Research Topics
Genomes and Genes | Brant IsaksonSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
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Publications
Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communicationBrant E Isakson
Robert M Berne Cardiovascular Research Center, and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, P O Box 801394, Charlottesville, VA 22908, USA
J Cell Sci 121:3664-73. 2008..This data implicates the MEJ as being a unique cell-signaling domain in the vasculature...
Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junctionBrant E Isakson
Department of Molecular Physiology and Biological Physics, Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville 22908, USA
Circ Res 100:246-54. 2007..We conclude that 1,4,5-trisphosphate and Ca2+ originating in the VSMCs induces the secondary increase in EC [Ca2+]i but stimulation of the ECs generates a Ca2+ dependent response in the VSMCs...- Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cellsBrant E Isakson
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, University of Virginia Charlottesville, Virginia 22908, USA
Respir Res 7:105. 2006.... - Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communicationBrant E Isakson
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Arterioscler Thromb Vasc Biol 26:2216-21. 2006..Lipoprotein-derived phospholipid oxidation products (OxPAPC) play a critical role in atherosclerosis, and we hypothesized that they may act as trigger molecules causing the changes in connexin expression... - Plasminogen activator inhibitor-1 regulates myoendothelial junction formationKatherine R Heberlein
Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Circ Res 106:1092-102. 2010..Plasminogen activator inhibitor-1 (PAI-1) is a biomarker for several vascular disease states; however, its target of action within the vessel wall is undefined... - Site-specific connexin phosphorylation is associated with reduced heterocellular communication between smooth muscle and endotheliumAdam C Straub
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
J Vasc Res 47:277-86. 2010..The functional consequences of phosphorylation state of the connexins (Cx) at the MEJ have not been explored... - Heterocellular contact at the myoendothelial junction influences gap junction organizationBrant E Isakson
Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville 22908, USA
Circ Res 97:44-51. 2005..We speculate that specific gap junction organization may be a vital component of EC-VSMC contact at the MEJ... - Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulationBrant E Isakson
Department of Molecular Physiology and Biological Physics, Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 290:H1199-205. 2006.... - Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylationBrant E Isakson
Department of Molecular Physiology and Biological Physics, University of Virginia Health Science System, Charlottesville, Virginia, USA
Am J Physiol Heart Circ Physiol 294:H2898-904. 2008.... - Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferationScott R Johnstone
University of Virginia School of Medicine, PO Box 801394 Charlottesville VA 29908, USA
Am J Pathol 175:916-24. 2009..Taken together, these results demonstrate that post-translational phosphorylation of Cx43 could be a key factor in the pathogenesis of atherosclerosis... - Biological and biophysical properties of vascular connexin channelsScott Johnstone
Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 29908, USA
Int Rev Cell Mol Biol 278:69-118. 2009.... - Connexins: gaps in our knowledge of vascular functionXavier F Figueroa
Department of Molecular Physiology and Biological Physics, Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
Physiology (Bethesda) 19:277-84. 2004.... - Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2Alexandra Kadl
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Circ Res 107:737-46. 2010..In atherosclerosis, oxidative tissue damage accompanies chronic inflammation; however, macrophage phenotypic changes in response to oxidatively modified molecules are not known... - The myoendothelial junction: breaking through the matrix?Katherine R Heberlein
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottsville, Virginia 22908, USA
Microcirculation 16:307-22. 2009..We will also highlight the need for novel approaches to studying the myoendothelial junction in order to comprehend the cellular biology associated with this structure... - Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstrictionMarie Billaud
Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Circ Res 109:80-5. 2011..Pannexins (Panx) are purine-releasing channels permeable to the vasoconstrictor ATP and thus may play a role in the coordination of vascular smooth muscle cell constriction... - Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wallAdam C Straub
Department of Molecular Physiology and Biological Physics, Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Arterioscler Thromb Vasc Biol 31:399-407. 2011..To determine whether S-nitrosylation of connexins (Cxs) modulates gap junction communication between endothelium and smooth muscle... - The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gatingEllen C Merrick
Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, 22908 0710, USA
Pflugers Arch 460:743-53. 2010..These studies suggest that modification of beta3S161 may be important in modulating Na-channel gating... - Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosisFaraaz B Chekeni
Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
Nature 467:863-7. 2010..Collectively, these data identify PANX1 as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases... - Vascular gap junctions in hypertensionXavier F Figueroa
, , , , Santiago, Chile
Hypertension 48:804-11. 2006 - Cell-cell communication in heterocellular cultures of alveolar epithelial cellsBrant E Isakson
Department of Physiology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
Am J Respir Cell Mol Biol 29:552-61. 2003..In conclusion, AT1 and AT2 cells have unique connexin profiles that allow for functional coupling and distinct intercellular pathways for coordination of Ca2+ signaling... - Culturing alveolar type I, alveolar type II, and mixed cell populations by altering the extracellular matrix promotes changes in intercellular signaling mechanismsScott Boitano
Department of Zollogy, University of Wyoming, Laramie, WY 82071-3166, USA
Chest 121:35S-36S. 2002 - Extracellular matrix-driven alveolar epithelial cell differentiation in vitroColin O Olsen
Arizona Respiratory Center, University of Arizona Health Sciences Center, Tucson, AZ 85724-5051, USA
Exp Lung Res 31:461-82. 2005....
Research Grants
- Vascular Cell Regulation of ConnexinsBrant Isakson; Fiscal Year: 2005..These results will be compared to similar experiments on in situ wild type and connexin KO animals. Combined, these methods will help delineate the physiological role of connexins between EC and SMC. ..
- Mechanisms of Heterocellular Signaling at the Myoendothelial JunctionBrant Isakson; Fiscal Year: 2009..We propose to study the ways in which vascular cells utilize this structure to maintain vascular function. ..
- Mechanisms of Heterocellular Signaling at the Myoendothelial JunctionBrant E Isakson; Fiscal Year: 2010..We propose to study the ways in which vascular cells utilize this structure to maintain vascular function. ..