, University of Miami School of Medicine, Miami, Florida 33136, USA
    Ann N Y Acad Sci 965:127-35. 2002
    ..These consequences may be relevant to the psychopathology of METH abuse. Sensitization is pertinent to compulsive drug-seeking behavior that is accompanied by desensitization to the rewarding effect of METH...
  46. ncbi Methamphetamine-induced selective dopaminergic neurotoxicity is accompanied by an increase in striatal nitrate in the mouse
    Karen L Anderson
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Gautier Building 503, 1011 NW 15th Street, Miami, FL 33136, USA
    Ann N Y Acad Sci 1074:225-33. 2006
    ....
  47. ncbi Binding of sigma-ligands to C57BL/6 mouse brain membranes: effects of monoamine oxidase inhibitors and subcellular distribution studies suggest the existence of sigma-receptor subtypes
    Y Itzhak
    Department of Biochemistry and Molecular Biology, REPSCEND Laboratories, University of Miami School of Medicine, Florida 33101
    J Pharmacol Exp Ther 257:141-8. 1991
    ..abstract truncated at 250 words)..
  48. ncbi Pharmacological modulators of nitric oxide signaling and contextual fear conditioning in mice
    Jonathan B Kelley
    Division of Neuroscience, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Psychopharmacology (Berl) 210:65-74. 2010
    ..Our recent studies have shown that nNOS knockout (KO) mice have a severe deficit in contextual fear conditioning compared to wild type (WT) counterparts (Kelley et al. 2009)...
  49. ncbi Role of peroxynitrite in methamphetamine-induced dopaminergic neurodegeneration and neuroprotection by antioxidants and selective NOS inhibitors
    Syed F Ali
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 1053:97-8. 2005

Research Grants12

  1. Reconsolidation and extinction processes in the treatment of drug addiction
    Yossef Itzhak; Fiscal Year: 2010
    ..abstract_text> ..
  2. Adolescent Exposure to Psychostimulants: Role of nNOS
    Yossef Itzhak; Fiscal Year: 2007
    ..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
  3. Substituted Amphetamines: NO-Dependent Mechanisms
    Yossef Itzhak; Fiscal Year: 2005
    ....